{"id":"https://openalex.org/W37868648","doi":null,"title":"[The pathogenesis of the systemic inflammatory response syndrome and compensatory antiinflammatory response syndrome following surgical stress].","display_name":"[The pathogenesis of the systemic inflammatory response syndrome and compensatory antiinflammatory response syndrome following surgical stress].","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W37868648","mag":"37868648","pmid":"https://pubmed.ncbi.nlm.nih.gov/12884773"},"language":"ja","primary_location":{"id":"pmid:12884773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12884773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Geka Gakkai zasshi","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101622447","display_name":"Satoshi Ono","orcid":"https://orcid.org/0000-0001-9137-4267","observed_orcids":["https://orcid.org/0000-0001-9137-4267"]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Ono","raw_affiliation_strings":["Department of Surgery I, National Defense Medical College, Tokorozawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery I, National Defense Medical College, Tokorozawa, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026777563","display_name":"Takashi Ichikura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Ichikura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113576958","display_name":"Hidetaka Mochizuki","orcid":"https://orcid.org/0009-0006-0271-0171","observed_orcids":["https://orcid.org/0009-0006-0271-0171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hidetaka Mochizuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1038,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.41956892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"104","issue":"7","first_page":"499","last_page":"505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.18930000066757202,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-inflammatory-response-syndrome","display_name":"systemic inflammatory response syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/compensatory-anti-inflammatory-response-syndrome","display_name":"compensatory anti-inflammatory response syndrome","score":0.9229999780654907},{"id":"https://openalex.org/keywords/surgical-stress","display_name":"surgical stress","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8989999890327454},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8479999899864197},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9679999947547913},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.5839999914169312},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9440000057220459},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cytokine-balance","display_name":"cytokine balance","score":0.7770000100135803},{"id":"https://openalex.org/keywords/anergy","display_name":"anergy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/infection-susceptibility","display_name":"infection susceptibility","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cell-surface-molecules","display_name":"cell surface molecules","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8562779426574707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7978464365005493},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7327635288238525},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6659256219863892},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6116053462028503},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5957371592521667},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.5943027138710022},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.5455935597419739},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.5021817684173584},{"id":"https://openalex.org/C2776098842","wikidata":"https://www.wikidata.org/wiki/Q17152720","display_name":"Surgical stress","level":2,"score":0.49911952018737793},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4730353057384491},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4478491544723511},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.4101412892341614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16185703873634338},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12069126963615417},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.09649008512496948}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004381","descriptor_name":"Duodenal Ulcer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007416","descriptor_name":"Intestinal Perforation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013505","descriptor_name":"Digestive System Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018746","descriptor_name":"Systemic Inflammatory Response Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D018746","descriptor_name":"Systemic Inflammatory Response Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12884773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12884773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Geka Gakkai zasshi","raw_type":"English Abstract"},{"id":"mag:37868648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12884773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W4210516164"],"related_works":["https://openalex.org/W3048598634","https://openalex.org/W4251502811","https://openalex.org/W2163102905","https://openalex.org/W2465357145","https://openalex.org/W2354680480","https://openalex.org/W2037418955","https://openalex.org/W4313374878","https://openalex.org/W2336677729","https://openalex.org/W2027226645","https://openalex.org/W2386976175"],"abstract_inverted_index":{"The":[0,108],"inflammation":[1,44,160,237],"charge":[2,45,161,238],"cells":[3,162],"such":[4,28],"as":[5,29,206],"the":[6,24,42,50,58,65,68,87,95,98,124,147,159,166,179,185,195,218,236],"macrophages,":[7],"neutrophils,":[8],"endothelial":[9],"cells,":[10],"and":[11,37,54,63,77,118,152,189,193,222,231],"fibroblasts":[12],"are":[13,39,80,114],"activated":[14,43],"in":[15,72,110,116,158,235],"surgical":[16,225],"sites":[17],"when":[18],"tissue":[19],"injury":[20],"occurs":[21],"due":[22],"to":[23,67,211],"operation.":[25],"Proinflammatory":[26],"cytokines":[27,48,102,113],"tumor":[30],"necrosis":[31],"factor":[32],"alpha,":[33],"interleukin":[34],"(IL)-1,":[35],"IL-6,":[36],"IL-8":[38],"induced":[40,106],"from":[41],"cells.":[46,239],"These":[47],"amplify":[49],"information":[51,66],"by":[52,184,227],"autocrine":[53],"paracrine":[55],"action,":[56],"induce":[57],"production":[59,99,151,230],"of":[60,100,149,155,168,220],"other":[61,96],"cytokines,":[62],"send":[64],"whole":[69],"body.":[70],"Increases":[71],"body":[73],"temperature,":[74],"pulse":[75],"rate,":[76],"leukocyte":[78],"counts":[79],"then":[81],"observed.":[82],"This":[83],"condition":[84,109],"is":[85,105,122,141,182,199],"called":[86,123],"systemic":[88],"inflammatory":[89],"response":[90,127],"syndrome":[91,128],"(SIRS)":[92],"clinically.":[93],"On":[94],"hand,":[97],"antiinflammatory":[101,112,126,190,197],"against":[103],"SIRS":[104,221],"simultaneously.":[107],"which":[111],"produced":[115],"excess":[117],"become":[119],"dominant":[120],"systemically":[121],"compensatory":[125,196],"(CARS).":[129],"No":[130],"standard":[131],"concrete":[132],"diagnosis":[133],"for":[134],"CARS":[135,140,223],"has":[136],"been":[137],"established,":[138],"although":[139],"a":[142,173],"pathogenetic":[143],"concept.":[144],"However,":[145],"recently":[146],"analysis":[148],"cytokine":[150,191,229],"various":[153],"types":[154],"surface":[156,232],"molecules":[157,234],"became":[163],"possible":[164],"with":[165,208],"development":[167],"molecular":[169],"biological":[170],"methods.":[171],"As":[172],"result,":[174],"it":[175,202],"was":[176],"found":[177],"that":[178],"immune":[180],"system":[181],"controlled":[183],"balance":[186],"between":[187],"proinflammatory":[188],"production,":[192],"if":[194],"reaction":[198],"sufficiently":[200],"severe,":[201],"will":[203],"manifest":[204],"clinically":[205],"anergy,":[207],"increased":[209],"susceptibility":[210],"infection.":[212],"In":[213],"this":[214],"manuscript,":[215],"we":[216],"explain":[217],"pathogenesis":[219],"following":[224],"stress":[226],"analyzing":[228],"membrane":[233]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}