{"id":"https://openalex.org/W40206965","doi":null,"title":"Cell death and autophagy in prion diseases (transmissible spongiform encephalopathies).","display_name":"Cell death and autophagy in prion diseases (transmissible spongiform encephalopathies).","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W40206965","mag":"40206965","pmid":"https://pubmed.ncbi.nlm.nih.gov/18368623"},"language":"en","primary_location":{"id":"pmid:18368623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18368623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia neuropathologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000781573","display_name":"Pawel Piotr Liberski","orcid":"https://orcid.org/0000-0001-6507-4682","observed_orcids":["https://orcid.org/0000-0001-6507-4682"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Pawe\u0142 P Liberski","raw_affiliation_strings":["Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechos\u0142owacka Str. 8/10, PL 92-216 Lodz, Poland. ppliber@csk.am.lodz.pl","Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechos\u0142owacka Str. 8/10, PL 92-216 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechos\u0142owacka Str. 8/10, PL 92-216 Lodz, Poland. ppliber@csk.am.lodz.pl","institution_ids":["https://openalex.org/I4210122071"]},{"raw_affiliation_string":"Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University of Lodz, Czechos\u0142owacka Str. 8/10, PL 92-216 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106267422","display_name":"David R. Brown","orcid":"https://orcid.org/0000-0002-0774-6660","observed_orcids":["https://orcid.org/0000-0002-0774-6660","https://orcid.org/0000-0002-8057-3532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David R Brown","raw_affiliation_strings":["Department of Biology & Biochemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology & Biochemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086353611","display_name":"Beata Sikorska","orcid":"https://orcid.org/0000-0002-6166-0729","observed_orcids":["https://orcid.org/0000-0002-6166-0729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beata Sikorska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015110041","display_name":"Byron W. Caughey","orcid":"https://orcid.org/0000-0002-3928-6101","observed_orcids":["https://orcid.org/0000-0002-3928-6101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Byron Caughey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111754420","display_name":"Paul Brown","orcid":"https://orcid.org/0000-0001-5778-3921","observed_orcids":["https://orcid.org/0000-0001-5778-3921"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.68,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.82207004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"46","issue":"1","first_page":"1","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.625},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9520000219345093},{"id":"https://openalex.org/keywords/scrapie","display_name":"scrapie","score":0.9309999942779541},{"id":"https://openalex.org/keywords/creutzfeldt-jakob-disease","display_name":"Creutzfeldt-Jakob disease","score":1.0},{"id":"https://openalex.org/keywords/gerstmann-straussler-scheinker-disease","display_name":"Gerstmann-Str\u00e4ussler-Scheinker disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neuronal-autophagy","display_name":"neuronal autophagy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6589999794960022},{"id":"https://openalex.org/keywords/autophagosomes","display_name":"autophagosomes","score":0.875},{"id":"https://openalex.org/keywords/phagophore","display_name":"phagophore","score":0.8330000042915344},{"id":"https://openalex.org/keywords/spongiform-change","display_name":"spongiform change","score":0.7649999856948853},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6269999742507935},{"id":"https://openalex.org/keywords/ultrastructure","display_name":"ultrastructure","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9166244268417358},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.7857915163040161},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.7051516771316528},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6584125757217407},{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.6303485631942749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6167460083961487},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5317671895027161},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5303806662559509},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.42258816957473755},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.39355048537254333},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.212074875831604},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.20540142059326172},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12849292159080505},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12553530931472778},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11325305700302124}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017096","descriptor_name":"Prion Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:18368623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18368623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia neuropathologica","raw_type":"Journal Article"},{"id":"mag:40206965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18368623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":217,"referenced_works":["https://openalex.org/W1919353","https://openalex.org/W11267032","https://openalex.org/W56828148","https://openalex.org/W60161883","https://openalex.org/W94090931","https://openalex.org/W202230252","https://openalex.org/W260452285","https://openalex.org/W297192346","https://openalex.org/W593173282","https://openalex.org/W1482715126","https://openalex.org/W1501494207","https://openalex.org/W1518703223","https://openalex.org/W1538599226","https://openalex.org/W1546700254","https://openalex.org/W1555231682","https://openalex.org/W1559460715","https://openalex.org/W1565265443","https://openalex.org/W1567267284","https://openalex.org/W1590689549","https://openalex.org/W1601881612","https://openalex.org/W1665321266","https://openalex.org/W1840182669","https://openalex.org/W1911014954","https://openalex.org/W1940885739","https://openalex.org/W1964207820","https://openalex.org/W1966134982","https://openalex.org/W1966227823","https://openalex.org/W1968590175","https://openalex.org/W1969415733","https://openalex.org/W1969523109","https://openalex.org/W1970101770","https://openalex.org/W1972594822","https://openalex.org/W1972644169","https://openalex.org/W1973758214","https://openalex.org/W1974433806","https://openalex.org/W1976207582","https://openalex.org/W1976881265","https://openalex.org/W1977432546","https://openalex.org/W1978525961","https://openalex.org/W1979645116","https://openalex.org/W1979856683","https://openalex.org/W1981659565","https://openalex.org/W1982013273","https://openalex.org/W1983292653","https://openalex.org/W1983773095","https://openalex.org/W1985541773","https://openalex.org/W1988005785","https://openalex.org/W1988146888","https://openalex.org/W1989280794","https://openalex.org/W1989801066","https://openalex.org/W1990365858","https://openalex.org/W1990496336","https://openalex.org/W1991825448","https://openalex.org/W1992380356","https://openalex.org/W1992777459","https://openalex.org/W1992933724","https://openalex.org/W1993772386","https://openalex.org/W1995227965","https://openalex.org/W1997973599","https://openalex.org/W1998038512","https://openalex.org/W1999689502","https://openalex.org/W1999758221","https://openalex.org/W2000427115","https://openalex.org/W2000966016","https://openalex.org/W2001312162","https://openalex.org/W2001464510","https://openalex.org/W2002295768","https://openalex.org/W2003074946","https://openalex.org/W2003676486","https://openalex.org/W2003887174","https://openalex.org/W2003938285","https://openalex.org/W2007554792","https://openalex.org/W2008964073","https://openalex.org/W2009125409","https://openalex.org/W2010238780","https://openalex.org/W2010745676","https://openalex.org/W2010802455","https://openalex.org/W2010864265","https://openalex.org/W2011196873","https://openalex.org/W2012337697","https://openalex.org/W2013679718","https://openalex.org/W2014388432","https://openalex.org/W2014408427","https://openalex.org/W2014742609","https://openalex.org/W2016660810","https://openalex.org/W2017330882","https://openalex.org/W2018407130","https://openalex.org/W2018567511","https://openalex.org/W2020258831","https://openalex.org/W2020312730","https://openalex.org/W2022131253","https://openalex.org/W2022607259","https://openalex.org/W2022680168","https://openalex.org/W2022993326","https://openalex.org/W2023290470","https://openalex.org/W2024613070","https://openalex.org/W2026534774","https://openalex.org/W2027111333","https://openalex.org/W2030402168","https://openalex.org/W2031445552","https://openalex.org/W2032244004","https://openalex.org/W2032706649","https://openalex.org/W2033268132","https://openalex.org/W2033367680","https://openalex.org/W2033601813","https://openalex.org/W2033917233","https://openalex.org/W2036645353","https://openalex.org/W2037138700","https://openalex.org/W2039386747","https://openalex.org/W2040609276","https://openalex.org/W2043400793","https://openalex.org/W2045831455","https://openalex.org/W2046205790","https://openalex.org/W2048173584","https://openalex.org/W2048523654","https://openalex.org/W2049055716","https://openalex.org/W2049987625","https://openalex.org/W2050093417","https://openalex.org/W2050710246","https://openalex.org/W2051968416","https://openalex.org/W2052517492","https://openalex.org/W2052853635","https://openalex.org/W2055793916","https://openalex.org/W2056641170","https://openalex.org/W2057418115","https://openalex.org/W2059277667","https://openalex.org/W2060107355","https://openalex.org/W2060941647","https://openalex.org/W2062354055","https://openalex.org/W2063561762","https://openalex.org/W2063691494","https://openalex.org/W2064568495","https://openalex.org/W2064584577","https://openalex.org/W2065193233","https://openalex.org/W2065698593","https://openalex.org/W2066743763","https://openalex.org/W2069361823","https://openalex.org/W2069485016","https://openalex.org/W2071212117","https://openalex.org/W2071742401","https://openalex.org/W2074150291","https://openalex.org/W2074400407","https://openalex.org/W2075442841","https://openalex.org/W2076133781","https://openalex.org/W2076847487","https://openalex.org/W2077657292","https://openalex.org/W2079521468","https://openalex.org/W2080671690","https://openalex.org/W2084063267","https://openalex.org/W2085805177","https://openalex.org/W2087174680","https://openalex.org/W2089246382","https://openalex.org/W2090175640","https://openalex.org/W2090202861","https://openalex.org/W2094297139","https://openalex.org/W2096510701","https://openalex.org/W2096794529","https://openalex.org/W2096816363","https://openalex.org/W2106306100","https://openalex.org/W2106922949","https://openalex.org/W2107660566","https://openalex.org/W2108086395","https://openalex.org/W2110420813","https://openalex.org/W2110484308","https://openalex.org/W2111648866","https://openalex.org/W2114549971","https://openalex.org/W2117064662","https://openalex.org/W2119616506","https://openalex.org/W2120130639","https://openalex.org/W2120361396","https://openalex.org/W2125522501","https://openalex.org/W2127568474","https://openalex.org/W2129777335","https://openalex.org/W2130285871","https://openalex.org/W2135894785","https://openalex.org/W2138498069","https://openalex.org/W2138645012","https://openalex.org/W2141757780","https://openalex.org/W2141976152","https://openalex.org/W2143969927","https://openalex.org/W2144467901","https://openalex.org/W2146705631","https://openalex.org/W2147017863","https://openalex.org/W2148354219","https://openalex.org/W2151169588","https://openalex.org/W2154109443","https://openalex.org/W2155866692","https://openalex.org/W2156848898","https://openalex.org/W2158707059","https://openalex.org/W2163067377","https://openalex.org/W2163376053","https://openalex.org/W2163981524","https://openalex.org/W2164599456","https://openalex.org/W2166840790","https://openalex.org/W2167503783","https://openalex.org/W2167907490","https://openalex.org/W2167916354","https://openalex.org/W2169109742","https://openalex.org/W2169760747","https://openalex.org/W2171147265","https://openalex.org/W2278124818","https://openalex.org/W2304202484","https://openalex.org/W2327641970","https://openalex.org/W2328267773","https://openalex.org/W2339865699","https://openalex.org/W2344511082","https://openalex.org/W2401269904","https://openalex.org/W2411498687","https://openalex.org/W2418109182","https://openalex.org/W2418883384","https://openalex.org/W2420625032","https://openalex.org/W2435337713","https://openalex.org/W2443413629","https://openalex.org/W2474773927","https://openalex.org/W2571798331","https://openalex.org/W2754124062","https://openalex.org/W2885806081"],"related_works":["https://openalex.org/W2745718161","https://openalex.org/W2007554792","https://openalex.org/W2146705631","https://openalex.org/W7099633955","https://openalex.org/W2418065750","https://openalex.org/W4299496667","https://openalex.org/W2121592144","https://openalex.org/W3081572556","https://openalex.org/W2338617749","https://openalex.org/W2011196873"],"abstract_inverted_index":{"Neuronal":[0],"autophagy,":[1],"like":[2],"apoptosis,":[3],"is":[4,51],"one":[5],"of":[6,9,38,49,56,64,71,81,85,91,94,115,138],"the":[7,35,57,69,72,82,86,113,136],"mechanisms":[8],"programmed":[10],"cell":[11],"death.":[12],"In":[13],"this":[14],"review,":[15],"we":[16,118],"summarize":[17],"current":[18],"information":[19],"about":[20],"autophagy":[21,121],"in":[22,41,103,108,127,135],"naturally":[23],"occurring":[24],"and":[25,31,74,110,131],"experimentally":[26],"induced":[27],"scrapie,":[28],"Creutzfeldt-Jakob":[29],"disease":[30],"Gerstmann-Str\u00e4ussler-Scheinker":[32],"syndrome":[33],"against":[34],"broad":[36],"background":[37],"neural":[39],"degenerations":[40],"transmissible":[42,128],"spongiform":[43,129,139],"encephalopathies":[44,130],"(TSEs).":[45],"Typically":[46],"a":[47,54,78,89,124],"sequence":[48],"events":[50],"observed:":[52],"from":[53],"part":[55],"neuronal":[58,104],"cytoplasm":[59,73,87],"sequestrated":[60],"by":[61],"concentric":[62],"arrays":[63],"double":[65],"membranes":[66],"(phagophores);":[67],"through":[68],"enclosure":[70],"membrane":[75],"proliferation;":[76],"to":[77],"final":[79],"transformation":[80],"large":[83],"area":[84],"into":[88],"collection":[90],"autophagic":[92,98],"vacuoles":[93,99],"different":[95],"sizes.":[96],"These":[97],"form":[100],"not":[101],"only":[102],"perikarya":[105],"but":[106],"also":[107],"neurites":[109],"synapses.":[111],"On":[112],"basis":[114],"ultrastructural":[116],"studies,":[117],"suggest":[119],"that":[120],"may":[122,132],"play":[123],"major":[125],"role":[126],"even":[133],"participate":[134],"formation":[137],"change.":[140]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}