{"id":"https://openalex.org/W379990449","doi":null,"title":"Proliferation and Differentiation of Human Hematopoietic Stem/Progenitor Cells Exposed to Low-dose X-irradiation","display_name":"Proliferation and Differentiation of Human Hematopoietic Stem/Progenitor Cells Exposed to Low-dose X-irradiation","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W379990449","mag":"379990449"},"language":"en","primary_location":{"id":"mag:379990449","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/40019745101","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036904904","display_name":"Masaru Yamaguchi","orcid":"https://orcid.org/0000-0002-8623-6596","observed_orcids":["https://orcid.org/0000-0002-8623-6596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaru Yamaguchi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8623-6596","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005124889","display_name":"Satoko Ebina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoko Ebina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067945916","display_name":"Ikuo Kashiwakura","orcid":"https://orcid.org/0000-0002-7399-1445","observed_orcids":["https://orcid.org/0000-0002-7399-1445"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuo Kashiwakura","raw_affiliation_strings":["Hirosaki University"],"raw_orcid":"https://orcid.org/0000-0002-7399-1445","affiliations":[{"raw_affiliation_string":"Hirosaki University","institution_ids":["https://openalex.org/I146516829"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":"2","first_page":"56","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.19359999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/low-dose-x-ray-irradiation","display_name":"low-dose X-ray irradiation","score":0.984000027179718},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/hematopoietic-differentiation","display_name":"hematopoietic differentiation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/gamma-h2ax-foci","display_name":"\u03b3H2AX foci","score":0.8859999775886536},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8600000143051147},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.5839999914169312},{"id":"https://openalex.org/keywords/cell-surface-antigens","display_name":"cell surface antigens","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7492144703865051},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6967707276344299},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6742649674415588},{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.604607105255127},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.552688717842102},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5253733396530151},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5007562637329102},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4901479184627533},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.4773117005825043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47213321924209595},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.42878690361976624},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41792672872543335},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4029151201248169},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3743324875831604},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.36753004789352417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10033270716667175},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:379990449","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/40019745101","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1967863323","https://openalex.org/W1987687711","https://openalex.org/W1990632598","https://openalex.org/W2006103220","https://openalex.org/W2006858132","https://openalex.org/W2008484243","https://openalex.org/W2036573425","https://openalex.org/W2039843910","https://openalex.org/W2051110133","https://openalex.org/W2070548474","https://openalex.org/W2073692681","https://openalex.org/W2092234690","https://openalex.org/W2105239540","https://openalex.org/W2111718042","https://openalex.org/W2114867673","https://openalex.org/W2123170994","https://openalex.org/W2125665207","https://openalex.org/W2126614953","https://openalex.org/W2157277703","https://openalex.org/W2177380697","https://openalex.org/W2243781553","https://openalex.org/W2323074670","https://openalex.org/W2397440041"],"related_works":["https://openalex.org/W2023234855","https://openalex.org/W7099834895","https://openalex.org/W2128926100","https://openalex.org/W2006858132","https://openalex.org/W2991216018","https://openalex.org/W4396903042","https://openalex.org/W753103395","https://openalex.org/W7099907760","https://openalex.org/W1979577251","https://openalex.org/W2513334820"],"abstract_inverted_index":{"hematopoietic":[0],"lineages,":[1],"and":[2,57,77,105,119,153],"are":[3],"extremely":[4],"sensitive":[5],"to":[6,12,70,129],"oxidative":[7],"stresses.":[8],"Exposure":[9],"of":[10,19,35,41,54,59,111,131,145,193],"HSPCs":[11,43],"ionizing":[13],"radiation":[14],"causes":[15],"a":[16,25,137],"marked":[17],"suppression":[18,192],"mature":[20],"blood":[21],"cell":[22,99,112],"production":[23],"in":[24,75,97,142,158],"dosedependent":[26],"manner.":[27],"However,":[28,136],"little":[29],"information":[30],"about":[31],"the":[32,39,51,55,143,159],"long-term":[33],"effects":[34],"low-dose":[36,60,71,185],"X-irradiation":[37,186],"on":[38,121,163,174,178],"stemness":[40],"human":[42,62],"has":[44],"been":[45],"reported.":[46],"The":[47,86,108],"present":[48],"study":[49],"investigated":[50],"biological":[52],"characteristics":[53],"differentiation":[56],"proliferation":[58],"X-irradiated":[61,106,125,156],"CD34+":[63,67],"HSPCs.":[64],"Highly":[65],"purified":[66],"cells":[68,122,132,150,157],"exposed":[69],"X-rays":[72],"were":[73,101,127,171],"cultured":[74,90],"liquid":[76,87],"semisolid":[78],"media":[79],"supplemented":[80],"with":[81,189],"an":[82],"optimal":[83],"cytokine":[84],"combination.":[85],"medium":[88],"was":[89,140],"for":[91],"14":[92,176],"days;":[93],"no":[94],"significant":[95,138],"differences":[96],"total":[98],"number":[100,144],"observed":[102,141],"between":[103,151],"nonirradiated":[104],"cultures.":[107],"expression":[109],"levels":[110],"surface":[113],"antigens":[114],"such":[115],"as":[116],"CD34,":[117],"CD38,":[118],"CD45":[120],"harvested":[123],"from":[124,133],"culture":[126],"similar":[128],"those":[130],"non-irradiated":[134,152],"culture.":[135],"reduction":[139],"burstforming":[146],"unit":[147],"erythroid":[148],"(BFU-E)":[149],"0.5":[154],"Gy":[155],"myeloid":[160],"progenitor":[161],"assay":[162],"day":[164,175,179],"14;":[165],"moreover,":[166],"concurrently,":[167],"radiation-induced":[168],"\u03b3-H2AX":[169],"foci":[170],"significantly":[172],"greater":[173],"than":[177],"0.":[180],"These":[181],"results":[182],"suggest":[183],"that":[184],"is":[187],"associated":[188],"clonal":[190],"growth":[191],"BFU-E":[194],"cells.":[195]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2016-06-24T00:00:00"}
