{"id":"https://openalex.org/W39226386","doi":null,"title":"Der diagnostische Zugewinn des Einsatzes eines Interferon-Gamma-Release-Assays zur Detektion einer latenten Tuberkulose vor Einleitung einer immunsuppressiven Therapie mit Biologika bei Patienten mit entz\u00fcndlich-rheumatischen Erkrankungen:Eine retrospektive Analyse der Anwendung in der klinischen Routine","display_name":"Der diagnostische Zugewinn des Einsatzes eines Interferon-Gamma-Release-Assays zur Detektion einer latenten Tuberkulose vor Einleitung einer immunsuppressiven Therapie mit Biologika bei Patienten mit entz\u00fcndlich-rheumatischen Erkrankungen:Eine retrospektive Analyse der Anwendung in der klinischen Routine","publication_year":2011,"publication_date":"2011-04-07","ids":{"openalex":"https://openalex.org/W39226386","mag":"39226386"},"language":"de","primary_location":{"id":"pmh:oai:epub.uni-regensburg.de:20313","doi":null,"is_oa":true,"landing_page_url":"https://epub.uni-regensburg.de/20313/1/Microsoft_Word_-_Promotion_Nessyt_Elektronische_Puplikation.pdf","pdf_url":"https://epub.uni-regensburg.de/20313/1/Microsoft_Word_-_Promotion_Nessyt_Elektronische_Puplikation.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://epub.uni-regensburg.de/20313/1/Microsoft_Word_-_Promotion_Nessyt_Elektronische_Puplikation.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014616396","display_name":"Felix Nessyt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Felix Nessyt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014616396"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12578","display_name":"Diagnosis and treatment of tuberculosis","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/latent-tuberculosis-infection","display_name":"latent tuberculosis infection","score":0.9279999732971191},{"id":"https://openalex.org/keywords/interferon-gamma-release-assay","display_name":"interferon-gamma release assay","score":0.9819999933242798},{"id":"https://openalex.org/keywords/quantiferon-tb-gold-in-tube","display_name":"QuantiFERON-TB Gold In-Tube","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tuberculosis-screening","display_name":"tuberculosis screening","score":0.6650000214576721},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.6690000295639038},{"id":"https://openalex.org/keywords/inflammatory-rheumatic-diseases","display_name":"inflammatory rheumatic diseases","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tuberculin-skin-test","display_name":"tuberculin skin test","score":0.8889999985694885},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/chest-x-ray","display_name":"chest radiography","score":0.8019999861717224},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/positive-predictive-value","display_name":"positive predictive value","score":0.5350000262260437},{"id":"https://openalex.org/keywords/sensitivity","display_name":"sensitivity","score":0.5450000166893005},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.8342099189758301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6580988764762878}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:epub.uni-regensburg.de:20313","doi":null,"is_oa":true,"landing_page_url":"https://epub.uni-regensburg.de/20313/1/Microsoft_Word_-_Promotion_Nessyt_Elektronische_Puplikation.pdf","pdf_url":"https://epub.uni-regensburg.de/20313/1/Microsoft_Word_-_Promotion_Nessyt_Elektronische_Puplikation.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-022479726","doi":null,"is_oa":false,"landing_page_url":"http://epub.uni-regensburg.de/20313/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Hochschulschrift"},{"id":"mag:39226386","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/20313/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:epub.uni-regensburg.de:20313","doi":null,"is_oa":true,"landing_page_url":"https://epub.uni-regensburg.de/20313/1/Microsoft_Word_-_Promotion_Nessyt_Elektronische_Puplikation.pdf","pdf_url":"https://epub.uni-regensburg.de/20313/1/Microsoft_Word_-_Promotion_Nessyt_Elektronische_Puplikation.pdf","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W39226386.pdf","grobid_xml":"https://content.openalex.org/works/W39226386.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7018322180","https://openalex.org/W2001984603","https://openalex.org/W2755555558","https://openalex.org/W1979545686","https://openalex.org/W7048069948","https://openalex.org/W7120411535","https://openalex.org/W7024374567","https://openalex.org/W4249535473","https://openalex.org/W2149188042","https://openalex.org/W2044137478"],"abstract_inverted_index":{"In":[0,272],"der":[1,33,83,126,130,138,151,223,231,235,255,273,288,300,311,339,347,350,353,362,382,399,438,443,461,465,493,495,498,503],"vorliegenden":[2,274,312,466,496],"Studie":[3,275],"wurde":[4,212],"bei":[5,119,197,264,282,381,422],"205":[6],"Patienten,":[7],"die":[8,104,161,202,205,285,397,530],"f\u00fcr":[9,103,182],"eine":[10,155,216,244,344,358,386,518],"Therapie":[11,167,287],"mit":[12,20,64,85,113,168,247,257,290,352,361,369,415,425,475,480],"Biologika":[13],"zur":[14,298,404],"Behandlung":[15],"entz\u00fcndlich-rheumatischer":[16],"Erkrankungen":[17],"evaluiert":[18],"wurden,":[19],"Hilfe":[21],"von":[22,135,190,199,513],"standardisierten":[23],"anamnestischen":[24],"Informationen,":[25],"R\u00f6ntgen-Thorax-Befund,":[26],"Tuberkulin-Hauttest":[27],"(THT)":[28],"und":[29,55,69,78,97,213,357,392,401,418,482,525],"einem":[30],"Interferon-Gamma-Release-Assay":[31],"(IGRA),":[32],"QuantiFeron\u00ae":[34],"-TB":[35],"Gold":[36],"In-Tube":[37],"(Hersteller":[38],"Cellestis,":[39],"Australien),":[40],"ein":[41,149,183,319,413],"Screening":[42,508],"auf":[43,75],"das":[44],"Vorhandensein":[45],"einer":[46,100,106,136,172,258,307,324,355,370,458,478,509],"LTBI":[47,107,203,263,289,510],"durchgef\u00fchrt.":[48],"Es":[49],"fanden":[50],"sich":[51,179,243,343],"hierbei":[52],"19":[53],"positive":[54,359],"18":[56],"undefinierte":[57,73,376],"IGRA-Ergebnisse.":[58],"Die":[59,111,428,453],"Ergebnisse":[60,71,398,494],"des":[61,116,140,280,384,402,406,430,446,521],"IGRA":[62,261,281,303,410,433,447,506],"wurden":[63],"den":[65,86,114,120,239,248,260,278],"anderen":[66,191],"LTBI-Screening-Verfahren":[67],"verglichen":[68],"diskordante":[70],"sowie":[72],"IGRA-Ergebnisse":[74,84,226,341,377,473],"m\u00f6gliche":[76],"Ursachen":[77],"Einflussfaktoren":[79],"hin":[80],"untersucht.\\nDie":[81],"\u00dcbereinstimmung":[82,112,246],"R\u00f6ntgen-Thorax-Befunden":[87],"war":[88,118,463],"niedrig,":[89],"was":[90],"als":[91,389],"Ausdruck":[92],"eines":[93,505],"niedrig":[94],"positiv-pr\u00e4diktiven":[95],"Wertes":[96],"geringer":[98],"Sensitivit\u00e4t":[99,420,445],"R\u00f6ntgen-Thorax":[101,403],"Aufnahme":[102],"Diagnose":[105],"gesehen":[108],"werden":[109,188],"kann.":[110],"Ergebnissen":[115],"THT":[117,141,249],"negativen":[121],"IGRA-Ergebnissen":[122,241],"relativ":[123,304],"hoch.":[124],"Aufgrund":[125],"anzunehmenden":[127],"z.T.":[128],"in":[129,174,229,460,464,529],"Vorgeschichte":[131,462],"erfolgten":[132],"BCG-Impfungen":[133],"ist":[134,147,314,411,434],"Abnahme":[137],"BCG-Interferenz":[139],"im":[142,162,296,309,364,448,487],"zeitlichen":[143],"Verlauf":[144],"auszugehen.":[145],"M\u00f6glicherweise":[146],"zus\u00e4tzlich":[148],"Teil":[150],"THT,":[152,451],"welche":[153],"durch":[154,160,204,215,259],"BCG-Impfung":[156,459],"falsch-positiv":[157],"ausgefallen":[158],"w\u00e4ren,":[159],"untersuchten":[163,176],"Studienkollektiv":[164,310],"h\u00e4ufig":[165,196],"vorbestehende":[166],"Kortikosteroiden":[169,481],"zu":[170],"erkl\u00e4ren.\\nBei":[171],"Patientin":[173],"dem":[175,435],"Kollektiv":[177],"ergaben":[178],"deutliche":[180],"Hinweise":[181],"falsch-negatives":[184],"IGRA-Ergebnis.":[185],"Solche":[186],"Einzelf\u00e4lle":[187],"auch":[189,321,421,528],"Autoren":[192],"beschrieben,":[193],"wobei":[194],"jedoch":[195],"Vorliegen":[198],"falsch-negativen":[200],"Ergebnissen,":[201],"konventionellen":[206,236,439],"Methoden":[207],"(THT,":[208],"R\u00f6ntgen-Thorax,":[209],"Anamnese)":[210],"definiert":[211],"nicht":[214,269,292],"sp\u00e4ter":[217],"aufgetretene":[218],"tats\u00e4chliche":[219],"TB-Reaktivierung.":[220],"Eine":[221],"\u00dcbersch\u00e4tzung":[222],"H\u00e4ufigkeit":[224,299,454],"falsch-negativer":[225],"w\u00e4re":[227,276],"hier":[228,393],"Anbetracht":[230],"diskutierten":[232],"niedrigeren":[233],"Spezifit\u00e4t":[234,417],"Diagnostik":[237],"m\u00f6glich.\\nBei":[238],"positiven":[240],"zeigte":[242],"niedrige":[245],"Ergebnissen.":[250],"So":[251],"w\u00e4ren":[252],"ca.":[253],"75%":[254],"Patienten":[256,284,368,424],"festgestellten":[262],"alleinigem":[265],"Einsatz":[266,279,306,437,504,512],"herk\u00f6mmlicher":[267],"Screening-Verfahren":[268],"diagnostiziert":[270],"worden.":[271,294],"ohne":[277],"zwei":[283],"indizierte":[286],"Isoniazid":[291],"durchgef\u00fchrt":[293,326],"Der":[295],"Vergleich":[297,449],"LTBI-Diagnosestellung":[301],"mittels":[302,432],"seltene":[305],"Isoniazid-Therapie":[308],"Arbeit":[313,467,497],"haupts\u00e4chlich":[315],"darin":[316],"begr\u00fcndet,":[317],"dass":[318,502],"LTBI-Screening":[320,535],"vor":[322,334,511,516],"Einleitung":[323],"Rituximab-Therapie":[325],"wurde,":[327],"hierf\u00fcr":[328],"aber":[329],"derzeit":[330],"keine":[331],"prophylaktische":[332],"LTBI-Therapie":[333],"Behandlungsbeginn":[335],"generell":[336],"empfohlen":[337],"wird.\\nBez\u00fcglich":[338],"undefinierten":[340],"fand":[342],"negative":[345],"Korrelation":[346,360],"quantitativen":[348],"IFN\u03b3-Produktion":[349],"Mitogen-Kontrollen":[351],"Dosis":[354],"Kortikosteroid-Vortherapie":[356],"Lymphozytenzellzahl":[363],"peripheren":[365,488],"Blut.":[366],"Bei":[367],"hochdosierten":[371],"Kortikosteroid-Therapie":[372,388],"traten":[373],"signifikant":[374],"h\u00e4ufiger":[375],"auf.":[378],"Somit":[379],"sollte":[380],"Interpretation":[383],"IGRA-Ergebnisses":[385],"hochdosierte":[387],"St\u00f6rfaktor":[390],"bedacht":[391],"besonders":[394],"sorgf\u00e4ltig":[395],"erg\u00e4nzend":[396],"Anamnese":[400],"Bewertung":[405],"LTBI-Risikos":[407],"herangezogen":[408],"werden.\\nDer":[409],"somit":[412],"Testverfahren":[414],"hoher":[416,419],"immunsupprimierten":[423],"entz\u00fcndlich-rheumatischen":[426],"Grunderkrankungen.":[427],"Erg\u00e4nzung":[429,520],"Screenings":[431,523],"alleinigen":[436],"Diagnostik,":[440],"insbesondere":[441,515],"aufgrund":[442,457,492],"h\u00f6heren":[444],"zum":[450,507,534],"\u00fcberlegen.":[452],"falsch-positiver":[455],"THT-Ergebnisse":[456],"vernachl\u00e4ssigbar":[468],"niedrig.":[469],"Das":[470],"Auftreten":[471],"undefinierter":[472],"stieg":[474],"zunehmender":[476],"Tagesdosis":[477],"Vortherapie":[479],"abnehmender":[483],"Anzahl":[484],"an":[485],"Lymphozyten":[486],"Blut":[489],"an.\\nZusammenfassend":[490],"kann":[491],"Schluss":[499],"gezogen":[500],"werden,":[501],"Biologika,":[514],"TNF\u03b1-Inhibitoren,":[517],"wichtige":[519],"bisherigen":[522],"darstellt":[524],"deshalb":[526],"folgerichtig":[527],"aktuellen":[531],"nationalen":[532],"Empfehlungen":[533],"aufgenommen":[536],"wurde.":[537]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}