{"id":"https://openalex.org/W401505223","doi":"https://doi.org/10.1182/blood.v122.21.4638.4638","title":"Maintenance Therapy With Decitabine After Allogeneic Hematopoietic Stem Cell Transplantation For Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome","display_name":"Maintenance Therapy With Decitabine After Allogeneic Hematopoietic Stem Cell Transplantation For Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W401505223","doi":"https://doi.org/10.1182/blood.v122.21.4638.4638","mag":"401505223"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.4638.4638","doi":"https://doi.org/10.1182/blood.v122.21.4638.4638","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.4638.4638","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041735776","display_name":"Iskra Pusic","orcid":"https://orcid.org/0000-0003-1725-5184","observed_orcids":["https://orcid.org/0000-0003-1725-5184"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iskra Pusic","raw_affiliation_strings":["Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048630838","display_name":"Jaebok Choi","orcid":"https://orcid.org/0000-0002-5590-087X","observed_orcids":["https://orcid.org/0000-0002-5590-087X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaebok Choi","raw_affiliation_strings":["Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020366313","display_name":"Noel Bernabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noel Bernabe","raw_affiliation_strings":["Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103189440","display_name":"Camille N. Abboud","orcid":"https://orcid.org/0000-0002-5469-8534","observed_orcids":["https://orcid.org/0000-0002-5469-8534"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Camille N. Abboud","raw_affiliation_strings":["Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105528827","display_name":"Peter Westervelt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Westervelt","raw_affiliation_strings":["Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026151069","display_name":"Ravi Vij","orcid":"https://orcid.org/0000-0001-8795-3610","observed_orcids":["https://orcid.org/0000-0001-8795-3610"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Vij","raw_affiliation_strings":["Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108089232","display_name":"Amanda F. Cashen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda F Cashen","raw_affiliation_strings":["Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101423957","display_name":"Geoffrey L. Uy","orcid":"https://orcid.org/0000-0002-7809-0996","observed_orcids":["https://orcid.org/0000-0002-7809-0996"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey L. Uy","raw_affiliation_strings":["Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090424930","display_name":"Keith E Stockerl-Goldstein","orcid":"https://orcid.org/0000-0002-7234-1715","observed_orcids":["https://orcid.org/0000-0002-7234-1715"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith E. Stockerl-Goldstein","raw_affiliation_strings":["Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA,","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065066309","display_name":"John F. DiPersio","orcid":"https://orcid.org/0000-0002-0429-3133","observed_orcids":["https://orcid.org/0000-0002-0429-3133"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F. Dipersio","raw_affiliation_strings":["Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.475,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.68016362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"122","issue":"21","first_page":"4638","last_page":"4638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.09880000352859497,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.949999988079071},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9300000071525574},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.7950000166893005},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.7409999966621399},{"id":"https://openalex.org/keywords/graft-versus-leukemia-effect","display_name":"graft-versus-leukemia effect","score":0.8410000205039978},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.9115156531333923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.736238420009613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6264677047729492},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.5860303640365601},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.5717236399650574},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5665876865386963},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5627442002296448},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5066426396369934},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5015554428100586},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.49403125047683716},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.4896250367164612},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44725021719932556},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36263519525527954},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.21683278679847717},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.13600802421569824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09600445628166199},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.4638.4638","doi":"https://doi.org/10.1182/blood.v122.21.4638.4638","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.4638.4638","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1781634362","https://openalex.org/W2981122202","https://openalex.org/W4387836829","https://openalex.org/W3173188761","https://openalex.org/W7153550616","https://openalex.org/W3194812359","https://openalex.org/W2551253683","https://openalex.org/W4396937412","https://openalex.org/W2558107506","https://openalex.org/W2337047365"],"abstract_inverted_index":{"Introduction":[0],"Disease":[1],"recurrence":[2],"is":[3,29,42,261,268,539,563,609],"the":[4,30,99,105,189,206,215,225,540,552,574],"major":[5,31],"cause":[6,32],"of":[7,33,57,101,107,165,172,195,209,352,399,446,459,466,479,543,554,579,590,595,602,612],"treatment":[8],"failure":[9],"after":[10,38,82,124,148,299,314,336,349,367,470,548,636],"allogeneic":[11],"hematopoietic":[12],"stem":[13],"cell":[14],"transplantation":[15],"(alloHSCT)":[16],"for":[17,169,311,319,331,557],"acute":[18,135,423,457,498],"myeloid":[19],"leukemia":[20],"(AML)":[21],"and":[22,36,50,68,84,131,146,158,236,248,256,287,291,325,333,361,393,415,429,461,485,503,519,565,592],"myelodysplastic":[23],"syndrome":[24],"(MDS).":[25],"Graft-versus-host":[26],"disease":[27,67,321],"(GVHD)":[28],"non-relapse":[34],"morbidity":[35],"mortality":[37],"alloHSCT.":[39,149,300,549,637],"Decitabine":[40,634],"(DAC)":[41],"a":[43,70,95,166,170,257,359,599,610],"hypomethylating":[44],"agent":[45],"that":[46,448,468,598],"irreversibly":[47],"binds":[48],"to":[49,55,78,139,223,426,501,583],"inhibits":[51],"DNA":[52,58],"methyltransferase-1,":[53],"leading":[54],"loss":[56],"methylation.":[59],"DAC":[60,74,91,153,353,380,428,447,467,480,544,550],"maintenance":[61,92,381,546,635],"may":[62,93],"help":[63],"eradicate":[64],"minimal":[65],"residual":[66],"facilitate":[69],"graft-versus-leukemia":[71],"effect.":[72],"Lower":[73],"doses":[75],"are":[76,373,628],"expected":[77],"be":[79,567,605],"better":[80],"tolerated":[81],"alloHSCT":[83,267],"equally":[85],"effective":[86],"in":[87,120,282,569,573],"promoting":[88],"hypomethylation.":[89],"Additionally,":[90],"have":[94,253,341,522],"favorable":[96],"effect":[97,106],"on":[98,375,433,451],"incidence":[100,594],"GVHD":[102,136,211,424,441,458,488,499,508,529,596],"by":[103],"enhancing":[104],"T-regulatory":[108],"lymphocytes":[109],"(Choi":[110],"et":[111],"al,":[112],"Blood,":[113],"2012).":[114],"Methods":[115],"Patients":[116],"(pts)":[117],"with":[118,126,284,443],"AML/MDS":[119],"complete":[121],"remission":[122],"(CR)":[123],"alloHSCT,":[125],"ANC>":[127],"1,500/mm3,":[128],"platelets>":[129],"50,000/mm3,":[130],"without":[132],"grade":[133,390,410,421,438],"III-IV":[134],"were":[137,221,242,246,355,388,409,581,617],"eligible":[138],"receive":[140,584],"DAC,":[141],"starting":[142,427],"between":[143],"day":[144],"+50":[145],"+100":[147],"We":[150],"investigated":[151],"4":[152],"doses:":[154],"5,":[155],"7.5,":[156],"10":[157],"15":[159,555],"mg/m2/day":[160],"IV":[161,439],"x":[162],"5":[163,237,249,326,558],"days":[164,559],"6-week":[167],"cycle,":[168],"total":[171],"8":[173,272,277,477,586],"cycles.":[174,587],"Each":[175],"cohort":[176,260],"contained":[177],"4-8":[178],"evaluable":[179],"patients.":[180],"The":[181,588],"Maximum":[182],"Tolerated":[183],"Dose":[184],"(MTD)":[185],"was":[186,213,228,382,396],"defined":[187],"as":[188,545],"maximum":[190],"dose":[191,201,553],"at":[192,214,358,551],"which<":[193],"20%":[194],"patients":[196],"experience":[197],"hematologic":[198],"or":[199],"non-hematologic":[200],"limiting":[202],"toxicities":[203,387,408,591],"(DLT)":[204],"during":[205],"1st":[207],"cycle":[208,307,445,465,517],"treatment.":[210],"prophylaxis":[212],"physician":[216,337],"discretion.":[217],"Results":[218],"19":[219],"pts":[220,233,273,280,302,318,330,335,340,372,419,474,511,572,580],"enrolled":[222],"date;":[224],"median":[226],"age":[227],"60":[229],"y":[230,366],"(22-66);":[231],"14":[232,244],"had":[234,420],"AML":[235],"MDS.":[238],"All":[239],"conditioning":[240],"regimens":[241],"myeloablative;":[243],"donors":[245],"unrelated":[247],"related.":[250],"3":[251,317,343,350],"cohorts":[252],"been":[254,405],"completed":[255,275,476],"final":[258],"4th":[259],"currently":[262],"enrolling.":[263],"Median":[264],"follow-up":[265],"from":[266,344,347],"24":[269],"mo":[270,298],"(7-36).":[271],"(44%)":[274],"all":[276,585],"cycles:":[278],"7":[279],"remain":[281],"CR":[283],"stable":[285],"counts":[286],"full":[288],"donor":[289],"chimerism":[290],"1":[292,309,362,435,453,504],"pt":[293,310,436,454,495,505],"developed":[294,437,455,481,496,506,526],"CNS-only":[295],"relapse":[296],"26":[297],"9":[301],"went":[303,513],"off":[304,369,514],"study":[305,376,515],"before":[306],"6:":[308],"poor":[312],"compliance":[313],"6":[315,339,561],"cycles,":[316,327],"relapsed":[320],"(after":[322],"1,":[323],"2":[324,329,334,346,371,418],"respectively),":[328],"sepsis,":[332],"decision.":[338],"died:":[342],"relapse,":[345,525],"sepsis":[348,364],"cycles":[351,478],"(they":[354],"not":[356,489,521,618],"neutropenic":[357],"time),":[360],"form":[363],">1":[365],"getting":[368],"study.":[370],"still":[374],"passed":[377],"3rd":[378],"cycle.":[379],"well":[383],"tolerated.":[384],"Associated":[385],"hematological":[386,400],"mostly":[389],"I/II":[391,411],"leukopenia":[392],"thrombocytopenia.":[394],"There":[395],"one":[397],"occurrence":[398],"DLT.":[401],"No":[402],"MTD":[403],"has":[404],"reached.":[406],"Non-hematological":[407],"nausea,":[412],"fatigue,":[413],"neuropathy,":[414],"transaminase":[416],"elevation.":[417],"I-II":[422],"prior":[425,516],"both":[430],"resolved":[431,450,469],"while":[432],"DAC;":[434,452],"gut":[440],"coinciding":[442],"first":[444,541],"completely":[449],"late":[456,497],"skin":[460,484],"liver":[462],"around":[463],"6th":[464],"few":[471],"wks.":[472],"2/8":[473],"who":[475,512],"very":[482],"mild":[483],"oral":[486],"chronic":[487,528],"requiring":[490,530],"any":[491],"systemic":[492],"therapy,":[493,502],"1/8":[494],"responding":[500],"overlap":[507],"syndrome.":[509],"4/7":[510],"6,":[518],"did":[520],"an":[523],"early":[524],"severe":[527],"intensive":[531],"immunosuppressive":[532],"therapy.":[533],"Conclusion":[534],"To":[535],"our":[536],"knowledge":[537],"this":[538],"report":[542],"therapy":[547],"mg/m2":[556],"every":[560],"weeks":[562],"safe":[564],"can":[566],"administered":[568],"heavily":[570],"pretreated":[571],"post-alloHSCT":[575],"setting.":[576],"Approximately":[577],"43%":[578],"able":[582],"lack":[589],"low":[593],"indicate":[597],"longer":[600],"period":[601],"administration":[603],"should":[604],"investigated.":[606],"Although":[607],"there":[608],"trend":[611],"increased":[613],"FOXP3":[614],"expression,":[615],"results":[616],"statistically":[619],"significant.":[620],"Further":[621],"correlative":[622],"studies,":[623,627],"including":[624],"genome-wide":[625],"methylation":[626],"ongoing.":[629],"Disclosures:":[630],"Off":[631],"Label":[632],"Use:":[633]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}