{"id":"https://openalex.org/W378264637","doi":null,"title":"Fc\u03b3-receptors in systemic autoimmune conditions : lessons from murine mercury-induced autoimmunity","display_name":"Fc\u03b3-receptors in systemic autoimmune conditions : lessons from murine mercury-induced autoimmunity","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W378264637","mag":"378264637"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:liu-19161","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19161","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19161","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042887581","display_name":"K. Martinsson","orcid":"https://orcid.org/0000-0003-4492-9172","observed_orcids":["https://orcid.org/0000-0003-4492-9172"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"K. Martinsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4492-9172","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042887581"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0763000026345253,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fc-gamma-receptor","display_name":"Fc gamma receptor","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mercury-induced-autoimmunity","display_name":"mercury-induced autoimmunity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/systemic-autoimmunity","display_name":"systemic autoimmunity","score":0.8809999823570251},{"id":"https://openalex.org/keywords/fcgammari","display_name":"Fc\u03b3RI","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fcgammariii","display_name":"Fc\u03b3RIII","score":0.9700000286102295},{"id":"https://openalex.org/keywords/fcgammariib","display_name":"Fc\u03b3RIIB","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fcrgamma-chain","display_name":"FcR\u03b3 chain","score":0.8830000162124634},{"id":"https://openalex.org/keywords/immune-complex-deposits","display_name":"immune complex deposits","score":0.7229999899864197},{"id":"https://openalex.org/keywords/antinucleolar-antibodies","display_name":"antinucleolar antibodies","score":0.925000011920929},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/h-2-complex","display_name":"H-2 complex","score":0.5400000214576721},{"id":"https://openalex.org/keywords/dba-1-mice","display_name":"DBA/1 mice","score":0.8259999752044678},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5720000267028809},{"id":"https://openalex.org/keywords/igg-subclasses","display_name":"IgG subclasses","score":0.4519999921321869},{"id":"https://openalex.org/keywords/t-cell-dependent-autoimmunity","display_name":"T cell-dependent autoimmunity","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.7696751952171326},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6770948171615601},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5650662183761597},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.5165625810623169},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5123785734176636},{"id":"https://openalex.org/C2779937669","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Mesangium","level":4,"score":0.4567878842353821},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4495283365249634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43851959705352783},{"id":"https://openalex.org/C2778474638","wikidata":"https://www.wikidata.org/wiki/Q575241","display_name":"Immune complex","level":3,"score":0.4351414442062378},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4328749179840088},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42248764634132385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3540661334991455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30865365266799927},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.25288987159729004},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2293303906917572},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.18124324083328247},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.13827836513519287}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:liu-19161","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19161","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:378264637","doi":null,"is_oa":false,"landing_page_url":"http://su.diva-portal.org/smash/get/diva2:223466/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:liu-19161","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19161","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":203,"referenced_works":["https://openalex.org/W21392567","https://openalex.org/W125322072","https://openalex.org/W178395831","https://openalex.org/W186317847","https://openalex.org/W1481966022","https://openalex.org/W1483123148","https://openalex.org/W1485993792","https://openalex.org/W1487018400","https://openalex.org/W1498464657","https://openalex.org/W1515279716","https://openalex.org/W1527011538","https://openalex.org/W1530035084","https://openalex.org/W1530235393","https://openalex.org/W1543381911","https://openalex.org/W1553780195","https://openalex.org/W1559928694","https://openalex.org/W1568498698","https://openalex.org/W1568601713","https://openalex.org/W1583599993","https://openalex.org/W1594649446","https://openalex.org/W1597232807","https://openalex.org/W1607576663","https://openalex.org/W1625123891","https://openalex.org/W1752699386","https://openalex.org/W1784417198","https://openalex.org/W1840251084","https://openalex.org/W1873045112","https://openalex.org/W1925369730","https://openalex.org/W1954637504","https://openalex.org/W1956221832","https://openalex.org/W1964265945","https://openalex.org/W1965476731","https://openalex.org/W1965719800","https://openalex.org/W1966160633","https://openalex.org/W1967581879","https://openalex.org/W1969134054","https://openalex.org/W1971349333","https://openalex.org/W1971572035","https://openalex.org/W1971951944","https://openalex.org/W1972108403","https://openalex.org/W1972515412","https://openalex.org/W1972624827","https://openalex.org/W1972913678","https://openalex.org/W1972999255","https://openalex.org/W1974206276","https://openalex.org/W1977631644","https://openalex.org/W1982658484","https://openalex.org/W1983351186","https://openalex.org/W1983940041","https://openalex.org/W1984689710","https://openalex.org/W1985577573","https://openalex.org/W1985705893","https://openalex.org/W1986431636","https://openalex.org/W1986977228","https://openalex.org/W1988233881","https://openalex.org/W1991756636","https://openalex.org/W1991929097","https://openalex.org/W1992237197","https://openalex.org/W1992737239","https://openalex.org/W1993652636","https://openalex.org/W1993883488","https://openalex.org/W1994836831","https://openalex.org/W1994978485","https://openalex.org/W1995795979","https://openalex.org/W1997320236","https://openalex.org/W1997445453","https://openalex.org/W1997531619","https://openalex.org/W1999034715","https://openalex.org/W1999157320","https://openalex.org/W2000748318","https://openalex.org/W2001039642","https://openalex.org/W2001170115","https://openalex.org/W2001825901","https://openalex.org/W2002411614","https://openalex.org/W2002496843","https://openalex.org/W2004913283","https://openalex.org/W2005284010","https://openalex.org/W2008981940","https://openalex.org/W2009145782","https://openalex.org/W2011037065","https://openalex.org/W2011291004","https://openalex.org/W2012349928","https://openalex.org/W2013367705","https://openalex.org/W2015012549","https://openalex.org/W2016708646","https://openalex.org/W2017357099","https://openalex.org/W2018276337","https://openalex.org/W2019846395","https://openalex.org/W2020857813","https://openalex.org/W2020957993","https://openalex.org/W2021970733","https://openalex.org/W2021978625","https://openalex.org/W2022446700","https://openalex.org/W2022643575","https://openalex.org/W2024503231","https://openalex.org/W2025208802","https://openalex.org/W2025663857","https://openalex.org/W2025705733","https://openalex.org/W2029257175","https://openalex.org/W2029498999","https://openalex.org/W2029993165","https://openalex.org/W2031167276","https://openalex.org/W2031321129","https://openalex.org/W2031882870","https://openalex.org/W2034408745","https://openalex.org/W2035433348","https://openalex.org/W2035770126","https://openalex.org/W2036277270","https://openalex.org/W2036608242","https://openalex.org/W2040146565","https://openalex.org/W2040572620","https://openalex.org/W2040777459","https://openalex.org/W2042797177","https://openalex.org/W2043503318","https://openalex.org/W2043528848","https://openalex.org/W2043791847","https://openalex.org/W2045006513","https://openalex.org/W2045066579","https://openalex.org/W2045220525","https://openalex.org/W2045751236","https://openalex.org/W2045960416","https://openalex.org/W2049265450","https://openalex.org/W2050149433","https://openalex.org/W2051827314","https://openalex.org/W2052100669","https://openalex.org/W2053246714","https://openalex.org/W2054504815","https://openalex.org/W2054688118","https://openalex.org/W2058071683","https://openalex.org/W2060364735","https://openalex.org/W2061268459","https://openalex.org/W2061489820","https://openalex.org/W2065988618","https://openalex.org/W2067465778","https://openalex.org/W2071026340","https://openalex.org/W2072154835","https://openalex.org/W2072577743","https://openalex.org/W2072737993","https://openalex.org/W2075714453","https://openalex.org/W2075901113","https://openalex.org/W2075938003","https://openalex.org/W2076016542","https://openalex.org/W2078902502","https://openalex.org/W2081382604","https://openalex.org/W2081689799","https://openalex.org/W2082354842","https://openalex.org/W2082615180","https://openalex.org/W2083861962","https://openalex.org/W2085406842","https://openalex.org/W2086334177","https://openalex.org/W2086542713","https://openalex.org/W2088203227","https://openalex.org/W2090045809","https://openalex.org/W2090580748","https://openalex.org/W2094521397","https://openalex.org/W2094820202","https://openalex.org/W2095565628","https://openalex.org/W2099704507","https://openalex.org/W2102243951","https://openalex.org/W2104496492","https://openalex.org/W2104741056","https://openalex.org/W2105237436","https://openalex.org/W2105905472","https://openalex.org/W2106364495","https://openalex.org/W2107085495","https://openalex.org/W2107277218","https://openalex.org/W2107558681","https://openalex.org/W2109502548","https://openalex.org/W2110154793","https://openalex.org/W2110990893","https://openalex.org/W2111920377","https://openalex.org/W2111940985","https://openalex.org/W2119554942","https://openalex.org/W2120855272","https://openalex.org/W2126678530","https://openalex.org/W2130867278","https://openalex.org/W2131846297","https://openalex.org/W2131875863","https://openalex.org/W2136574336","https://openalex.org/W2138896366","https://openalex.org/W2140407684","https://openalex.org/W2140530350","https://openalex.org/W2147181840","https://openalex.org/W2148274875","https://openalex.org/W2149103649","https://openalex.org/W2152621712","https://openalex.org/W2160781113","https://openalex.org/W2165294837","https://openalex.org/W2169012266","https://openalex.org/W2169442471","https://openalex.org/W2169948324","https://openalex.org/W2169965373","https://openalex.org/W2182567877","https://openalex.org/W2183356344","https://openalex.org/W2327593719","https://openalex.org/W2397299408","https://openalex.org/W2399209427","https://openalex.org/W2406965583","https://openalex.org/W2414217939","https://openalex.org/W2417724971","https://openalex.org/W2992495561","https://openalex.org/W4313341280","https://openalex.org/W4322387791"],"related_works":["https://openalex.org/W217263062","https://openalex.org/W622040019","https://openalex.org/W1965476731","https://openalex.org/W2081923592","https://openalex.org/W2133281539","https://openalex.org/W7098708121","https://openalex.org/W1784417198","https://openalex.org/W7096296656","https://openalex.org/W4313341280","https://openalex.org/W1582141173"],"abstract_inverted_index":{"In":[0,373,533],"this":[1],"thesis":[2],"we":[3],"investigated":[4],"the":[5,47,59,103,165,181,184,194,208,212,241,246,252,293,301,306,317,321,329,375,412,426,440,448,457,475,481,522,540],"role":[6],"of":[7,31,61,105,121,152,161,190,211,268,342,422,442,453,460,468,472,480,490,506,525,536],"activating":[8,50,111,213],"(Fc\u03b3RI,":[9,113],"Fc\u03b3RIII)":[10],"and":[11,24,42,51,55,92,115,124,129,137,154,173,217,221,228,232,295,336,346,378,385,450,456,477,493,543],"inhibitory":[12,52,185],"(Fc\u03b3RIIB)":[13],"Fc\u03b3-receptors":[14],"on":[15,102,513],"systemic":[16,88],"autoimmunity":[17,32,73],"using":[18],"two":[19],"mouse":[20],"strains,":[21],"DBA/1":[22,204,297,337,356],"(H-2q)":[23],"BALB/c":[25,108,290,335],"mice":[26,79,109,141,148,182,205,263,291,298,338,358,402,414,463,529],"(H-2d),":[27],"susceptible":[28,78],"to":[29,140,178,237,273,282,309,349,369,419,486,518],"induction":[30],"by":[33,85,157,447,502,521],"mercury":[34],"(Hg).":[35],"Fc-receptors":[36],"for":[37,207,320,439,474,531],"IgG":[38],"(Fc\u03b3R)":[39],"link":[40],"cellular":[41],"humoral":[43],"immune":[44,53],"responses,":[45],"control":[46],"balance":[48],"between":[49],"responses":[54],"are":[56,100,437],"important":[57,319,438],"in":[58,75,81,98,164,171,193,257,288,296,322,355,382,399,411,462,509,528],"development":[60,271],"several":[62],"autoimmune":[63,70],"diseases.":[64],"Mercury":[65],"induces":[66],"a":[67,158,226,265,363,487],"T":[68],"cell-dependent":[69],"condition,":[71],"Hg-induced":[72],"(HgIA)":[74],"genetically":[76],"(H-2s,q,f,t2)":[77],"characterized":[80],"its":[82],"fullblown":[83],"type":[84],"lymphoproliferation,":[86],"hypergammaglobulinemia,":[87],"immune-complex":[89],"(IC)":[90],"deposits":[91,133,163,192,201,444,455],"antinucleolar":[93],"antibodies":[94],"(ANoA).":[95],"All":[96],"manifestations":[97],"HgIA":[99,323,510],"dependent":[101,512],"presence":[104],"IFN-\u03b3.":[106],"Hg-treated":[107,261,332],"lacking":[110,183,292,299,464],"Fc\u03b3Rs":[112],"Fc\u03b3III":[114,216],"Fc\u03b5RI)":[116,218],"showed":[117,187,225,264,339],"significantly":[118,397],"higher":[119],"levels":[120,151,459],"both":[122,289,343,383,539],"IgG1-":[123,153],"IgG2a-CIC":[125,155],"whereas":[126,197],"renal":[127,166,172,195],"mesangial":[128],"vessel":[130,175,198],"wall":[131,199],"IC":[132,162,191,200,443,454],"were":[134,202],"severely":[135],"delayed":[136,227,449],"reduced/abolished,":[138],"compared":[139,236,272,308,348,368,403],"without":[142],"mutations":[143],"(wild":[144],"type,":[145],"wt).":[146],"Wt":[147],"developed":[149],"modest":[150],"followed":[156],"distinct":[159],"formation":[160,441,452],"glomerular":[167],"mesangium,":[168,196],"as":[169,445],"well":[170],"splenic":[174],"walls.":[176],"Compared":[177],"wt":[179,238,274,310,350,357,384,405,413],"mice,":[180],"Fc\u03b3RIIB":[186,262,333,537],"similar":[188],"titres":[189],"reduced.":[203],"deficient":[206,334,371,387,401,530],"FcR\u03b3-chain":[209],"(lack":[210],"receptors":[214],"Fc\u03b3RI,":[215],"or":[219,244,304],"Fc\u03b3RIII":[220,258,307,315,370,386,400,436,469,514],"treated":[222,359],"with":[223,284,360,404],"Hg":[224,242,285,361,391],"attenuated":[229,253,287],"IgG1,":[230],"IgG2a":[231],"IgG2b":[233,269],"ANoA":[234,254,270,482,497],"response":[235,255,280,483,498],"mice.":[239,259,275,311,351,372,388,406],"Increasing":[240],"dose":[243],"prolonging":[245],"treatment":[247,283,392],"time":[248],"could":[249,415],"not":[250,416],"override":[251],"seen":[256],"Female":[260],"significant":[266],"increase":[267,341,421,505],"The":[276,352,407,466,496,504],"total":[277,376],"serum":[278,325,344,507,541],"IgG1":[279,326,345,508,542],"due":[281,485],"was":[286,396],"Fc\u03b3-chain,":[294],"either":[300],"Fc\u03b3-":[302],"chain":[303],"specifically":[305],"This":[312],"indicates":[313],"that":[314,435],"is":[316,470,499,511,516],"receptor":[318],"characteristic":[324],"response.":[327,545],"On":[328],"other":[330],"hand,":[331],"an":[340,420],"IgE":[347,544],"cytokine":[353],"profile":[354,367,380,410],"revealed":[362],"more":[364],"marked":[365],"Th1":[366,409,491],"contrast,":[374,534],"Th2":[377],"Th17":[379],"increased":[381,408],"However,":[389],"during":[390],"IL-21":[393],"mRNA":[394],"expression":[395,467,489,524],"reduced":[398,451,488],"be":[417,519],"attributed":[418],"IFN-\u03b3":[423,428],"secretion":[424],"from":[425],"major":[427],"cell":[429],"source,":[430],"NK":[431],"cells.":[432],"We":[433],"conclude":[434],"shown":[446],"high":[458],"CIC":[461],"Fc\u03b3RIII.":[465,532],"also":[471],"importance":[473],"rapidity":[476],"final":[478],"strength":[479],"probably":[484],"cytokines":[492],"inflammatory":[494],"factors.":[495],"modestly":[500],"counter-regulated":[501],"Fc\u03b3RIIB.":[503],"which":[515],"likely":[517],"mediated":[520],"low":[523],"IL-":[526],"21":[527],"lack":[535],"increases":[538]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}