{"id":"https://openalex.org/W38222645","doi":null,"title":"Induction of forestomach lesions in rats by oral administrations of naturally occurring antioxidants for 4 weeks.","display_name":"Induction of forestomach lesions in rats by oral administrations of naturally occurring antioxidants for 4 weeks.","publication_year":1987,"publication_date":"1987-04-01","ids":{"openalex":"https://openalex.org/W38222645","mag":"38222645","pmid":"https://pubmed.ncbi.nlm.nih.gov/3108210"},"language":"en","primary_location":{"id":"pmid:3108210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3108210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102399027","display_name":"Masao Hirose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Hirose","raw_affiliation_strings":["First Department of Pathology, Nagoya City University Medical school"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Nagoya City University Medical school","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109838728","display_name":"Atsuko Masuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Masuda","raw_affiliation_strings":["First Department of Pathology, Nagoya City University Medical school"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Nagoya City University Medical school","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056413456","display_name":"Katsumi Imaida","orcid":"https://orcid.org/0000-0003-2548-1683","observed_orcids":["https://orcid.org/0000-0003-2548-1683"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Imaida","raw_affiliation_strings":["First Department of Pathology, Nagoya City University Medical school"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Nagoya City University Medical school","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111546456","display_name":"Masataka Kagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Kagawa","raw_affiliation_strings":["First Department of Pathology, Nagoya City University Medical school"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Nagoya City University Medical school","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101702011","display_name":"Hiroyuki Tsuda","orcid":"https://orcid.org/0000-0001-7992-6217","observed_orcids":["https://orcid.org/0000-0001-7992-6217"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Tsuda","raw_affiliation_strings":["First Department of Pathology, Nagoya City University Medical school"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Nagoya City University Medical school","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111785203","display_name":"Nobuyuki Ito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Ito","raw_affiliation_strings":["First Department of Pathology, Nagoya City University Medical school"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Nagoya City University Medical school","institution_ids":["https://openalex.org/I33858575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":null,"apc_paid":null,"fwci":2.0246,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.84774601,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"78","issue":"4","first_page":"317","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/forestomach-carcinogenesis","display_name":"forestomach carcinogenesis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/butylated-hydroxyanisole","display_name":"butylated hydroxyanisole","score":0.8769999742507935},{"id":"https://openalex.org/keywords/butylated-hydroxytoluene","display_name":"butylated hydroxytoluene","score":0.9980000257492065},{"id":"https://openalex.org/keywords/caffeic-acid","display_name":"caffeic acid","score":0.9070000052452087},{"id":"https://openalex.org/keywords/sesamol","display_name":"sesamol","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gallic-acid","display_name":"gallic acid","score":0.9470000267028809},{"id":"https://openalex.org/keywords/syringic-acid","display_name":"syringic acid","score":0.9679999947547913},{"id":"https://openalex.org/keywords/chlorogenic-acid","display_name":"chlorogenic acid","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ferulic-acid","display_name":"ferulic acid","score":0.9789999723434448},{"id":"https://openalex.org/keywords/eugenol","display_name":"eugenol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/esculin","display_name":"esculin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dietary-antioxidants","display_name":"dietary antioxidants","score":0.5920000076293945},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2778407507","wikidata":"https://www.wikidata.org/wiki/Q418080","display_name":"Sesamol","level":3,"score":0.9488954544067383},{"id":"https://openalex.org/C2781418880","wikidata":"https://www.wikidata.org/wiki/Q409401","display_name":"Butylated hydroxyanisole","level":3,"score":0.9236903190612793},{"id":"https://openalex.org/C2779661893","wikidata":"https://www.wikidata.org/wiki/Q221945","display_name":"Butylated hydroxytoluene","level":3,"score":0.8893297910690308},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.7413241267204285},{"id":"https://openalex.org/C2780117898","wikidata":"https://www.wikidata.org/wiki/Q421964","display_name":"Chlorogenic acid","level":2,"score":0.6074737310409546},{"id":"https://openalex.org/C2779383672","wikidata":"https://www.wikidata.org/wiki/Q408428","display_name":"Syringic acid","level":4,"score":0.5797087550163269},{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.5762245655059814},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5729491114616394},{"id":"https://openalex.org/C25205856","wikidata":"https://www.wikidata.org/wiki/Q522113","display_name":"Proventriculus","level":2,"score":0.4938974976539612},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.48343145847320557},{"id":"https://openalex.org/C2780213334","wikidata":"https://www.wikidata.org/wiki/Q417362","display_name":"Ferulic acid","level":2,"score":0.48328378796577454},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4566757380962372},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.4489056468009949},{"id":"https://openalex.org/C2780470866","wikidata":"https://www.wikidata.org/wiki/Q423357","display_name":"Eugenol","level":2,"score":0.41028547286987305},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.40686866641044617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3738126754760742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23406660556793213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2280023992061615},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08592140674591064},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002083","descriptor_name":"Butylated Hydroxyanisole","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002084","descriptor_name":"Butylated Hydroxytoluene","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005707","descriptor_name":"Gallic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052117","descriptor_name":"Benzodioxoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3108210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3108210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"},{"id":"mag:38222645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3108210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1553323643","https://openalex.org/W1826417692","https://openalex.org/W1969842031","https://openalex.org/W2004347124","https://openalex.org/W2005359555","https://openalex.org/W2008672761","https://openalex.org/W2013517796","https://openalex.org/W2044415061","https://openalex.org/W2051020914","https://openalex.org/W2051064202","https://openalex.org/W2080176294","https://openalex.org/W2089673350","https://openalex.org/W2113332962","https://openalex.org/W2168237329","https://openalex.org/W2173056841","https://openalex.org/W2202569613"],"related_works":["https://openalex.org/W1987293950","https://openalex.org/W2009330071","https://openalex.org/W180317820","https://openalex.org/W59409346","https://openalex.org/W2063576134","https://openalex.org/W2068130137","https://openalex.org/W1966989031","https://openalex.org/W111896625","https://openalex.org/W2070785107","https://openalex.org/W2076336558"],"abstract_inverted_index":{"The":[0],"effects":[1],"of":[2,14,24,34,65,76],"naturally":[3,115],"occurring":[4,116],"antioxidants":[5,117],"on":[6],"rat":[7,128],"forestomach":[8,31,78,100],"epithelium":[9],"were":[10,39],"compared":[11],"with":[12],"those":[13],"synthetic":[15],"antioxidants,":[16],"butylated":[17,21],"hydroxyanisole":[18],"(BHA)":[19],"and":[20,102,107,121],"hydroxytoluene":[22],"(BHT),":[23],"which":[25],"the":[26,77,86,90,99,110,127],"former":[27],"is":[28],"a":[29,63],"known":[30],"carcinogen.":[32],"Groups":[33],"five":[35],"F344":[36],"male":[37],"rats":[38],"given":[40],"diet":[41],"containing":[42],"BHA,":[43],"BHT,":[44],"gallic":[45],"acid,":[46,48,51,53,55],"syringic":[47],"sesamol,":[49],"caffeic":[50,93],"chlorogenic":[52],"ferulic":[54],"eugenol":[56],"or":[57,69],"esculin":[58],"for":[59,67,71],"4":[60],"weeks":[61],"at":[62],"level":[64],"0.7%":[66],"BHT":[68],"2%":[70],"other":[72],"compounds.":[73],"Histological":[74],"examination":[75],"showed":[79,118],"that":[80],"BHA":[81],"induced":[82,95,104],"hyperplasia":[83,97,108,125],"mainly":[84],"in":[85,109,126],"prefundic":[87],"region":[88],"near":[89],"esophageal":[91],"orifice,":[92],"acid":[94],"pronounced":[96],"throughout":[98],"epithelium,":[101],"sesamol":[103],"large":[105],"ulcers":[106],"central":[111],"region.":[112],"Thus,":[113],"these":[114],"different":[119],"toxicities":[120],"abilities":[122],"to":[123],"induce":[124],"forestomach.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}