{"id":"https://openalex.org/W400367039","doi":"https://doi.org/10.5551/jat1973.9.4_659","title":"Anti-Atherosclerotic Activity of AZ 1355, Ethyl 10, 11-Dihydro-4-Methoxydibenz [b, f] [1, 4] Oxazepine-8-Carboxylate","display_name":"Anti-Atherosclerotic Activity of AZ 1355, Ethyl 10, 11-Dihydro-4-Methoxydibenz [b, f] [1, 4] Oxazepine-8-Carboxylate","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W400367039","doi":"https://doi.org/10.5551/jat1973.9.4_659","mag":"400367039"},"language":"en","primary_location":{"id":"doi:10.5551/jat1973.9.4_659","doi":"https://doi.org/10.5551/jat1973.9.4_659","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1973.9.4_659","pdf_url":"https://www.jstage.jst.go.jp/article/jat1973/9/4/9_4_659/_pdf","source":{"id":"https://openalex.org/S4210238089","display_name":"The Journal of Japan Atherosclerosis Society","issn_l":"0386-2682","issn":["0386-2682","2185-8284"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Japan Atherosclerosis Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/jat1973/9/4/9_4_659/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076032914","display_name":"Sakae Wada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sakae WADA","raw_affiliation_strings":["Research Laboratories, Chugai Pharmaceutical Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Chugai Pharmaceutical Co. Ltd","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109867656","display_name":"Masuo Koizumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masuo KOIZUMI","raw_affiliation_strings":["Research Laboratories, Chugai Pharmaceutical Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Chugai Pharmaceutical Co. Ltd","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011077301","display_name":"Tomohiro Neichi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro NEICHI","raw_affiliation_strings":["Research Laboratories, Chugai Pharmaceutical Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Chugai Pharmaceutical Co. Ltd","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113922236","display_name":"Tamotsu Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tamotsu YAMAZAKI","raw_affiliation_strings":["Research Laboratories, Chugai Pharmaceutical Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Chugai Pharmaceutical Co. Ltd","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019131429","display_name":"Fusayo Onoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fusayo ONODA","raw_affiliation_strings":["Research Laboratories, Chugai Pharmaceutical Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Chugai Pharmaceutical Co. Ltd","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032998860","display_name":"Hiroshi Nakakimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi NAKAKIMURA","raw_affiliation_strings":["Research Laboratories, Chugai Pharmaceutical Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Chugai Pharmaceutical Co. Ltd","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113699056","display_name":"Kunio Ando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunio ANDO","raw_affiliation_strings":["Research Laboratories, Chugai Pharmaceutical Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Chugai Pharmaceutical Co. Ltd","institution_ids":["https://openalex.org/I4405254473"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405254473"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.06032142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"4","first_page":"659","last_page":"669"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.35519999265670776,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypolipidemic-activity","display_name":"hypolipidemic activity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/atherosclerosis-prevention","display_name":"atherosclerosis prevention","score":0.7239999771118164},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.7739999890327454},{"id":"https://openalex.org/keywords/serum-triglycerides","display_name":"serum triglycerides","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8889999985694885},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/clofibrate","display_name":"clofibrate","score":0.6639999747276306},{"id":"https://openalex.org/keywords/lipid-rich-diet","display_name":"lipid-rich diet","score":0.7110000252723694},{"id":"https://openalex.org/keywords/drug-metabolites","display_name":"drug metabolites","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7654188871383667},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6755006313323975},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5440411567687988},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.532840371131897},{"id":"https://openalex.org/C2779496979","wikidata":"https://www.wikidata.org/wiki/Q2701912","display_name":"Clofibrate","level":2,"score":0.4664544463157654},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.4411375820636749},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.4289029836654663},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3531654477119446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23433750867843628},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1265363097190857},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5551/jat1973.9.4_659","doi":"https://doi.org/10.5551/jat1973.9.4_659","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1973.9.4_659","pdf_url":"https://www.jstage.jst.go.jp/article/jat1973/9/4/9_4_659/_pdf","source":{"id":"https://openalex.org/S4210238089","display_name":"The Journal of Japan Atherosclerosis Society","issn_l":"0386-2682","issn":["0386-2682","2185-8284"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Japan Atherosclerosis Society","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5551/jat1973.9.4_659","doi":"https://doi.org/10.5551/jat1973.9.4_659","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1973.9.4_659","pdf_url":"https://www.jstage.jst.go.jp/article/jat1973/9/4/9_4_659/_pdf","source":{"id":"https://openalex.org/S4210238089","display_name":"The Journal of Japan Atherosclerosis Society","issn_l":"0386-2682","issn":["0386-2682","2185-8284"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Japan Atherosclerosis Society","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W400367039.pdf","grobid_xml":"https://content.openalex.org/works/W400367039.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1904672355","https://openalex.org/W1954754708","https://openalex.org/W1964836458","https://openalex.org/W1981159906","https://openalex.org/W1994038246","https://openalex.org/W2011335599","https://openalex.org/W2017009530","https://openalex.org/W2044201960","https://openalex.org/W2045111989","https://openalex.org/W2045187633","https://openalex.org/W2058994566","https://openalex.org/W2067618927","https://openalex.org/W2082176634","https://openalex.org/W2114298209","https://openalex.org/W2140482107","https://openalex.org/W2146993786","https://openalex.org/W2224199798","https://openalex.org/W2318504971","https://openalex.org/W2321686618","https://openalex.org/W2327767578","https://openalex.org/W2605414664","https://openalex.org/W6600863334"],"related_works":["https://openalex.org/W1994038246","https://openalex.org/W2980703787","https://openalex.org/W2009431940","https://openalex.org/W2413876463","https://openalex.org/W2412597043","https://openalex.org/W1986381254","https://openalex.org/W2077014005","https://openalex.org/W1544207996","https://openalex.org/W1966298130","https://openalex.org/W1998406079"],"abstract_inverted_index":{"The":[0,118,128,340],"efficacy":[1],"of":[2,24,30,121,160,165,170,185,202,268,275,295,342],"AZ":[3,16,69,78,108,122,155,171,177,186,241,250,302,317,327,330,343],"1355":[4,17,32,70,79,109,123,156,172,222,242,247,303,328],"(300mg/kg,":[5],"po)":[6],"was":[7,26,80,124,131,271,315],"compared":[8],"with":[9,74],"clofibrate":[10],"(CPIB)":[11],"using":[12,126],"Triton":[13],"hyperlipidemic":[14],"mice.":[15],"reduced":[18,62,110,132],"serum":[19,64,112,129,167],"cholesterol":[20,65,150],"and":[21,35,66,173,199,206,213,219,234,249,285,298,329,337,347],"the":[22,55,63,75,111,139,145,166,200,227,237,245,256,265,282,288,305],"magnitude":[23],"reduction":[25],"similar":[27,334],"to":[28,44,93,279,335],"that":[29,184,274],"CPIB.AZ":[31],"(50,":[33],"100mg/kg)":[34],"CPIB":[36,61,116],"(100mg/kg)":[37,86,142],"were":[38,57,87,210,215],"given":[39,88],"orally":[40,89],"for":[41,90,152],"4":[42,91],"weeks":[43,92],"rats":[45,56,198,257],"fed":[46,58,96,147],"on":[47,59,97,148,188],"either":[48,98],"CE-2":[49,99],"or":[50,100,232],"a":[51,101,158,293],"lipid-rich":[52,76],"diet.":[53,104],"When":[54],"CE-2,":[60],"triglyceride":[67,113,130],"but":[68,312,323],"did":[71],"not.":[72],"But":[73,264],"diet":[77,151],"more":[81,114],"effective":[82],"than":[83,115,183,273],"CPIB.Both":[84],"agents":[85,270],"golden":[94],"hamsters":[95],"10%":[102],"butter":[103],"With":[105],"both":[106,269],"diets":[107],"did.":[117],"dose-response":[119],"relationship":[120],"examined":[125],"hamsters.":[127],"by":[133,230,262],"doses":[134],"above":[135,223,239],"25mg/kg.":[136],"In":[137],"addition,":[138],"highest":[140],"dose":[141,159],"elevated":[143],"HDL-cholesterol.In":[144],"rabbits":[146],"1%":[149],"12":[153],"weeks,":[154],"at":[157,308],"80mg/kg":[161],"inhibited":[162,236,244,304,320],"an":[163,352],"elevation":[164],"cholesterol.The":[168],"effects":[169],"its":[174],"major":[175,283],"metabolite,":[176],"1355F":[178,251,318,331,344],"(having":[179],"hypolipidemic":[180],"activity":[181,267],"weaker":[182,272],"1355)":[187],"platelet":[189],"aggregation":[190,228,238],"in":[191,197],"vitro,":[192],"arachidonic":[193],"acid":[194],"(AA)":[195],"shock":[196],"formation":[201,314],"Prostaglandin":[203],"I2":[204],"(PGI2)":[205],"thromboxane":[207],"A2":[208],"(TXA2)":[209],"studied.":[211],"PGI2":[212],"TXA2":[214],"determined":[216],"as":[217,281,287,351],"6-ketoPGF1\u03b1":[218,286,313,325],"TXB2,":[220],"respectively.AZ":[221],"15\u03bcM":[224],"partially":[225],"prevented":[226],"induced":[229,261],"collagen":[231],"AA":[233],"completely":[235],"250\u03bcM.":[240],"weakly":[243],"aggregation.AZ":[246],"(po)":[248],"(po,":[252],"iv)":[253],"dosedependently":[254],"protected":[255],"from":[258],"stroke":[259],"death":[260],"AA.":[263],"protective":[266],"aspirin.AA":[276],"is":[277],"converted":[278],"TXB2":[280,306,321,346],"product":[284],"minor":[289],"product,":[290],"when":[291],"incubated":[292],"mixture":[294],"rat":[296],"platelets":[297],"swine":[299],"aortic":[300],"microsomes.":[301],"synthesis":[307],"concentration":[309],"higher":[310],"13\u03bcM,":[311],"unaltered.":[316],"also":[319],"synthesis,":[322],"accelerated":[324],"production.":[326],"exerted":[332],"activities":[333],"aspirin":[336],"imidazole,":[338],"respectively.":[339],"properties":[341],"concerning":[345],"6-ketoPGF1":[348],"are":[349],"favorable":[350],"anti-atherosclerotic":[353],"agent.":[354]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}