{"id":"https://openalex.org/W38734845","doi":null,"title":"R\u00e9gulation de l'activit\u00e9 du facteur de transcription HIF-1 et de l'expression du VEGF","display_name":"R\u00e9gulation de l'activit\u00e9 du facteur de transcription HIF-1 et de l'expression du VEGF","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W38734845","mag":"38734845"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/757691","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/757691","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037017778","display_name":"Caroline Treins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Caroline Treins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5037017778"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.4456000030040741,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.4456000030040741,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.2079000025987625,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.18140000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1","display_name":"HIF-1","score":0.968999981880188},{"id":"https://openalex.org/keywords/vegf-expression","display_name":"VEGF expression","score":0.8339999914169312},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.7730000019073486},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.4180000126361847},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9599999785423279},{"id":"https://openalex.org/keywords/retinal-epithelial-cells","display_name":"retinal epithelial cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.843999981880188},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7130123972892761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6635416150093079},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.430264949798584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30334028601646423},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1452203392982483},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05055344104766846}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/757691","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/757691","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:38734845","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2004NICE4037","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":128,"referenced_works":["https://openalex.org/W61257829","https://openalex.org/W593956759","https://openalex.org/W1066096829","https://openalex.org/W1509303906","https://openalex.org/W1565554071","https://openalex.org/W1612332414","https://openalex.org/W1774405497","https://openalex.org/W1895492708","https://openalex.org/W1964527179","https://openalex.org/W1966089580","https://openalex.org/W1969806729","https://openalex.org/W1978744203","https://openalex.org/W1979787711","https://openalex.org/W1989480064","https://openalex.org/W1990189726","https://openalex.org/W1992588896","https://openalex.org/W1994647433","https://openalex.org/W1994860012","https://openalex.org/W1997873535","https://openalex.org/W1999111214","https://openalex.org/W2001909877","https://openalex.org/W2002642565","https://openalex.org/W2004841089","https://openalex.org/W2006327127","https://openalex.org/W2008357004","https://openalex.org/W2010845500","https://openalex.org/W2018432380","https://openalex.org/W2020206304","https://openalex.org/W2026975571","https://openalex.org/W2029209385","https://openalex.org/W2030995864","https://openalex.org/W2031172597","https://openalex.org/W2032710553","https://openalex.org/W2033637395","https://openalex.org/W2033945189","https://openalex.org/W2035213839","https://openalex.org/W2040854254","https://openalex.org/W2043820708","https://openalex.org/W2045161614","https://openalex.org/W2048731485","https://openalex.org/W2050575057","https://openalex.org/W2054497088","https://openalex.org/W2064364366","https://openalex.org/W2064395864","https://openalex.org/W2064522587","https://openalex.org/W2066928792","https://openalex.org/W2071425043","https://openalex.org/W2080178959","https://openalex.org/W2081381440","https://openalex.org/W2082135472","https://openalex.org/W2084610464","https://openalex.org/W2085365047","https://openalex.org/W2086461762","https://openalex.org/W2088170072","https://openalex.org/W2091095045","https://openalex.org/W2093169400","https://openalex.org/W2094508018","https://openalex.org/W2095449411","https://openalex.org/W2116780979","https://openalex.org/W2118369999","https://openalex.org/W2119163447","https://openalex.org/W2125688336","https://openalex.org/W2128569032","https://openalex.org/W2131313714","https://openalex.org/W2137570578","https://openalex.org/W2140729981","https://openalex.org/W2157220384","https://openalex.org/W2164279637","https://openalex.org/W2166362771","https://openalex.org/W2180665610","https://openalex.org/W2189423943","https://openalex.org/W2278265378","https://openalex.org/W2298502448","https://openalex.org/W2319213750","https://openalex.org/W2471327201","https://openalex.org/W2472932079","https://openalex.org/W2518877395","https://openalex.org/W2553340305","https://openalex.org/W2560904168","https://openalex.org/W2575229100","https://openalex.org/W2579985252","https://openalex.org/W2605254160","https://openalex.org/W2624824537","https://openalex.org/W2675099414","https://openalex.org/W2732125787","https://openalex.org/W2732855055","https://openalex.org/W2761715556","https://openalex.org/W2763095717","https://openalex.org/W2765086913","https://openalex.org/W2783482715","https://openalex.org/W2790033423","https://openalex.org/W2791706917","https://openalex.org/W2792290000","https://openalex.org/W2792647185","https://openalex.org/W2793557861","https://openalex.org/W2794721650","https://openalex.org/W2795166058","https://openalex.org/W2801520101","https://openalex.org/W2807971858","https://openalex.org/W2891856527","https://openalex.org/W2899207030","https://openalex.org/W2909203648","https://openalex.org/W2954730802","https://openalex.org/W2980970243","https://openalex.org/W2990647796","https://openalex.org/W2991501104","https://openalex.org/W2997254057","https://openalex.org/W2998236767","https://openalex.org/W3008661242","https://openalex.org/W3008978467","https://openalex.org/W3011912470","https://openalex.org/W3017388152","https://openalex.org/W3024310521","https://openalex.org/W3033464201","https://openalex.org/W3037424989","https://openalex.org/W3043706001","https://openalex.org/W3047753107","https://openalex.org/W3092382083","https://openalex.org/W3111704445","https://openalex.org/W3123971848","https://openalex.org/W3131420565","https://openalex.org/W3184038640","https://openalex.org/W3199820970","https://openalex.org/W3211395335","https://openalex.org/W4200157796","https://openalex.org/W4285308866","https://openalex.org/W4297928960","https://openalex.org/W6655752349"],"related_works":["https://openalex.org/W6986794759","https://openalex.org/W2152667555","https://openalex.org/W2109146504","https://openalex.org/W1986429916","https://openalex.org/W7100764492","https://openalex.org/W2128302057","https://openalex.org/W2393994286","https://openalex.org/W2070135193","https://openalex.org/W1021171487","https://openalex.org/W1975303892"],"abstract_inverted_index":{"Nous":[0,38,116],"avons":[1,117],"\u00e9tudi\u00e9":[2],"les":[3,71,144,187],"m\u00e9canismes":[4,145,207],"mol\u00e9culaires":[5],"impliqu\u00e9s":[6],"dans":[7,32],"la":[8,96,124,159,170,173,235],"r\u00e9gulation":[9,97,147],"de":[10,22,47,68,73,78,95,101,126,135,146,154,158,165,172,177,182,189,197,203,215,222,234],"l'expression":[11,56,82,140],"du":[12,45,60,83,141],"VEGF":[13,84],"(Vascular":[14],"Endothelial":[15],"Growth":[16,30],"Factor)":[17],"en":[18],"r\u00e9ponse":[19],"aux":[20],"produits":[21,72,188],"glycation,":[23,190],"\u00e0":[24,27,169],"l'insuline":[25,120,155,191],"et":[26,58,81,110,121,138,176,192,205],"l'IGF-1":[28,122,166,193],"(Insulin-like":[29],"Factor-1),":[31],"des":[33,89,179,201,206,228],"cellules":[34],"\u00e9pith\u00e9liales":[35],"r\u00e9tiniennes":[36],"humaines.":[37],"nous":[39,65],"sommes":[40],"particuli\u00e8rement":[41],"int\u00e9ress\u00e9s":[42],"au":[43],"r\u00f4le":[44],"facteur":[46,77,134,196],"transcription":[48,79,136,198],"HIF-1":[49,80,137,199],"(Hypoxia":[50],"Inducible":[51],"Factor-1).":[52],"L'albumine":[53],"glyqu\u00e9e":[54],"induit":[55],"g\u00e9nique":[57],"prot\u00e9ique":[59],"VEGF.":[61],"L'utilisation":[62],"d'inhibiteurs":[63],"sp\u00e9cifiques":[64],"a":[66],"permis":[67],"montrer":[69],"que":[70,119,163,186],"glycation":[74],"activent":[75,132,194],"le":[76,133,195,232],"par":[85,200,218],"une":[86],"voie":[87,160,174],"d\u00e9pendante":[88,157,168],"MAP-kinases,":[90],"ERK1/2.":[91],"HIF-1,":[92],"acteur":[93],"majeur":[94],"hypoxique,":[98],"est":[99,106,113,156,167],"form\u00e9":[100],"deux":[102],"sous-unit\u00e9s,":[103],"HIF-1a":[104,127],"qui":[105,112,209],"d\u00e9grad\u00e9e":[107],"sous":[108],"normoxie,":[109],"HIF-1b":[111],"constitutivement":[114],"exprim\u00e9e.":[115],"montr\u00e9":[118],"stimulent":[123,139],"traduction":[125],"permettant":[128],"ainsi":[129],"son":[130],"accumulation,":[131],"VEGF,":[142],"mais":[143],"semblent":[148,210],"\u00eatre":[149,211],"diff\u00e9rents.":[150],"En":[151],"effet,":[152],"l'action":[153,164],"PI-3-kinase/PKB/mTOR,":[161],"alors":[162],"fois":[171],"PI-3-kinase/PKB/mTOR":[175],"celle":[178],"MAP-kinases.":[180],"L'ensemble":[181],"nos":[183],"r\u00e9sultats":[184],"sugg\u00e8re":[185],"cascades":[202],"signalisation":[204],"distincts":[208],"pour":[212],"l'essentiel":[213],"diff\u00e9rents":[214,224],"ceux":[216],"utilis\u00e9s":[217],"l'hypoxie.":[219],"L'action":[220],"conjugu\u00e9e":[221],"ces":[223],"facteurs":[225],"doit":[226],"avoir":[227],"effets":[229],"d\u00e9vastateurs":[230],"sur":[231],"d\u00e9veloppement":[233],"r\u00e9tinopathie":[236],"diab\u00e9tique.":[237]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
