{"id":"https://openalex.org/W3883059","doi":null,"title":"Free sphingosine in control and stimulated human neutrophils","display_name":"Free sphingosine in control and stimulated human neutrophils","publication_year":1987,"publication_date":"1987-05-01","ids":{"openalex":"https://openalex.org/W3883059","mag":"3883059"},"language":"en","primary_location":{"id":"mag:3883059","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/6150476","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002672605","display_name":"Alfred H. Merrill","orcid":"https://orcid.org/0000-0002-6673-968X","observed_orcids":["https://orcid.org/0000-0002-6673-968X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alfred H. Merrill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043665968","display_name":"Emily Wilson","orcid":"https://orcid.org/0000-0002-8658-4072","observed_orcids":["https://orcid.org/0000-0002-8658-4072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily Wilson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8658-4072","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025076770","display_name":"E. Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015420482","display_name":"Richard E. Mullins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard E. Mullins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032077625","display_name":"Dennis C. Liotta","orcid":"https://orcid.org/0000-0002-7736-7113","observed_orcids":["https://orcid.org/0000-0002-7736-7113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis C. Liotta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049024406","display_name":"J. David Lambeth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. David Lambeth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00028474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-neutrophils","display_name":"human neutrophils","score":0.9380000233650208},{"id":"https://openalex.org/keywords/protein-kinase-c-inhibition","display_name":"protein kinase C inhibition","score":0.8029999732971191},{"id":"https://openalex.org/keywords/respiratory-burst","display_name":"respiratory burst","score":0.9520000219345093},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.8050000071525574},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9860000014305115},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.8629999756813049},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.9374517798423767},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.6442830562591553},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6319432854652405},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.6171913743019104},{"id":"https://openalex.org/C2780656570","wikidata":"https://www.wikidata.org/wiki/Q5090627","display_name":"N-Formylmethionine leucyl-phenylalanine","level":4,"score":0.5550588965415955},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5293437242507935},{"id":"https://openalex.org/C2777700496","wikidata":"https://www.wikidata.org/wiki/Q7576797","display_name":"Sphingosine kinase","level":5,"score":0.5079556107521057},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49630528688430786},{"id":"https://openalex.org/C99971728","wikidata":"https://www.wikidata.org/wiki/Q838181","display_name":"Respiratory burst","level":2,"score":0.49581536650657654},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.49481528997421265},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4764043390750885},{"id":"https://openalex.org/C198677920","wikidata":"https://www.wikidata.org/wiki/Q3299937","display_name":"Neutrophile","level":3,"score":0.46193233132362366},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4457104802131653},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.4403129816055298},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.4176230728626251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3308207392692566},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.31082430481910706},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18403801321983337}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3883059","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/6150476","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.41999998688697815}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1596414504","https://openalex.org/W274679289","https://openalex.org/W1984696891","https://openalex.org/W2105369923","https://openalex.org/W2139685042","https://openalex.org/W1507367690","https://openalex.org/W1998475310","https://openalex.org/W1546385411","https://openalex.org/W1607893122","https://openalex.org/W1975836015"],"abstract_inverted_index":{"Exogenous":[0],"long-chain":[1,35,118],"(sphingoid)":[2],"bases":[3,36,119],"are":[4,96],"potent":[5],"inhibitors":[6],"of":[7,17,90,100,114,132],"protein":[8,115],"kinase":[9,116],"C":[10],"in":[11,24,37,53,102,124],"vitro":[12],"and":[13,41,45],"the":[14,67,107,112,130],"oxidative":[15],"burst":[16],"human":[18],"neutrophils.":[19],"To":[20],"assess":[21],"their":[22],"involvement":[23],"neutrophil":[25,126],"function,":[26],"high-performance":[27],"liquid":[28],"chromatography":[29],"was":[30,51,85],"used":[31],"to":[32,98,110,129],"quantitate":[33],"free":[34,81],"neutrophils":[38,56,103],"incubated":[39],"with":[40,76],"without":[42],"N-formyl-methionyl-leucyl-phenylalanine":[43],"(fMLP)":[44],"phorbol":[46],"12-myristate":[47],"13-acetate":[48],"(PMA).":[49],"Sphingosine":[50],"present":[52],"freshly":[54],"isolated":[55],"at":[57,65],"6.1":[58],"+/-":[59],"1.1":[60],"pmol/10W":[61],"cells.":[62],"During":[63],"incubation":[64],"37,":[66],"level":[68],"increased":[69],"several":[70],"fold;":[71],"further":[72],"increases":[73],"were":[74],"obtained":[75],"fMLP":[77],"whereas":[78],"PMA":[79],"decreased":[80],"sphingosine.":[82],"This":[83],"sphingosine":[84],"apparently":[86],"derived":[87],"from":[88],"hydrolysis":[89],"complex":[91],"sphingolipids.":[92],"Since":[93],"endogenous":[94],"levels":[95],"comparable":[97],"those":[99],"diacylglycerols":[101],"and,":[104],"hence,":[105],"within":[106],"range":[108],"expected":[109],"affect":[111],"activity":[113],"C,":[117],"may":[120],"serve":[121],"a":[122],"role":[123],"modulating":[125],"functions":[127],"related":[128],"action":[131],"this":[133],"enzyme.":[134]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}
