{"id":"https://openalex.org/W38160372","doi":"https://doi.org/10.5694/j.1326-5377.1990.tb136897.x","title":"Development of AIDS in a cohort of HIV\u2010seropositive homosexual men in Australia","display_name":"Development of AIDS in a cohort of HIV\u2010seropositive homosexual men in Australia","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W38160372","doi":"https://doi.org/10.5694/j.1326-5377.1990.tb136897.x","mag":"38160372","pmid":"https://pubmed.ncbi.nlm.nih.gov/1975423"},"language":"en","primary_location":{"id":"doi:10.5694/j.1326-5377.1990.tb136897.x","doi":"https://doi.org/10.5694/j.1326-5377.1990.tb136897.x","is_oa":false,"landing_page_url":"https://doi.org/10.5694/j.1326-5377.1990.tb136897.x","pdf_url":null,"source":{"id":"https://openalex.org/S13978405","display_name":"The Medical Journal of Australia","issn_l":"0025-729X","issn":["0025-729X","1326-5377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Journal of Australia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113767296","display_name":"Brett Tindall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Brett Tindall","raw_affiliation_strings":["National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, St Vincent's Medical Centre, 376 Victoria Street, Darlinghurst, NSW, 2010","Reprints: Mr Brett Tindall"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, St Vincent's Medical Centre, 376 Victoria Street, Darlinghurst, NSW, 2010","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Reprints: Mr Brett Tindall","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052871866","display_name":"Cheryl E. Swanson","orcid":"https://orcid.org/0000-0002-8872-3750","observed_orcids":["https://orcid.org/0000-0002-8872-3750"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Cheryl E Swanson","raw_affiliation_strings":["National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, St Vincent's Medical Centre, 376 Victoria Street, Darlinghurst, NSW, 2010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, St Vincent's Medical Centre, 376 Victoria Street, Darlinghurst, NSW, 2010","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107834622","display_name":"David A. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David A Cooper","raw_affiliation_strings":["Centre for Immunology, St Vincent's Hospital, Sydney","National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, St Vincent's Medical Centre, 376 Victoria Street, Darlinghurst, NSW, 2010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital, Sydney","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, St Vincent's Medical Centre, 376 Victoria Street, Darlinghurst, NSW, 2010","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113767296"],"corresponding_institution_ids":["https://openalex.org/I31746571"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.462,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.60953697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"153","issue":"5","first_page":"260","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.1348000019788742,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aids-progression","display_name":"AIDS progression","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.7739999890327454},{"id":"https://openalex.org/keywords/gay-men","display_name":"gay men","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.9070000052452087},{"id":"https://openalex.org/keywords/lymphocyte-count","display_name":"lymphocyte count","score":0.9240000247955322},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.9850000143051147},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5920000076293945},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.765999972820282},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.6520000100135803},{"id":"https://openalex.org/keywords/opportunistic-infection-prophylaxis","display_name":"opportunistic infection prophylaxis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/patient-monitoring","display_name":"patient monitoring","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.7088865041732788},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6334775686264038},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5960997939109802},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4936548173427582},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3565177917480469},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1949346959590912},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.10105597972869873}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000206","descriptor_name":"Actuarial Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001315","descriptor_name":"Australia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006716","descriptor_name":"Homosexuality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5694/j.1326-5377.1990.tb136897.x","doi":"https://doi.org/10.5694/j.1326-5377.1990.tb136897.x","is_oa":false,"landing_page_url":"https://doi.org/10.5694/j.1326-5377.1990.tb136897.x","pdf_url":null,"source":{"id":"https://openalex.org/S13978405","display_name":"The Medical Journal of Australia","issn_l":"0025-729X","issn":["0025-729X","1326-5377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Journal of Australia","raw_type":"journal-article"},{"id":"pmid:1975423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1975423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Medical journal of Australia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W60005868","https://openalex.org/W69301831","https://openalex.org/W105330680","https://openalex.org/W1804736467","https://openalex.org/W1873564233","https://openalex.org/W1976351474","https://openalex.org/W1977691157","https://openalex.org/W1994980898","https://openalex.org/W1996492073","https://openalex.org/W1999557076","https://openalex.org/W2003974160","https://openalex.org/W2004051713","https://openalex.org/W2043015697","https://openalex.org/W2046669154","https://openalex.org/W2048706882","https://openalex.org/W2050026299","https://openalex.org/W2058311915","https://openalex.org/W2064806150","https://openalex.org/W2084181643","https://openalex.org/W2086652528","https://openalex.org/W2111632718","https://openalex.org/W2128994431","https://openalex.org/W2158562439","https://openalex.org/W2164079971","https://openalex.org/W2168585757","https://openalex.org/W2214201596","https://openalex.org/W2322541596","https://openalex.org/W2333399282","https://openalex.org/W2336541137","https://openalex.org/W2339910025","https://openalex.org/W2418847381","https://openalex.org/W2464760832","https://openalex.org/W2797588280","https://openalex.org/W2946440120","https://openalex.org/W4238541000","https://openalex.org/W4245862068","https://openalex.org/W4252302328","https://openalex.org/W4252979211"],"related_works":["https://openalex.org/W2086652528","https://openalex.org/W2292943859","https://openalex.org/W2048706882","https://openalex.org/W2322541596","https://openalex.org/W1965665382","https://openalex.org/W2168697577","https://openalex.org/W2062027604","https://openalex.org/W2084797799","https://openalex.org/W7095620737","https://openalex.org/W2050026299"],"abstract_inverted_index":{"The":[0],"Sydney":[1],"AIDS":[2,173],"Prospective":[3],"Study":[4],"is":[5],"a":[6,65,73,98,106,115,135],"cohort":[7],"study":[8,163,227],"of":[9,26,62,75,81,89,126,160,170,178,189,201],"1057":[10],"homosexual":[11],"men":[12,29],"enrolled":[13],"between":[14],"February":[15],"1984":[16],"and":[17,97,134,242,247,255],"January":[18],"1985.":[19],"By":[20],"June":[21],"30,":[22],"1989,":[23],"111":[24],"(26.8%)":[25],"the":[27,44,52,82,110,152,158,167,184,198,222,249],"414":[28],"who":[30],"were":[31,56,205,213],"seropositive":[32],"for":[33,157,197,219,239,243,251],"antibodies":[34],"to":[35,172,194,208],"human":[36],"immunodeficiency":[37,46],"virus":[38],"(HIV)":[39],"at":[40],"enrollment":[41],"had":[42],"developed":[43],"acquired":[45],"syndrome":[47],"(AIDS).":[48],"On":[49],"univariate":[50],"analysis":[51],"following":[53,111],"baseline":[54],"factors":[55,112],"significantly":[57],"associated":[58],"with":[59],"subsequent":[60,199],"development":[61,159,200],"AIDS:":[63],"splenomegaly;":[64],"lymphocyte":[66,84,116],"count":[67,117,145],"less":[68,78,92,102,118,129,139,146],"than":[69,79,93,103,119,130,140,147],"1500":[70,120],"x":[71,95,121,132,149],"10(6)/L;":[72,96,122,133],"percentage":[74],"CD4+":[76,90,127,143],"cells":[77,91,128],"20%":[80],"total":[83],"count;":[85],"an":[86,123],"absolute":[87,124],"number":[88,125,188],"200":[94,131,148],"CD4+:":[99,136],"CD8+":[100,137],"ratio":[101,138],"1.00.":[104,141],"In":[105],"proportional":[107],"hazards":[108],"model":[109],"retained":[113],"significance:":[114],"A":[142,187],"cell":[144],"10(6)/L":[150],"carried":[151],"greatest":[153],"relative":[154],"risk":[155],"(3.99)":[156],"AIDS.":[161,202],"This":[162],"has":[164],"confirmed":[165],"that":[166],"appreciable":[168],"rates":[169,224],"progression":[171],"demonstrated":[174],"in":[175,183,225,259],"overseas":[176],"cohorts":[177],"HIV-infected":[179,240,260],"persons":[180,241],"also":[181],"apply":[182],"Australian":[185],"context.":[186],"laboratory":[190],"variables":[191],"was":[192],"found":[193],"be":[195,229],"predictive":[196],"As":[203],"we":[204],"not":[206],"able":[207],"determine":[209],"accurately":[210],"whether":[211],"subjects":[212],"receiving":[214],"antiretroviral":[215],"treatment":[216],"or":[217],"prophylaxis":[218],"opportunistic":[220],"infections":[221],"observed":[223],"this":[226],"should":[228],"seen":[230],"as":[231],"minimum":[232],"estimates.":[233],"These":[234],"findings":[235],"have":[236],"important":[237],"implications":[238],"public":[244],"health":[245],"planning,":[246],"emphasise":[248],"need":[250],"regular":[252],"clinical":[253],"monitoring":[254],"T-cell":[256],"subset":[257],"enumeration":[258],"persons.":[261]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}