{"id":"https://openalex.org/W385704401","doi":null,"title":"Quantification and characterization of uncertainty in metabolic engineering","display_name":"Quantification and characterization of uncertainty in metabolic engineering","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W385704401","mag":"385704401"},"language":"en","primary_location":{"id":"pmh:oai:infoscience.epfl.ch:98648","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/98648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://infoscience.epfl.ch/record/98648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056011141","display_name":"Vassily Hatzimanikatis A","orcid":"https://orcid.org/0000-0001-6432-4694","observed_orcids":["https://orcid.org/0000-0001-6432-4694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vassily Hatzimanikatis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6432-4694","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017539699","display_name":"\u0130nan\u00e7 Birol","orcid":"https://orcid.org/0000-0003-0950-7839","observed_orcids":["https://orcid.org/0000-0003-0950-7839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0130nan\u00e7 Birol","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0950-7839","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053770947","display_name":"Jiaxiao M. Shi","orcid":"https://orcid.org/0000-0001-8397-3729","observed_orcids":["https://orcid.org/0000-0001-8397-3729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiaxiao Shi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8397-3729","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100674985","display_name":"Liqing Wang","orcid":"https://orcid.org/0000-0001-7600-6992","observed_orcids":["https://orcid.org/0000-0001-7600-6992"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liqing Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7600-6992","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.9409999847412109},{"id":"https://openalex.org/keywords/uncertainty-quantification","display_name":"uncertainty quantification","score":0.9520000219345093},{"id":"https://openalex.org/keywords/metabolic-flux-analysis","display_name":"metabolic flux analysis","score":0.7179999947547913},{"id":"https://openalex.org/keywords/metabolic-control-analysis","display_name":"metabolic control analysis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/rate-limiting-step","display_name":"rate-determining step","score":0.7239999771118164},{"id":"https://openalex.org/keywords/central-carbon-metabolism","display_name":"central carbon metabolism","score":0.7549999952316284},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9369999766349792},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9869999885559082},{"id":"https://openalex.org/keywords/nonparametric-statistics","display_name":"nonparametric statistics","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.8604310154914856},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.8084728717803955},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.5736244916915894},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5707264542579651},{"id":"https://openalex.org/C70818257","wikidata":"https://www.wikidata.org/wiki/Q502671","display_name":"Metabolic control analysis","level":3,"score":0.5510431528091431},{"id":"https://openalex.org/C160941953","wikidata":"https://www.wikidata.org/wiki/Q6822342","display_name":"Metabolic flux analysis","level":3,"score":0.5149574875831604},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4694846272468567},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4596185088157654},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4184378981590271},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.414273202419281},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40705302357673645},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3512093722820282},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3076825737953186},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29994481801986694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2816965579986572},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.21827873587608337},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.16742458939552307},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.14870372414588928},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08978709578514099},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:infoscience.epfl.ch:98648","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/98648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:98648","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/98648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"conference proceedings"},{"id":"mag:385704401","doi":null,"is_oa":false,"landing_page_url":"https://infoscience.epfl.ch/record/98648","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:infoscience.epfl.ch:98648","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/98648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2161227644","https://openalex.org/W818874298","https://openalex.org/W652317705","https://openalex.org/W2521105713","https://openalex.org/W2266907177","https://openalex.org/W94864208","https://openalex.org/W370226741","https://openalex.org/W2012938657","https://openalex.org/W2022238394","https://openalex.org/W2080853550"],"abstract_inverted_index":{"One":[0],"of":[1,12,27,37,44,64,78,95,124,131,140,147,158,165,188,205,219,224],"the":[2,10,13,25,34,38,42,52,62,76,96,122,129,138,141,144,148,156,162,166,186,189,192,203,206,216],"central":[3,193],"problems":[4],"in":[5,41,107,196,212,221],"metabolic":[6,58,66,79,86,97,101,125,132,149,168,173,207],"engineering":[7,59,102,126,208],"deals":[8],"with":[9,215],"identification":[11,48,123,204],"\"rate":[14],"limiting":[15],"steps\",":[16],"i.e.":[17],"enzymes":[18,39],"whose":[19],"activities":[20],"one":[21],"should":[22],"manipulate":[23],"towards":[24],"achievement":[26],"a":[28,92,114],"desirable":[29],"performance.":[30],"However,":[31],"uncertainty":[32],"about":[33,75,137,155],"kinetic":[35],"characteristics":[36],"involved":[40],"pathway":[43,98],"interest":[45],"makes":[46],"such":[47,104],"almost":[49],"impossible.":[50],"On":[51],"other":[53],"hand,":[54],"extensive":[55],"research":[56],"within":[57],"has":[60],"enabled":[61],"estn.":[63],"intracellular":[65],"fluxes.":[67,150],"Such":[68],"information,":[69],"while":[70],"it":[71,88],"provides":[72],"significant":[73],"understanding":[74],"functioning":[77],"pathways":[80,133,142,195],"and,":[81],"some":[82],"times,":[83],"guidance":[84],"for":[85,128,202],"engineering,":[87],"does":[89],"not":[90],"allow":[91],"quant.":[93],"prediction":[94],"responses":[99],"to":[100,191,226],"actions,":[103],"as":[105],"changes":[106,211],"enzyme":[108,213],"activities.":[109],"We":[110,181],"have":[111],"recently":[112],"developed":[113],"method":[115,190],"that":[116],"overcomes":[117],"these":[118],"limitations":[119],"and":[120,143,161,178,184,199],"allows":[121],"targets":[127],"manipulation":[130],"based":[134],"on":[135],"information":[136],"stoichiometry":[139,157],"assocd.":[145,167],"values":[146,164],"The":[151],"framework":[152],"employs":[153],"knowledge":[154],"biochem.":[159],"networks":[160],"estd.":[163],"fluxes,":[169],"modeling":[170],"concepts":[171],"from":[172],"control":[174],"anal.,":[175],"computational":[176],"methods,":[177],"nonparametric":[179],"statistics.":[180],"will":[182],"present":[183],"discuss":[185],"application":[187],"carbon":[194],"E.":[197],"coli":[198],"S.":[200],"cerevisiae":[201],"strategies":[209],"(i.e.,":[210],"activities)":[214],"highest":[217],"probability":[218],"success":[220],"optimizing":[222],"conversion":[223],"glucose":[225],"ethanol.":[227],"[on":[228],"SciFinder":[229],"(R)]":[230]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}