{"id":"https://openalex.org/W37614095","doi":null,"title":"Regulation of milk fat synthesis by dietary fatty acids.","display_name":"Regulation of milk fat synthesis by dietary fatty acids.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W37614095","mag":"37614095"},"language":"en","primary_location":{"id":"pmh:oai:drum.lib.umd.edu:1903/8363","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/8363","pdf_url":"http://hdl.handle.net/1903/8363","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1903/8363","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008797549","display_name":"Anil K.G. Kadegowda","orcid":"https://orcid.org/0000-0003-2288-9026","observed_orcids":["https://orcid.org/0000-0003-2288-9026"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anil K.G. Kadegowda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2288-9026","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008797549"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10098","display_name":"Ruminant Nutrition and Digestive Physiology","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10098","display_name":"Ruminant Nutrition and Digestive Physiology","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11226","display_name":"Milk Quality and Mastitis in Dairy Cows","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/milk-fat-synthesis","display_name":"milk fat synthesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dietary-fatty-acids","display_name":"dietary fatty acids","score":0.9900000095367432},{"id":"https://openalex.org/keywords/conjugated-linoleic-acid","display_name":"conjugated linoleic acid","score":0.9079999923706055},{"id":"https://openalex.org/keywords/srebp-1c","display_name":"SREBP-1c","score":0.8420000076293945},{"id":"https://openalex.org/keywords/chrebp","display_name":"ChREBP","score":0.9120000004768372},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.8960000276565552},{"id":"https://openalex.org/keywords/insig1","display_name":"INSIG1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/liver-lipogenesis","display_name":"liver lipogenesis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/ppargamma-agonists","display_name":"PPAR\u03b3 agonists","score":0.765999972820282},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dairy-cows","display_name":"dairy cattle","score":0.7490000128746033},{"id":"https://openalex.org/keywords/lactating-mice","display_name":"lactating mice","score":0.7440000176429749},{"id":"https://openalex.org/keywords/de-novo-lipogenesis","display_name":"de novo lipogenesis","score":0.6790000200271606},{"id":"https://openalex.org/keywords/fatty-acid-desaturation","display_name":"fatty acid desaturation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/triacylglycerol-biosynthesis","display_name":"triglyceride synthesis","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6484002470970154},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.52601557970047},{"id":"https://openalex.org/C3020171069","wikidata":"https://www.wikidata.org/wiki/Q909729","display_name":"Milk fat","level":3,"score":0.5243161916732788},{"id":"https://openalex.org/C3020020386","wikidata":"https://www.wikidata.org/wiki/Q127980","display_name":"Dietary fat","level":2,"score":0.41458332538604736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32822614908218384},{"id":"https://openalex.org/C2778717857","wikidata":"https://www.wikidata.org/wiki/Q818405","display_name":"Linseed oil","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:drum.lib.umd.edu:1903/8363","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/8363","pdf_url":"http://hdl.handle.net/1903/8363","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:37614095","doi":null,"is_oa":false,"landing_page_url":"https://drum.lib.umd.edu/handle/1903/8363","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:drum.lib.umd.edu:1903/8363","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1903/8363","pdf_url":"http://hdl.handle.net/1903/8363","source":{"id":"https://openalex.org/S4306401518","display_name":"University Libraries (University of Maryland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66946132","host_organization_name":"University of Maryland, College Park","host_organization_lineage":["https://openalex.org/I66946132"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.875,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W37614095.pdf","grobid_xml":"https://content.openalex.org/works/W37614095.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1590731909","https://openalex.org/W1881485015","https://openalex.org/W1970829656","https://openalex.org/W1974657416","https://openalex.org/W1988975733","https://openalex.org/W1989032536","https://openalex.org/W1991126206","https://openalex.org/W2028091332","https://openalex.org/W2082152301","https://openalex.org/W2093903037","https://openalex.org/W2097349510","https://openalex.org/W2110467642","https://openalex.org/W2336194301","https://openalex.org/W2747152737","https://openalex.org/W2763585649","https://openalex.org/W2767486991","https://openalex.org/W2768921565","https://openalex.org/W2789964983","https://openalex.org/W2800976225","https://openalex.org/W2803926494","https://openalex.org/W2806437990","https://openalex.org/W2898600863","https://openalex.org/W2907750428","https://openalex.org/W2910518528","https://openalex.org/W2949166765","https://openalex.org/W2953815811","https://openalex.org/W2969591627","https://openalex.org/W2970804155","https://openalex.org/W3042336167","https://openalex.org/W3093341700","https://openalex.org/W3093971275","https://openalex.org/W3183543213","https://openalex.org/W4205557650","https://openalex.org/W4297459331","https://openalex.org/W4299627282","https://openalex.org/W4365786653","https://openalex.org/W6658903236","https://openalex.org/W7052647445"],"related_works":["https://openalex.org/W54490945","https://openalex.org/W2124307313","https://openalex.org/W4386842713","https://openalex.org/W2100212859","https://openalex.org/W2462413652","https://openalex.org/W2121422007","https://openalex.org/W2327974810","https://openalex.org/W2804140667","https://openalex.org/W2111426359","https://openalex.org/W2760989900"],"abstract_inverted_index":{"The":[0,247,292],"objectives":[1],"of":[2,63,83,106,132,140,176,196,232,249,262,304,327],"this":[3],"thesis":[4],"research":[5],"were":[6,31,77,115,147,206,218,290],"to":[7,33,58,79,108,154,187,193,299],"determine":[8],"the":[9,35,59,81,120,130,141,184,200,225,325,335],"molecular":[10],"mechanisms":[11,158],"by":[12,220,224],"which":[13,178],"dietary":[14],"fatty":[15,181,203,237],"acids":[16,182,204],"(FA)":[17],"regulate":[18],"lipogenic":[19,94,133,215,296,332],"gene":[20,216,297],"expression":[21,131,217,259,298],"and":[22,28,40,67,88,98,103,112,128,145,168,213,234,252,273,280,337],"milk":[23,38,47,91,191,211,244,319,343],"fat":[24,39,48,92,192,209,245,320,344],"synthesis.":[25,321,345],"Principal":[26],"component":[27],"multivariate":[29],"analyses":[30],"conducted":[32],"establish":[34,155],"relationship":[36],"between":[37],"FA":[41,251,271,293,311,328],"concentrations":[42],"in":[43,56,73,96,110,117,160,183,190,267,284,317,329,342],"lactating":[44,161],"cows":[45],"fed":[46,119],"depressing":[49],"(MFD)":[50],"diets.":[51],"This":[52,228],"analysis":[53],"showed":[54],"that":[55,230],"addition":[57],"established":[60],"inhibitory":[61],"effect":[62],"t10c12":[64,170],"CLA,":[65],"t7-18:1":[66,107],"t7c9-CLA":[68,109],"isomers":[69,87],"might":[70,240,313],"be":[71,241],"involved":[72],"MFD.":[74],"Lactating":[75],"mice":[76,118],"used":[78],"test":[80],"effects":[82,248],"several":[84],"individual":[85,250],"trans-18:1":[86],"t10c12-CLA":[89,124],"on":[90,257],"synthesis,":[93,270,277],"genes":[95,264],"liver":[97,113],"mammary":[99,111,214,295,331],"tissues.":[100],"Both":[101],"MFD":[102,127],"extensive":[104],"conversion":[105],"tissues":[114],"shown":[116],"t7-18:1.":[121],"As":[122],"expected,":[123],"feeding":[125],"caused":[126],"reduced":[129],"transcription":[134],"factor":[135,340],"(TF)":[136],"SREBP-1C.":[137],"Potential":[138],"roles":[139,266],"TF":[142],"ChREBP,":[143],"PPARG,":[144],"INSIG1":[146],"also":[148],"established.":[149],"A":[150],"subsequent":[151],"study":[152],"aimed":[153],"whether":[156],"these":[157],"operated":[159],"dairy":[162],"cows.":[163],"Compared":[164],"with":[165,265,309],"un-infused":[166],"controls":[167],"a":[169,194,253,285,315],"CLA":[171],"negative":[172],"control,":[173],"post-ruminal":[174],"infusion":[175],"butterfat":[177,221],"contains":[179],"all":[180],"same":[185],"proportion":[186],"those":[188],"found":[189],"mixture":[195],"fats":[197],"containing":[198],"only":[199],"long":[201],"chain":[202,236],"(LCFA)":[205],"examined.":[207,291],"Milk":[208],"content,":[210],"yield":[212],"increased":[219],"but":[222],"not":[223],"LCFA":[226],"mixture.":[227],"suggested":[229],"rates":[231],"short":[233],"medium":[235],"acid":[238],"synthesis":[239],"limiting":[242],"for":[243],"production.":[246],"PPAR\u03b3-specific":[254],"agonist":[255],"(Rosiglitazone)":[256],"mRNA":[258],"via":[260],"qPCR":[261],"19":[263],"de":[268,305],"novo":[269,306],"uptake":[272],"transport,":[274],"desaturation,":[275],"triacylglycerol":[276],"transcriptional":[278,339],"regulation,":[279],"nuclear":[281],"receptor":[282],"signaling":[283],"MACT":[286],"cell":[287],"culture":[288],"system":[289],"regulated":[294],"different":[300],"extents.":[301],"PPAR-\u03b3":[302],"activation":[303],"lipogenesis":[307],"coupled":[308],"exogenous":[310],"availability":[312],"play":[314],"role":[316,326],"regulating":[318,330],"These":[322],"experiments":[323],"demonstrate":[324],"pathways,":[333],"highlighting":[334],"complexity":[336],"multiple":[338],"involvement":[341]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}