{"id":"https://openalex.org/W39113591","doi":null,"title":"The Genomic Landscape of the Old Order Amish.","display_name":"The Genomic Landscape of the Old Order Amish.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W39113591","mag":"39113591"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/86255","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/86255","pdf_url":"https://hdl.handle.net/2027.42/86255","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/86255","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113432636","display_name":"Van Hout","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Van Hout","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056602466","display_name":"V Cristopher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Cristopher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.22990000247955322,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/old-order-amish","display_name":"Old Order Amish","score":1.0},{"id":"https://openalex.org/keywords/population-isolates","display_name":"isolated populations","score":0.7289999723434448},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8790000081062317},{"id":"https://openalex.org/keywords/1000-genomes-project","display_name":"1000 Genomes Project","score":0.7889999747276306},{"id":"https://openalex.org/keywords/haplotype-reference-panel","display_name":"haplotype reference panel","score":0.8730000257492065},{"id":"https://openalex.org/keywords/inbreeding-coefficient","display_name":"inbreeding coefficient","score":0.8180000185966492},{"id":"https://openalex.org/keywords/autozygosity","display_name":"autozygosity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/population-bottleneck","display_name":"population bottleneck","score":0.7580000162124634},{"id":"https://openalex.org/keywords/genetic-drift","display_name":"genetic drift","score":0.9559999704360962},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.49799999594688416},{"id":"https://openalex.org/keywords/lancaster-county-pennsylvania","display_name":"Lancaster County, Pennsylvania","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.5386379361152649},{"id":"https://openalex.org/C182306322","wikidata":"https://www.wikidata.org/wiki/Q1779371","display_name":"Order (exchange)","level":2,"score":0.5194206237792969},{"id":"https://openalex.org/C53553401","wikidata":"https://www.wikidata.org/wiki/Q47307","display_name":"Genealogy","level":1,"score":0.43898648023605347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33574187755584717},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.3296055793762207},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.1928606927394867},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.07216387987136841},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/86255","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/86255","pdf_url":"https://hdl.handle.net/2027.42/86255","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:39113591","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/86255","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/86255","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/86255","pdf_url":"https://hdl.handle.net/2027.42/86255","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5272168108","display_name":null,"funder_award_id":"41977033","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6213190626","display_name":null,"funder_award_id":"2022YFD1900602","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8314328180","display_name":null,"funder_award_id":"2022YFD1500303","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W39113591.pdf","grobid_xml":"https://content.openalex.org/works/W39113591.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W649384440","https://openalex.org/W1921969326","https://openalex.org/W1963799703","https://openalex.org/W1973769499","https://openalex.org/W1980991473","https://openalex.org/W1984046516","https://openalex.org/W1985414816","https://openalex.org/W1989190966","https://openalex.org/W1990544019","https://openalex.org/W1991968981","https://openalex.org/W1993638580","https://openalex.org/W1999412878","https://openalex.org/W2002343937","https://openalex.org/W2005935256","https://openalex.org/W2006712471","https://openalex.org/W2015408724","https://openalex.org/W2022177992","https://openalex.org/W2024642024","https://openalex.org/W2027229495","https://openalex.org/W2027465591","https://openalex.org/W2032167303","https://openalex.org/W2039480559","https://openalex.org/W2040680124","https://openalex.org/W2042413629","https://openalex.org/W2044054947","https://openalex.org/W2048289494","https://openalex.org/W2049388504","https://openalex.org/W2050821039","https://openalex.org/W2051808171","https://openalex.org/W2052235739","https://openalex.org/W2055300468","https://openalex.org/W2057688723","https://openalex.org/W2061100095","https://openalex.org/W2061684375","https://openalex.org/W2062689489","https://openalex.org/W2066276433","https://openalex.org/W2067302979","https://openalex.org/W2072038834","https://openalex.org/W2073593854","https://openalex.org/W2073917725","https://openalex.org/W2074813927","https://openalex.org/W2078156505","https://openalex.org/W2081872599","https://openalex.org/W2082447493","https://openalex.org/W2086699924","https://openalex.org/W2089875214","https://openalex.org/W2091583677","https://openalex.org/W2092922183","https://openalex.org/W2093657574","https://openalex.org/W2095560101","https://openalex.org/W2096682774","https://openalex.org/W2096916467","https://openalex.org/W2098684474","https://openalex.org/W2100169779","https://openalex.org/W2107916366","https://openalex.org/W2121286926","https://openalex.org/W2124277514","https://openalex.org/W2124586775","https://openalex.org/W2127840950","https://openalex.org/W2134599124","https://openalex.org/W2135325722","https://openalex.org/W2137073429","https://openalex.org/W2137776860","https://openalex.org/W2141088880","https://openalex.org/W2141810183","https://openalex.org/W2153345301","https://openalex.org/W2153362877","https://openalex.org/W2156719275","https://openalex.org/W2160563455","https://openalex.org/W2161633633","https://openalex.org/W2161644980","https://openalex.org/W2162530578","https://openalex.org/W2166501262","https://openalex.org/W2167695374","https://openalex.org/W2169688840","https://openalex.org/W2170009526","https://openalex.org/W2171777347","https://openalex.org/W2176831518","https://openalex.org/W2319462502","https://openalex.org/W2984750994"],"related_works":["https://openalex.org/W2412883289","https://openalex.org/W2074813927","https://openalex.org/W435494308","https://openalex.org/W644863348","https://openalex.org/W1507673234","https://openalex.org/W2332980952","https://openalex.org/W6977227072","https://openalex.org/W2588044969","https://openalex.org/W4413022968","https://openalex.org/W2948324115"],"abstract_inverted_index":{"The":[0],"Old":[1],"Order":[2],"Amish":[3],"(OOA)":[4],"of":[5,17,37,69,80,93,105,133,156,193,204,226,252,270,295,316,321,331,347],"Lancaster":[6],"County":[7],"Pennsylvania":[8],"are":[9,189],"a":[10,14,34,117,139,153,268,312],"population":[11,94,155],"isolate":[12],"with":[13,311],"census":[15],"size":[16],"~35,000":[18],"individuals":[19,151],"who":[20],"descended":[21],"from":[22,25,186,272],"~200":[23],"immigrants":[24],"Western":[26],"Europe":[27],"in":[28,39,83,135,197,237,263,298,334],"the":[29,75,84,91,100,120,136,178,198,202,224,238,264,273,288,293,299,319,332,335],"early":[30],"1700s.":[31],"They":[32],"have":[33],"long":[35],"history":[36,57],"participation":[38],"genetic":[40,81,97,195],"studies,":[41],"for":[42,110,122,191,212,255],"which":[43],"their":[44,55,60,65],"genealogical":[45],"records":[46],"and":[47,78,96,129,152,172,180,220,245,249,282,291,308],"simple":[48],"lifestyle":[49],"offer":[50],"substantial":[51],"research":[52],"advantages.":[53],"However,":[54],"demographic":[56],"has":[58],"altered":[59],"genomic":[61,131,279],"landscape":[62,71],"relative":[63],"to":[64,74,340],"European":[66,157],"counterparts.":[67],"Knowledge":[68],"this":[70,87],"is":[72,338],"critical":[73],"design,":[76],"execution,":[77],"interpretation":[79],"studies":[82],"OOA.":[85,137,199,239,265],"In":[86],"dissertation,":[88],"I":[89,146,216,277,302,326],"evaluate":[90,217],"consequences":[92],"bottleneck":[95],"drift":[98],"on":[99,119,234,287],"empirical":[101,222],"and/or":[102],"expected":[103],"distribution":[104,294],"1)":[106],"linkage":[107],"disequilibrium":[108],"(LD)":[109],"common":[111,162,194],"variants,":[112],"2)":[113],"rare":[114,213,256],"variation":[115,196],"(with":[116],"focus":[118],"implications":[121],"imputation":[123,235,253],"accuracy":[124,236,254],"using":[125,227,258,267],"an":[126],"external":[127],"population)":[128],"3)":[130],"estimates":[132],"inbreeding":[134,280,285,314,333,341],"Using":[138],"high-density":[140,274],"Single":[141],"Nucleotide":[142],"Polymorphism":[143],"(SNP)":[144],"map,":[145],"compare":[147,283],"LD":[148,173],"between":[149,177,306],"OOA":[150,179,230,289,336],"reference":[154,232],"ancestry":[158],"(HapMap":[159],"CEU).":[160],"For":[161],"SNPs":[163,214,257,271],"(Minor":[164],"Allele":[165],"Frequency":[166],"(MAF)":[167],"\u2265":[168],"0.05),":[169],"allele":[170],"frequencies":[171],"profiles":[174],"were":[175],"similar":[176],"CEU.":[181],"Thus,":[182],"public":[183],"resources":[184,262],"constructed":[185],"CEU":[187,228],"data":[188],"appropriate":[190],"analyses":[192],"To":[200],"assess":[201],"portability":[203],"deep":[205],"sequencing":[206],"resources,":[207],"e.g.,":[208],"1000":[209,259],"Genomes":[210,260],"Project,":[211],"(MAF<0.05),":[215],"(via":[218],"simulation":[219],"small-scale":[221],"study)":[223],"impact":[225],"versus":[229],"haplotype":[231],"panels":[233],"My":[240],"results":[241],"establish":[242,327],"likely":[243],"lower":[244],"upper":[246],"bounds":[247],"(0.50":[248],"0.75,":[250],"respectively)":[251],"Project-like":[261],"Finally,":[266],"subset":[269],"map":[275],"above,":[276],"estimate":[278],"coefficients":[281],"them":[284],"conditional":[286],"pedigree,":[290],"describe":[292],"autozygous":[296],"segments":[297],"study":[300],"participants.":[301],"observed":[303],"strong":[304],"agreement":[305],"genomic-":[307],"pedigree-based":[309],"estimates,":[310],"mean":[313],"coefficient":[315],"~0.035,":[317],"approximately":[318,329],"offspring":[320,346],"half":[322],"1st":[323],"cousins.":[324,349],"Furthermore,":[325],"that":[328],"92%":[330],"pedigree":[337],"due":[339],"loops":[342],"more":[343],"distant":[344],"than":[345],"2nd":[348]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
