{"id":"https://openalex.org/W37711131","doi":"https://doi.org/10.1055/s-0031-1300117","title":"Wirksamkeit eines standardisierten Extraktes aus frischen Crataegus-Beeren auf Belastungstoleranz und Lebensqualit\u00e4t bei Patienten mit Herzinsuffizienz (NYHA II)","display_name":"Wirksamkeit eines standardisierten Extraktes aus frischen Crataegus-Beeren auf Belastungstoleranz und Lebensqualit\u00e4t bei Patienten mit Herzinsuffizienz (NYHA II)","publication_year":2011,"publication_date":"2011-12-26","ids":{"openalex":"https://openalex.org/W37711131","doi":"https://doi.org/10.1055/s-0031-1300117","mag":"37711131","pmid":"https://pubmed.ncbi.nlm.nih.gov/11715631"},"language":"de","primary_location":{"id":"doi:10.1055/s-0031-1300117","doi":"https://doi.org/10.1055/s-0031-1300117","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0031-1300117","pdf_url":null,"source":{"id":"https://openalex.org/S132758211","display_name":"Arzneimittelforschung","issn_l":"0004-4172","issn":["0004-4172","1616-7066"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittelforschung","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112271917","display_name":"Norbert H. Rietbrock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Norbert Rietbrock","raw_affiliation_strings":["Institut f\u00fcr Klinische Pharmakologie der Johann Wolfgang Goethe-Universit\u00e4t Frankfurt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Klinische Pharmakologie der Johann Wolfgang Goethe-Universit\u00e4t Frankfurt","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017403906","display_name":"Markus Hamel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Hamel","raw_affiliation_strings":["CPR Clinical Pharmacological Research and Therapy GmbH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CPR Clinical Pharmacological Research and Therapy GmbH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057759217","display_name":"Bernd Hempel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127105","display_name":"Robugen (Germany)","ror":"https://ror.org/029gjrw67","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210127105"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Hempel","raw_affiliation_strings":["Robugen GmbH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robugen GmbH","institution_ids":["https://openalex.org/I4210127105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011960561","display_name":"Veselin L. Mitrovi\u0107","orcid":"https://orcid.org/0000-0001-5783-2164","observed_orcids":["https://orcid.org/0000-0001-5783-2164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veselin Mitrovic","raw_affiliation_strings":["CPR Clinical Pharmacological Research and Therapy GmbH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CPR Clinical Pharmacological Research and Therapy GmbH","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tanja Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125765","display_name":"Institut f\u00fcr Klinische Forschung und Entwicklung","ror":"https://ror.org/02z95d405","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210125765"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tanja Schmidt","raw_affiliation_strings":["Klinisches Forschungsinstitut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinisches Forschungsinstitut","institution_ids":["https://openalex.org/I4210125765"]}]},{"author_position":"last","author":{"id":null,"display_name":"Gerhard Wolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125765","display_name":"Institut f\u00fcr Klinische Forschung und Entwicklung","ror":"https://ror.org/02z95d405","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210125765"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard Wolf","raw_affiliation_strings":["Klinisches Forschungsinstitut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinisches Forschungsinstitut","institution_ids":["https://openalex.org/I4210125765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3778,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.65180506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"51","issue":"10","first_page":"793","last_page":"798"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13238","display_name":"Botanical Studies and Applications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13238","display_name":"Botanical Studies and Applications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hawthorn","display_name":"hawthorn","score":0.9449999928474426},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9800000190734863},{"id":"https://openalex.org/keywords/exercise-tolerance","display_name":"exercise tolerance","score":0.984000027179718},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.984000027179718},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.8029999732971191},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8653507232666016},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7568470239639282},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6317460536956787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4621376097202301},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.4452704191207886},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4324072003364563},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.42133229970932007},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.41776642203330994},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.36774978041648865},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004417","descriptor_name":"Dyspnea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D027825","descriptor_name":"Crataegus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0031-1300117","doi":"https://doi.org/10.1055/s-0031-1300117","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0031-1300117","pdf_url":null,"source":{"id":"https://openalex.org/S132758211","display_name":"Arzneimittelforschung","issn_l":"0004-4172","issn":["0004-4172","1616-7066"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittelforschung","raw_type":"journal-article"},{"id":"pmid:11715631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11715631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2129065666","https://openalex.org/W4239265115","https://openalex.org/W2003109530","https://openalex.org/W165752886","https://openalex.org/W4250297695","https://openalex.org/W1973938650","https://openalex.org/W2404513578","https://openalex.org/W2043917173","https://openalex.org/W2412013160","https://openalex.org/W2338585326"],"abstract_inverted_index":{"Standardized":[0],"extracts":[1],"of":[2,26,41,45,56,96,105,140,151,154,165,171,203,207,219,224,227,256,260],"Crataegus":[3,47,262],"leaves":[4],"and":[5,15,54,102,134,254],"blossoms":[6],"are":[7],"said":[8],"to":[9,148,222],"have":[10],"positive":[11,13],"inotropic,":[12],"dromotropic":[14],"negative":[16],"bathmotropic":[17],"effects.":[18],"Clinical":[19],"trials":[20],"produce":[21],"evidence":[22],"for":[23],"an":[24,201],"improvement":[25],"symptoms":[27],"in":[28,60,85,169,266],"patients":[29,71,267],"with":[30,74,144,268],"congestive":[31,269],"heart":[32,270],"failure":[33,271],"(NYHA":[34,272],"II).":[35],"In":[36,63,174],"this":[37],"trial":[38,69],"the":[39,103,108,138,141,175,178,204,225,230,252,275],"efficacy":[40,92,253],"a":[42,64,111,124,149,257],"standardized":[43,258],"extract":[44,259],"fresh":[46,261],"berries":[48,263],"(Rob":[49,264],"10)":[50,265],"on":[51,110],"exercise":[52,83,152],"tolerance":[53],"quality":[55,95],"life":[57,97,166],"was":[58,88],"studied":[59],"88":[61],"patients.":[62],"three-month":[65],"placebo-controlled,":[66],"randomized,":[67],"double-blind":[68],"these":[70],"were":[72,115,121],"treated":[73],"Rob":[75,145,172,188],"10":[76,146,189],"(3":[77],"x":[78],"25":[79],"drops":[80],"daily).":[81],"Total":[82],"time":[84,153],"bicycle":[86],"ergometry":[87],"defined":[89],"as":[90,117,130,132],"primary":[91],"variable,":[93],"while":[94],"(Minnesota":[98],"Questionnaire),":[99],"Dyspnea-Fatigue":[100,198],"Index":[101,199],"assessment":[104,226],"dyspnea":[106,228,232],"by":[107,182,229,234],"patient":[109],"visual":[112],"analogous":[113],"scale":[114],"chosen":[116],"secondary":[118],"parameters.":[119],"Investigations":[120],"performed":[122],"after":[123,137],"two":[125],"week":[126],"placebo":[127,158],"run-in":[128],"period":[129],"well":[131],"6":[133],"12":[135],"weeks":[136],"onset":[139],"study.":[142],"Treatment":[143],"led":[147],"increase":[150,202],"38.9":[155],"s":[156],"vs":[157,185,190,193,210,212,215,237,240,243],"(95%":[159],"confidence":[160],"interval":[161],"5.7-72.1":[162],"s).":[163],"Quality":[164],"improved":[167],"accordingly":[168],"favour":[170],"10.":[173],"Minnesota":[176],"Questionnaire,":[177],"total":[179,205],"score":[180,206],"fell":[181],"31%":[183],"(30.6":[184],"44.1)":[186],"under":[187,195,217,246],"18%":[191],"(34.6":[192],"42.4)":[194],"placebo.":[196,220,247],"The":[197,248],"demonstrated":[200],"12%":[208],"(9.41":[209],"8.37)":[211],"8%":[213],"(8.92":[214],"8.26)":[216],"administration":[218],"According":[221],"findings":[223],"patient,":[231],"decreased":[233],"11%":[235],"(50.5":[236],"56.6":[238],"mm)":[239,245],"4%":[241],"(54.8":[242],"57.3":[244],"present":[249],"study":[250],"proves":[251],"safety":[255],"II)":[273],"regarding":[274],"parameters":[276],"evaluated.":[277]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
