{"id":"https://openalex.org/W401200871","doi":null,"title":"D\u00e9saturation d'acides gras polyinsatur\u00e9s dans les microsomes h\u00e9patiques de rat : influence de l'age, de l'ob\u00e9sit\u00e9 et des acides gamma-linol\u00e9nique et arachidonique alimentaires","display_name":"D\u00e9saturation d'acides gras polyinsatur\u00e9s dans les microsomes h\u00e9patiques de rat : influence de l'age, de l'ob\u00e9sit\u00e9 et des acides gamma-linol\u00e9nique et arachidonique alimentaires","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W401200871","mag":"401200871"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/21687","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/21687","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/21687","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022782015","display_name":"C. Maniongui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"C. Maniongui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022782015"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fatty-acid-desaturation","display_name":"fatty acid desaturation","score":0.906000018119812},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.8889999985694885},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8410000205039978},{"id":"https://openalex.org/keywords/genetic-obesity","display_name":"genetic obesity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/zucker-rats","display_name":"Zucker rats","score":0.7329999804496765},{"id":"https://openalex.org/keywords/gamma-linolenic-acid","display_name":"gamma-linolenic acid","score":0.9210000038146973},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.984000027179718},{"id":"https://openalex.org/keywords/dietary-fatty-acids","display_name":"dietary fatty acids","score":0.7620000243186951},{"id":"https://openalex.org/keywords/essential-fatty-acids","display_name":"essential fatty acids","score":0.7350000143051147},{"id":"https://openalex.org/keywords/lipid-composition","display_name":"lipid composition","score":0.6179999709129333},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/omega-6-fatty-acids","display_name":"omega-6 fatty acids","score":0.8659999966621399},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":1.0}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6862602233886719},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5568594932556152},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.36597901582717896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2922843098640442},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.18104663491249084}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/21687","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/21687","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:401200871","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/1992DIJOS033","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/21687","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/21687","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W120862625","https://openalex.org/W6995842053","https://openalex.org/W7027980271","https://openalex.org/W2023962980","https://openalex.org/W351896782","https://openalex.org/W2084800988","https://openalex.org/W1977893019","https://openalex.org/W7055455730","https://openalex.org/W3112075873","https://openalex.org/W4299808577"],"abstract_inverted_index":{"Les":[0,169],"effets":[1],"du":[2,11,106,148],"vieillissement":[3],"et":[4,38,62,72,127,132,238],"de":[5,29,31,96,103,154,157,171,194,198,201,229,246],"l'obesite":[6,147,202],"genetique":[7],"sur":[8,75],"certains":[9],"aspects":[10],"metabolisme":[12],"des":[13,35,51,56,69,101,182,221,243],"lipides":[14,57,183],"sont":[15,44,185,231,236],"etudies":[16,95],"chez":[17],"le":[18,207],"rat":[19,149,162,167],"en":[20,53,174,186,188,196],"realisant":[21],"deux":[22],"types":[23],"d'etudes.":[24],"Tout":[25],"d'abord,":[26],"les":[27,41,86,118,129,178,191,204,212,227],"activites":[28,102,156,228],"desaturation":[30,104,195,230],"trois":[32],"acides":[33,54,70,175,179,213,222],"gras":[34,55,176,180,214,223],"series":[36],"n-6":[37],"n-3":[39],"par":[40,159],"microsomes":[42],"hepatiques":[43],"etudiees":[45],"in":[46],"vitro.":[47],"Ensuite,":[48],"la":[49,172,219,241,247],"determination":[50],"compositions":[52],"corporels":[58,184],"(foie,":[59],"tissu":[60],"adipeux":[61],"serum)":[63],"est":[64,79,115,144],"determinee.":[65],"De":[66,210],"plus,":[67,211],"l'influence":[68],"gamma-linolenique":[71],"arachidonique":[73],"alimentaire":[74],"ces":[76],"memes":[77],"parametres":[78],"egalement":[80],"etudiee.":[81],"Dans":[82,139],"une":[83,140,152],"premiere":[84],"partie,":[85,142],"resultats":[87,235],"montrent":[88],"que":[89,146],"l'evolution":[90,114],"avec":[91,190],"l'age":[92,199],"(7":[93],"ages":[94,133],"1,5":[97],"a":[98,122,136,240],"24":[99,137],"mois)":[100,126],"depend":[105],"substrat":[107],"etudie,":[108],"mais":[109],"pour":[110,117,128,203],"chacun":[111],"d'entre":[112],"eux,":[113],"differente":[116],"rats":[119,130],"jeunes":[120],"(1,5":[121],"3":[123],"ou":[124,165,200],"6":[125,135],"adultes":[131],"(de":[134],"mois).":[138],"deuxieme":[141],"il":[143],"montre":[145],"Zucker":[150,163],"induit":[151],"inhibition":[153],"certaines":[155],"desaturation,":[158],"comparaison":[160],"au":[161,166,216],"mince":[164],"Wistar.":[168],"variations":[170],"composition":[173],"(notamment":[177],"essentiels)":[181],"general":[187],"accord":[189],"changements":[192],"d'activites":[193],"fonction":[197],"animaux":[205],"recevant":[206],"regime":[208,217],"temoin.":[209],"additionnes":[215],"favorisent":[218],"biosynthese":[220],"polyinsatures,":[224],"meme":[225],"si":[226],"quelquefois":[232],"inhibees.":[233],"Ces":[234],"expliques":[237],"discutes":[239],"lumiere":[242],"donnees":[244],"recentes":[245],"litterature.":[248]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}