{"id":"https://openalex.org/W37933889","doi":null,"title":"Identification and functional analyses of novel protein interactions and post-translational modifications for the transcription factor deformed epidermal autoregulatory factor-1","display_name":"Identification and functional analyses of novel protein interactions and post-translational modifications for the transcription factor deformed epidermal autoregulatory factor-1","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W37933889","mag":"37933889"},"language":"en","primary_location":{"id":"pmh:oai:opensiuc.lib.siu.edu:dissertations-1033","doi":null,"is_oa":false,"landing_page_url":"https://opensiuc.lib.siu.edu/dissertations/33","pdf_url":null,"source":{"id":"https://openalex.org/S4377196411","display_name":"OpenSIUC (Southern Illinois University Carbondale)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I110378019","host_organization_name":"Southern Illinois University Carbondale","host_organization_lineage":["https://openalex.org/I110378019"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052009072","display_name":"Philip J. Jensik","orcid":"https://orcid.org/0000-0001-6726-1510","observed_orcids":["https://orcid.org/0000-0001-6726-1510"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Philip J. Jensik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6726-1510","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052009072"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.15649999678134918,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.12880000472068787,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9279999732971191},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ku70","display_name":"Ku70","score":0.8690000176429749},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.7210000157356262},{"id":"https://openalex.org/keywords/protein-arginine-methylation","display_name":"arginine methylation","score":0.890999972820282},{"id":"https://openalex.org/keywords/cdk5","display_name":"cyclin-dependent kinase 5","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dna-binding-domain","display_name":"DNA-binding domain","score":0.7250000238418579},{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.678936779499054},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5101562142372131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47675666213035583},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43359848856925964},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43004310131073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2777095437049866},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10544481873512268},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:opensiuc.lib.siu.edu:dissertations-1033","doi":null,"is_oa":false,"landing_page_url":"https://opensiuc.lib.siu.edu/dissertations/33","pdf_url":null,"source":{"id":"https://openalex.org/S4377196411","display_name":"OpenSIUC (Southern Illinois University Carbondale)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I110378019","host_organization_name":"Southern Illinois University Carbondale","host_organization_lineage":["https://openalex.org/I110378019"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations","raw_type":"text"},{"id":"mag:37933889","doi":null,"is_oa":false,"landing_page_url":"https://opensiuc.lib.siu.edu/cgi/viewcontent.cgi?article=1033&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6800000071525574}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1866273761","https://openalex.org/W1981719219","https://openalex.org/W1995621893","https://openalex.org/W1999074857","https://openalex.org/W2027729613","https://openalex.org/W2044964290","https://openalex.org/W2049879016","https://openalex.org/W2051978340","https://openalex.org/W2062352406","https://openalex.org/W2068618703","https://openalex.org/W2079653702","https://openalex.org/W2081354202","https://openalex.org/W2081853028","https://openalex.org/W2087866161","https://openalex.org/W2093556738","https://openalex.org/W2122810793","https://openalex.org/W2136408173","https://openalex.org/W2145854034","https://openalex.org/W2169115139","https://openalex.org/W2586300209","https://openalex.org/W2762554738","https://openalex.org/W2765467523","https://openalex.org/W2885009200","https://openalex.org/W2943802448","https://openalex.org/W2967223702","https://openalex.org/W3018219574","https://openalex.org/W3018233192","https://openalex.org/W3116309065","https://openalex.org/W4281734177"],"related_works":["https://openalex.org/W2148875674","https://openalex.org/W110968218","https://openalex.org/W4384501685","https://openalex.org/W2087411126","https://openalex.org/W1513145417","https://openalex.org/W650244141","https://openalex.org/W17265099","https://openalex.org/W2033733508","https://openalex.org/W1536050266","https://openalex.org/W1963827845"],"abstract_inverted_index":{"Deformed":[0],"Epidermal":[1],"Autoregulatory":[2],"Factor-1":[3],"(DEAF-1)":[4],"is":[5],"a":[6,96,106,112,129,136],"transcription":[7],"factor":[8],"that":[9,114,201],"binds":[10],"TTCG":[11],"motifs":[12],"and":[13,21,41,79,111,134,160,176,214],"has":[14],"roles":[15],"in":[16],"fetal":[17],"development,":[18],"clinical":[19],"depression":[20],"cancer.":[22],"In":[23,192],"order":[24],"to":[25,87,149,170],"further":[26],"our":[27],"understanding":[28],"of":[29,44,53,62,66,124,131,147,153,164,183,216],"the":[30,49,57,63,67,151,154,165,184],"DEAF-1":[31,38,54,81,93,120,127,148,158,189],"protein,":[32],"this":[33],"study":[34],"characterizes":[35],"previously":[36],"unidentified":[37],"interacting":[39,60],"proteins":[40],"post-translational":[42],"modifications":[43],"DEAF-1.":[45,204,217],"A":[46],"region":[47],"encompassing":[48],"DNA":[50,108],"binding":[51],"domain":[52,61,78],"interacts":[55],"with":[56,174],"C-terminal":[58,77],"Bax":[59],"Ku70":[64,70,116],"subunit":[65],"DNA-PK":[68],"holoenzyme.":[69],"acts":[71],"as":[72,95,198],"an":[73],"anti-apoptotic":[74],"protein":[75,98],"through":[76,105],"so":[80],"was":[82],"assessed":[83],"for":[84],"its":[85],"ability":[86],"influence":[88],"apoptosis":[89],"after":[90,99],"various":[91],"stimuli.":[92,101],"acted":[94],"pro-apoptotic":[97,121,190],"intrinsic":[100],"Apoptotic":[102],"activities":[103],"occurred":[104],"nuclear,":[107],"independent":[109],"mechanism":[110],"mutation":[113,163],"eliminated":[115],"interactions":[117,173],"also":[118,135,177],"inhibited":[119],"activities.":[122,191],"Analysis":[123],"mammalian":[125],"purified":[126],"indicated":[128],"number":[130],"phosphorylation":[132,186],"sites":[133,156,187],"methylated":[137,166],"arginine":[138,167],"residue.":[139],"Various":[140],"assays":[141,195],"were":[142],"performed":[143],"on":[144,157],"mutated":[145],"forms":[146],"determine":[150],"significance":[152],"modified":[155],"functions":[159],"properties.":[161],"Lysine":[162],"site":[168],"appeared":[169],"augment":[171],"protein-protein":[172],"itself":[175],"Ku70.":[178],"Alanine":[179],"mutations":[180],"at":[181],"three":[182],"identified":[185,196],"increased":[188],"vitro":[193],"kinase":[194,200],"CDK5":[197],"potential":[199,211],"can":[202],"phosphorylate":[203],"These":[205],"studies":[206],"provide":[207],"new":[208],"insight":[209],"into":[210],"functions,":[212],"properties,":[213],"regulation":[215]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}