{"id":"https://openalex.org/W40039067","doi":null,"title":"Inhibition of tumor growth in xenografted nude mice with adenovirus-mediated endostatin gene comparison with recombinant endostatin protein.","display_name":"Inhibition of tumor growth in xenografted nude mice with adenovirus-mediated endostatin gene comparison with recombinant endostatin protein.","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W40039067","mag":"40039067","pmid":"https://pubmed.ncbi.nlm.nih.gov/15603709"},"language":"en","primary_location":{"id":"pmid:15603709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15603709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Comparative Study"},"parent_works":[],"lineage":["https://openalex.org/W40039067"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109938382","display_name":"Zhi-hui Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-hui Liang","raw_affiliation_strings":["Cancer Center, Sun Yat-sen University, Guangzhou 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Sun Yat-sen University, Guangzhou 510060, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112718253","display_name":"Pei-hong Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pei-hong Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361347","display_name":"Li Li","orcid":"https://orcid.org/0009-0002-7408-4908","observed_orcids":["https://orcid.org/0009-0002-7408-4908","https://orcid.org/0000-0003-2314-8246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100698889","display_name":"Gang Xue","orcid":"https://orcid.org/0000-0003-2828-5717","observed_orcids":["https://orcid.org/0000-0003-2828-5717"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gang Xue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110204257","display_name":"Yi\u2010Xin Zeng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-xin Zeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110826413","display_name":"Wen-lin Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-lin Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.251,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.74674416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"117","issue":"12","first_page":"1809","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endostatin","display_name":"endostatin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.7760000228881836},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7919999957084656},{"id":"https://openalex.org/keywords/intratumoral-injection","display_name":"intratumoral injection","score":0.6840000152587891},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.4830000102519989},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.6620000004768372},{"id":"https://openalex.org/keywords/bel-7402-cells","display_name":"BEL-7402 cells","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.3160000145435333},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.48500001430511475},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C75920679","wikidata":"https://www.wikidata.org/wiki/Q359012","display_name":"Endostatin","level":3,"score":0.9665298461914062},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6389232873916626},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6080184578895569},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5334916710853577},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47789037227630615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42424917221069336},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36015185713768005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3550482392311096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27173852920532227},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.13954639434814453},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06694743037223816},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043169","descriptor_name":"Endostatins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D043169","descriptor_name":"Endostatins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043169","descriptor_name":"Endostatins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15603709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15603709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Comparative Study"},{"id":"mag:40039067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15603709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:946414063","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85656X/200412/12128020.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541197","display_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2012923756","https://openalex.org/W2154150796","https://openalex.org/W2381881651","https://openalex.org/W1978929016","https://openalex.org/W2386179790","https://openalex.org/W2377505210","https://openalex.org/W2009927268","https://openalex.org/W2348700773","https://openalex.org/W2128052373","https://openalex.org/W2353418620"],"abstract_inverted_index":{"BACKGROUND:":[0],"Inhibition":[1],"of":[2,33,41,60,73,87,109,124,127,130,132,148,164,178,197,199,216,222,231,268,278,288,299,319,327,329,346,360,371,404,414,425,428],"tumor":[3,116,172,182,203,219,279,333,364],"growth":[4,86,220,403],"by":[5,27,54,78,186,207,235,247,355,394],"endostatin":[6,36,62,74,96,154,179,200,291,330,361,429],"has":[7,24],"been":[8,25],"shown":[9],"to":[10,274,383],"be":[11,52],"an":[12],"effective":[13],"strategy":[14],"in":[15,18,29,55,106,181,202,261,332,363,430,442],"cancer":[16],"therapy":[17,76,392],"mice.":[19,112],"However,":[20,260,310],"its":[21],"widespread":[22],"application":[23],"hampered":[26],"difficulties":[28],"a":[30,79,122,162,168,395,411,437],"large-scale":[31],"production":[32],"the":[34,42,45,61,69,85,107,171,218,239,251,297,317,368,376,402],"recombinant":[35,80,95,289,396],"protein,":[37,43],"rapid":[38],"loss":[39],"bioactivity":[40,445],"and":[44,58,71,139,246,351,381,444],"cumbersome":[46],"daily":[47,159,286],"administration.":[48],"These":[49],"limitations":[50],"could":[51],"resolved":[53],"vivo":[56,431,443],"delivery":[57],"expression":[59,177,328,427,441],"gene.":[63],"In":[64],"this":[65,262],"study,":[66,263],"we":[67],"observed":[68],"effect":[70],"advantage":[72],"gene":[75,391],"mediated":[77,393],"adenoviral":[81,397],"vector":[82,398],"(Ad/hEndo)":[83],"on":[84],"hepatocellular":[88,405],"carcinoma":[89,100,406],"BEL-7402":[90,101,407],"xenografted":[91,408],"tumors,":[92],"comparison":[93],"with":[94,226,238,250,282,344,420],"protein.":[97],"METHODS:":[98],"Hepatocellular":[99],"cells":[102],"were":[103,120,205,233],"inoculated":[104],"subcutaneously":[105,160],"flank":[108],"Balb/c":[110],"nude":[111],"Nine":[113],"days":[114,312,340],"after":[115,192,313,341,379],"cell":[117],"inoculation,":[118],"animals":[119],"given":[121],"cycle":[123],"four":[125],"courses":[126,215],"intra-tumoral":[128],"injections":[129],"Ad/hEndo":[131,193,232,264,345,434],"5":[133,269],"x":[134,141,228,270,348,416],"10(8)":[135,271],"pfu":[136,143,230,272,350,418],"(low-dose":[137],"group)":[138,145,305],"1":[140,227,347,415],"10(9)":[142,229,349,417],"(high-dose":[144],"at":[146,161,167,265,336,375,410],"intervals":[147],"six":[149],"days,":[150,296],"respectively.":[151,259],"Recombinant":[152],"human":[153,290],"protein":[155,201,292],"(rhEndo)":[156,293],"was":[157,184,306,321,335],"administrated":[158],"dose":[163,267,413],"10":[165],"mg.kg(-1).d(-1)":[166],"site":[169],"nearby":[170],"for":[173,294],"ten":[174],"days.":[175],"The":[176,325,423],"mRNA":[180,331,372],"tissue":[183,204,334,365],"analyzed":[185],"reverse":[187],"transcription-polymerase":[188],"chain":[189],"reaction":[190],"(RT-PCR)":[191],"injection.":[194],"Dynamic":[195,358],"changes":[196],"concentration":[198,362],"quantitated":[206],"enzyme-linked":[208],"immunosorbent":[209],"assay":[210],"(ELISA).":[211],"RESULTS:":[212],"After":[213,285],"4":[214],"treatment,":[217],"rates":[221],"high-dose":[223],"treated":[224],"group":[225,242,255,302],"inhibited":[234,401],"42.26%":[236],"compared":[237,249,281,419],"Ad/LacZ":[240],"control":[241,254,283],"(P":[243,256],"=":[244,257],"0.001)":[245],"46.26%":[248],"NIH":[252],"buffer":[253],"0.003),":[258],"low":[266],"failed":[273],"demonstrate":[275],"significant":[276],"inhibition":[277],"growth,":[280],"groups.":[284,422],"administration":[287,342],"9":[295],"ratio":[298,318],"T/C":[300,320],"(rhEndo":[301],"versus":[303],"PBS":[304],"less":[307],"than":[308,323],"47%.":[309],"two":[311],"rhEndo":[314],"treatment":[315],"ceased,":[316],"more":[322],"50%.":[324],"peak":[326],"2":[337],"or":[338],"3":[339],"intratumorally":[343],"gradually":[352],"dropped":[353,382],"undetectable":[354],"day":[356,378],"7.":[357],"analysis":[359,424],"showed":[366],"that":[367,433],"highest":[369],"level":[370,385],"is":[373],"up":[374],"third":[377],"injection,":[380],"basal":[384],"three":[386],"weeks":[387],"later.":[388],"CONCLUSIONS:":[389],"Endostatin":[390],"had":[399,435],"significantly":[400],"tumors":[409],"high":[412],"other":[421],"dynamic":[426],"indicated":[432],"acquired":[436],"high-level,":[438],"relatively":[439],"long-term":[440],"capability.":[446]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
