{"id":"https://openalex.org/W40092525","doi":"https://doi.org/10.21236/ada575292","title":"Prevention and Treatment of Heterotopic Ossification","display_name":"Prevention and Treatment of Heterotopic Ossification","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W40092525","doi":"https://doi.org/10.21236/ada575292","mag":"40092525"},"language":"en","primary_location":{"id":"doi:10.21236/ada575292","doi":"https://doi.org/10.21236/ada575292","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada575292","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005242855","display_name":"Alan R. Davis","orcid":"https://orcid.org/0000-0001-7469-6205","observed_orcids":["https://orcid.org/0000-0001-7469-6205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan R. Davis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036501203","display_name":"Elizabeth A. Olmsted\u2010Davis","orcid":"https://orcid.org/0000-0001-9457-1848","observed_orcids":["https://orcid.org/0000-0001-9457-1848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth A. Olmsted-Davis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031467230","display_name":"Michael H. Heggeness","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Heggeness","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033181354","display_name":"Jennifer West","orcid":"https://orcid.org/0000-0001-8708-921X","observed_orcids":["https://orcid.org/0000-0001-8708-921X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer West","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032199131","display_name":"Ronke Olabisis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronke Olabisis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051587177","display_name":"Francis H. Gannon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francis Gannon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069516360","display_name":"John A. Hipp","orcid":"https://orcid.org/0000-0002-2008-3523","observed_orcids":["https://orcid.org/0000-0002-2008-3523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Hipp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12960","display_name":"Heterotopic Ossification and Related Conditions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12960","display_name":"Heterotopic Ossification and Related Conditions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heterotopic-ossification","display_name":"heterotopic ossification","score":1.0},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9760000109672546},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.8050000071525574},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.9340000152587891},{"id":"https://openalex.org/keywords/war-injuries","display_name":"war injuries","score":0.7680000066757202},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9319999814033508},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.8579999804496765},{"id":"https://openalex.org/keywords/wound-microenvironment","display_name":"wound microenvironment","score":0.6259999871253967},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C2780650075","wikidata":"https://www.wikidata.org/wiki/Q5747886","display_name":"Heterotopic ossification","level":2,"score":0.9397972822189331},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4100268483161926},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.36014989018440247},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.21952471137046814}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21236/ada575292","doi":"https://doi.org/10.21236/ada575292","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada575292","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3024774463","https://openalex.org/W1493719084","https://openalex.org/W227158685","https://openalex.org/W4413027864","https://openalex.org/W7121231312","https://openalex.org/W7126283499","https://openalex.org/W2914913031","https://openalex.org/W3032663311","https://openalex.org/W1993959445","https://openalex.org/W1578388451"],"abstract_inverted_index":{"Abstract":[0],":":[1],"The":[2],"factors":[3],"contributing":[4],"to":[5,19,69,84,134,169],"heterotopic":[6,79,88,136],"ossification":[7],"(HO),":[8],"the":[9,27,57,60,74,101,114,123,147,171,189],"formation":[10,44,81],"of":[11,62,64,76,100,103,174],"bone":[12,43,50,80],"in":[13,40,47,71,78,82,146,158,181],"abnormal":[14],"soft-tissue":[15],"locations,":[16],"are":[17,128],"beginning":[18],"emerge,":[20],"but":[21],"very":[22],"little":[23],"is":[24,45,142,161,178],"known":[25],"about":[26],"microenvironmental":[28],"conditions":[29],"that":[30,125,140,150,180],"promote":[31],"this":[32,194],"often":[33],"devastating":[34],"disease.":[35],"Using":[36],"a":[37,143,162],"murine":[38],"model":[39],"which":[41,159],"endochondral":[42],"triggered":[46],"muscle":[48],"by":[49],"morphogenetic":[51],"protein":[52],"2":[53],"(BMP2),":[54],"we":[55,184],"studied":[56],"changes":[58],"near":[59],"site":[61],"injection":[63],"BMP2-expressing":[65],"cells.":[66],"We":[67,90,105,119,138,165],"propose":[68],"study":[70,170],"more":[72,129],"detail":[73],"role":[75],"adipocytes":[77],"order":[83],"prevent":[85],"or":[86,200],"treat":[87],"ossification.":[89,137],"will":[91,106,120],"augment":[92],"our":[93],"current":[94],"microarray":[95],"analysis":[96,99],"and":[97,111,116],"immunohistochemical":[98],"kinetics":[102],"HO.":[104,175],"compare,":[107],"using":[108],"histology,":[109],"immunohistochemistry,":[110],"micro":[112],"CT":[113],"mouse":[115],"human":[117],"lesions.":[118],"also":[121,167,187],"address":[122],"reason":[124],"combat":[126],"wounds":[127],"likely":[130],"than":[131],"civilian":[132],"trauma":[133],"develop":[135],"hypothesize":[139],"there":[141],"basic":[144],"difference":[145],"injury":[148,157],"pattern/mechanism":[149],"may":[151],"impact":[152],"nerves,":[153],"recapitulating":[154],"spinal":[155],"cord":[156],"HO":[160,183],"major":[163],"problem.":[164],"therefore":[166],"plan":[168],"neuronal":[172],"component":[173],"Finally,":[176],"it":[177],"important":[179],"blocking":[182],"do":[185],"not":[186],"block":[188],"normal":[190],"fracture":[191],"repair":[192],"process;":[193],"latter":[195],"process":[196],"should":[197],"be":[198],"intact":[199],"even":[201],"augmented.":[202]},"counts_by_year":[],"updated_date":"2026-03-25T13:04:00.132906","created_date":"2016-06-24T00:00:00"}