{"id":"https://openalex.org/W3914049","doi":null,"title":"Using Developmental Trajectories of Cognitive Performance and Cardiovascular Risk Factors for the Early Prediction of Alzheimer's Disease and Vascular Dementia in Late Adulthood","display_name":"Using Developmental Trajectories of Cognitive Performance and Cardiovascular Risk Factors for the Early Prediction of Alzheimer's Disease and Vascular Dementia in Late Adulthood","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W3914049","mag":"3914049"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt6gb0020n","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6gb0020n","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063492783","display_name":"Jennifer Koontz","orcid":"https://orcid.org/0000-0002-7201-1118","observed_orcids":["https://orcid.org/0000-0002-7201-1118"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer Koontz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7201-1118","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063492783"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":1.0},{"id":"https://openalex.org/keywords/dementia-prediction","display_name":"dementia prediction","score":0.7850000262260437},{"id":"https://openalex.org/keywords/episodic-memory","display_name":"episodic memory","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.7990000247955322},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cognitive-trajectories","display_name":"cognitive trajectories","score":0.47699999809265137},{"id":"https://openalex.org/keywords/latent-growth-curve-models","display_name":"latent growth curve models","score":0.5270000100135803},{"id":"https://openalex.org/keywords/mixed-dementia","display_name":"mixed dementia","score":0.6660000085830688},{"id":"https://openalex.org/keywords/old-age","display_name":"old age","score":0.6200000047683716},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.40700000524520874},{"id":"https://openalex.org/keywords/educational-attainment","display_name":"educational attainment","score":0.578000009059906},{"id":"https://openalex.org/keywords/mental-status","display_name":"mental status","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7407705187797546},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5270516872406006},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5260474681854248},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4991438388824463},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.4988372325897217},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.47288742661476135},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.47050756216049194},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.4684075713157654},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.4645620882511139},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.43323057889938354},{"id":"https://openalex.org/C2780176501","wikidata":"https://www.wikidata.org/wiki/Q5690755","display_name":"Health and Retirement Study","level":2,"score":0.430146187543869},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4244888722896576},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.42288723587989807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3943125605583191},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3349035382270813},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.22602546215057373},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20756950974464417},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09256064891815186}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt6gb0020n","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6gb0020n","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:3914049","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt6gb0020n/qt6gb0020n.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W12540215","https://openalex.org/W16029853","https://openalex.org/W65830589","https://openalex.org/W165338889","https://openalex.org/W567735055","https://openalex.org/W618738878","https://openalex.org/W1493919779","https://openalex.org/W1508951920","https://openalex.org/W1881082621","https://openalex.org/W1971559855","https://openalex.org/W1986286400","https://openalex.org/W1992251283","https://openalex.org/W1994817905","https://openalex.org/W2003962273","https://openalex.org/W2019077981","https://openalex.org/W2021181758","https://openalex.org/W2023899218","https://openalex.org/W2030164772","https://openalex.org/W2035228196","https://openalex.org/W2036362108","https://openalex.org/W2042123357","https://openalex.org/W2048943469","https://openalex.org/W2055736359","https://openalex.org/W2072371192","https://openalex.org/W2075434561","https://openalex.org/W2075471409","https://openalex.org/W2081841031","https://openalex.org/W2081935144","https://openalex.org/W2086630609","https://openalex.org/W2086797502","https://openalex.org/W2087119258","https://openalex.org/W2088655169","https://openalex.org/W2093588915","https://openalex.org/W2095786670","https://openalex.org/W2098878950","https://openalex.org/W2103609019","https://openalex.org/W2103991884","https://openalex.org/W2105835982","https://openalex.org/W2106011751","https://openalex.org/W2106619606","https://openalex.org/W2106805149","https://openalex.org/W2109620996","https://openalex.org/W2112150247","https://openalex.org/W2113779343","https://openalex.org/W2113865982","https://openalex.org/W2114489169","https://openalex.org/W2116145543","https://openalex.org/W2129827820","https://openalex.org/W2130867391","https://openalex.org/W2130945481","https://openalex.org/W2131515650","https://openalex.org/W2132232005","https://openalex.org/W2133488570","https://openalex.org/W2145995125","https://openalex.org/W2147668927","https://openalex.org/W2147954981","https://openalex.org/W2157359173","https://openalex.org/W2158894504","https://openalex.org/W2167179215","https://openalex.org/W2171236187","https://openalex.org/W2262819477","https://openalex.org/W2324392187","https://openalex.org/W2341205300","https://openalex.org/W4210821588"],"related_works":["https://openalex.org/W180957169","https://openalex.org/W1996304178","https://openalex.org/W2116620918","https://openalex.org/W4224264912","https://openalex.org/W2256592194","https://openalex.org/W1503981640","https://openalex.org/W2001480477","https://openalex.org/W2012290039","https://openalex.org/W4389450974","https://openalex.org/W2062146618"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,14,26,41,43,60,66,96,104,110,167,171,183,193,196,220,231,235,244,258,267,289,297,309],"this":[3],"thesis":[4],"is":[5],"to":[6,48,120,126,150,161,263,281,322,330,333],"examine":[7,282],"risk":[8,119,189,261,337],"factors":[9,90,190,340],"present":[10],"before":[11,153],"the":[12,17,31,70,86,146,163,218,224,242,248,265,271,307,319],"diagnosis":[13,154,195],"dementia":[15,81,142,284],"in":[16,51,85,157,247,318,342],"Aging,":[18],"Demographics":[19],"and":[20,33,46,58,100,117,187,203,233,338],"Memory":[21],"Study":[22,35],"(ADAMS),":[23],"a":[24,37,52,129,151,287,301],"sample":[25,40],"856":[27],"participants":[28,290],"chosen":[29],"from":[30,69,145,148,316],"Health":[32],"Retirement":[34],"(HRS),":[36],"nationally":[38],"representative":[39],"persons":[42],"retiring":[44],"age":[45,240],"older,":[47],"take":[49],"part":[50],"clinical":[53],"assessment":[54],"for":[55],"cognitive":[56,339],"impairment":[57],"collection":[59],"other":[61],"health":[62],"information.":[63],"A":[64],"subset":[65],"330":[67],"individuals":[68],"ADAMS":[71],"study":[72],"diagnosed":[73,134],"with":[74,135,291],"either":[75,136,172],"Alzheimer\u00a1\u00a6s":[76,137],"disease":[77,138],"(AD)":[78,139],"or":[79,140,174],"vascular":[80,141,292],"(VaD)":[82],"was":[83,124,279],"considered":[84],"primary":[87],"analyses.":[88],"Risk":[89],"examined":[91],"were":[92,155,191,208,312],"age,":[93,180],"gender,":[94,181],"years":[95],"education,":[97],"APO-f\u00d5":[98],"status,":[99],"empirical":[101],"Bayes":[102],"estimates":[103],"latent":[105],"growth":[106],"curve":[107],"trajectory":[108],"components":[109],"longitudinal":[111,204],"episodic":[112,185,236],"memory":[113,186,237],"performance,":[114],"mental":[115,205],"status":[116,206],"cardiovascular":[118,188,260],"test":[121],"whether":[122,128],"it":[123],"possible":[125],"discriminate":[127],"participant":[130],"would":[131],"be":[132,331],"later":[133,194],"(VaD).":[143],"Data":[144],"HRS":[147],"up":[149],"decade":[152],"used":[156],"logistic":[158],"regression":[159],"analyses":[160,321],"find":[162],"best":[164],"fitting":[165],"model":[166],"prediction":[168],"into":[169,223,270,294],"groups":[170,296],"AD":[173,197,225,249,272,304],"VaD.":[175],"Results":[176],"showed":[177],"that":[178,311],"while":[179],"number":[182],"APO-f\u00d5f\u00a4alleles,":[184],"predictive":[192],"versus":[198,300],"VaD":[199],"subtypes,":[200],"educational":[201],"attainment":[202],"trajectories":[207],"not":[209],"significant":[210],"predictors.":[211],"Each":[212],"APO-f\u00d5f\u00a4":[213],"allele":[214],"more":[215,302,327],"than":[216],"doubled":[217],"odds":[219,243,266],"being":[221,245,268],"classified":[222,246,269,314],"group":[226,250,273,305],"(OR":[227,274],"=2.48).":[228],"Higher":[229],"levels":[230],"performance":[232],"maintenance":[234],"ability":[238],"across":[239],"decreased":[241,315],"(ORIntercept":[251],"=":[252,275],"0.92;":[253],"ORSlope=":[254],"0.79).":[255],"Every":[256],"unit":[257],"increased":[259],"tended":[262],"decrease":[264],"0.77).":[276],"An":[277],"attempt":[278],"made":[280],"mixed":[283,298,343],"cases":[285,299,310],"by":[286],"re-categorization":[288],"pathology":[293],"new":[295],"\u00a1\u00a5pure\u00a1\u00a6":[303],"but":[306],"percent":[308],"correctly":[313],"79.7%":[317],"original":[320],"77.9%":[323],"once":[324],"re-organized,":[325],"indicating":[326],"may":[328],"need":[329],"done":[332],"get":[334],"at":[335],"underlying":[336],"involved":[341],"dementia.":[344]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
