{"id":"https://openalex.org/W378965824","doi":null,"title":"Influence des oestrog\u00e8nes sur les macrophages murins et leurs r\u00e9ponses inflammatoires","display_name":"Influence des oestrog\u00e8nes sur les macrophages murins et leurs r\u00e9ponses inflammatoires","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W378965824","mag":"378965824"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/820953","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/820953","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/820953","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024400535","display_name":"Bertrand Calippe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bertrand Calippe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024400535"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.10170000046491623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.8199999928474426},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9610000252723694},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9570000171661377},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8259999752044678},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8220000267028809},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.7699999809265137},{"id":"https://openalex.org/keywords/thioglycolate","display_name":"thioglycolate","score":0.7429999709129333},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9509999752044678},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.8370000123977661},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.578000009059906},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7654110193252563},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4273528456687927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3359488546848297}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/820953","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/820953","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:378965824","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2009PA077001","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/820953","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/820953","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1930249563","https://openalex.org/W2113583367","https://openalex.org/W2744249036","https://openalex.org/W2736081000","https://openalex.org/W4313386776","https://openalex.org/W1973133098","https://openalex.org/W380490015","https://openalex.org/W2599883686","https://openalex.org/W4224094393","https://openalex.org/W2084036708"],"abstract_inverted_index":{"Il":[0],"est":[1,181],"etabli":[2],"que":[3,104,149,204],"les":[4,7,24,35,46,75,150,162,196,215,229],"\u0153strogenes":[5,27,179],"influencent":[6],"reponses":[8,52,76,230],"immunes":[9],"et":[10,18,48,68],"inflammatoires":[11,77,231],"au":[12,128],"cours":[13],"de":[14,21,37,51,95,108,123,134,137,142,172,202,207,211,226],"divers":[15],"processus":[16],"physiologiques":[17,67],"physiopathologiques.":[19],"Afin":[20],"mieux":[22],"caracteriser":[23],"effets":[25],"des":[26,65,78,88,144,167,178,232],"sur":[28,45,169,228],"le":[29,72,118,189],"systeme":[30],"immuno-inflammatoire,":[31],"nous":[32,102,199],"avons":[33],"etudie":[34],"consequences":[36],"l'exposition":[38],"chronique":[39],"a":[40,82],"l'\u0153stradiol":[41],"(E2)":[42],"in":[43,91,234],"vivo":[44,86,92],"macrophages":[47,79,233],"leurs":[49],"capacites":[50],"inflammatoires.":[53],"Des":[54],"souris":[55],"C57BI/6J":[56],"ovariectomisees":[57],"ont":[58,200],"ete":[59],"traitees":[60],"pendant":[61],"4":[62],"semaines":[63],"avec":[64],"doses":[66],"stables":[69],"d'E2,":[70],"dans":[71,161,184,188,195,214],"but":[73],"d'etudier":[74],"peritoneaux":[80],"suite":[81],"leur":[83],"activation":[84],"ex":[85],"par":[87,93,112,117,132],"LPS":[89],"ou":[90,116,174,192],"l'injection":[94],"thioglycolate.":[96,119],"Dans":[97],"ces":[98],"deux":[99,163],"conditions":[100],"d'activation,":[101],"montrons":[103,147],"I'E2":[105,227],"majore":[106],"l'expression":[107,175,210],"cytokines":[109],"pro-inflammatoires":[110],"induite":[111],"l'activation":[113,143],"du":[114,176],"TLR4":[115],"Cet":[120],"effet":[121,159,224],"pro-inflammatoire":[122,206],"l'hormone":[124],"semble":[125],"etre":[126],"explique,":[127],"moins":[129],"en":[130],"partie,":[131],"l'inhibition":[133],"la":[135],"voie":[136],"signalisation":[138],"PI3K/Akt,":[139],"regulateur":[140],"negatif":[141],"TLR.":[145],"Nous":[146],"egalement":[148],"concentrations":[151],"endogenes":[152],"d'oestrogenes":[153],"sont":[154],"suffisantes":[155],"pour":[156],"produire":[157],"cet":[158],"proinflammatoire":[160],"situations":[164],"experimentales.":[165],"Enfin,":[166],"travaux":[168],"differents":[170],"modeles":[171],"souris,":[173],"recepteur":[177,213],"alpha":[180],"invalide":[182],"soit":[183,187],"l'organisme":[185],"entier,":[186],"compartiment":[190],"hematopoietique":[191],"encore":[193],"exclusivement":[194],"cellules":[197],"myeloides,":[198],"permis":[201],"montrer":[203],"l'effet":[205],"PE2":[208],"necessite":[209],"ce":[212],"macrophages.":[216],"Ces":[217],"donnees":[218],"constituent":[219],"une":[220],"premiere":[221],"preuve":[222],"d'un":[223],"direct":[225],"vivo.":[235]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
