{"id":"https://openalex.org/W39038529","doi":null,"title":"Pharmacotherapy for Parkinson's Disease - Observations and Innovations","display_name":"Pharmacotherapy for Parkinson's Disease - Observations and Innovations","publication_year":2011,"publication_date":"2011-06-13","ids":{"openalex":"https://openalex.org/W39038529","mag":"39038529"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-3354","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3354","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3354","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080271966","display_name":"Dag Nyholm","orcid":"https://orcid.org/0000-0001-9776-7715","observed_orcids":["https://orcid.org/0000-0001-9776-7715"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dag Nyholm","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9776-7715","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080271966"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/levodopa","display_name":"levodopa","score":0.8659999966621399},{"id":"https://openalex.org/keywords/levodopa-pharmacokinetics","display_name":"levodopa pharmacokinetics","score":0.9430000185966492},{"id":"https://openalex.org/keywords/motor-fluctuations","display_name":"motor fluctuations","score":0.9049999713897705},{"id":"https://openalex.org/keywords/motor-complications","display_name":"motor complications","score":0.7889999747276306},{"id":"https://openalex.org/keywords/sustained-release-tablets","display_name":"sustained-release tablets","score":0.906000018119812},{"id":"https://openalex.org/keywords/levodopa-carbidopa","display_name":"levodopa/carbidopa","score":0.7630000114440918},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.765999972820282},{"id":"https://openalex.org/keywords/symptom-self-assessment","display_name":"symptom self-assessment","score":0.7360000014305115},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5898427963256836},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.5277037024497986},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4877801537513733},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.44293415546417236},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.422122597694397},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-3354","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3354","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:39038529","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/ETH/8630","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-3354","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3354","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":270,"referenced_works":["https://openalex.org/W11112138","https://openalex.org/W25940130","https://openalex.org/W37389757","https://openalex.org/W99762335","https://openalex.org/W135531847","https://openalex.org/W162487658","https://openalex.org/W173218471","https://openalex.org/W175006040","https://openalex.org/W175938201","https://openalex.org/W199354732","https://openalex.org/W201588874","https://openalex.org/W1430103840","https://openalex.org/W1481697456","https://openalex.org/W1489370470","https://openalex.org/W1505424913","https://openalex.org/W1513519866","https://openalex.org/W1533091812","https://openalex.org/W1562359367","https://openalex.org/W1616315782","https://openalex.org/W1671798294","https://openalex.org/W1854755157","https://openalex.org/W1866157615","https://openalex.org/W1936067042","https://openalex.org/W1955121811","https://openalex.org/W1964137058","https://openalex.org/W1964979925","https://openalex.org/W1965714500","https://openalex.org/W1966175399","https://openalex.org/W1967180868","https://openalex.org/W1968672404","https://openalex.org/W1968793574","https://openalex.org/W1969018656","https://openalex.org/W1969280474","https://openalex.org/W1969614153","https://openalex.org/W1970797730","https://openalex.org/W1971002934","https://openalex.org/W1971506756","https://openalex.org/W1975360612","https://openalex.org/W1975743268","https://openalex.org/W1977307550","https://openalex.org/W1977484828","https://openalex.org/W1980286722","https://openalex.org/W1980987944","https://openalex.org/W1982569878","https://openalex.org/W1982786179","https://openalex.org/W1982924711","https://openalex.org/W1983032722","https://openalex.org/W1983046432","https://openalex.org/W1984439185","https://openalex.org/W1985133850","https://openalex.org/W1987086879","https://openalex.org/W1988713263","https://openalex.org/W1989002864","https://openalex.org/W1989917688","https://openalex.org/W1990320712","https://openalex.org/W1991152368","https://openalex.org/W1991201604","https://openalex.org/W1991349201","https://openalex.org/W1991603311","https://openalex.org/W1991699170","https://openalex.org/W1992482234","https://openalex.org/W1993226137","https://openalex.org/W1993478531","https://openalex.org/W1995262065","https://openalex.org/W1995544693","https://openalex.org/W1996046462","https://openalex.org/W1996610693","https://openalex.org/W1997394907","https://openalex.org/W1997739756","https://openalex.org/W1998450231","https://openalex.org/W1998534190","https://openalex.org/W1999103951","https://openalex.org/W1999326187","https://openalex.org/W1999893655","https://openalex.org/W2000993232","https://openalex.org/W2001398927","https://openalex.org/W2001664620","https://openalex.org/W2002106653","https://openalex.org/W2003342670","https://openalex.org/W2003670766","https://openalex.org/W2003861040","https://openalex.org/W2004153344","https://openalex.org/W2004818860","https://openalex.org/W2005105502","https://openalex.org/W2005468874","https://openalex.org/W2006375474","https://openalex.org/W2006463029","https://openalex.org/W2007711114","https://openalex.org/W2008119031","https://openalex.org/W2008507019","https://openalex.org/W2009161818","https://openalex.org/W2010299478","https://openalex.org/W2010723753","https://openalex.org/W2011475407","https://openalex.org/W2012244628","https://openalex.org/W2013338623","https://openalex.org/W2015094863","https://openalex.org/W2016609173","https://openalex.org/W2017055459","https://openalex.org/W2018391979","https://openalex.org/W2019021573","https://openalex.org/W2019172353","https://openalex.org/W2019465732","https://openalex.org/W2019922751","https://openalex.org/W2020799630","https://openalex.org/W2020800817","https://openalex.org/W2020950927","https://openalex.org/W2021463563","https://openalex.org/W2024397203","https://openalex.org/W2024962747","https://openalex.org/W2025247403","https://openalex.org/W2025720422","https://openalex.org/W2029632110","https://openalex.org/W2030419352","https://openalex.org/W2030730789","https://openalex.org/W2031529979","https://openalex.org/W2032138788","https://openalex.org/W2032251866","https://openalex.org/W2032642652","https://openalex.org/W2034010958","https://openalex.org/W2034770217","https://openalex.org/W2035001837","https://openalex.org/W2035049053","https://openalex.org/W2035172064","https://openalex.org/W2039800786","https://openalex.org/W2040647981","https://openalex.org/W2042308210","https://openalex.org/W2047328154","https://openalex.org/W2048051000","https://openalex.org/W2049047445","https://openalex.org/W2049689856","https://openalex.org/W2050760829","https://openalex.org/W2052510409","https://openalex.org/W2052529053","https://openalex.org/W2055377447","https://openalex.org/W2056233773","https://openalex.org/W2056884057","https://openalex.org/W2057278085","https://openalex.org/W2057788173","https://openalex.org/W2058450302","https://openalex.org/W2059230798","https://openalex.org/W2059378567","https://openalex.org/W2059423763","https://openalex.org/W2059545710","https://openalex.org/W2061530817","https://openalex.org/W2061747526","https://openalex.org/W2062322582","https://openalex.org/W2062596342","https://openalex.org/W2064419430","https://openalex.org/W2064828061","https://openalex.org/W2064996887","https://openalex.org/W2066217835","https://openalex.org/W2067856703","https://openalex.org/W2070555349","https://openalex.org/W2071948427","https://openalex.org/W2072788041","https://openalex.org/W2074010758","https://openalex.org/W2074446038","https://openalex.org/W2075424719","https://openalex.org/W2075857365","https://openalex.org/W2075952655","https://openalex.org/W2076642666","https://openalex.org/W2076870705","https://openalex.org/W2078548179","https://openalex.org/W2078692158","https://openalex.org/W2078883956","https://openalex.org/W2080091650","https://openalex.org/W2080357105","https://openalex.org/W2081967462","https://openalex.org/W2082088794","https://openalex.org/W2082246186","https://openalex.org/W2084189094","https://openalex.org/W2084657660","https://openalex.org/W2084669272","https://openalex.org/W2084971970","https://openalex.org/W2085518524","https://openalex.org/W2086128426","https://openalex.org/W2086414180","https://openalex.org/W2089132727","https://openalex.org/W2090337651","https://openalex.org/W2090428143","https://openalex.org/W2091664599","https://openalex.org/W2092462980","https://openalex.org/W2092980697","https://openalex.org/W2095389365","https://openalex.org/W2095889210","https://openalex.org/W2096711507","https://openalex.org/W2098072912","https://openalex.org/W2102672739","https://openalex.org/W2103425651","https://openalex.org/W2103964804","https://openalex.org/W2107507666","https://openalex.org/W2109717262","https://openalex.org/W2112008896","https://openalex.org/W2112816318","https://openalex.org/W2112921127","https://openalex.org/W2113629806","https://openalex.org/W2114122417","https://openalex.org/W2115222037","https://openalex.org/W2119080350","https://openalex.org/W2119095179","https://openalex.org/W2125320763","https://openalex.org/W2125561398","https://openalex.org/W2125697933","https://openalex.org/W2126499376","https://openalex.org/W2130696280","https://openalex.org/W2131721815","https://openalex.org/W2133527614","https://openalex.org/W2133652459","https://openalex.org/W2133829654","https://openalex.org/W2134886133","https://openalex.org/W2135374245","https://openalex.org/W2137566057","https://openalex.org/W2139085451","https://openalex.org/W2139425233","https://openalex.org/W2142201438","https://openalex.org/W2142690102","https://openalex.org/W2144727555","https://openalex.org/W2146400446","https://openalex.org/W2146662310","https://openalex.org/W2147111512","https://openalex.org/W2150028758","https://openalex.org/W2154761807","https://openalex.org/W2155848097","https://openalex.org/W2156806817","https://openalex.org/W2157150089","https://openalex.org/W2157522178","https://openalex.org/W2158311794","https://openalex.org/W2158342248","https://openalex.org/W2158526969","https://openalex.org/W2159036016","https://openalex.org/W2161197727","https://openalex.org/W2161509926","https://openalex.org/W2161960967","https://openalex.org/W2163129438","https://openalex.org/W2165732693","https://openalex.org/W2166942975","https://openalex.org/W2167227624","https://openalex.org/W2167274043","https://openalex.org/W2169161939","https://openalex.org/W2169593475","https://openalex.org/W2170149470","https://openalex.org/W2244209634","https://openalex.org/W2321544597","https://openalex.org/W2322912881","https://openalex.org/W2337142316","https://openalex.org/W2340133307","https://openalex.org/W2398958027","https://openalex.org/W2404222273","https://openalex.org/W2406430691","https://openalex.org/W2409123857","https://openalex.org/W2410023738","https://openalex.org/W2410295430","https://openalex.org/W2415795186","https://openalex.org/W2416850163","https://openalex.org/W2417678449","https://openalex.org/W2419008133","https://openalex.org/W2419442406","https://openalex.org/W2421623688","https://openalex.org/W2427209312","https://openalex.org/W2430879907","https://openalex.org/W2439379608","https://openalex.org/W2442383969","https://openalex.org/W2460714368","https://openalex.org/W2461633631","https://openalex.org/W2463821227","https://openalex.org/W2469782370","https://openalex.org/W2551900282","https://openalex.org/W2563241409","https://openalex.org/W7116897901"],"related_works":["https://openalex.org/W2577807847","https://openalex.org/W2536028718","https://openalex.org/W2514015092","https://openalex.org/W1996813582","https://openalex.org/W3198896895","https://openalex.org/W2032251866","https://openalex.org/W2143807044","https://openalex.org/W2282362772","https://openalex.org/W2788630676","https://openalex.org/W2020849440"],"abstract_inverted_index":{"Pharmacotherapy":[0],"for":[1,23,104,117,163,179,256,289,295],"Parkinson\u2019s":[2],"disease":[3],"(PD)":[4],"is":[5,133,172,209,252],"based":[6],"on":[7,35,185],"levodopa,":[8,94],"the":[9,20,30,42,126,181,194,204,244,253,270],"most":[10,197],"effective":[11],"dopaminergic":[12],"drug.":[13],"The":[14,65,233],"development":[15,135],"of":[16,32,62,67,93,136,148,157,169,203,207,250,281],"motor":[17,36,99,257],"complications":[18],"constitutes":[19],"major":[21,254],"challenge":[22],"new":[24,161],"or":[25,150,283],"refined":[26],"therapies.":[27],"To":[28,247],"evaluate":[29],"impact":[31,66],"levodopa":[33,54,68,106,251,273],"pharmacokinetics":[34,69,249],"function,":[37],"an":[38],"observational":[39],"study":[40],"in":[41,52,58,73,90,96,146,200,211,259,272],"patients\u2019":[43],"home":[44],"environment":[45],"was":[46,56,70,122,183,226,241],"carried":[47],"out.":[48],"A":[49,101,160,222],"high":[50],"variability":[51,89],"plasma":[53,91],"levels":[55,92],"found":[57],"all":[59],"patients,":[60],"irrespective":[61],"treatment":[63],"regimen.":[64],"further":[71],"studied":[72],"a":[74,154,229],"crossover":[75],"trial":[76],"comparing":[77],"sustained-release":[78],"tablets":[79,142],"and":[80,111,196,235,266],"continuous":[81],"daytime":[82],"intestinal":[83],"infusion.":[84,285],"Infusion":[85],"produced":[86],"significantly":[87,97],"decreased":[88],"resulting":[95],"normalised":[98],"function.":[100],"permanent":[102],"system":[103],"long-term":[105,127],"infusion":[107,139],"has":[108],"been":[109,115],"developed":[110],"28":[112],"patients":[113,186],"have":[114],"followed":[116],"87":[118],"patient-years.":[119],"Motor":[120],"response":[121],"generally":[123],"preserved":[124],"during":[125],"observation":[128],"period,":[129],"implying":[130],"that":[131],"there":[132],"no":[134],"tolerance":[137],"to":[138,192,263,267],"therapy.":[140],"Levodopa":[141],"are":[143,217,293],"normally":[144],"used":[145],"multiples":[147],"50":[149],"100":[151],"mg,":[152],"thus":[153,236],"rough":[155],"estimate":[156],"individual":[158],"dosage.":[159],"concept":[162],"individualising":[164],"levodopa/carbidopa":[165],"doses":[166],"with":[167,187,219,228,243],"microtablets":[168,182,282],"5/1.25":[170],"mg":[171],"under":[173],"development.":[174],"An":[175],"electronic":[176,224,245],"drug-dispensing":[177],"device":[178],"administering":[180],"tested":[184],"PD.":[188,260],"All":[189],"were":[190,198],"able":[191],"handle":[193],"dispenser":[195],"interested":[199],"future":[201],"use":[202],"concept.":[205],"Self-assessment":[206],"symptoms":[208],"accurate":[210],"PD,":[212],"but":[213],"traditional":[214],"paper":[215,231],"diaries":[216,288],"associated":[218],"low":[220],"compliance.":[221],"wireless":[223],"diary":[225],"compared":[227],"corresponding":[230],"diary.":[232,246],"time-stamped":[234],"completely":[237],"reliable":[238],"patient":[239,287],"compliance":[240],"88%":[242],"conclude,":[248],"determinant":[255],"fluctuations":[258,271],"Every":[261],"effort":[262],"individualise":[264],"dosage":[265],"smooth":[268],"out":[269],"concentrations":[274],"should":[275],"be":[276],"made,":[277],"e.g.":[278],"by":[279],"means":[280],"enteral":[284],"Electronic":[286],"real-time":[290],"data":[291],"capture":[292],"suitable":[294],"PD":[296],"studies.":[297]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
