{"id":"https://openalex.org/W39215153","doi":"https://doi.org/10.1016/j.jpba.2006.08.010","title":"Does a stable isotopically labeled internal standard always correct analyte response?","display_name":"Does a stable isotopically labeled internal standard always correct analyte response?","publication_year":2006,"publication_date":"2006-09-08","ids":{"openalex":"https://openalex.org/W39215153","doi":"https://doi.org/10.1016/j.jpba.2006.08.010","mag":"39215153","pmid":"https://pubmed.ncbi.nlm.nih.gov/16959461"},"language":"en","primary_location":{"id":"doi:10.1016/j.jpba.2006.08.010","doi":"https://doi.org/10.1016/j.jpba.2006.08.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpba.2006.08.010","pdf_url":null,"source":{"id":"https://openalex.org/S174893293","display_name":"Journal of Pharmaceutical and Biomedical Analysis","issn_l":"0731-7085","issn":["0731-7085","1873-264X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Biomedical Analysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101484553","display_name":"Sherry C. Wang","orcid":"https://orcid.org/0000-0002-3836-6089","observed_orcids":["https://orcid.org/0000-0002-3836-6089"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherry Wang","raw_affiliation_strings":["Worldwide Bioanalysis, Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Pharm 709 Swedeland Rd., King of Prussia, PA 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Bioanalysis, Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Pharm 709 Swedeland Rd., King of Prussia, PA 19406, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110181270","display_name":"Matthew J. Cyronak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Cyronak","raw_affiliation_strings":["Worldwide Bioanalysis, Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Pharm 709 Swedeland Rd., King of Prussia, PA 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Bioanalysis, Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Pharm 709 Swedeland Rd., King of Prussia, PA 19406, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"last","author":{"id":null,"display_name":"Eric Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric Yang","raw_affiliation_strings":["Worldwide Bioanalysis, Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Pharm 709 Swedeland Rd., King of Prussia, PA 19406, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldwide Bioanalysis, Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Pharm 709 Swedeland Rd., King of Prussia, PA 19406, USA","institution_ids":["https://openalex.org/I4210114143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210114143"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":10.8717,"has_fulltext":false,"cited_by_count":408,"citation_normalized_percentile":{"value":0.99480159,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"43","issue":"2","first_page":"701","last_page":"707"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deuterated-internal-standards","display_name":"deuterated internal standards","score":0.7799999713897705},{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ion-suppression","display_name":"ion suppression","score":0.6710000038146973},{"id":"https://openalex.org/keywords/deuterium-isotope-effect","display_name":"deuterium isotope effect","score":0.902999997138977},{"id":"https://openalex.org/keywords/human-plasma","display_name":"human plasma","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.9471310377120972},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9184547662734985},{"id":"https://openalex.org/C190925216","wikidata":"https://www.wikidata.org/wiki/Q900775","display_name":"Internal standard","level":3,"score":0.8115217685699463},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.714294970035553},{"id":"https://openalex.org/C137535248","wikidata":"https://www.wikidata.org/wiki/Q4914691","display_name":"Bioanalysis","level":2,"score":0.5894336700439453},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.5427827835083008},{"id":"https://openalex.org/C171679685","wikidata":"https://www.wikidata.org/wiki/Q3707695","display_name":"Isotope dilution","level":3,"score":0.5390730500221252},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5373204350471497},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.5007820129394531},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.47036027908325195},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.4515697658061981},{"id":"https://openalex.org/C71043704","wikidata":"https://www.wikidata.org/wiki/Q17144692","display_name":"Selected reaction monitoring","level":4,"score":0.4279945492744446},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.4164830446243286},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077261","descriptor_name":"Carvedilol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017879","descriptor_name":"Isothiocyanates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018674","descriptor_name":"Adrenergic Antagonists","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018674","descriptor_name":"Adrenergic Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jpba.2006.08.010","doi":"https://doi.org/10.1016/j.jpba.2006.08.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpba.2006.08.010","pdf_url":null,"source":{"id":"https://openalex.org/S174893293","display_name":"Journal of Pharmaceutical and Biomedical Analysis","issn_l":"0731-7085","issn":["0731-7085","1873-264X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Biomedical Analysis","raw_type":"journal-article"},{"id":"pmid:16959461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16959461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical and biomedical analysis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1969976381","https://openalex.org/W2007455664","https://openalex.org/W2016968987","https://openalex.org/W2019346496","https://openalex.org/W2026081029","https://openalex.org/W2035059069","https://openalex.org/W2037626129","https://openalex.org/W2050195284","https://openalex.org/W2050226999","https://openalex.org/W2081428502","https://openalex.org/W2104273743","https://openalex.org/W2110984352","https://openalex.org/W2117645760","https://openalex.org/W2134472266","https://openalex.org/W2144957010"],"related_works":["https://openalex.org/W2134472266","https://openalex.org/W7160417153","https://openalex.org/W4224882451","https://openalex.org/W1980201472","https://openalex.org/W7135171069","https://openalex.org/W4415027878","https://openalex.org/W2030652657","https://openalex.org/W2006656345","https://openalex.org/W2030253332","https://openalex.org/W1477512010"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":36},{"year":2018,"cited_by_count":31},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":38},{"year":2012,"cited_by_count":28}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}