{"id":"https://openalex.org/W40090363","doi":null,"title":"Stimulation of capillary tube polymorph migration: an indirect glucocorticoid effect on microtubular function.","display_name":"Stimulation of capillary tube polymorph migration: an indirect glucocorticoid effect on microtubular function.","publication_year":1978,"publication_date":"1978-09-01","ids":{"openalex":"https://openalex.org/W40090363","mag":"40090363","pmid":"https://pubmed.ncbi.nlm.nih.gov/216508","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537436"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1537436","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537436","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537436","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076760629","display_name":"Robin D. Stevenson","orcid":"https://orcid.org/0000-0002-9463-1385","observed_orcids":["https://orcid.org/0000-0002-9463-1385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R D Stevenson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072902925","display_name":"AILEEN C. GRAY","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A C Gray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113685543","display_name":"N.P. Lucie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N P Lucie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6202,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.6545928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"33","issue":"3","first_page":"478","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.1680999994277954,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.1680999994277954,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtubule-polymerization","display_name":"microtubule assembly","score":0.859000027179718},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7409999966621399},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/vinblastine","display_name":"vinblastine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nocodazole","display_name":"nocodazole","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heavy-water","display_name":"heavy water","score":0.9449999928474426},{"id":"https://openalex.org/keywords/microtubule-stabilization","display_name":"microtubule stabilization","score":0.7369999885559082},{"id":"https://openalex.org/keywords/mononuclear-phagocytes","display_name":"mononuclear phagocytes","score":0.7900000214576721},{"id":"https://openalex.org/keywords/peptide-hormones","display_name":"peptide hormones","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C2779363559","wikidata":"https://www.wikidata.org/wiki/Q2506092","display_name":"Nocodazole","level":4,"score":0.7514052391052246},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.6191569566726685},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5950334668159485},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.5326324105262756},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.5149300694465637},{"id":"https://openalex.org/C2781298581","wikidata":"https://www.wikidata.org/wiki/Q223093","display_name":"IBMX","level":4,"score":0.4885061979293823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47748681902885437},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.47069787979125977},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4420603811740875},{"id":"https://openalex.org/C2776162396","wikidata":"https://www.wikidata.org/wiki/Q4983616","display_name":"Bucladesine","level":3,"score":0.42129719257354736},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4155750274658203},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3997885286808014},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3833765983581543},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3434847593307495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30282261967658997},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23354056477546692},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.18096673488616943},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.16738221049308777},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14115729928016663},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11462974548339844}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007978","descriptor_name":"Levamisole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1537436","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537436","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:216508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/216508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:40090363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/216508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1537436","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537436","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W26312224","https://openalex.org/W99062839","https://openalex.org/W145906516","https://openalex.org/W164722089","https://openalex.org/W1488609485","https://openalex.org/W1534412090","https://openalex.org/W1547566916","https://openalex.org/W1602784471","https://openalex.org/W1849576273","https://openalex.org/W1975458302","https://openalex.org/W1990051197","https://openalex.org/W1995000837","https://openalex.org/W2005966649","https://openalex.org/W2035639417","https://openalex.org/W2044937040","https://openalex.org/W2049059366","https://openalex.org/W2058474512","https://openalex.org/W2090278122","https://openalex.org/W2091485569","https://openalex.org/W2104611667","https://openalex.org/W2108564800","https://openalex.org/W2125642013","https://openalex.org/W2155062305","https://openalex.org/W2155276817","https://openalex.org/W2328047889","https://openalex.org/W2341719812","https://openalex.org/W2398063135","https://openalex.org/W2405680329","https://openalex.org/W2408702897","https://openalex.org/W2409180550","https://openalex.org/W2409505459","https://openalex.org/W2411339929"],"related_works":["https://openalex.org/W164722089","https://openalex.org/W2078241318","https://openalex.org/W2409505459","https://openalex.org/W2345660792","https://openalex.org/W2078897172","https://openalex.org/W2108332168","https://openalex.org/W2011523895","https://openalex.org/W2160682637","https://openalex.org/W2033000175","https://openalex.org/W1970190101"],"abstract_inverted_index":{"Polymorph":[0],"migration":[1,38],"stimulator":[2],"(PMS)":[3],"is":[4,69],"a":[5],"peptide":[6,117],"factor":[7],"produced":[8],"by":[9,95,108],"an":[10,102],"in":[11,111],"vitro":[12],"reaction":[13],"between":[14],"glucocorticoids":[15],"and":[16,44,74,77],"human":[17,40],"mononuclear":[18],"phagocytes.":[19],"This":[20],"study":[21],"was":[22],"undertaken":[23],"to":[24,54,84],"determine":[25],"the":[26,29,35,97,112],"significance":[27],"of":[28,32,39,47,99],"stimulatory":[30],"effect":[31,103],"PMS":[33,93],"on":[34],"capillary":[36,86],"tube":[37,87],"polymorphs.":[41],"Colchicine,":[42],"vinblastine":[43],"Nocodazole,":[45],"all":[46],"which":[48,60,104],"inhibit":[49],"microtubular":[50,72],"assembly,":[51],"are":[52,81],"shown":[53],"stimulate":[55,85],"migration.":[56,64,88],"Conversely,":[57],"deuterium":[58],"oxide":[59],"stabilizes":[61],"microtubules":[62],"inhibits":[63],"Increased":[65],"intracellular":[66],"cyclic":[67,79,109],"AMP":[68,80,110],"associated":[70],"with":[71],"inhibition":[73],"isoprenaline,":[75],"theophylline":[76],"dibutyryl":[78],"also":[82],"found":[83],"These":[89],"results":[90],"suggest":[91],"that":[92],"acts":[94],"inhibiting":[96],"assembly":[98],"polymorph":[100],"microtubules,":[101],"may":[105],"be":[106],"mediated":[107],"same":[113],"manner":[114],"as":[115],"other":[116],"hormones.":[118]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}