{"id":"https://openalex.org/W3867873","doi":"https://doi.org/10.1007/978-1-4939-0398-6_10","title":"Single Nucleotide Polymorphisms at the TNFAIP3/A20 Locus and Susceptibility/Resistance to Inflammatory and Autoimmune Diseases","display_name":"Single Nucleotide Polymorphisms at the TNFAIP3/A20 Locus and Susceptibility/Resistance to Inflammatory and Autoimmune Diseases","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W3867873","doi":"https://doi.org/10.1007/978-1-4939-0398-6_10","mag":"3867873","pmid":"https://pubmed.ncbi.nlm.nih.gov/25302371"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4939-0398-6_10","doi":"https://doi.org/10.1007/978-1-4939-0398-6_10","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4939-0398-6_10","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W596178376","display_name":"The Multiple Therapeutic Targets of A20"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043689441","display_name":"Alessandra Antonia Mele","orcid":"https://orcid.org/0000-0002-9187-4859","observed_orcids":["https://orcid.org/0000-0002-9187-4859"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandra Mele","raw_affiliation_strings":["Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, and The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, and The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051550545","display_name":"Jes\u00fas Revuelta\u2010Cervantes","orcid":"https://orcid.org/0000-0001-7293-7204","observed_orcids":["https://orcid.org/0000-0001-7293-7204"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus Revuelta Cervantes","raw_affiliation_strings":["Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, and The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, and The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044231028","display_name":"Victor Chien","orcid":"https://orcid.org/0009-0004-8533-0582","observed_orcids":["https://orcid.org/0009-0004-8533-0582"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Chien","raw_affiliation_strings":["Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, and The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, and The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012210174","display_name":"David J. Friedman","orcid":"https://orcid.org/0000-0002-0301-9298","observed_orcids":["https://orcid.org/0000-0002-0301-9298"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Friedman","raw_affiliation_strings":["Department of Medicine, Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048165415","display_name":"Christiane J. Ferran","orcid":"https://orcid.org/0000-0002-3379-7998","observed_orcids":["https://orcid.org/0000-0002-3379-7998"]},"institutions":[{"id":"https://openalex.org/I4210143899","display_name":"Center for Vascular Biology Research","ror":"https://ror.org/04wsv7966","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210143899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christiane Ferran","raw_affiliation_strings":["Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210143899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048165415"],"corresponding_institution_ids":["https://openalex.org/I4210143899"],"apc_list":null,"apc_paid":null,"fwci":7.5752,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.96725146,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"809","issue":null,"first_page":"163","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.17569999396800995,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.1670999974012375,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9890000224113464},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7020000219345093},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":1.0},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.902999997138977},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf-kappab-inhibition","display_name":"NF-\u03baB inhibition","score":0.8560000061988831},{"id":"https://openalex.org/keywords/disease-susceptibility","display_name":"disease susceptibility","score":0.7730000019073486},{"id":"https://openalex.org/keywords/disease-resistance","display_name":"disease resistance","score":0.6589999794960022},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6825417280197144},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5963833332061768},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5946726202964783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3997221887111664},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39349859952926636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3241181969642639},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22938057780265808},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.22589269280433655}],"mesh":[{"descriptor_ui":"D000072598","descriptor_name":"Tumor Necrosis Factor alpha-Induced Protein 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-4939-0398-6_10","doi":"https://doi.org/10.1007/978-1-4939-0398-6_10","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4939-0398-6_10","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:25302371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25302371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2433946935","display_name":null,"funder_award_id":"R21 DK19822","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2838752391","display_name":"Improved liver function and regeneration with A20","funder_award_id":"R01DK063275","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7313013384","display_name":"Vascular Remodeling in Transplant Arteriosclerosis","funder_award_id":"R01HL080130","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8785007944","display_name":null,"funder_award_id":"5T32 HL00734","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306388","display_name":"Iacocca Family Foundation","ror":"https://ror.org/04geqe079"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1518966484","https://openalex.org/W1602927283","https://openalex.org/W1801258811","https://openalex.org/W1941358101","https://openalex.org/W1963819091","https://openalex.org/W1963897987","https://openalex.org/W1974007339","https://openalex.org/W1983668987","https://openalex.org/W1988924112","https://openalex.org/W1995747121","https://openalex.org/W1996670815","https://openalex.org/W1998634450","https://openalex.org/W2001154705","https://openalex.org/W2008954476","https://openalex.org/W2013299181","https://openalex.org/W2013304729","https://openalex.org/W2014759828","https://openalex.org/W2015516540","https://openalex.org/W2016932623","https://openalex.org/W2023073368","https://openalex.org/W2023746082","https://openalex.org/W2024592727","https://openalex.org/W2024670158","https://openalex.org/W2025002041","https://openalex.org/W2025649687","https://openalex.org/W2027941153","https://openalex.org/W2030919445","https://openalex.org/W2031580483","https://openalex.org/W2031585752","https://openalex.org/W2032639657","https://openalex.org/W2037368171","https://openalex.org/W2037458235","https://openalex.org/W2037461172","https://openalex.org/W2042103448","https://openalex.org/W2042187887","https://openalex.org/W2043801813","https://openalex.org/W2045113343","https://openalex.org/W2055514573","https://openalex.org/W2068477028","https://openalex.org/W2073127025","https://openalex.org/W2073167340","https://openalex.org/W2073453659","https://openalex.org/W2075363094","https://openalex.org/W2094835139","https://openalex.org/W2101116570","https://openalex.org/W2101981157","https://openalex.org/W2103175976","https://openalex.org/W2105806829","https://openalex.org/W2107477403","https://openalex.org/W2111753897","https://openalex.org/W2114041992","https://openalex.org/W2118212618","https://openalex.org/W2125612801","https://openalex.org/W2128952811","https://openalex.org/W2129761445","https://openalex.org/W2134783591","https://openalex.org/W2143112748","https://openalex.org/W2148430942","https://openalex.org/W2151138840","https://openalex.org/W2155256921","https://openalex.org/W2156558117","https://openalex.org/W2157134038","https://openalex.org/W2158799486","https://openalex.org/W2160515792","https://openalex.org/W2166781237","https://openalex.org/W2170384553","https://openalex.org/W2299513640","https://openalex.org/W2329872997","https://openalex.org/W3134084687","https://openalex.org/W3149947358","https://openalex.org/W4211241312","https://openalex.org/W4236836788","https://openalex.org/W4252685066","https://openalex.org/W4254864063","https://openalex.org/W4292083220","https://openalex.org/W4300503127"],"related_works":["https://openalex.org/W2324384121","https://openalex.org/W2790240574","https://openalex.org/W2315322117","https://openalex.org/W2771216575","https://openalex.org/W2970301236","https://openalex.org/W1963819091","https://openalex.org/W4237494949","https://openalex.org/W2002970321","https://openalex.org/W7169524787","https://openalex.org/W4385686661"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}