{"id":"https://openalex.org/W37825277","doi":"https://doi.org/10.1007/978-94-011-2044-9_31","title":"Optimisation of \u03b1-Interferon Expression of Namalwa Cells","display_name":"Optimisation of \u03b1-Interferon Expression of Namalwa Cells","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W37825277","doi":"https://doi.org/10.1007/978-94-011-2044-9_31","mag":"37825277"},"language":"en","primary_location":{"id":"doi:10.1007/978-94-011-2044-9_31","doi":"https://doi.org/10.1007/978-94-011-2044-9_31","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-94-011-2044-9_31","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Cell Technology: Basic & Applied Aspects","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2487989151","display_name":"Animal Cell Technology: Basic & Applied Aspects"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053686700","display_name":"S.C. Musgrave","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. C. Musgrave","raw_affiliation_strings":["Biotechnology Development Laboratories, The Wellcome Foundation, Beckenham, UK","The Wellcome Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Development Laboratories, The Wellcome Foundation, Beckenham, UK","institution_ids":["https://openalex.org/I87048295"]},{"raw_affiliation_string":"The Wellcome Foundation","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Douglas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Y. Douglas","raw_affiliation_strings":["Biotechnology Development Laboratories, The Wellcome Foundation, Beckenham, UK","The Wellcome Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Development Laboratories, The Wellcome Foundation, Beckenham, UK","institution_ids":["https://openalex.org/I87048295"]},{"raw_affiliation_string":"The Wellcome Foundation","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076228426","display_name":"Guy T. Layton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. Layton","raw_affiliation_strings":["Management Services Division, The Wellcome Foundation, Beckenham, UK","The Wellcome Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Management Services Division, The Wellcome Foundation, Beckenham, UK","institution_ids":["https://openalex.org/I87048295"]},{"raw_affiliation_string":"The Wellcome Foundation","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000836064","display_name":"Jessica B. MERRETT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Merrett","raw_affiliation_strings":["Management Services Division, The Wellcome Foundation, Beckenham, UK","The Wellcome Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Management Services Division, The Wellcome Foundation, Beckenham, UK","institution_ids":["https://openalex.org/I87048295"]},{"raw_affiliation_string":"The Wellcome Foundation","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111660176","display_name":"Michelle F. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. F. Scott","raw_affiliation_strings":["Biotechnology Development Laboratories, The Wellcome Foundation, Beckenham, UK","The Wellcome Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Development Laboratories, The Wellcome Foundation, Beckenham, UK","institution_ids":["https://openalex.org/I87048295"]},{"raw_affiliation_string":"The Wellcome Foundation","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011937333","display_name":"C. A. Caulcott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. A. Caulcott","raw_affiliation_strings":["Biotechnology Development Laboratories, The Wellcome Foundation, Beckenham, UK","The Wellcome Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Development Laboratories, The Wellcome Foundation, Beckenham, UK","institution_ids":["https://openalex.org/I87048295"]},{"raw_affiliation_string":"The Wellcome Foundation","institution_ids":["https://openalex.org/I87048295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I87048295"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"223","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.35030001401901245,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9240000247955322},{"id":"https://openalex.org/keywords/namalwa-cells","display_name":"Namalwa cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/interferon-production","display_name":"interferon production","score":0.6570000052452087},{"id":"https://openalex.org/keywords/sodium-butyrate","display_name":"sodium butyrate","score":0.9359999895095825},{"id":"https://openalex.org/keywords/culture-supernatant","display_name":"culture supernatant","score":0.6480000019073486},{"id":"https://openalex.org/keywords/process-optimization","display_name":"process optimization","score":0.6299999952316284},{"id":"https://openalex.org/keywords/scale-up","display_name":"scale-up","score":0.6710000038146973},{"id":"https://openalex.org/keywords/biopharmaceutical-manufacturing","display_name":"biopharmaceutical manufacturing","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2780127873","wikidata":"https://www.wikidata.org/wiki/Q1055751","display_name":"Sendai virus","level":3,"score":0.9313657283782959},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.7953541874885559},{"id":"https://openalex.org/C139149728","wikidata":"https://www.wikidata.org/wiki/Q335201","display_name":"Laboratory flask","level":2,"score":0.5259095430374146},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.49228110909461975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49020320177078247},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4354701042175293},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.401405930519104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3737921118736267},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-94-011-2044-9_31","doi":"https://doi.org/10.1007/978-94-011-2044-9_31","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-94-011-2044-9_31","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Cell Technology: Basic & Applied Aspects","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W274279394","https://openalex.org/W1539246675","https://openalex.org/W2161574373"],"related_works":["https://openalex.org/W318146330","https://openalex.org/W2169285765","https://openalex.org/W2431263479","https://openalex.org/W2262751450","https://openalex.org/W111272237","https://openalex.org/W2144847982","https://openalex.org/W1755993996","https://openalex.org/W2249962279","https://openalex.org/W2436925366","https://openalex.org/W2088913921"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}