{"id":"https://openalex.org/W38259661","doi":null,"title":"Serum amyloid A protein and C-reactive protein in systemic amyloidosis.","display_name":"Serum amyloid A protein and C-reactive protein in systemic amyloidosis.","publication_year":1985,"publication_date":"1985-10-01","ids":{"openalex":"https://openalex.org/W38259661","mag":"38259661","pmid":"https://pubmed.ncbi.nlm.nih.gov/4085162"},"language":"en","primary_location":{"id":"pmid:4085162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4085162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012884078","display_name":"Morie Abraham Gertz","orcid":"https://orcid.org/0000-0002-3853-5196","observed_orcids":["https://orcid.org/0000-0002-3853-5196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Gertz","raw_affiliation_strings":["Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113788210","display_name":"Martha M. Skinner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Skinner","raw_affiliation_strings":["Boston University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109845356","display_name":"Jean D. Sipe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D Sipe","raw_affiliation_strings":["Boston University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111414379","display_name":"Alan S. Cohen","orcid":"https://orcid.org/0009-0005-4099-9271","observed_orcids":["https://orcid.org/0009-0005-4099-9271"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A S Cohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023193953","display_name":"Robert A. Kyle","orcid":"https://orcid.org/0000-0003-4763-4580","observed_orcids":["https://orcid.org/0000-0003-4763-4580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Kyle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5109,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.91149974,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"3","issue":"4","first_page":"317","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-amyloid-a","display_name":"serum amyloid A","score":0.8989999890327454},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/systemic-amyloidosis","display_name":"systemic amyloidosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/al-amyloidosis","display_name":"AL amyloidosis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/aa-amyloidosis","display_name":"AA amyloidosis","score":1.0},{"id":"https://openalex.org/keywords/familial-amyloidosis","display_name":"familial amyloidosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acute-phase-response","display_name":"acute phase response","score":0.968999981880188},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.9409999847412109},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C55359608","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum amyloid A","level":3,"score":0.8765344619750977},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.8684911727905273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8240475654602051},{"id":"https://openalex.org/C2910060150","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum Amyloid A Protein","level":4,"score":0.8212854266166687},{"id":"https://openalex.org/C164585084","wikidata":"https://www.wikidata.org/wiki/Q12133588","display_name":"Nephelometry","level":3,"score":0.8047852516174316},{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.7635378241539001},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6726816296577454},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.6344146132469177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.622853696346283},{"id":"https://openalex.org/C2780029684","wikidata":"https://www.wikidata.org/wiki/Q14891716","display_name":"Serum amyloid P component","level":4,"score":0.5278149843215942},{"id":"https://openalex.org/C2777007455","wikidata":"https://www.wikidata.org/wiki/Q2844591","display_name":"AA amyloidosis","level":4,"score":0.5255069732666016},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.47958675026893616},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.4700193405151367},{"id":"https://openalex.org/C2780945303","wikidata":"https://www.wikidata.org/wiki/Q4652470","display_name":"Primary systemic amyloidosis","level":4,"score":0.4641590714454651},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3801535964012146},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.30526456236839294},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29966849088668823},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.29337283968925476},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29044440388679504},{"id":"https://openalex.org/C2779537928","wikidata":"https://www.wikidata.org/wiki/Q1144618","display_name":"Familial Mediterranean fever","level":3,"score":0.1261257827281952},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.11368262767791748},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.08729976415634155},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07697409391403198},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000685","descriptor_name":"Serum Amyloid A Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4085162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4085162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Comparative Study"},{"id":"mag:38259661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4085162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2409904711","https://openalex.org/W1991369445","https://openalex.org/W44413466","https://openalex.org/W2134847406","https://openalex.org/W2331851916","https://openalex.org/W2323655508","https://openalex.org/W409312172","https://openalex.org/W1969396279","https://openalex.org/W1979688302","https://openalex.org/W44767614"],"abstract_inverted_index":{"In":[0,53],"106":[1],"patients":[2],"with":[3],"systemic":[4,54],"amyloidosis":[5,98,101],"(56":[6],"primary,":[7],"27":[8],"secondary,":[9],"and":[10,23,33,49,114],"23":[11],"familial),":[12],"serum":[13],"amyloid":[14],"A":[15],"protein":[16,25,89],"(SAA)":[17],"was":[18,27,57],"measured":[19,28],"by":[20,29],"solid-phase":[21],"radioimmunoassay":[22],"C-reactive":[24],"(CRP)":[26],"rate":[30],"nephelometry.":[31],"SAA":[32,56,113],"CRP":[34,61,115],"concentrations":[35],"were":[36],"highly":[37],"correlated":[38],"(r":[39],"=":[40],"0.75,":[41],"P":[42],"less":[43],"than":[44,60],"0.001)":[45],"throughout":[46],"the":[47,66,80,104,110,118],"normal":[48],"abnormal":[50],"concentration":[51],"ranges.":[52],"amyloidosis,":[55],"more":[58],"sensitive":[59],"as":[62],"an":[63],"indicator":[64],"of":[65,82,87,96,106],"acute-phase":[67,88],"response,":[68],"particularly":[69],"in":[70,117],"secondary":[71,100],"amyloidosis.":[72,84],"Acute-phase":[73],"proteins":[74],"are":[75],"only":[76],"occasionally":[77],"increased":[78],"during":[79],"course":[81],"familial":[83],"The":[85],"overlap":[86],"levels":[90,116],"does":[91],"not":[92],"permit":[93],"reliable":[94],"separation":[95],"primary":[97],"from":[99],"solely":[102],"on":[103],"basis":[105],"such":[107],"studies":[108],"despite":[109],"significantly":[111],"higher":[112],"latter.":[119]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
