{"id":"https://openalex.org/W38611617","doi":"https://doi.org/10.1016/s0021-9258(19)86716-9","title":"Interaction of coagulation factor V and factor Va with platelets.","display_name":"Interaction of coagulation factor V and factor Va with platelets.","publication_year":1979,"publication_date":"1979-10-01","ids":{"openalex":"https://openalex.org/W38611617","doi":"https://doi.org/10.1016/s0021-9258(19)86716-9","mag":"38611617","pmid":"https://pubmed.ncbi.nlm.nih.gov/114524"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)86716-9","doi":"https://doi.org/10.1016/s0021-9258(19)86716-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)86716-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)86716-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016607188","display_name":"Paula B. Tracy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.B. Tracy","raw_affiliation_strings":["From the Hematology and Rheumatology Research Sections, Mayo Clinic, Rochester, Minnesota 55901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hematology and Rheumatology Research Sections, Mayo Clinic, Rochester, Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111570228","display_name":"James McInnes Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.M. Peterson","raw_affiliation_strings":["From the Hematology and Rheumatology Research Sections, Mayo Clinic, Rochester, Minnesota 55901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hematology and Rheumatology Research Sections, Mayo Clinic, Rochester, Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108417472","display_name":"Michael E. Nesheim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.E. Nesheim","raw_affiliation_strings":["From the Hematology and Rheumatology Research Sections, Mayo Clinic, Rochester, Minnesota 55901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hematology and Rheumatology Research Sections, Mayo Clinic, Rochester, Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112773910","display_name":"Frederic C. McDuffie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F.C. McDuffie","raw_affiliation_strings":["From the Hematology and Rheumatology Research Sections, Mayo Clinic, Rochester, Minnesota 55901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hematology and Rheumatology Research Sections, Mayo Clinic, Rochester, Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075389112","display_name":"Kenneth G. Mann","orcid":"https://orcid.org/0000-0003-1878-263X","observed_orcids":["https://orcid.org/0000-0003-1878-263X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.G. Mann","raw_affiliation_strings":["From the Hematology and Rheumatology Research Sections, Mayo Clinic, Rochester, Minnesota 55901"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hematology and Rheumatology Research Sections, Mayo Clinic, Rochester, Minnesota 55901","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":10.0683,"has_fulltext":false,"cited_by_count":168,"citation_normalized_percentile":{"value":0.98536814,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"254","issue":"20","first_page":"10354","last_page":"10361"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.1534000039100647,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-v","display_name":"factor V","score":0.968999981880188},{"id":"https://openalex.org/keywords/factor-va","display_name":"factor Va","score":0.9150000214576721},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.8100000023841858},{"id":"https://openalex.org/keywords/platelet-binding-sites","display_name":"platelet binding sites","score":0.7450000047683716},{"id":"https://openalex.org/keywords/high-affinity-binding-sites","display_name":"high-affinity binding sites","score":0.5899999737739563},{"id":"https://openalex.org/keywords/low-affinity-binding-sites","display_name":"low-affinity binding sites","score":0.9700000286102295},{"id":"https://openalex.org/keywords/dissociation-constant","display_name":"dissociation constant","score":0.7519999742507935},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.609000027179718},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/bovine-platelets","display_name":"bovine platelets","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7938874363899231},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.6888244152069092},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6673790812492371},{"id":"https://openalex.org/C2777444498","wikidata":"https://www.wikidata.org/wiki/Q423701","display_name":"Factor X","level":4,"score":0.6201892495155334},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5972908735275269},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.5453959107398987},{"id":"https://openalex.org/C2776046644","wikidata":"https://www.wikidata.org/wiki/Q422831","display_name":"Factor V","level":3,"score":0.5144753456115723},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.49511638283729553},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4279389977455139},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.42043691873550415},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27824950218200684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2091311514377594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15044188499450684},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14861568808555603},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13060855865478516},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.12966829538345337},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05544784665107727},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005779","descriptor_name":"Immunodiffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)86716-9","doi":"https://doi.org/10.1016/s0021-9258(19)86716-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)86716-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:114524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/114524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)86716-9","doi":"https://doi.org/10.1016/s0021-9258(19)86716-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)86716-9","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W235933110","https://openalex.org/W258376682","https://openalex.org/W1492100345","https://openalex.org/W1519085965","https://openalex.org/W1531550096","https://openalex.org/W1540596657","https://openalex.org/W1544711420","https://openalex.org/W1554919783","https://openalex.org/W1561534093","https://openalex.org/W1625660792","https://openalex.org/W1963569037","https://openalex.org/W1983649348","https://openalex.org/W1992650719","https://openalex.org/W1993351233","https://openalex.org/W1994419975","https://openalex.org/W2028414268","https://openalex.org/W2050511169","https://openalex.org/W2056871814","https://openalex.org/W2065156100","https://openalex.org/W2070598525","https://openalex.org/W2083983988","https://openalex.org/W2095224270","https://openalex.org/W2096326108","https://openalex.org/W2165557940","https://openalex.org/W2248183091","https://openalex.org/W2287738335","https://openalex.org/W2315828430","https://openalex.org/W2325134317","https://openalex.org/W2395269396","https://openalex.org/W2399096342","https://openalex.org/W2409866331","https://openalex.org/W4234160012","https://openalex.org/W4237010208","https://openalex.org/W4247621043"],"related_works":["https://openalex.org/W2946345864","https://openalex.org/W1544665815","https://openalex.org/W1604706922","https://openalex.org/W1988451474","https://openalex.org/W2017423159","https://openalex.org/W1519085965","https://openalex.org/W2058669232","https://openalex.org/W2056871814","https://openalex.org/W2992778570","https://openalex.org/W2945433919"],"abstract_inverted_index":{"Bovine":[0,39],"platelet":[1,28,40,62,87,101,251,280,295],"and":[2,18,54,102,115,133,197,226,298],"plasma":[3,15,48,103],"Factor":[4,16,22,41,49,63,70,81,105,146,182,190,201,224,227,237,246,266,269,274,287,310],"V":[5,17,23,42,50,64,71,82,106,114,191,202,225,238,267,275,288],"were":[6,73],"compared":[7],"using":[8,31,51],"antisera":[9],"raised":[10],"to":[11,92,118,142,176,192,205,231,242,283,291,304],"purified":[12],"single":[13,207],"chain":[14],"the":[19,26,36,78,85,100,232,243,262,279,284,292,305],"quantity":[20,79],"of":[21,61,77,80,111,156,166,189,209,215,264,273,286,307],"associated":[24,277],"with":[25,35,125,151,211,278],"bovine":[27,47,86,127],"was":[29,120,253],"established":[30],"a":[32,89,206,212],"radioimmunoassay":[33,53],"developed":[34],"same":[37],"antisera.":[38],"is":[43,194,281,301],"immunochemically":[44],"indistinguishable":[45],"from":[46],"both":[52,112,229],"immunodiffusion":[55],"as":[56,161,163,178,180],"comparative":[57],"techniques.":[58],"Radioimmunoassay":[59],"quantitation":[60],"indicated":[65,222],"that":[66,99,223,299],"593":[67],"+":[68],"139":[69],"molecules":[72,148,184,203,276,289],"present/platelet.":[74],"Bioassay":[75],"assessment":[76],"present":[83],"in":[84],"gave":[88],"value":[90,300],"similar":[91,282,303],"this":[93],"(666":[94],"f":[95],"124),":[96],"further":[97],"suggesting":[98],"derived":[104],"are":[107,137,149,185],"identical.":[108],"The":[109,187,271],"binding":[110,140,164,188,248,263,296,312],"iz51-Factor":[113],"-Factor":[116],"Va":[117,130,147,183,228,247,311],"platelets":[119,193],"also":[121,195,302],"measured.":[122],"When":[123],"incubated":[124],"washed":[126],"platelets,":[128],"1251-Factor":[129],"underwent":[131],"saturable":[132,196],"exchangeable":[134],"binding.":[135],"There":[136],"high":[138,244,308],"affinity":[139,169,234,245,294,309],"sites":[141,165,210],"which":[143,177],"approximately":[144],"900":[145],"bound/platelet":[150],"an":[152],"apparent":[153],"dissociation":[154,213],"constant":[155,214],"3":[157,172,216],"x":[158,217],"lo-\u201d":[159],"M,":[160],"well":[162],"slightly":[167],"lower":[168,233],"(Z&":[170],"=":[171],"X":[173],"lo-\u2019":[174,218],"M)":[175],"many":[179],"3500":[181],"bound/platelet.":[186],"exchangeable.":[198],"Approximately":[199],"800":[200],"bind":[204,230,241],"class":[208],"M.":[219],"Exchange":[220],"studies":[221],"sites;":[235],"however,":[236],"does":[239],"not":[240,254],"sites.":[249,313],"Thrombin-induced":[250],"activation":[252],"required":[255],"for,":[256],"nor":[257],"had":[258],"any":[259],"effect":[260],"on,":[261],"either":[265],"or":[268],"Va.":[270],"number":[272,285,306],"bound":[290],"low":[293],"sites,":[297]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}