{"id":"https://openalex.org/W37735786","doi":"https://doi.org/10.1007/978-1-4612-0303-2_14","title":"Myogenic (Stretch-Induced) and Flow-Regulated Tone of Human Pial Arteries","display_name":"Myogenic (Stretch-Induced) and Flow-Regulated Tone of Human Pial Arteries","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W37735786","doi":"https://doi.org/10.1007/978-1-4612-0303-2_14","mag":"37735786"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4612-0303-2_14","doi":"https://doi.org/10.1007/978-1-4612-0303-2_14","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-0303-2_14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Human Brain Circulation","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2490969886","display_name":"The Human Brain Circulation"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110155440","display_name":"John A. Bevan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Bevan","raw_affiliation_strings":["Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016918961","display_name":"Rosemary D. Bevan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosemary D. Bevan","raw_affiliation_strings":["Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059967769","display_name":"Alynn Klaasen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alynn Klaasen","raw_affiliation_strings":["Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056663869","display_name":"Paul L. Penar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Penar","raw_affiliation_strings":["Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054284129","display_name":"Tina Poseno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina Poseno","raw_affiliation_strings":["Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110001069","display_name":"Carrie L. Walters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie L. Walters","raw_affiliation_strings":["Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111236770"],"apc_list":null,"apc_paid":null,"fwci":0.7743,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58695652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"179","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myogenic-tone","display_name":"myogenic tone","score":0.8510000109672546},{"id":"https://openalex.org/keywords/stretch-induced-contraction","display_name":"stretch-induced contraction","score":0.7009999752044678},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.5569999814033508},{"id":"https://openalex.org/keywords/pial-arteries","display_name":"pial arteries","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cerebral-autoregulation","display_name":"cerebral autoregulation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.8859999775886536},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.652999997138977},{"id":"https://openalex.org/keywords/intraluminal-pressure","display_name":"intraluminal pressure","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C2777032099","wikidata":"https://www.wikidata.org/wiki/Q1225425","display_name":"Dilator","level":2,"score":0.9037085771560669},{"id":"https://openalex.org/C171614378","wikidata":"https://www.wikidata.org/wiki/Q5064093","display_name":"Cerebral arteries","level":2,"score":0.716139554977417},{"id":"https://openalex.org/C119671327","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral circulation","level":2,"score":0.6248199343681335},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6004560589790344},{"id":"https://openalex.org/C58336856","wikidata":"https://www.wikidata.org/wiki/Q6947924","display_name":"Myogenic contraction","level":3,"score":0.481388121843338},{"id":"https://openalex.org/C2779265215","wikidata":"https://www.wikidata.org/wiki/Q1647118","display_name":"Pia mater","level":2,"score":0.4280407726764679},{"id":"https://openalex.org/C84359808","wikidata":"https://www.wikidata.org/wiki/Q13365173","display_name":"Cerebral autoregulation","level":4,"score":0.41066259145736694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3949124217033386},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.37018004059791565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34249937534332275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3364456295967102},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.28086480498313904},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.17375445365905762},{"id":"https://openalex.org/C111774379","wikidata":"https://www.wikidata.org/wiki/Q1364253","display_name":"Autoregulation","level":3,"score":0.16418668627738953}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4612-0303-2_14","doi":"https://doi.org/10.1007/978-1-4612-0303-2_14","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-0303-2_14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Human Brain Circulation","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1567244432","https://openalex.org/W1569974693","https://openalex.org/W1970917803","https://openalex.org/W1987245561","https://openalex.org/W2000961219","https://openalex.org/W2003071296","https://openalex.org/W2034525310","https://openalex.org/W2117712849","https://openalex.org/W2120661964","https://openalex.org/W2131436118","https://openalex.org/W2140966377","https://openalex.org/W2148972087","https://openalex.org/W2149428386","https://openalex.org/W2159301145","https://openalex.org/W2339804370","https://openalex.org/W2465383018","https://openalex.org/W2479176018","https://openalex.org/W2886557052"],"related_works":["https://openalex.org/W2169810565","https://openalex.org/W2288025658","https://openalex.org/W2272411931","https://openalex.org/W2119595385","https://openalex.org/W1639701648","https://openalex.org/W2032033330","https://openalex.org/W2072647102","https://openalex.org/W2046807513","https://openalex.org/W2059020577","https://openalex.org/W75000204"],"abstract_inverted_index":{"The":[0],"normally":[1],"functioning":[2],"cerebral":[3,30],"circulation":[4],"effectively":[5],"autoregulates,":[6],"the":[7,54,70,87,107,117,160,177,184,190],"vascular":[8],"adjustments":[9],"responsible":[10],"for":[11,114,165],"this":[12,79],"prob\u00adably":[13],"occurring":[14],"in":[15,27,40,53,92,134,157],"pial":[16,97],"arteries":[17,98,120,136],"of":[18,29,33,65,95,137],"all":[19],"sizes.":[20],"It":[21],"has":[22,129],"been":[23],"shown":[24],"that":[25,149],"changes":[26,91,156],"diameter":[28],"blood":[31],"vessels":[32],"several":[34],"animal":[35],"species":[36],"can":[37],"take":[38],"place":[39],"response":[41],"to":[42,58,106,131],"perivascular":[43],"neural":[44],"(constric\u00adtor":[45],"or":[46],"dilator)":[47],"activity,":[48],"and":[49,61,89,153,174,183],"through":[50],"local":[51,162],"mechanisms":[52],"vessel":[55],"wall":[56],"responsive":[57],"intraluminal":[59],"pressure":[60,88],"flow.":[62],"A":[63],"variety":[64],"fac\u00adtors,":[66],"mainly":[67],"metabolic,":[68],"influence":[69,128],"intracerebral":[71],"vasculature":[72],"(for":[73],"references":[74],"see":[75],"ref.":[76],"1).":[77],"In":[78],"chapter,":[80],"we":[81],"will":[82],"describe":[83],"experimental":[84,182],"observations":[85],"on":[86],"flow-initiated":[90],"vascu\u00adlar":[93],"tone":[94,158],"human":[96,135,166],"obtained":[99],"during":[100],"surgery.":[101],"These":[102,168],"ves\u00adsels":[103],"were":[104,170],"transported":[105],"Totman":[108],"Laboratory":[109],"from":[110],"various":[111],"Neurosurgical":[112],"Centers":[113],"experimentation.":[115],"Only":[116],"larger":[118],"cere\u00adbral":[119],"are":[121,159],"influenced":[122],"by":[123,172,176],"sympathetic":[124],"nerves.":[125],"Dilator":[126],"nerves":[127],"yet":[130],"be":[132,187],"observed":[133],"any":[138],"size":[139],"(see":[140],"Chapter":[141],"6).":[142],"2":[143],"Thus,":[144],"it":[145],"would":[146],"seem":[147],"likely":[148],"stretch-induced":[150],"myo\u00adgenic":[151],"contraction":[152],"shear":[154],"stress-initiated":[155],"dominant":[161],"regulating":[163],"processes":[164],"arteries.":[167],"keywords":[169,185],"added":[171],"machine":[173],"not":[175],"authors.":[178],"This":[179],"process":[180],"is":[181],"may":[186],"updated":[188],"as":[189],"learning":[191],"algorithm":[192],"improves.":[193]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}
