{"id":"https://openalex.org/W39938555","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.830.6","title":"The Expression and Functional Role of Syndecan 4 in Breast Cancer","display_name":"The Expression and Functional Role of Syndecan 4 in Breast Cancer","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W39938555","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.830.6","mag":"39938555"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.830.6","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.830.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.830.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049929072","display_name":"Maria Elisabeth Lendorf","orcid":"https://orcid.org/0000-0002-8165-9653","observed_orcids":["https://orcid.org/0000-0002-8165-9653"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Elisabeth Lendorf","raw_affiliation_strings":["Biomedical sciences, BRIC Biomedicine institute Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical sciences, BRIC Biomedicine institute Copenhagen Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051382096","display_name":"John Couchman","orcid":"https://orcid.org/0000-0003-3409-7093","observed_orcids":["https://orcid.org/0000-0003-3409-7093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John R Couchman","raw_affiliation_strings":["Biomedical sciences, BRIC Biomedicine institute Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical sciences, BRIC Biomedicine institute Copenhagen Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047986299","display_name":"Ulla M. Wewer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulla M Wewer","raw_affiliation_strings":["Biomedical sciences, BRIC Biomedicine institute Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical sciences, BRIC Biomedicine institute Copenhagen Denmark","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110012600","display_name":"Hinke A.B. Multhaupt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hinke A.B. Multhaupt","raw_affiliation_strings":["Biomedical sciences, BRIC Biomedicine institute Copenhagen Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical sciences, BRIC Biomedicine institute Copenhagen Denmark","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00465146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syndecan-4","display_name":"syndecan-4","score":0.9580000042915344},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9610000252723694},{"id":"https://openalex.org/keywords/heparan-sulfate-proteoglycans","display_name":"heparan sulfate proteoglycans","score":0.9959999918937683},{"id":"https://openalex.org/keywords/podosomes","display_name":"podosomes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/invadopodia","display_name":"invadopodia","score":1.0},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8220000267028809},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.902999997138977},{"id":"https://openalex.org/keywords/cortactin","display_name":"cortactin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tumor-cell-morphology","display_name":"tumor cell morphology","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C65001120","wikidata":"https://www.wikidata.org/wiki/Q14912913","display_name":"Syndecan 1","level":3,"score":0.8991290330886841},{"id":"https://openalex.org/C200786668","wikidata":"https://www.wikidata.org/wiki/Q3498029","display_name":"Invadopodia","level":4,"score":0.824021577835083},{"id":"https://openalex.org/C2776000893","wikidata":"https://www.wikidata.org/wiki/Q14906154","display_name":"Cortactin","level":4,"score":0.7610974311828613},{"id":"https://openalex.org/C141073059","wikidata":"https://www.wikidata.org/wiki/Q7207063","display_name":"Podosome","level":4,"score":0.6575800776481628},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5428005456924438},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5280595421791077},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.498410701751709},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46082791686058044},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.44656872749328613},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43033647537231445},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4294975996017456},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4159579575061798},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3702065348625183},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.33560705184936523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13344401121139526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.830.6","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.830.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.830.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4296554901","https://openalex.org/W2154931831","https://openalex.org/W3146420817","https://openalex.org/W3170183626","https://openalex.org/W4213209397","https://openalex.org/W3176877288","https://openalex.org/W150636694","https://openalex.org/W2061273916","https://openalex.org/W3169343149","https://openalex.org/W4327622548"],"abstract_inverted_index":{"The":[0],"syndecans":[1],"are":[2,22,149],"a":[3,49,54,96,192],"four\u2010member":[4],"family":[5],"of":[6,63,87,98,160],"transmembrane":[7],"cell":[8,29,44,57,64,78,106,197],"surface":[9,107],"heparan":[10],"sulfate":[11],"proteoglycans":[12],"(HSPG)":[13],"expressed":[14],"in":[15,28,56,60,89,99,102,109,154,194],"both":[16],"developing":[17],"and":[18,32,46,59,101,157,177,183,199],"adult":[19],"tissue.":[20],"They":[21],"believed":[23],"to":[24,41,131,138,151],"have":[25],"regulatory":[26],"roles":[27],"adhesion,":[30],"proliferation":[31],"differentiation.":[33],"In":[34],"cancer,":[35],"syndecan":[36],"expression":[37],"has":[38],"been":[39],"shown":[40],"regulate":[42],"tumour":[43],"behaviour":[45,159],"serve":[47],"as":[48,143,181],"prognostic":[50],"marker.":[51],"Syndecan\u20104":[52],"plays":[53,191],"role":[55,86,193],"adhesion":[58],"the":[61,68,85,139,155],"regulation":[62],"migration.":[65],"It":[66],"is":[67,82,92],"second":[69],"most":[70,75],"abundant":[71],"HSPG":[72],"produced":[73],"by":[74,95,116],"breast":[76,111,126,195],"carcinoma":[77,112,127],"lines.":[79],"However,":[80],"little":[81],"known":[83,142],"about":[84],"syndecan\u20104":[88,108,130,190],"malignancy":[90],"which":[91,135],"under":[93],"investigation":[94],"combination":[97],"vivo":[100],"vitro":[103],"studies.":[104],"Epithelial":[105],"clinical":[110],"samples":[113],"was":[114],"detected":[115],"immunoperoxidase":[117],"staining":[118],"at":[119,168],"varying":[120],"intensity":[121],"levels.":[122],"Using":[123],"immunofluorescence":[124],"microscopy,":[125],"cells":[128],"localized":[129],"discrete,":[132],"circular":[133],"structures":[134,148],"may":[136],"correspond":[137],"morphological":[140],"organelles":[141],"podosomes":[144],"or":[145],"invadopodia.":[146],"These":[147,186],"thought":[150],"be":[152],"involved":[153],"migratory":[156],"invasive":[158],"cancer":[161,196],"cells.":[162],"Double\u2010staining":[163],"for":[164],"podosome/invadopodia":[165],"markers":[166],"showed":[167],"least":[169],"partial":[170],"co\u2010localization":[171],"with":[172],"syndecan\u20104.":[173],"Markers":[174],"included":[175],"integrins":[176],"cytoskeletal":[178],"proteins":[179],"such":[180],"cortactin,":[182],"src\u2010family":[184],"kinases.":[185],"results":[187],"suggest":[188],"that":[189],"migration":[198],"invasion.":[200]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
