{"id":"https://openalex.org/W37654800","doi":null,"title":"Augmented expression of glomerular basement membrane specific type IV collagen isoforms (alpha3-alpha5) in experimental membranous nephropathy.","display_name":"Augmented expression of glomerular basement membrane specific type IV collagen isoforms (alpha3-alpha5) in experimental membranous nephropathy.","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W37654800","mag":"37654800","pmid":"https://pubmed.ncbi.nlm.nih.gov/9625527"},"language":"en","primary_location":{"id":"pmid:9625527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9625527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Association of American Physicians","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005680978","display_name":"Andrew W. Minto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A W Minto","raw_affiliation_strings":["Evans Memorial Department of Clinical Research, Boston University Medical Center, MA 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evans Memorial Department of Clinical Research, Boston University Medical Center, MA 02118, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004654560","display_name":"Raghu Kalluri","orcid":"https://orcid.org/0000-0002-2190-547X","observed_orcids":["https://orcid.org/0000-0002-2190-547X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Kalluri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076711794","display_name":"Masaki Togawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Togawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029061765","display_name":"Eline C. Bergijk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E C Bergijk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089921339","display_name":"Paul D. Killen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P D Killen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062211530","display_name":"David J. Salant","orcid":"https://orcid.org/0000-0002-3866-3120","observed_orcids":["https://orcid.org/0000-0002-3866-3120"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D J Salant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5578,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.64701827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"110","issue":"3","first_page":"207","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membranous-nephropathy","display_name":"membranous nephropathy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.675000011920929},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9419999718666077},{"id":"https://openalex.org/keywords/glomerular-basement-membrane","display_name":"glomerular basement membrane","score":0.9490000009536743},{"id":"https://openalex.org/keywords/passive-heymann-nephritis","display_name":"passive Heymann nephritis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/podocytes","display_name":"podocytes","score":0.9459999799728394},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.8460000157356262},{"id":"https://openalex.org/keywords/complement-depletion","display_name":"complement depletion","score":0.7580000162124634},{"id":"https://openalex.org/keywords/mesangium","display_name":"mesangium","score":0.7599999904632568},{"id":"https://openalex.org/keywords/glomerular-injury","display_name":"glomerular injury","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.7727193236351013},{"id":"https://openalex.org/C2779937669","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Mesangium","level":4,"score":0.6574438810348511},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5915644764900208},{"id":"https://openalex.org/C2777107211","wikidata":"https://www.wikidata.org/wiki/Q7860610","display_name":"Type IV collagen","level":4,"score":0.5535861253738403},{"id":"https://openalex.org/C2776115139","wikidata":"https://www.wikidata.org/wiki/Q1753456","display_name":"Glomerular basement membrane","level":4,"score":0.5243865847587585},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5040668249130249},{"id":"https://openalex.org/C2775946357","wikidata":"https://www.wikidata.org/wiki/Q1713037","display_name":"Membranous nephropathy","level":4,"score":0.4933876097202301},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.48689284920692444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4732927680015564},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4707501530647278},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.4409196376800537},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4362291693687439},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.42237389087677},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3513021767139435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31992053985595703},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.21853595972061157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1791003942489624},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.09731307625770569},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07416170835494995},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015433","descriptor_name":"Glomerulonephritis, Membranous","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D015433","descriptor_name":"Glomerulonephritis, Membranous","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015433","descriptor_name":"Glomerulonephritis, Membranous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9625527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9625527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Association of American Physicians","raw_type":"Journal Article"},{"id":"mag:37654800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9625527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3537795957","display_name":"FREE RADICAL LIPID PEROXIDATION DAMAGE","funder_award_id":"5r01dk039225-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7200784987","display_name":"COLLAGEN IV GENE TRANSCRIPTION IN CPK/CPK MICE","funder_award_id":"5r01dk044848-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W46311059","https://openalex.org/W574954792","https://openalex.org/W1951957301","https://openalex.org/W2139512858","https://openalex.org/W2322370072","https://openalex.org/W4287328075"],"related_works":["https://openalex.org/W2045549618","https://openalex.org/W103190227","https://openalex.org/W2019555524","https://openalex.org/W2073552422","https://openalex.org/W1991380643","https://openalex.org/W1946428094","https://openalex.org/W2092194949","https://openalex.org/W2006265966","https://openalex.org/W2021416732","https://openalex.org/W4206161563"],"abstract_inverted_index":{"In":[0,158,196,219],"human":[1,265],"and":[2,11,30,43,47,63,68,75,137,170,235,257,264],"experimental":[3,263],"membranous":[4,97,266],"nephropathy,":[5],"new":[6,139],"extracellular":[7],"matrix":[8],"accumulates":[9],"between,":[10],"eventually":[12],"surrounds,":[13],"immune":[14],"deposits":[15,177],"on":[16,214],"the":[17,21,28,45,51,65,76,83,117,124,138,151,168,207,227,252],"subepithelial":[18],"aspect":[19],"of":[20,32,50,71,85,96,106,119,126,141,153,162,178,199,209,226,238,254],"glomerular":[22,149],"basement":[23,54],"membrane":[24,55],"(GBM).":[25],"To":[26],"define":[27],"nature":[29],"source":[31],"this":[33,156],"newly":[34],"deposited":[35],"matrix,":[36],"we":[37,221],"studied":[38],"by":[39,242],"in":[40,88,116,155,167,185,193,245,262],"situ":[41],"hybridization":[42],"immunohistology":[44],"production":[46,225,237],"tissue":[48],"deposition":[49],"recently":[52],"defined":[53],"type":[56,72,79,179,230,239],"IV":[57,73,231],"collagen":[58,81,232,241],"chain":[59],"isoforms":[60,70,233],"alpha3,":[61],"alpha4,":[62],"alpha5,":[64],"mesangium-specific":[66],"alpha1":[67,111,142],"alpha2":[69],"collagen,":[74],"fibrillar":[77],"interstitial":[78],"I":[80,180,240],"during":[82],"development":[84],"immunological":[86,127],"injury":[87,128,154],"passive":[89],"Heymann":[90],"nephritis":[91],"(PHN),":[92],"a":[93],"rodent":[94],"model":[95],"nephropathy.":[98,267],"Our":[99],"results":[100],"show":[101],"that":[102],"steady-state":[103],"mRNA":[104,212],"levels":[105,161],"alpha3-alpha5":[107,164,234],"(IV)":[108,112,136,190,211],"but":[109],"not":[110],"are":[113],"significantly":[114],"increased":[115,160,224],"glomeruli":[118],"rats":[120,197],"with":[121,174],"PHN":[122,194,205],"at":[123],"peak":[125,208],"after":[129,204],"14":[130,216],"days.":[131],"Increased":[132],"signal":[133],"for":[134,188,201],"alpha4":[135,210],"appearance":[140],"(I)":[143],"could":[144],"be":[145],"clearly":[146],"localized":[147],"to":[148,251],"podocytes,":[150],"target":[152],"model.":[157],"addition,":[159],"immunoreactive":[163],"were":[165],"visible":[166],"peripheral":[169],"paramesangial":[171],"GBM":[172,229],"together":[173],"de":[175],"novo":[176],"collagen.":[181],"A":[182],"modest":[183],"increase":[184],"mesangial":[186],"staining":[187],"alpha1/alpha2":[189],"was":[191,217],"present":[192],"glomeruli.":[195],"depleted":[198],"complement":[200],"5":[202],"days":[203],"induction,":[206],"expression":[213],"day":[215],"blunted.":[218],"conclusion,":[220],"have":[222],"shown":[223],"intrinsic":[228],"ectopic":[236],"injured":[243],"podocytes":[244],"PHN.":[246],"These":[247],"changes":[248],"may":[249],"contribute":[250],"formation":[253],"an":[255],"expanded":[256],"disorganized":[258],"GBM,":[259],"as":[260],"seen":[261]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
