{"id":"https://openalex.org/W387901416","doi":null,"title":"Protein and mRNA Studies of Rat FA1/Pref-1/dlk","display_name":"Protein and mRNA Studies of Rat FA1/Pref-1/dlk","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W387901416","mag":"387901416"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-7773","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7773","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7773","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006165918","display_name":"Gabriella Persdotter Hedlund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gabriella Persdotter Hedlund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006165918"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preadipocyte-factor-1","display_name":"preadipocyte factor-1","score":0.890999972820282},{"id":"https://openalex.org/keywords/pref-1","display_name":"Pref-1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.6570000052452087},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.6570000052452087},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8550000190734863},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/goto-kakizaki-rats","display_name":"Goto-Kakizaki rats","score":0.9580000042915344},{"id":"https://openalex.org/keywords/zucker-rats","display_name":"Zucker rats","score":0.9319999814033508},{"id":"https://openalex.org/keywords/amniotic-fluid","display_name":"amniotic fluid","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/visceral-adipose-tissue","display_name":"visceral adipose tissue","score":0.7789999842643738},{"id":"https://openalex.org/keywords/subcutaneous-adipose-tissue","display_name":"subcutaneous adipose tissue","score":0.9649999737739563},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9259999990463257},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8460000157356262},{"id":"https://openalex.org/keywords/endocrine-tissues","display_name":"endocrine tissues","score":0.5690000057220459},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2780178468","wikidata":"https://www.wikidata.org/wiki/Q3551060","display_name":"Zona glomerulosa","level":4,"score":0.8541345596313477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7134037017822266},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5707886219024658},{"id":"https://openalex.org/C2777597313","wikidata":"https://www.wikidata.org/wiki/Q934888","display_name":"Adrenal medulla","level":3,"score":0.5684712529182434},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5610525012016296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5477941036224365},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5174344182014465},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.48762455582618713},{"id":"https://openalex.org/C2777977426","wikidata":"https://www.wikidata.org/wiki/Q19065","display_name":"Adrenal cortex","level":2,"score":0.47581130266189575},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.435257226228714},{"id":"https://openalex.org/C2778736161","wikidata":"https://www.wikidata.org/wiki/Q3301573","display_name":"Zona fasciculata","level":3,"score":0.432463139295578},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32449227571487427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2256096601486206},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1896362602710724},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.1440311074256897},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08526644110679626},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-7773","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7773","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:387901416","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/8275","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-7773","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7773","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W123291453","https://openalex.org/W1589576417","https://openalex.org/W1591100132","https://openalex.org/W1608841109","https://openalex.org/W1827910261","https://openalex.org/W1886903604","https://openalex.org/W1956103182","https://openalex.org/W1965068894","https://openalex.org/W1966280378","https://openalex.org/W1967589170","https://openalex.org/W1972472164","https://openalex.org/W1983942535","https://openalex.org/W1986447155","https://openalex.org/W1987296553","https://openalex.org/W1989846089","https://openalex.org/W1990351921","https://openalex.org/W1991054443","https://openalex.org/W1992806829","https://openalex.org/W1994784206","https://openalex.org/W1994937206","https://openalex.org/W1997337352","https://openalex.org/W1997400948","https://openalex.org/W1997725308","https://openalex.org/W2001423343","https://openalex.org/W2002225356","https://openalex.org/W2002555959","https://openalex.org/W2004140403","https://openalex.org/W2005381157","https://openalex.org/W2009818179","https://openalex.org/W2012754868","https://openalex.org/W2012951157","https://openalex.org/W2015171716","https://openalex.org/W2018636748","https://openalex.org/W2021674088","https://openalex.org/W2024597586","https://openalex.org/W2030486405","https://openalex.org/W2050146183","https://openalex.org/W2050375120","https://openalex.org/W2054556155","https://openalex.org/W2054753350","https://openalex.org/W2056435902","https://openalex.org/W2058262230","https://openalex.org/W2061848803","https://openalex.org/W2064574277","https://openalex.org/W2065583064","https://openalex.org/W2069400890","https://openalex.org/W2071944952","https://openalex.org/W2077427931","https://openalex.org/W2077452107","https://openalex.org/W2080504370","https://openalex.org/W2080825616","https://openalex.org/W2083219932","https://openalex.org/W2084354321","https://openalex.org/W2089106590","https://openalex.org/W2089838855","https://openalex.org/W2095130119","https://openalex.org/W2096388724","https://openalex.org/W2104977244","https://openalex.org/W2105874505","https://openalex.org/W2110484284","https://openalex.org/W2111562658","https://openalex.org/W2112246274","https://openalex.org/W2115630287","https://openalex.org/W2116032027","https://openalex.org/W2119263162","https://openalex.org/W2121572054","https://openalex.org/W2124683859","https://openalex.org/W2125231020","https://openalex.org/W2126455347","https://openalex.org/W2128888529","https://openalex.org/W2130078845","https://openalex.org/W2132358997","https://openalex.org/W2133545915","https://openalex.org/W2136348413","https://openalex.org/W2138369394","https://openalex.org/W2140803065","https://openalex.org/W2141474102","https://openalex.org/W2142991134","https://openalex.org/W2143604340","https://openalex.org/W2144852134","https://openalex.org/W2159115343","https://openalex.org/W2163998285","https://openalex.org/W2164019905","https://openalex.org/W2166920965","https://openalex.org/W2183807225","https://openalex.org/W2275813718","https://openalex.org/W2322888109","https://openalex.org/W2330798375","https://openalex.org/W2955280550"],"related_works":["https://openalex.org/W1807347349","https://openalex.org/W1591100132","https://openalex.org/W2024597586","https://openalex.org/W2058262230","https://openalex.org/W2056435902","https://openalex.org/W2160631763","https://openalex.org/W1956103182","https://openalex.org/W2077452107","https://openalex.org/W2138369394","https://openalex.org/W336181703"],"abstract_inverted_index":{"The":[0,43,89,265],"timing":[1],"of":[2,11,32,60,64,103,120,142,151,166,219,223,237,253,268],"cell":[3],"differentiation":[4],"is":[5,23,35,231,240],"important":[6],"for":[7,57,235],"development":[8],"and":[9,15,68,82,99,109,117,134,148,153,179,202,245,275],"renewal":[10],"well":[12],"functioning":[13],"organs":[14],"tissues.":[16,88],"One":[17],"protein":[18,34,122,164],"involved":[19],"in":[20,39,46,86,105,132,144,168,182,192,208,243,255,283],"this":[21,33,47,214],"process":[22],"Preadipocyte":[24],"factor":[25],"1":[26],"(Pref-1).":[27],"Most":[28],"likely,":[29],"the":[30,51,58,118,121,163,172,183,195,209,220,229,251,284],"role":[31],"to":[36,76,126,186,194,263,277],"maintain":[37],"cells":[38],"an":[40,54,232],"undifferentiated":[41],"state.":[42],"work":[44],"presented":[45],"thesis,":[48],"has":[49],"employed":[50],"rat":[52,96,230],"as":[53],"animal":[55,215],"model":[56,216,234],"studies":[59,137,236],"Pref-1.":[61],"Rat":[62],"models":[63],"obesity":[65],"(Zucker,":[66],"ZO)":[67],"type":[69,224],"II":[70,225],"diabetes":[71],"(Goto-Kakizaki,":[72],"GK)":[73],"were":[74,123,206],"used":[75],"determine":[77],"metabolic":[78,281],"influence":[79,162],"on":[80],"Pref-1":[81,90,104,116,143,167,175,239,254,269],"adipokine":[83],"mRNA":[84,176,204,266],"expression":[85,165,252,267],"adipose":[87,188,273],"cleavage":[91],"product":[92],"was":[93,111,177,190,270],"purified":[94],"from":[95],"amniotic":[97,107],"fluid":[98,108],"physicochemically":[100],"characterised.":[101],"Concentration":[102],"serum,":[106],"urine":[110],"determined":[112],"by":[113,280],"ELISA.":[114],"Soluble":[115],"compartmentalisation":[119],"highly":[124,241],"similar":[125,139],"what":[127],"had":[128],"previously":[129],"been":[130],"demonstrated":[131,276],"mice":[133],"humans.":[135],"Immunohistochemistry":[136],"displayed":[138],"staining":[140],"patterns":[141],"adrenal":[145],"glands,":[146],"ovaries":[147],"pituitary":[149],"glands":[150],"non-pregnant":[152],"pregnant":[154],"rats.":[155,197],"This":[156],"suggests":[157],"that":[158,213],"pregnancy":[159],"do":[160],"not":[161,260],"these":[169],"organs.":[170],"In":[171,227],"GK":[173],"rats,":[174],"altered":[178,207,271],"a":[180],"decrease":[181],"visceral":[184],"compared":[185],"subcutaneous":[187],"depots":[189,274],"demonstrated,":[191],"contrast":[193],"ZO":[196],"Additionally,":[198],"adiponectin,":[199],"leptin,":[200],"IL-6":[201],"TNF-\u03b1":[203],"levels":[205],"diabetic":[210],"strain,":[211],"indicating":[212],"expresses":[217],"many":[218],"typical":[221],"features":[222],"diabetes.":[226],"conclusion,":[228],"appropriate":[233],"FA1/Pref-1/dlk.":[238],"elevated":[242],"fetal":[244],"maternal":[246],"serum":[247],"during":[248],"pregnancy.":[249,264],"However,":[250],"some":[256],"endocrine":[257],"tissues":[258],"did":[259],"alter":[261],"due":[262],"between":[272],"be":[278],"affected":[279],"disturbances":[282],"animals.":[285]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}