{"id":"https://openalex.org/W37921669","doi":null,"title":"Estudios gen\u00f3micos y funcionales en Anaplasma marginale y en bacterias intracelulares de la clase alfa-proteobacteria y su relaci\u00f3n con la reducci\u00f3n del genoma","display_name":"Estudios gen\u00f3micos y funcionales en Anaplasma marginale y en bacterias intracelulares de la clase alfa-proteobacteria y su relaci\u00f3n con la reducci\u00f3n del genoma","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W37921669","mag":"37921669"},"language":"es","primary_location":{"id":"pmh:oai:RDI UBA:aextesis:tesis_n5196_Nunez_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5196_Nunez","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/20.500.12110/tesis_n5196_Nunez","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103421225","display_name":"Pablo Alfredo Nu\u00f1ez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pablo Alfredo Nu\u00f1ez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103421225"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anaplasma-marginale","display_name":"Anaplasma marginale","score":1.0},{"id":"https://openalex.org/keywords/rickettsiales","display_name":"Rickettsiales","score":0.7480000257492065},{"id":"https://openalex.org/keywords/alphaproteobacteria","display_name":"Alphaproteobacteria","score":0.8420000076293945},{"id":"https://openalex.org/keywords/genome-reduction","display_name":"genome reduction","score":0.6430000066757202},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.6389999985694885},{"id":"https://openalex.org/keywords/twin-arginine-translocation-pathway","display_name":"twin-arginine translocation pathway","score":0.7400000095367432},{"id":"https://openalex.org/keywords/outer-membrane-proteins","display_name":"outer membrane proteins","score":0.5149999856948853},{"id":"https://openalex.org/keywords/antigenic-proteins","display_name":"antigenic proteins","score":0.753000020980835},{"id":"https://openalex.org/keywords/brucella-abortus","display_name":"Brucella abortus","score":0.652999997138977},{"id":"https://openalex.org/keywords/brucella-suis","display_name":"Brucella suis","score":0.4869999885559082},{"id":"https://openalex.org/keywords/brucella-melitensis","display_name":"Brucella melitensis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/brucella-canis","display_name":"Brucella canis","score":0.6399999856948853},{"id":"https://openalex.org/keywords/brucella-ovis","display_name":"Brucella ovis","score":0.550000011920929},{"id":"https://openalex.org/keywords/brucella-suis-biovar-2","display_name":"Brucella suis biovar 2","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2776732713","wikidata":"https://www.wikidata.org/wiki/Q136644","display_name":"Rickettsiales","level":3,"score":0.5272527933120728},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.516569972038269},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.2911418676376343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2848312258720398},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.061331868171691895},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05126073956489563}],"mesh":[],"locations_count":8,"locations":[{"id":"pmh:oai:RDI UBA:aextesis:tesis_n5196_Nunez_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5196_Nunez","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:americanae.aecid.es:3065952","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12110/tesis_n5196_Nunez","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"http://purl.org/coar/resource_type/c_db06"},{"id":"pmh:oai:americanae.aecid.es:3078279","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12123/6269","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:INTA Digital (INTA)","raw_type":"http://purl.org/coar/resource_type/c_db06"},{"id":"pmh:snrd:Tesis_5196_Nunez","doi":null,"is_oa":true,"landing_page_url":"http://digital.bl.fcen.uba.ar/gsdl-282/cgi-bin/library.cgi?a=d&amp;c=tesis&amp;d=Tesis_5196_Nunez","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:tesis:tesis_n5196_Nunez","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5196_Nunez","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital (UBA-FCEN)","raw_type":"http://purl.org/coar/resource_type/c_db06"},{"id":"pmh:oai:localhost:20.500.12123/6269","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12123/6269","pdf_url":"https://bibliotecadigital.exactas.uba.ar/download/tesis/tesis_n5196_Nunez.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:INTA Digital (INTA)","raw_type":"http://purl.org/coar/resource_type/c_db06"},{"id":"pmh:oai:RDI UBA:aextesis:Tesis_5196_Nunez_oai","doi":null,"is_oa":false,"landing_page_url":"http://digital.bl.fcen.uba.ar/gsdl-282/cgi-bin/library.cgi?a=d&amp;c=tesis&amp;d=Tesis_5196_Nunez","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Tesis Doctoral"},{"id":"mag:37921669","doi":null,"is_oa":false,"landing_page_url":"http://digital.bl.fcen.uba.ar/download/tesis/tesis_n5196_Nunez.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:RDI UBA:aextesis:tesis_n5196_Nunez_oai","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12110/tesis_n5196_Nunez","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W37921669.pdf","grobid_xml":"https://content.openalex.org/works/W37921669.grobid-xml"},"referenced_works_count":158,"referenced_works":["https://openalex.org/W22096773","https://openalex.org/W1521733510","https://openalex.org/W1575452420","https://openalex.org/W1584246476","https://openalex.org/W1825286507","https://openalex.org/W1858013354","https://openalex.org/W1913187248","https://openalex.org/W1922885451","https://openalex.org/W1935158889","https://openalex.org/W1936630560","https://openalex.org/W1962639209","https://openalex.org/W1964786222","https://openalex.org/W1967093917","https://openalex.org/W1968136381","https://openalex.org/W1968698890","https://openalex.org/W1979029445","https://openalex.org/W1979941190","https://openalex.org/W1980218465","https://openalex.org/W1980480371","https://openalex.org/W1981871034","https://openalex.org/W1982309495","https://openalex.org/W1987035427","https://openalex.org/W1988829912","https://openalex.org/W1989723405","https://openalex.org/W1990706294","https://openalex.org/W1992972416","https://openalex.org/W1994591309","https://openalex.org/W1996672306","https://openalex.org/W1999177695","https://openalex.org/W1999990902","https://openalex.org/W2000167356","https://openalex.org/W2001660209","https://openalex.org/W2002575158","https://openalex.org/W2006990204","https://openalex.org/W2007325254","https://openalex.org/W2007459530","https://openalex.org/W2008293899","https://openalex.org/W2013410948","https://openalex.org/W2015083882","https://openalex.org/W2015945437","https://openalex.org/W2018526864","https://openalex.org/W2025623875","https://openalex.org/W2026158852","https://openalex.org/W2027558100","https://openalex.org/W2028867815","https://openalex.org/W2031396235","https://openalex.org/W2032619610","https://openalex.org/W2036501925","https://openalex.org/W2040346946","https://openalex.org/W2045801003","https://openalex.org/W2048160774","https://openalex.org/W2049469847","https://openalex.org/W2052470499","https://openalex.org/W2053644844","https://openalex.org/W2054755820","https://openalex.org/W2061077158","https://openalex.org/W2061732951","https://openalex.org/W2065442831","https://openalex.org/W2066848052","https://openalex.org/W2068620164","https://openalex.org/W2068784215","https://openalex.org/W2068908467","https://openalex.org/W2071651020","https://openalex.org/W2072000635","https://openalex.org/W2073173536","https://openalex.org/W2074439439","https://openalex.org/W2077640701","https://openalex.org/W2079341662","https://openalex.org/W2080128896","https://openalex.org/W2080294836","https://openalex.org/W2086918719","https://openalex.org/W2088014274","https://openalex.org/W2089016671","https://openalex.org/W2092604303","https://openalex.org/W2094214505","https://openalex.org/W2096804397","https://openalex.org/W2097312542","https://openalex.org/W2097634886","https://openalex.org/W2099247658","https://openalex.org/W2099249565","https://openalex.org/W2100380298","https://openalex.org/W2100808143","https://openalex.org/W2103188931","https://openalex.org/W2104328914","https://openalex.org/W2105022650","https://openalex.org/W2105964359","https://openalex.org/W2105965702","https://openalex.org/W2105986552","https://openalex.org/W2106727650","https://openalex.org/W2107424557","https://openalex.org/W2108575112","https://openalex.org/W2108737135","https://openalex.org/W2110899053","https://openalex.org/W2111967267","https://openalex.org/W2112667567","https://openalex.org/W2114101120","https://openalex.org/W2118744524","https://openalex.org/W2118785817","https://openalex.org/W2119445385","https://openalex.org/W2119499389","https://openalex.org/W2120569397","https://openalex.org/W2121870069","https://openalex.org/W2122757996","https://openalex.org/W2125090992","https://openalex.org/W2125377246","https://openalex.org/W2126809954","https://openalex.org/W2127111522","https://openalex.org/W2128110461","https://openalex.org/W2129617994","https://openalex.org/W2130096080","https://openalex.org/W2130136137","https://openalex.org/W2130167351","https://openalex.org/W2131877044","https://openalex.org/W2133032443","https://openalex.org/W2135544968","https://openalex.org/W2137095432","https://openalex.org/W2137119243","https://openalex.org/W2137475545","https://openalex.org/W2140494270","https://openalex.org/W2142479580","https://openalex.org/W2143332887","https://openalex.org/W2144035267","https://openalex.org/W2144990074","https://openalex.org/W2145025086","https://openalex.org/W2145066558","https://openalex.org/W2148054445","https://openalex.org/W2148342439","https://openalex.org/W2148844706","https://openalex.org/W2149781820","https://openalex.org/W2150426811","https://openalex.org/W2151627181","https://openalex.org/W2152049964","https://openalex.org/W2155904518","https://openalex.org/W2157748357","https://openalex.org/W2159957100","https://openalex.org/W2161403102","https://openalex.org/W2161746138","https://openalex.org/W2163091231","https://openalex.org/W2163321402","https://openalex.org/W2164154943","https://openalex.org/W2164751980","https://openalex.org/W2165379126","https://openalex.org/W2166123594","https://openalex.org/W2166406784","https://openalex.org/W2167208380","https://openalex.org/W2167220787","https://openalex.org/W2169823811","https://openalex.org/W2171913440","https://openalex.org/W2175448016","https://openalex.org/W2180837713","https://openalex.org/W2242053395","https://openalex.org/W2242146517","https://openalex.org/W2314481069","https://openalex.org/W2411301094","https://openalex.org/W2431906598","https://openalex.org/W4320801390","https://openalex.org/W4407201373","https://openalex.org/W7098002754"],"related_works":["https://openalex.org/W7026555331","https://openalex.org/W7218041559","https://openalex.org/W2513727748","https://openalex.org/W2790437269","https://openalex.org/W2027558100","https://openalex.org/W2248735445","https://openalex.org/W1587956443","https://openalex.org/W1618876148","https://openalex.org/W2996611911","https://openalex.org/W2886961523"],"abstract_inverted_index":{"La":[0,176,261,638,677],"subdivisi\u00f3n":[1,30],"\u03b1-":[2],"de":[3,14,28,68,108,126,136,141,172,180,182,186,189,200,202,221,233,258,265,267,278,286,296,313,335,338,349,352,354,356,359,366,375,380,398,430,439,446,451,459,466,476,478,481,485,496,502,513,516,520,522,545,554,563,584,596,611,615,641,646,648,653,662,672,679,681,696,704,710,718,724,752,763,766,777],"la":[4,55,69,81,134,137,173,219,244,279,311,324,336,347,373,437,449,454,486,492,508,511,514,702,705,708,716,737,746,761],"clase":[5,174,706],"proteobacteria":[6],"representa":[7,191],"un":[8,192,389,406,517,581,685,764],"grupo":[9,765],"sumamente":[10],"diverso":[11],"y":[12,25,58,100,113,119,133,139,153,161,185,209,291,401,432,491,636,675,699,707,714,772],"heterog\u00e9neo":[13],"bacterias":[15,204,385,402,562,767],"con":[16,205,210,227,363,530,561,580],"una":[17,235,304,330,376],"gran":[18,39,78,287],"variabilidad":[19],"en":[20,84,91,98,101,106,110,114,123,128,149,169,224,255,283,300,316,327,344,414,418,427,442,507,524,533,542,559,575,591,605,619,621,651,657,688,745,760],"sus":[21,124],"caracter\u00edsticas":[22],"gen\u00f3micas,":[23],"biol\u00f3gicas":[24],"ecol\u00f3gicas.":[26],"Dentro":[27],"esta":[29],"se":[31,63,147,308,321,588,599,625,665],"encuentra":[32],"el":[33,111,170,421,549,552,644,721],"orden":[34,167,756],"Rickettsiales":[35,168,757],"que":[36,51,76,230,297,396,462,541,593,630,712,734,741,768],"ha":[37],"cobrado":[38],"importancia":[40],"durante":[41],"los":[42,187,197,339,350,360,364,474,555,594,606,616,668,694,719,725,730,742,753],"\u00faltimos":[43],"a\u00f1os":[44],"por":[45,74,195,693],"agrupar":[46],"a":[47,158,323,378,409,494,527,569,728,736,740],"diversos":[48,622],"pat\u00f3genos":[49,285,775],"emergentes":[50,776],"resultan":[52],"relevantes":[53,429],"para":[54,369,469,667,758],"salud":[56,59],"p\u00fablica":[57],"animal.":[60],"Entre":[61],"ellos,":[62],"destaca":[64],"Anaplasma":[65],"marginale,":[66],"causante":[67],"Anaplasmosis":[70],"bovina":[71],"enfermedad":[72],"transmitida":[73],"garrapatas":[75],"tiene":[77],"impacto":[79],"sobre":[80],"actividad":[82],"ganadera":[83],"nuestro":[85],"pa\u00eds.":[86],"Es":[87],"importante":[88,194],"concentrar":[89],"esfuerzos":[90],"comprender":[92],"mejor":[93],"las":[94,121,203,206,211,460,543,576,612],"preguntas:":[95],"\u00bfQu\u00e9":[96],"tienen":[97],"com\u00fan":[99],"qu\u00e9":[102],"difieren":[103],"estos":[104,464],"organismos":[105,164,397,525,754],"t\u00e9rminos":[107,129],"informaci\u00f3n":[109,276],"genoma":[112],"su":[115,250,314,471],"biolog\u00eda?":[116],"\u00bfPodemos":[117],"identificar":[118],"explicar":[120],"diferencias":[122],"capacidades":[125],"adaptaci\u00f3n":[127,377,431,493],"del":[130,166,178,213,263,281,392,403,488,755],"contenido":[131],"g\u00e9nico":[132],"conservaci\u00f3n":[135,312],"estructura":[138,325],"funci\u00f3n":[140],"determinados":[142],"mecanismos":[143,379,475,495,680],"moleculares?":[144],"Este":[145,216,572],"trabajo":[146],"centra":[148],"aspectos":[150],"inmunol\u00f3gicos,":[151],"funcionales":[152],"evolutivos":[154,603],"tomando":[155],"como":[156,247,252,417,473,499,551,601,633,664,774],"modelo":[157],"A.":[159,225,289,301,345,415],"marginale":[160,226,290,302,346,416],"analizando":[162],"comparativamente":[163],"relacionados":[165],"contexto":[171],"\u03b1-proteobacteria.":[175],"caracterizaci\u00f3n":[177,262,762],"conjunto":[179],"prote\u00ednas":[181,223,268,367,447],"membrana":[183],"externa":[184],"sistemas":[188,340],"secreci\u00f3n":[190,266],"desaf\u00edo":[193],"ser":[196],"principales":[198],"blancos":[199],"interacci\u00f3n":[201],"c\u00e9lulas":[207,212],"hospedadoras":[208],"sistema":[214,264,282,298,393,422],"inmune.":[215],"estudio":[217,773],"permiti\u00f3":[218],"identificaci\u00f3n":[220],"dos":[222,284],"capacidad":[228],"antig\u00e9nica":[229],"fueron":[231],"capaces":[232],"estimular":[234],"respuesta":[236],"inmune":[237],"espec\u00edfica.":[238],"Estudios":[239],"futuros":[240],"permitir\u00e1n":[241],"verificar":[242],"experimentalmente":[243],"localizaci\u00f3n":[245],"superficial,":[246],"tambi\u00e9n":[248,501,565],"corroborar":[249],"potencialidad":[251],"ant\u00edgenos":[253],"protectivos":[254],"nuevas":[256],"formulaciones":[257],"vacunas":[259],"racionales.":[260],"\u201cTwin":[269],"Arginine":[270],"translocaci\u00f3n":[271],"pathway":[272],"(Tat)\u201d":[273],"aporta":[274],"nueva":[275],"acerca":[277,458,723],"funcionalidad":[280,315],"relevancia:":[288],"B.":[292,419],"abortus.":[293],"A":[294,483],"pesar":[295],"Tat":[299,423],"presentan":[303],"organizaci\u00f3n":[305,320,450,717],"gen\u00f3mica":[306,598],"fragmentada,":[307],"pudo":[309,626],"demostrar":[310],"este":[317,479],"organismo.":[318],"Esta":[319],"opone":[322],"cl\u00e1sica":[326],"operon":[328,489],"bajo":[329,659],"\u00fanica":[331],"secuencia":[332],"regulatoria":[333],"caracter\u00edstica":[334],"mayor\u00eda":[337],"proteicos":[341],"multi-componentes.":[342],"Asimismo,":[343],"diferencia":[348],"niveles":[351,365],"abundancia":[353],"ARNm":[355],"cada":[357],"uno":[358],"genes":[361,440,617,658,669],"correlaciona":[362],"descriptos":[368,505],"complejos":[370,443],"funcionales,":[371],"sugiriendo":[372],"existencia":[374,515],"regulaci\u00f3n":[381,497,649],"alternativos":[382],"gen-espec\u00edficos.":[383],"Las":[384],"intracelulares":[386,529],"estrictas":[387],"tendr\u00edan":[388],"uso":[390,407],"limitado":[391],"Tat,":[394],"mientras":[395],"vida":[399],"libre":[400],"suelo":[404],"presentar\u00edan":[405],"moderado":[408],"alto.":[410],"Sin":[411],"embargo,":[412],"tanto":[413,468,548,628],"abortus":[420],"podr\u00eda":[424],"estar":[425],"involucrado":[426],"procesos":[428,465,595,602,695,711,731],"patog\u00e9nesis.":[433],"Los":[434],"procariotas":[435],"coordinan":[436],"transcripci\u00f3n":[438],"involucrados":[441],"metab\u00f3licos":[444],"o":[445],"mediante":[448],"operones.":[452],"En":[453,535],"actualidad,existen":[455],"diferentes":[456,607,613],"hip\u00f3tesis":[457,512],"fuerzas":[461],"rigen":[463],"organizaci\u00f3n,":[467],"determinar":[470],"origen":[472],"mantenimiento":[477],"tipo":[480],"estructura.":[482],"partir":[484],"fragmentaci\u00f3n":[487,521,642],"tat":[490],"gen-espec\u00edficos,":[498],"as\u00ed":[500],"otros":[503,570],"casos":[504],"recientemente":[506],"literatura,":[509],"surgi\u00f3":[510],"proceso":[518,582],"generalizado":[519,583],"operones":[523,556,620],"asociados":[526],"ambientes":[528],"genomas":[531,546,564,652],"reducidos":[532],"tama\u00f1o.":[534],"tal":[536],"sentido,":[537],"fue":[538],"posible":[539],"comprobar":[540],"\u03b1-proteobacterias":[544,577],"peque\u00f1os":[547,566],"n\u00famero":[550],"largo":[553],"era":[557],"menor":[558],"comparaci\u00f3n":[560],"pero":[567],"pertenecientes":[568],"grupos.":[571],"comportamiento":[573],"observado":[574],"ser\u00eda":[578],"compatible":[579],"fragmentaci\u00f3n.":[585],"Estos":[586],"resultados":[587,629],"explicar\u00edan":[589],"teniendo":[590],"cuenta":[592],"reducci\u00f3n":[597],"describieron":[600],"independientes":[604],"linajes.":[608],"Del":[609],"an\u00e1lisis":[610],"propiedades":[614],"presentes":[618],"grupos":[623],"filogen\u00e9ticos":[624],"detectar":[627],"reflejan":[631],"diversidad":[632,703],"patrones":[634],"consistentes":[635],"conservados.":[637],"mayor":[639],"frecuencia":[640],"supone":[643],"incremento":[645],"regiones":[647],"gen-espec\u00edficas":[650],"tama\u00f1o":[654],"reducido,":[655],"y/o":[656],"escasa":[660],"presi\u00f3n":[661],"selecci\u00f3n,":[663],"observa":[666],"menos":[670],"persistentes,":[671],"baja":[673],"expresi\u00f3n":[674],"no-esenciales.":[676],"aparici\u00f3n":[678],"control":[682,686],"gen-espec\u00edfico":[683],"versus":[684],"concertado":[687],"oper\u00f3n":[689],"estar\u00eda":[690],"fuertemente":[691],"influenciado":[692],"mutaci\u00f3n,":[697],"selecci\u00f3n":[698],"deriva.":[700],"Dada":[701],"complejidad":[709],"afectan":[713],"determinan":[715],"cromosomas,":[720],"conocimiento":[722,750],"mismos":[726],"ayudar\u00e1":[727],"conocer":[729],"celulares,":[732],"moleculares":[733],"subyacen":[735],"diversidad.":[738],"Aspiramos":[739],"estudios":[743],"realizados":[744],"tesis":[747],"aporten":[748],"al":[749],"general":[751],"avanzar":[759],"requiere":[769],"m\u00e1s":[770],"atenci\u00f3n":[771],"amplia":[778],"distribuci\u00f3n.":[779]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
