{"id":"https://openalex.org/W39182999","doi":"https://doi.org/10.1176/jnp.9.4.556","title":"Major and minor depression in Alzheimer's disease: prevalence and impact","display_name":"Major and minor depression in Alzheimer's disease: prevalence and impact","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W39182999","doi":"https://doi.org/10.1176/jnp.9.4.556","mag":"39182999","pmid":"https://pubmed.ncbi.nlm.nih.gov/9447496"},"language":"en","primary_location":{"id":"doi:10.1176/jnp.9.4.556","doi":"https://doi.org/10.1176/jnp.9.4.556","is_oa":false,"landing_page_url":"https://doi.org/10.1176/jnp.9.4.556","pdf_url":null,"source":{"id":"https://openalex.org/S50352613","display_name":"Journal of Neuropsychiatry","issn_l":"0895-0172","issn":["0895-0172","1545-7222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4320800570","host_organization_name":"American Psychiatric Association Publishing","host_organization_lineage":["https://openalex.org/P4320800570","https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association Publishing","American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuropsychiatry and Clinical Neurosciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W39182999"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024200262","display_name":"Constantine George Lyketsos","orcid":"https://orcid.org/0000-0003-3827-4720","observed_orcids":["https://orcid.org/0000-0003-3827-4720"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C G Lyketsos","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111887392","display_name":"Cynthia Steele","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Steele","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113994995","display_name":"Lori Baker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Baker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059057591","display_name":"Elizabeth M. Galik","orcid":"https://orcid.org/0000-0002-7337-8018","observed_orcids":["https://orcid.org/0000-0002-7337-8018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Galik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028331612","display_name":"Susan Kopunek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Kopunek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Steinberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Steinberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"A Warren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Warren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.8451,"has_fulltext":false,"cited_by_count":325,"citation_normalized_percentile":{"value":0.96502498,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"9","issue":"4","first_page":"556","last_page":"561"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7639999985694885},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.8510000109672546},{"id":"https://openalex.org/keywords/minor-depression","display_name":"minor depression","score":0.9890000224113464},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.6449999809265137},{"id":"https://openalex.org/keywords/activities-of-daily-living","display_name":"activities of daily living","score":0.9459999799728394},{"id":"https://openalex.org/keywords/wandering","display_name":"wandering","score":0.9359999895095825},{"id":"https://openalex.org/keywords/falls","display_name":"falls","score":0.6460000276565552},{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.6579999923706055},{"id":"https://openalex.org/keywords/caregiver-burden","display_name":"caregiver burden","score":0.8730000257492065},{"id":"https://openalex.org/keywords/dementia-comorbidity","display_name":"dementia comorbidity","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7831790447235107},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7461698651313782},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.5269061923027039},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.482484370470047},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4678424596786499},{"id":"https://openalex.org/C79544238","wikidata":"https://www.wikidata.org/wiki/Q423243","display_name":"Activities of daily living","level":2,"score":0.4609421491622925},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4584505259990692},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4247647523880005},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.416729211807251},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.32855889201164246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17173174023628235},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1176/jnp.9.4.556","doi":"https://doi.org/10.1176/jnp.9.4.556","is_oa":false,"landing_page_url":"https://doi.org/10.1176/jnp.9.4.556","pdf_url":null,"source":{"id":"https://openalex.org/S50352613","display_name":"Journal of Neuropsychiatry","issn_l":"0895-0172","issn":["0895-0172","1545-7222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4320800570","host_organization_name":"American Psychiatric Association Publishing","host_organization_lineage":["https://openalex.org/P4320800570","https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association Publishing","American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuropsychiatry and Clinical Neurosciences","raw_type":"journal-article"},{"id":"pmid:9447496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9447496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuropsychiatry and clinical neurosciences","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.459.9524","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.459.9524","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ps.psychiatryonline.org/data/Journals/NP/3850/556.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W6243660","https://openalex.org/W68901995","https://openalex.org/W112877255","https://openalex.org/W197695037","https://openalex.org/W201461438","https://openalex.org/W297515935","https://openalex.org/W1506726456","https://openalex.org/W1539382539","https://openalex.org/W1630027882","https://openalex.org/W1688235741","https://openalex.org/W1847168837","https://openalex.org/W1966941221","https://openalex.org/W1971028729","https://openalex.org/W1975174873","https://openalex.org/W1978429824","https://openalex.org/W1988632686","https://openalex.org/W1991517279","https://openalex.org/W2013245744","https://openalex.org/W2019307017","https://openalex.org/W2026448245","https://openalex.org/W2041933303","https://openalex.org/W2045753206","https://openalex.org/W2048637672","https://openalex.org/W2064255232","https://openalex.org/W2069304323","https://openalex.org/W2078054968","https://openalex.org/W2080958203","https://openalex.org/W2081872868","https://openalex.org/W2087109735","https://openalex.org/W2092759377","https://openalex.org/W2093067961","https://openalex.org/W2094772434","https://openalex.org/W2152692871","https://openalex.org/W2156220037","https://openalex.org/W2160456898","https://openalex.org/W2222302077","https://openalex.org/W2287771232","https://openalex.org/W2413690364","https://openalex.org/W2414630900","https://openalex.org/W2467798782","https://openalex.org/W4210957923","https://openalex.org/W4256342650"],"related_works":["https://openalex.org/W2165840219","https://openalex.org/W4388118450","https://openalex.org/W4388118465","https://openalex.org/W4406050980","https://openalex.org/W4248066452","https://openalex.org/W2084991453","https://openalex.org/W2179179739","https://openalex.org/W2121365327","https://openalex.org/W1630027882"],"abstract_inverted_index":{"One":[0],"hundred":[1],"nine":[2],"outpatients":[3],"with":[4,60,94],"Alzheimer's":[5],"disease":[6],"(AD)":[7],"were":[8],"neuropsychiatrically":[9],"evaluated":[10],"and":[11,26,34,52,73,98,106,113,117,123,130],"rated":[12],"on":[13],"standardized":[14],"measures":[15],"of":[16,19,37,83],"depression,":[17],"activities":[18],"daily":[20],"living":[21],"(ADL),":[22],"nonmood":[23,67,95,118],"behavioral":[24,68,96],"disturbance,":[25],"burdensome":[27],"events":[28],"such":[29],"as":[30,71],"serious":[31,76],"wandering,":[32,77],"falls,":[33],"accidents.":[35],"Distribution":[36],"depression":[38,50,54,57,90,108,132],"scores":[39],"revealed":[40],"three":[41],"patient":[42],"groups:":[43],"very":[44],"few":[45],"depressive":[46],"symptoms":[47],"(51%),":[48],"minor":[49,107],"(27%),":[51],"major":[53,105],"(22%).":[55],"Major":[56],"was":[58,91],"associated":[59,93],"substantially":[61],"greater":[62],"impairment":[63],"in":[64,111,133],"ADL,":[65],"worse":[66],"disturbance":[69,97],"(such":[70],"aggression),":[72],"more":[74],"frequent":[75],"even":[78],"after":[79],"adjusting":[80],"for":[81],"severity":[82],"dementia":[84],"or":[85],"comorbid":[86],"health":[87],"problems.":[88],"Minor":[89],"also":[92],"wandering.":[99],"The":[100],"authors":[101],"conclude":[102],"that":[103],"both":[104,121],"are":[109,126],"common":[110],"AD":[112],"produce":[114],"considerable":[115],"mood":[116],"morbidity":[119],"affecting":[120],"patients":[122],"caregivers.":[124],"Efforts":[125],"warranted":[127],"to":[128],"identify":[129],"treat":[131],"AD.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
