{"id":"https://openalex.org/W37587401","doi":null,"title":"Changes induced in the bioelectric activity of rat subcortical nervous structures by Gerovital H3 and Aslavital as compared to procaine.","display_name":"Changes induced in the bioelectric activity of rat subcortical nervous structures by Gerovital H3 and Aslavital as compared to procaine.","publication_year":1988,"publication_date":"1988-07-01","ids":{"openalex":"https://openalex.org/W37587401","mag":"37587401","pmid":"https://pubmed.ncbi.nlm.nih.gov/3144011"},"language":"en","primary_location":{"id":"pmid:3144011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3144011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiologie (Bucarest)","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Pop","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Pop","raw_affiliation_strings":["University of Cluj-Napoca, Department of Biology, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cluj-Napoca, Department of Biology, Romania","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014719809","display_name":"Corneliu Tarba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Tarba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00092064,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"3","first_page":"137","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.3716000020503998,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.3716000020503998,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.2305999994277954,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.0649000033736229,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/procaine","display_name":"procaine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"EEG","score":0.6660000085830688},{"id":"https://openalex.org/keywords/lateral-hypothalamus","display_name":"lateral hypothalamus","score":0.9789999723434448},{"id":"https://openalex.org/keywords/reticular-formation","display_name":"reticular formation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/intravenous-injection","display_name":"intravenous injection","score":0.6510000228881836},{"id":"https://openalex.org/keywords/wave-frequency","display_name":"wave frequency","score":0.5090000033378601},{"id":"https://openalex.org/keywords/wave-amplitude","display_name":"wave amplitude","score":0.9900000095367432},{"id":"https://openalex.org/keywords/epileptiform-activity","display_name":"epileptiform activity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/drug-effects-on-the-brain","display_name":"drug effects on the brain","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C2780553513","wikidata":"https://www.wikidata.org/wiki/Q17118003","display_name":"Midbrain reticular formation","level":4,"score":0.8286541700363159},{"id":"https://openalex.org/C2779828710","wikidata":"https://www.wikidata.org/wiki/Q423741","display_name":"Procaine","level":2,"score":0.8165367841720581},{"id":"https://openalex.org/C2778655484","wikidata":"https://www.wikidata.org/wiki/Q750588","display_name":"Reticular formation","level":3,"score":0.7957059741020203},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.7006064057350159},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5540039539337158},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4628670811653137},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.4521416425704956},{"id":"https://openalex.org/C95190701","wikidata":"https://www.wikidata.org/wiki/Q3268002","display_name":"Reticular connective tissue","level":2,"score":0.44998642802238464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4396113157272339},{"id":"https://openalex.org/C2780714764","wikidata":"https://www.wikidata.org/wiki/Q17125841","display_name":"Lateral hypothalamus","level":3,"score":0.42542898654937744},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4014515280723572},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3785376250743866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2792816758155823},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2647964358329773}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011343","descriptor_name":"Procaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011343","descriptor_name":"Procaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012154","descriptor_name":"Reticular Formation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012154","descriptor_name":"Reticular Formation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3144011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3144011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiologie (Bucarest)","raw_type":"Comparative Study"},{"id":"mag:37587401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3144011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W16491492","https://openalex.org/W1115500699","https://openalex.org/W1986678411","https://openalex.org/W2043299701","https://openalex.org/W2044508901","https://openalex.org/W2064023438","https://openalex.org/W2064852150","https://openalex.org/W2132853322","https://openalex.org/W2147161932","https://openalex.org/W2154259323","https://openalex.org/W2163531945","https://openalex.org/W2335933008","https://openalex.org/W2435058322","https://openalex.org/W2563236085","https://openalex.org/W2611267400","https://openalex.org/W2620426481","https://openalex.org/W2623077503","https://openalex.org/W2800578988","https://openalex.org/W2889721339","https://openalex.org/W2945513992","https://openalex.org/W2955079055","https://openalex.org/W3092419037","https://openalex.org/W3144107308","https://openalex.org/W4213000093","https://openalex.org/W4220699435","https://openalex.org/W4226343164","https://openalex.org/W4362578929"],"related_works":["https://openalex.org/W2410427339","https://openalex.org/W2573151497","https://openalex.org/W2315030153","https://openalex.org/W2406262049","https://openalex.org/W2502848889","https://openalex.org/W2008876543","https://openalex.org/W2165587396","https://openalex.org/W1979409715","https://openalex.org/W1964902403","https://openalex.org/W2483940027"],"abstract_inverted_index":{"Intravenous":[0],"injection":[1],"of":[2,24,33,74,120,126,135,165,168,203,208,222],"Gerovital":[3,75,190],"H3":[4,191],"and":[5,97,167,189,192,226],"procaine":[6,188],"(20":[7],"mg/kg":[8,18],"b.w.)":[9,19],"into":[10],"white":[11],"Wistar":[12],"rats":[13],"anaesthetized":[14],"with":[15],"nembutal":[16],"(40":[17],"produces":[20],"a":[21,67,121,133,201],"constant":[22],"decrease":[23],"the":[25,31,34,41,59,63,72,82,86,90,100,104,113,127,148,152,163,169,180,209],"wave":[26,52,83,91,181],"frequency,":[27],"more":[28,69,95,156],"visible":[29,70],"at":[30],"level":[32],"lateral":[35,60,114,153],"hypothalamus,":[36,61],"but":[37,62],"also":[38,55],"present":[39],"in":[40,58,71,89,103,112,151,176,220],"midbrain":[42],"reticular":[43,105],"formation":[44,106],"(the":[45],"two":[46,171],"subcortical":[47],"nervous":[48,231],"structures":[49],"studied).":[50],"The":[51,212],"amplitude":[53],"is":[54,138,184],"decreased,":[56],"especially":[57],"differences":[64,213],"gradually":[65],"recover,":[66],"fact":[68],"case":[73,178],"H3.":[76],"Aslavital":[77,166,199],"has":[78],"similar":[79],"effects":[80,164],"on":[81],"amplitude,":[84,182],"whereas":[85],"changes":[87,149],"produced":[88,150],"frequency":[92,101],"are":[93,107,155,215],"generally":[94,139],"superficial":[96,157],"transitory.":[98],"Moreover,":[99],"variations":[102],"opposite":[108,140],"to":[109,141],"those":[110],"observed":[111,143,175,214],"hypothalamus":[115,154],"(i.e.,":[116],"an":[117],"increase":[118],"instead":[119],"decrease).":[122],"Direct":[123],"intrahypothalamic":[124],"administration":[125],"drugs":[128,172],"(16":[129],"micrograms":[130],"procaine/animal)":[131],"induces":[132,200],"pattern":[134],"responses":[136],"which":[137,183],"that":[142],"for":[144,179],"intravenous":[145],"injection.":[146],"Also,":[147],"this":[158,177],"time.":[159],"An":[160],"opposition":[161],"between":[162],"other":[170],"can":[173],"be":[174],"usually":[185],"increased":[186],"by":[187,194,218],"decreased":[193],"Aslavital.":[195],"In":[196],"many":[197],"cases,":[198],"burst":[202],"positive":[204],"sharp":[205],"waves":[206],"reminiscent":[207],"epileptiform":[210],"abnormality.":[211],"tentatively":[216],"explained":[217],"us":[219],"terms":[221],"dose,":[223],"drug":[224],"composition":[225],"selective":[227],"action":[228],"upon":[229],"different":[230],"structures.":[232]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}