{"id":"https://openalex.org/W39333375","doi":"https://doi.org/10.1007/978-1-59259-019-3_13","title":"The 5-HT1B Knockout Mouse","display_name":"The 5-HT1B Knockout Mouse","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W39333375","doi":"https://doi.org/10.1007/978-1-59259-019-3_13","mag":"39333375"},"language":"en","primary_location":{"id":"mag:39333375","doi":"https://doi.org/10.1007/978-1-59259-019-3_13","is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007%2F978-1-59259-019-3_13.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022932542","display_name":"Kimberly A. Scearce-Levie","orcid":"https://orcid.org/0000-0003-0568-802X","observed_orcids":["https://orcid.org/0000-0003-0568-802X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimberly Scearce\u2010Levie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040427737","display_name":"Ren\u00e9 Hen","orcid":"https://orcid.org/0000-0002-7763-4162","observed_orcids":["https://orcid.org/0000-0002-7763-4162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ren\u00e9 Hen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7763-4162","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.26,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.45362587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"341","last_page":"373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht1b-receptor","display_name":"5-HT1B receptor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.7639999985694885},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.4959999918937683},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.8560000061988831},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cocaine","display_name":"cocaine","score":0.6710000038146973},{"id":"https://openalex.org/keywords/alcohol","display_name":"alcohol","score":0.6909999847412109},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mesolimbic-dopamine-system","display_name":"mesolimbic dopamine system","score":0.7369999885559082},{"id":"https://openalex.org/keywords/brain-reward","display_name":"brain reward","score":0.578000009059906},{"id":"https://openalex.org/keywords/conditioned-place-preference","display_name":"conditioned place preference","score":0.7099999785423279},{"id":"https://openalex.org/keywords/drug-self-administration","display_name":"self-administration","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C76725341","wikidata":"https://www.wikidata.org/wiki/Q1893126","display_name":"Inbred strain","level":3,"score":0.7259340882301331},{"id":"https://openalex.org/C35124327","wikidata":"https://www.wikidata.org/wiki/Q5159285","display_name":"Conditioned place preference","level":3,"score":0.5922760963439941},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.5585492253303528},{"id":"https://openalex.org/C2778140631","wikidata":"https://www.wikidata.org/wiki/Q2026938","display_name":"Opiate","level":3,"score":0.5470371246337891},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4952050745487213},{"id":"https://openalex.org/C2776286997","wikidata":"https://www.wikidata.org/wiki/Q2880966","display_name":"Dopaminergic pathways","level":4,"score":0.4890378415584564},{"id":"https://openalex.org/C3018481051","wikidata":"https://www.wikidata.org/wiki/Q3184856","display_name":"Drugs of abuse","level":3,"score":0.4764276444911957},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45549166202545166},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.44085898995399475},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.4250754117965698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.384848028421402},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29589927196502686},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.26649242639541626},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.23363140225410461},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:39333375","doi":"https://doi.org/10.1007/978-1-59259-019-3_13","is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007%2F978-1-59259-019-3_13.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W28942404","https://openalex.org/W637205171","https://openalex.org/W1602674087","https://openalex.org/W1618289512","https://openalex.org/W1767656477","https://openalex.org/W1770320011","https://openalex.org/W1947805135","https://openalex.org/W1954830520","https://openalex.org/W1982956447","https://openalex.org/W1986968685","https://openalex.org/W1993339449","https://openalex.org/W1993354858","https://openalex.org/W1994514599","https://openalex.org/W1997278612","https://openalex.org/W1998075304","https://openalex.org/W2001211304","https://openalex.org/W2001865657","https://openalex.org/W2005384970","https://openalex.org/W2005657014","https://openalex.org/W2005820090","https://openalex.org/W2009243814","https://openalex.org/W2009449932","https://openalex.org/W2020547623","https://openalex.org/W2028595610","https://openalex.org/W2031101928","https://openalex.org/W2032911818","https://openalex.org/W2035615794","https://openalex.org/W2038874217","https://openalex.org/W2045227177","https://openalex.org/W2046983320","https://openalex.org/W2051487428","https://openalex.org/W2055317220","https://openalex.org/W2055549282","https://openalex.org/W2061196572","https://openalex.org/W2070019933","https://openalex.org/W2072561798","https://openalex.org/W2076475195","https://openalex.org/W2080421284","https://openalex.org/W2081201957","https://openalex.org/W2093710529","https://openalex.org/W2099146816","https://openalex.org/W2111431369","https://openalex.org/W2122592499","https://openalex.org/W2153556827","https://openalex.org/W2153853866","https://openalex.org/W2162811260","https://openalex.org/W2254674914","https://openalex.org/W2292598483","https://openalex.org/W2417011347","https://openalex.org/W2434828314"],"related_works":["https://openalex.org/W2027782928","https://openalex.org/W4300778898","https://openalex.org/W2033766968","https://openalex.org/W1838164932","https://openalex.org/W1618289512","https://openalex.org/W1981800062","https://openalex.org/W2032746917","https://openalex.org/W2090850029","https://openalex.org/W2062123657","https://openalex.org/W1756245993"],"abstract_inverted_index":{"There":[0],"is":[1,198],"increasing":[2],"evidence":[3],"for":[4,25,149,157],"the":[5,12,29,85,105,119,129,140,152,165,168,172,181,203,215,225,232],"existence":[6,182,204],"of":[7,20,28,66,104,121,131,142,151,160,162,183,193,195,205,218,221,235],"genetic":[8,144,178],"determinants":[9],"that":[10,84,98,146,187,209],"underlie":[11,188],"large":[13],"individual":[14],"differences":[15,57,86,154],"in":[16,31,58,87,155,199,214,231],"vulnerability":[17],"to":[18,35,40,60,101,190,211],"drugs":[19,65,161,194],"abuse.":[21,196],"In":[22,49,118,223],"human":[23],"males,":[24],"example,":[26],"40\u201350%":[27],"variance":[30],"alcohol":[32],"preference":[33,156],"appears":[34],"be":[36,212],"genetically":[37],"determined,":[38],"according":[39],"twin":[41],"studies,":[42,44],"adoption":[43],"and":[45,51,63,76,108,127,135,171,239],"familial":[46],"studies":[47,81,179],"(1).":[48],"mice":[50],"rats,":[52],"inbred":[53,91,124,133],"strains":[54,92,125,134],"display":[55],"marked":[56],"responses":[59,70],"alcohol,":[61,170,238],"cocaine,":[62,167],"other":[64],"abuse":[67],"(2).":[68,117],"Such":[69],"include":[71],"locomotor":[72],"activation,":[73],"drug":[74,88],"self-administration,":[75],"conditioned":[77],"place":[78],"preference.":[79],"Genetic":[80],"have":[82],"revealed":[83],"responsiveness":[89],"between":[90],"are":[93,147,229],"mediated":[94],"by":[95],"several":[96,143],"genes":[97],"each":[99],"contribute":[100],"a":[102],"fraction":[103],"phenotypic":[106],"difference":[107],"have,":[109],"therefore,":[110],"been":[111],"named":[112],"quantitative":[113],"trait":[114],"loci":[115,145],"(QTLs)":[116],"case":[120],"two":[122],"mouse":[123],"(C57BL/6":[126],"DBA/2),":[128],"use":[130],"recombinant":[132],"QTL":[136],"analysis":[137],"has":[138],"allowed":[139],"identification":[141],"responsible":[148],"most":[150],"strain":[153],"different":[158,191,219],"categories":[159,192],"abuse,":[163],"including":[164],"psychostimulant":[166],"sedative":[169],"opiate":[173],"morphine":[174],"(2,3).":[175],"Therefore,":[176],"such":[177],"suggest":[180],"common":[184],"molecular":[185],"mechanisms":[186],"vulnerabilities":[189],"This":[197],"good":[200],"agreement":[201],"with":[202],"brain":[206],"reward":[207],"pathways":[208,228],"appear":[210],"involved":[213,230],"hedonic":[216],"effects":[217],"classes":[220],"drugs.":[222],"particular,":[224],"mesolimbic":[226],"dopaminergic":[227],"rewarding":[233],"properties":[234],"psychostimulants,":[236],"opiates,":[237],"nicotine":[240],"(4).":[241]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}