{"id":"https://openalex.org/W397934313","doi":"https://doi.org/10.1097/ccm.0000000000001096","title":"Progranulin Reduced Neuronal Cell Death by Activation of Sortilin 1 Signaling Pathways After Subarachnoid Hemorrhage in Rats","display_name":"Progranulin Reduced Neuronal Cell Death by Activation of Sortilin 1 Signaling Pathways After Subarachnoid Hemorrhage in Rats","publication_year":2015,"publication_date":"2015-05-25","ids":{"openalex":"https://openalex.org/W397934313","doi":"https://doi.org/10.1097/ccm.0000000000001096","mag":"397934313","pmid":"https://pubmed.ncbi.nlm.nih.gov/26010686","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4750384"},"language":"en","primary_location":{"id":"doi:10.1097/ccm.0000000000001096","doi":"https://doi.org/10.1097/ccm.0000000000001096","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ccm.0000000000001096","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4750384/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100374387","display_name":"Bo Li","orcid":"https://orcid.org/0000-0002-0154-3088","observed_orcids":["https://orcid.org/0000-0002-0154-3088","https://orcid.org/0000-0003-2120-3125"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210104291","display_name":"General Hospital of Jinan Military Command","ror":"https://ror.org/019nf3y14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104291"]},{"id":"https://openalex.org/I4210157767","display_name":"Jinan Military General Hospital","ror":"https://ror.org/05chjan92","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210157767"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Bo Li","raw_affiliation_strings":["Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","Department of Neurosurgery, Jinan General Military Hospital, Jinan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Neurosurgery, Jinan General Military Hospital, Jinan, People's Republic of China","institution_ids":["https://openalex.org/I4210104291","https://openalex.org/I4210157767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101682946","display_name":"Yue He","orcid":"https://orcid.org/0000-0002-7242-2363","observed_orcids":["https://orcid.org/0000-0002-7242-2363"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yue He","raw_affiliation_strings":["Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","Department of Neurosurgery, Tongji Hospital, Wuhan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Neurosurgery, Tongji Hospital, Wuhan, People's Republic of China","institution_ids":["https://openalex.org/I4210160344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101756647","display_name":"Liang Xu","orcid":"https://orcid.org/0000-0001-8884-1733","observed_orcids":["https://orcid.org/0000-0001-8884-1733"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Liang Xu","raw_affiliation_strings":["Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028263710","display_name":"Qin Hu","orcid":"https://orcid.org/0000-0002-2270-8822","observed_orcids":["https://orcid.org/0000-0002-2270-8822"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qin Hu","raw_affiliation_strings":["Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101438217","display_name":"Junjia Tang","orcid":"https://orcid.org/0000-0002-1020-7748","observed_orcids":["https://orcid.org/0000-0002-1020-7748"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Junjia Tang","raw_affiliation_strings":["Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100459043","display_name":"Yujie Chen","orcid":"https://orcid.org/0000-0002-9905-9138","observed_orcids":["https://orcid.org/0000-0002-9905-9138","https://orcid.org/0000-0002-5140-1993"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210131174","display_name":"Southwest Hospital","ror":"https://ror.org/02jn36537","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131174"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yujie Chen","raw_affiliation_strings":["Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210131174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004014354","display_name":"Jiping Tang","orcid":"https://orcid.org/0000-0002-2392-9280","observed_orcids":["https://orcid.org/0000-0002-2392-9280"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jiping Tang","raw_affiliation_strings":["Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002260928","display_name":"Hua Feng","orcid":"https://orcid.org/0000-0003-4489-9217","observed_orcids":["https://orcid.org/0000-0003-4489-9217","https://orcid.org/0009-0003-0762-1854"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210131174","display_name":"Southwest Hospital","ror":"https://ror.org/02jn36537","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131174"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Feng","raw_affiliation_strings":["Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210131174"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100342753","display_name":"John H. Zhang","orcid":"https://orcid.org/0000-0002-4319-4285","observed_orcids":["https://orcid.org/0000-0002-4319-4285"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Zhang","raw_affiliation_strings":["Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Division of Physiology, Loma Linda University School of Medicine, Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0208,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.74008888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"43","issue":"8","first_page":"e304","last_page":"e311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.06210000067949295,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sort1","display_name":"SORT1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/subarachnoid-hemorrhage","display_name":"subarachnoid hemorrhage","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9919999837875366},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.796999990940094},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8820000290870667},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9330000281333923},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/early-brain-injury","display_name":"early brain injury","score":0.703000009059906},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7739999890327454},{"id":"https://openalex.org/keywords/endovascular-perforation","display_name":"endovascular perforation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.7210000157356262},{"id":"https://openalex.org/keywords/neurological-deficit","display_name":"neurological deficit","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2777736543","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid hemorrhage","level":2,"score":0.9060804843902588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8379038572311401},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5493112802505493},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5157887935638428},{"id":"https://openalex.org/C2780813603","wikidata":"https://www.wikidata.org/wiki/Q268930","display_name":"Subarachnoid space","level":3,"score":0.4396606683731079},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.42621710896492004},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3772439956665039},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3735356628894806},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3693346381187439},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34119248390197754},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3311193287372589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11891412734985352},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0839914083480835},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.0669286847114563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099183","descriptor_name":"Sortilin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013345","descriptor_name":"Subarachnoid Hemorrhage","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/ccm.0000000000001096","doi":"https://doi.org/10.1097/ccm.0000000000001096","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ccm.0000000000001096","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:26010686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26010686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4750384","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4750384/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Crit Care Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4750384","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4750384/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Crit Care Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1302020094","display_name":null,"funder_award_id":"NS 082184","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G244152347","display_name":"Center for Brain Hemorrhage Research","funder_award_id":"P01NS082184","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6930736567","display_name":"Neurovascular Protection for Early Brain Injury after SAH","funder_award_id":"R01NS081740","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1972414732","https://openalex.org/W1973674165","https://openalex.org/W1985967806","https://openalex.org/W1986029990","https://openalex.org/W1991790798","https://openalex.org/W1995964483","https://openalex.org/W2005731595","https://openalex.org/W2012157443","https://openalex.org/W2013900800","https://openalex.org/W2014635801","https://openalex.org/W2027460468","https://openalex.org/W2032134195","https://openalex.org/W2035176557","https://openalex.org/W2048766205","https://openalex.org/W2061653882","https://openalex.org/W2062780433","https://openalex.org/W2073164785","https://openalex.org/W2088675309","https://openalex.org/W2113556948","https://openalex.org/W2118653134","https://openalex.org/W2140447941","https://openalex.org/W2148500292","https://openalex.org/W2156512271","https://openalex.org/W2163357760","https://openalex.org/W2169645346"],"related_works":["https://openalex.org/W1960493131","https://openalex.org/W7161826806","https://openalex.org/W2012453230","https://openalex.org/W567799983","https://openalex.org/W7097406088","https://openalex.org/W2354466322","https://openalex.org/W3087064204","https://openalex.org/W2770345329","https://openalex.org/W3165173988","https://openalex.org/W2031706510"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Progranulin":[1,75],"has":[2],"been":[3],"reported":[4],"to":[5,164,295],"have":[6,293],"neuroprotective":[7],"actions":[8],"in":[9,30,54],"cultured":[10],"neurons.":[11],"This":[12],"study":[13],"investigated":[14],"the":[15,131,166,180,262],"effect":[16],"of":[17,133,175,190,213,255,265],"recombinant":[18,60,192,223,242,267,277,290],"rat":[19,191,266],"progranulin":[20,61,160,176,193,215,224,230,243,256,268,278,291],"on":[21],"early":[22,297],"brain":[23,96,195,298],"injury":[24,299],"after":[25,72,106,152,186,208,219,238,272],"subarachnoid":[26,73,87,107,153,187,209,220,239,273,301],"hemorrhage.":[27,74,108,154,188,221,240,274],"DESIGN:":[28],"Controlled":[29],"vivo":[31],"laboratory":[32],"study.":[33],"SETTING:":[34],"Animal":[35],"research":[36],"laboratory.":[37],"SUBJECTS:":[38],"Two":[39],"hundred":[40],"thirty":[41],"adult":[42],"male":[43],"Sprague-Dawley":[44],"rats":[45,55],"weighing":[46],"280-320":[47],"g.":[48],"INTERVENTIONS:":[49],"Subarachnoid":[50,90],"hemorrhage":[51,88,91,302],"was":[52,66,79,111,162],"induced":[53],"by":[56,81,113,146],"endovascular":[57],"perforation.":[58],"Rat":[59,222,241,276,289],"(1":[62],"and":[63,95,103,125,141,178,198,205,285],"3":[64],"ng)":[65],"administrated":[67,80],"intracerebroventricularly":[68,82],"at":[69,83,101,149,183,202,235,269],"1.5":[70],"hours":[71,105,151,185,207,237,271],"small":[76],"interfering":[77],"RNA":[78],"1":[84,158,260],"day":[85],"before":[86],"induction.":[89],"grade,":[92],"neurologic":[93,200,217],"score,":[94],"water":[97,196],"content":[98,197],"were":[99,144],"measured":[100],"24":[102,150,184,204,236,270],"72":[104,206],"Neural":[109],"apoptosis":[110,234],"evaluated":[112],"double":[114],"immunofluorescence":[115],"staining":[116],"using":[117],"terminal":[118],"deoxynucleotidyl":[119],"transferase-mediated":[120],"uridine":[121],"5'-triphosphate-biotin":[122],"nick-end":[123],"labeling":[124],"neuronal":[126,227,233,280],"nuclei.":[127],"For":[128],"mechanistic":[129],"study,":[130],"expression":[132,174],"progranulin,":[134],"phosphorylated":[135],"Akt,":[136,137],"p-Erk,":[138],"Erk,":[139],"Bcl-2,":[140],"cleaved":[142],"caspase-3":[143,252],"analyzed":[145],"Western":[147],"blot":[148],"siRNA":[155],"for":[156,300],"sortilin":[157,259,283],"(a":[159],"receptor)":[161],"used":[163],"intervene":[165],"downstream":[167],"pathway.":[168,288],"MEASUREMENTS":[169],"AND":[170],"MAIN":[171],"RESULTS:":[172],"The":[173],"decreased":[177,194],"reached":[179],"lowest":[181],"point":[182],"Administration":[189],"improved":[199],"functions":[201],"both":[203],"hemorrhage,":[210],"while":[211,229],"knockdown":[212],"endogenous":[214],"aggravated":[216],"deficits":[218],"treatment":[225],"reduced":[226,251],"apoptosis,":[228],"deficiency":[231],"promoted":[232,244],"Akt":[245],"activation,":[246],"increased":[247],"Bcl-2":[248],"level,":[249],"but":[250],"level.":[253],"Knockdown":[254],"binding":[257],"factor":[258],"abolished":[261],"beneficial":[263],"effects":[264],"CONCLUSION:":[275],"alleviated":[279],"death":[281],"via":[282],"1-mediated":[284],"Akt-related":[286],"antiapoptosis":[287],"may":[292],"potentials":[294],"ameliorate":[296],"patients.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
