{"id":"https://openalex.org/W38773346","doi":null,"title":"Novel effects of beraprost sodium on vasculatures.","display_name":"Novel effects of beraprost sodium on vasculatures.","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W38773346","mag":"38773346","pmid":"https://pubmed.ncbi.nlm.nih.gov/20357746"},"language":"en","primary_location":{"id":"pmid:20357746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20357746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International angiology : a journal of the International Union of Angiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056779739","display_name":"Akira Sugawara","orcid":"https://orcid.org/0000-0003-4511-8101","observed_orcids":["https://orcid.org/0000-0003-4511-8101"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Sugawara","raw_affiliation_strings":["Department of Advanced Biological Sciences for Regeneration,Tohoku University Graduate School of Medicine, Sendai, Japan. akiras2i@mail.tains.tohoku.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Biological Sciences for Regeneration,Tohoku University Graduate School of Medicine, Sendai, Japan. akiras2i@mail.tains.tohoku.ac.jp","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013252958","display_name":"Masataka Kudo","orcid":"https://orcid.org/0000-0001-5916-1202","observed_orcids":["https://orcid.org/0000-0001-5916-1202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kudo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Saito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Saito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072404313","display_name":"Koichi Matsuda","orcid":"https://orcid.org/0000-0001-7292-2686","observed_orcids":["https://orcid.org/0000-0001-7292-2686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Matsuda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087285678","display_name":"Akira Uruno","orcid":"https://orcid.org/0000-0002-9224-0161","observed_orcids":["https://orcid.org/0000-0002-9224-0161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Uruno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066495888","display_name":"Sadayoshi Ito","orcid":"https://orcid.org/0000-0002-5092-3626","observed_orcids":["https://orcid.org/0000-0002-5092-3626"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4204,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.63860983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"29","issue":"2 Suppl","first_page":"28","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.04479999840259552,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beraprost-sodium","display_name":"beraprost sodium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostacyclin-analogues","display_name":"prostacyclin analogues","score":0.9800000190734863},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.7799999713897705},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8050000071525574},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/camp-protein-kinase-a-pathway","display_name":"cAMP/protein kinase A pathway","score":0.9399999976158142},{"id":"https://openalex.org/keywords/capillary-like-tube-formation","display_name":"capillary tube formation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.925000011920929},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.7639999985694885},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7080000042915344},{"id":"https://openalex.org/keywords/ppardelta","display_name":"PPAR\u03b4","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.7986251711845398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7775571346282959},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.7655460834503174},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.6344473361968994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5278539657592773},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5070807933807373},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4895097017288208},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.46592116355895996},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4528062343597412},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.40863484144210815},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34958088397979736},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.2966809570789337},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2050999104976654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1346096396446228},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13322928547859192}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001157","descriptor_name":"Arterial Occlusive Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:20357746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20357746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International angiology : a journal of the International Union of Angiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2887898813","https://openalex.org/W431899837","https://openalex.org/W1980390570","https://openalex.org/W652294319","https://openalex.org/W2193976733","https://openalex.org/W2094497997","https://openalex.org/W2396820753","https://openalex.org/W2040683779","https://openalex.org/W2094971868","https://openalex.org/W2291886032"],"abstract_inverted_index":{"Beraprost":[0],"sodium":[1],"(BPS)":[2],"is":[3],"a":[4],"stable":[5],"orally":[6],"active":[7],"prostacyclin":[8],"analogue":[9],"with":[10,167,182],"vasodilatory":[11],"and":[12,15,26,51,144,171],"anti-platelet":[13],"effects,":[14],"has":[16],"been":[17],"widely":[18],"used":[19],"as":[20,69,71],"therapeutics":[21],"for":[22,165,177],"pulmonary":[23,168],"artery":[24,169],"hypertension":[25,170],"chronic":[27,172],"arterial":[28,173],"obstruction.":[29],"In":[30],"order":[31],"to":[32,108,189],"elucidate":[33],"its":[34],"effects":[35,43,84,196],"on":[36,46,87],"endothelium,":[37],"we":[38,123],"first":[39],"examined":[40],"the":[41,198],"short-term":[42],"of":[44,64,85,193,200],"BPS":[45,65,86,105,132,136,159,195],"nitric":[47],"oxide":[48],"(NO)":[49],"production":[50,68],"endothelial":[52,60,145,183],"NO":[53,67,120],"synthase":[54],"(eNOS)":[55],"activation":[56],"using":[57,94,128],"bovine":[58],"aortic":[59],"cells.":[61],"Short-term":[62],"treatment":[63],"induced":[66],"well":[70],"eNOS":[72],"phosphorylation":[73],"at":[74],"Ser-1179":[75],"mediated":[76,113],"via":[77,114,119],"cAMP/protein":[78],"kinase":[79],"A":[80],"(PKA)":[81],"pathway.":[82],"The":[83],"capillary-like":[88,110],"tube":[89,111],"formation":[90,112],"were":[91],"next":[92],"determined":[93],"human":[95,100],"umbilical":[96],"vein":[97],"ECs":[98],"(HUVECs)/normal":[99],"dermal":[101],"fibroblasts":[102],"co-culture":[103],"system.":[104],"was":[106],"observed":[107],"induce":[109],"cAMP/PKA":[115],"pathway,":[116],"but":[117,175],"not":[118,163],"generation.":[121],"Finally,":[122],"performed":[124],"DNA":[125],"microarray":[126],"analyses":[127],"RNA":[129],"extracted":[130],"from":[131],"treated":[133],"HUVECs.":[134],"Interestingly,":[135],"up-regulated":[137],"several":[138,149],"genes":[139,150],"involved":[140,151],"in":[141,152],"angiogenesis,":[142],"anti-atherosclerosis,":[143],"function,":[146],"while":[147],"down-regulated":[148],"atherosclerosis.":[153],"Our":[154],"data":[155],"therefore":[156],"indicate":[157],"that":[158],"may":[160],"be":[161],"useful":[162],"only":[164],"patients":[166,180],"obstruction,":[174],"also":[176],"general":[178],"atherosclerotic":[179],"complicated":[181],"dysfunction.":[184],"Further":[185],"studies":[186],"are":[187],"needed":[188],"clarify":[190],"molecular":[191],"mechanisms":[192],"these":[194],"including":[197],"involvement":[199],"peroxisome":[201],"proliferator-activated":[202],"receptor-delta.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}