{"id":"https://openalex.org/W38448582","doi":null,"title":"Comparison of biomarkers of oxidative stress and cardiovascular disease in humans and chimpanzees (Pan troglodytes).","display_name":"Comparison of biomarkers of oxidative stress and cardiovascular disease in humans and chimpanzees (Pan troglodytes).","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W38448582","mag":"38448582","pmid":"https://pubmed.ncbi.nlm.nih.gov/19619420","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2733297"},"language":"en","primary_location":{"id":"pmid:19619420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19619420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2733297/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018885962","display_name":"Elaine N. Videan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801617088","display_name":"Holloman Air Force Base","ror":"https://ror.org/030bv9h77","country_code":"US","type":"government","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2801617088","https://openalex.org/I4210089612","https://openalex.org/I4210102105"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine N Videan","raw_affiliation_strings":["Alamogordo Primate Facility, Holloman AFB, New Mexico. elaine.videan@crl.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alamogordo Primate Facility, Holloman AFB, New Mexico. elaine.videan@crl.com","institution_ids":["https://openalex.org/I2801617088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039901993","display_name":"Christopher B. Heward","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher B Heward","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075636671","display_name":"Kajal Chowdhury","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kajal Chowdhury","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"John Plummer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Plummer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110662713","display_name":"Yali Su","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yali Su","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108550788","display_name":"Richard G. Cutler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard G Cutler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4765,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.76866301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"59","issue":"3","first_page":"287","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9369999766349792},{"id":"https://openalex.org/keywords/chimpanzees","display_name":"chimpanzees","score":0.8510000109672546},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.7559999823570251},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.652999997138977},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5759999752044678},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.7699999809265137},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lipoprotein-a","display_name":"lipoprotein(a)","score":0.7609999775886536},{"id":"https://openalex.org/keywords/5-hydroxymethyl-2-deoxyuridine","display_name":"5-hydroxymethyl-2'-deoxyuridine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/8-isoprostane","display_name":"8-isoprostane","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ceruloplasmin","display_name":"ceruloplasmin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.8560000061988831},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.8889999985694885},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.7940000295639038},{"id":"https://openalex.org/keywords/tocopherols","display_name":"tocopherols","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.5929999947547913},{"id":"https://openalex.org/keywords/comparative-biology","display_name":"comparative biology","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8487152457237244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6313947439193726},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5476981997489929},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4905702471733093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4626888036727905},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.41981983184814453},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.41637736558914185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34399503469467163}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008017","descriptor_name":"Life Expectancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19619420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19619420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:2733297","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2733297/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Med","raw_type":"Text"},{"id":"mag:38448582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19619420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2733297","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2733297/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W88900607","https://openalex.org/W113714250","https://openalex.org/W126725029","https://openalex.org/W171081901","https://openalex.org/W615077283","https://openalex.org/W1646979794","https://openalex.org/W1826130753","https://openalex.org/W1842458233","https://openalex.org/W1907663195","https://openalex.org/W1948619662","https://openalex.org/W1951954685","https://openalex.org/W1966078997","https://openalex.org/W1966582616","https://openalex.org/W1971136149","https://openalex.org/W1976886927","https://openalex.org/W1978224152","https://openalex.org/W1978884036","https://openalex.org/W1980980693","https://openalex.org/W1981361599","https://openalex.org/W1983358553","https://openalex.org/W1984236954","https://openalex.org/W1985891284","https://openalex.org/W1987457816","https://openalex.org/W1989348728","https://openalex.org/W1992394779","https://openalex.org/W1995009104","https://openalex.org/W1995802581","https://openalex.org/W1998563250","https://openalex.org/W1999364007","https://openalex.org/W2000405107","https://openalex.org/W2002373438","https://openalex.org/W2002835167","https://openalex.org/W2003576911","https://openalex.org/W2005500023","https://openalex.org/W2007044921","https://openalex.org/W2008532809","https://openalex.org/W2009977850","https://openalex.org/W2011860275","https://openalex.org/W2012231244","https://openalex.org/W2013795977","https://openalex.org/W2018061370","https://openalex.org/W2020277922","https://openalex.org/W2022770339","https://openalex.org/W2024519593","https://openalex.org/W2025209734","https://openalex.org/W2025909569","https://openalex.org/W2028162396","https://openalex.org/W2028584094","https://openalex.org/W2030172671","https://openalex.org/W2035758977","https://openalex.org/W2038015968","https://openalex.org/W2042684962","https://openalex.org/W2043031422","https://openalex.org/W2048005287","https://openalex.org/W2049301066","https://openalex.org/W2054005523","https://openalex.org/W2055992775","https://openalex.org/W2064644800","https://openalex.org/W2067247047","https://openalex.org/W2067345612","https://openalex.org/W2069478329","https://openalex.org/W2071103375","https://openalex.org/W2074473663","https://openalex.org/W2077039927","https://openalex.org/W2082094347","https://openalex.org/W2083180104","https://openalex.org/W2087123045","https://openalex.org/W2093878085","https://openalex.org/W2094794822","https://openalex.org/W2094865265","https://openalex.org/W2095014707","https://openalex.org/W2097107776","https://openalex.org/W2101861123","https://openalex.org/W2101872116","https://openalex.org/W2104608589","https://openalex.org/W2104856141","https://openalex.org/W2106245887","https://openalex.org/W2108881007","https://openalex.org/W2109544293","https://openalex.org/W2113007696","https://openalex.org/W2114651971","https://openalex.org/W2115672981","https://openalex.org/W2115830594","https://openalex.org/W2116876868","https://openalex.org/W2117807415","https://openalex.org/W2118935778","https://openalex.org/W2120730641","https://openalex.org/W2120967386","https://openalex.org/W2125522185","https://openalex.org/W2127078503","https://openalex.org/W2127922258","https://openalex.org/W2128159470","https://openalex.org/W2131913960","https://openalex.org/W2132816856","https://openalex.org/W2145511446","https://openalex.org/W2145635335","https://openalex.org/W2147239346","https://openalex.org/W2150619497","https://openalex.org/W2152543924","https://openalex.org/W2155931459","https://openalex.org/W2158913228","https://openalex.org/W2162756265","https://openalex.org/W2163137114","https://openalex.org/W2163699282","https://openalex.org/W2169155656","https://openalex.org/W2171674972","https://openalex.org/W2171974937","https://openalex.org/W2315403385","https://openalex.org/W2315512556","https://openalex.org/W2329593255","https://openalex.org/W2412364248"],"related_works":["https://openalex.org/W3087442279","https://openalex.org/W6958120980","https://openalex.org/W2005457113","https://openalex.org/W3085130314","https://openalex.org/W2986936895","https://openalex.org/W6907417408","https://openalex.org/W2169042792","https://openalex.org/W6996126699","https://openalex.org/W3138629153","https://openalex.org/W3094707111"],"abstract_inverted_index":{"In":[0,121],"the":[1,7,11,116,143,153,189,199],"oxidative":[2,56,96,154,165,214],"stress":[3,155,166],"hypothesis":[4,156],"of":[5,13,46,78,83,103,115,127,142,157,164,180,192,201,208],"aging,":[6,158],"aging":[8,59],"process":[9],"is":[10,194],"result":[12,200],"cumulative":[14],"damage":[15],"by":[16,152],"reactive":[17],"oxygen":[18],"species.":[19],"Humans":[20],"and":[21,34,58,63,89,105,112,119,131,135,148,167,205],"chimpanzees":[22,33,62,69,123,160],"are":[23,36],"remarkably":[24],"similar;":[25],"but":[26],"humans":[27,193],"live":[28],"twice":[29],"as":[30,32,99,137,139],"long":[31],"therefore":[35],"believed":[37],"to":[38,50],"age":[39],"at":[40,71,195],"a":[41,108,168],"slower":[42],"rate.":[43],"The":[44],"purpose":[45],"this":[47],"study":[48],"was":[49],"compare":[51],"biomarkers":[52],"for":[53,74,172],"cardiovascular":[54,75,144,173,209],"disease,":[55,174],"stress,":[57,97],"between":[60],"male":[61,68,159],"humans.":[64],"Compared":[65],"with":[66,178,212],"men,":[67],"were":[70],"increased":[72,95],"risk":[73,171,207],"disease":[76,210],"because":[77],"their":[79],"significantly":[80,100],"higher":[81,101,109,113,162,170],"levels":[82,102,114,126,141,163],"fibrinogen,":[84],"IGF1,":[85],"insulin,":[86],"lipoprotein":[87],"a,":[88],"large":[90],"high-density":[91],"lipoproteins.":[92],"Chimpanzees":[93],"showed":[94],"measured":[98],"5-hydroxymethyl-2-deoxyuridine":[104],"8-iso-prostaglandin":[106],"F(2alpha),":[107],"peroxidizability":[110],"index,":[111],"prooxidants":[117],"ceruloplasmin":[118],"copper.":[120],"addition,":[122],"had":[124],"decreased":[125,140],"antioxidants,":[128],"including":[129],"alpha-":[130],"beta-carotene,":[132],"beta-cryptoxanthin,":[133],"lycopene,":[134],"tocopherols,":[136],"well":[138],"protection":[145],"factors":[146],"albumin":[147],"bilirubin.":[149],"As":[150],"predicted":[151],"exhibit":[161],"much":[169],"particularly":[175],"cardiomyopathy,":[176],"compared":[177],"men":[179],"equivalent":[181],"age.":[182],"Given":[183],"these":[184],"results,":[185],"we":[186],"hypothesize":[187],"that":[188],"longer":[190],"lifespan":[191],"least":[196],"in":[197],"part":[198],"greater":[202],"antioxidant":[203],"capacity":[204],"lower":[206,213],"associated":[211],"stress.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}