{"id":"https://openalex.org/W38345379","doi":null,"title":"Parity and Neu oncogene activation in breast cancer risk and mammary carcinogenesis","display_name":"Parity and Neu oncogene activation in breast cancer risk and mammary carcinogenesis","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W38345379","mag":"38345379"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:dissertations-3611","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3095923","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054375076","display_name":"Susan E. Moody","orcid":"https://orcid.org/0009-0002-7714-1170","observed_orcids":["https://orcid.org/0009-0002-7714-1170"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Susan E. Moody","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-7714-1170","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054375076"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.23770000040531158,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.10300000011920929,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parity","display_name":"parity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/neu-oncogene","display_name":"neu oncogene","score":0.9279999732971191},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.628000020980835},{"id":"https://openalex.org/keywords/tgfbeta3","display_name":"TGF-beta3","score":0.7770000100135803},{"id":"https://openalex.org/keywords/mammary-gland-gene-expression","display_name":"mammary gland gene expression","score":0.8429999947547913},{"id":"https://openalex.org/keywords/mammary-adenocarcinoma","display_name":"mammary adenocarcinoma","score":0.8349999785423279},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.7519999742507935},{"id":"https://openalex.org/keywords/mouse-mammary-tumor-model","display_name":"mouse mammary tumor model","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6769173741340637},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5933177471160889},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5113963484764099},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.4927220642566681},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4628770351409912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39818450808525085},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3672228753566742},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3590487241744995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3289560079574585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32089298963546753},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.0900377631187439}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.upenn.edu:dissertations-3611","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3095923","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"mag:38345379","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=3611&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W115125409","https://openalex.org/W1487731794","https://openalex.org/W1498169316","https://openalex.org/W1517732299","https://openalex.org/W1881850874","https://openalex.org/W1973881052","https://openalex.org/W1977044565","https://openalex.org/W2009933870","https://openalex.org/W2010222872","https://openalex.org/W2016983859","https://openalex.org/W2075001230","https://openalex.org/W2089734064","https://openalex.org/W2130713219","https://openalex.org/W2131950300","https://openalex.org/W2156410597","https://openalex.org/W2291675306","https://openalex.org/W2315027248","https://openalex.org/W2394658251","https://openalex.org/W2604481266","https://openalex.org/W2613362156","https://openalex.org/W2678992970","https://openalex.org/W2737895097","https://openalex.org/W2883959012","https://openalex.org/W2886851488","https://openalex.org/W2915824722","https://openalex.org/W3006930853","https://openalex.org/W3012400351","https://openalex.org/W3025022288","https://openalex.org/W3038091633","https://openalex.org/W3045387409","https://openalex.org/W3090413519","https://openalex.org/W3093964219","https://openalex.org/W3135217127","https://openalex.org/W3138484572","https://openalex.org/W3139404812","https://openalex.org/W3184850586","https://openalex.org/W3187065261","https://openalex.org/W3204998025","https://openalex.org/W3207929838","https://openalex.org/W4210453757","https://openalex.org/W4210859852","https://openalex.org/W4220833705","https://openalex.org/W4223502512","https://openalex.org/W4281563136","https://openalex.org/W4281645619","https://openalex.org/W4281732693","https://openalex.org/W4282980662","https://openalex.org/W4283812631","https://openalex.org/W4317390676","https://openalex.org/W4367396725","https://openalex.org/W4381283699","https://openalex.org/W4385403777","https://openalex.org/W4385955916","https://openalex.org/W4394743773","https://openalex.org/W6772662403"],"related_works":["https://openalex.org/W41495580","https://openalex.org/W1543013389","https://openalex.org/W2009094206","https://openalex.org/W7096907694","https://openalex.org/W1986932828","https://openalex.org/W2029981991","https://openalex.org/W2954508509","https://openalex.org/W1995395570","https://openalex.org/W1528540722","https://openalex.org/W2133336743"],"abstract_inverted_index":{"Epidemiological":[0],"studies":[1],"have":[2,48,75,91,110],"consistently":[3],"demonstrated":[4],"that":[5,47,85,127,196,229,242,272,326],"women":[6,29],"who":[7,30,35],"undergo":[8],"their":[9],"first":[10,36],"full-term":[11,51],"pregnancy":[12,52],"early":[13,123],"in":[14,26,130,172,177,291,309,336],"life":[15],"are":[16,53],"at":[17],"a":[18,38,50,112,175,182,331,346],"significantly":[19,54],"reduced":[20],"risk":[21],"of":[22,43,102,115,134,141,148,155,160,220,256,276,286,296,312,321,330],"developing":[23],"breast":[24],"cancer,":[25],"comparison":[27],"to":[28,62,87,97,168,212,217,246,267,344],"never":[31],"bear":[32,37],"children":[33],"or":[34],"child":[39],"after":[40],"the":[41,67,83,131,139,142,190,257,263,273,287,292,310,318],"age":[42],"35.":[44],"Similarly,":[45],"rodents":[46],"completed":[49],"protected":[55],"against":[56,204],"chemically-induced":[57],"mammary":[58,107,187,206,233],"tumorigenesis,":[59],"as":[60,152,154,260,262],"compared":[61],"age-matched":[63],"nulliparous":[64,103],"controls.":[65],"However,":[66,193,298],"molecular":[68,156],"mechanisms":[69,84],"underlying":[70],"this":[71,198,214],"naturally-occurring":[72],"protective":[73,203],"effect":[74,345],"not":[76,202],"been":[77],"elucidated.":[78],"To":[79],"gain":[80],"insight":[81],"into":[82],"contribute":[86],"parity-induced":[88,178],"protection,":[89,179],"we":[90,166,180,194,209],"used":[92],"high":[93],"density":[94],"oligonucleotide":[95],"microarrays":[96],"analyze":[98],"global":[99],"transcription":[100],"profiles":[101],"and":[104,138,146,159,225,238,241,324],"parous":[105],"rodent":[106],"glands.":[108],"We":[109,125,227],"identified":[111],"robust":[113],"panel":[114],"genes":[116],"whose":[117],"expression":[118],"is":[119,201,342],"persistently":[120],"altered":[121],"by":[122],"parity.":[124],"determined":[126,228],"parity":[128,200],"results":[129],"persistent":[132],"down-regulation":[133],"several":[135,147],"growth-promoting":[136],"molecules,":[137],"upregulation":[140],"growth-inhibitory":[143],"molecule":[144],"TGF\u03b23":[145],"its":[149],"transcriptional":[150],"targets,":[151],"well":[153,261],"differentiation":[157],"markers":[158],"immune":[161],"cell":[162],"markers.":[163],"Since":[164],"ultimately":[165,305],"wished":[167],"test":[169],"candidate":[170],"molecules":[171],"vivo":[173],"for":[174,185,284],"role":[176],"developed":[181],"murine":[183],"model":[184,215],"inducible":[186],"carcinogenesis":[188],"using":[189],"Neu":[191,251,283],"oncogene.":[192],"found":[195],"within":[197],"system":[199,216],"Neu-induced":[205,221],"tumorigenesis.":[207],"Nonetheless,":[208],"were":[210],"able":[211],"utilize":[213],"study":[218],"aspects":[219],"tumor":[222,278,307],"regression,":[223],"metastasis,":[224],"recurrence.":[226],"these":[230,277],"mice":[231,304],"develop":[232,247,306],"adenocarcinomas":[234],"with":[235,300],"short":[236],"latency":[237],"complete":[239],"penetrance,":[240],"most":[243,293,303],"also":[244],"proceed":[245],"pulmonary":[248,264],"metastases.":[249],"Upon":[250],"transgene":[252,313],"withdrawal,":[253],"essentially":[254],"all":[255],"primary":[258],"tumors":[259],"metastases":[265],"regress":[266],"an":[268],"undetectable":[269],"state,":[270,289],"indicating":[271],"vast":[274],"majority":[275],"cells":[279],"remain":[280],"dependent":[281],"upon":[282],"maintenance":[285],"transformed":[288],"even":[290],"advanced":[294],"stages":[295],"malignancy.":[297],"consistent":[299],"clinical":[301,338],"experience,":[302],"recurrences":[308],"absence":[311],"expression.":[314],"These":[315],"findings":[316],"parallel":[317],"natural":[319],"history":[320],"human":[322],"cancers":[323],"suggest":[325],"while":[327],"therapeutic":[328],"targeting":[329],"single":[332],"pathway":[333],"may":[334],"result":[335],"significant":[337],"responses,":[339],"such":[340],"therapy":[341],"unlikely":[343],"cure.":[347]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}