{"id":"https://openalex.org/W37394658","doi":null,"title":"[Preclinical prognosis of pyracetam and picamilon safety based on acute toxicity data].","display_name":"[Preclinical prognosis of pyracetam and picamilon safety based on acute toxicity data].","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W37394658","mag":"37394658","pmid":"https://pubmed.ncbi.nlm.nih.gov/14558352"},"language":"ru","primary_location":{"id":"pmid:14558352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14558352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eksperimental'naia i klinicheskaia farmakologiia","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023036218","display_name":"L I Bugaeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155623535","display_name":"Volgograd State Medical University","ror":"https://ror.org/04q6a0352","country_code":"RU","type":"education","lineage":["https://openalex.org/I155623535"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L I Bugaeva","raw_affiliation_strings":["Institute of Pharmacology, Volgograd State Medical Academy, pl. Pavshikh Bortsov 1a, Volgograd, 400066 Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, Volgograd State Medical Academy, pl. Pavshikh Bortsov 1a, Volgograd, 400066 Russia","institution_ids":["https://openalex.org/I155623535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081710389","display_name":"\u0410. \u0410. \u0421\u043f\u0430\u0441\u043e\u0432","orcid":"https://orcid.org/0000-0002-7185-4826","observed_orcids":["https://orcid.org/0000-0002-7185-4826"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A A Spasov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051575460","display_name":"\u0412 \u0415 \u0412\u0435\u0440\u043e\u0432\u0441\u043a\u0438\u0439","orcid":"https://orcid.org/0000-0001-5944-9572","observed_orcids":["https://orcid.org/0000-0001-5944-9572"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V E Verovski\u012d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029138168","display_name":"Igor Nikolayevich Iezhitsa","orcid":"https://orcid.org/0000-0002-2852-8486","observed_orcids":["https://orcid.org/0000-0002-2852-8486"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I N Iezhitsa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00428535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"4","first_page":"43","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.26759999990463257,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.1120000034570694,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piracetam","display_name":"piracetam","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nootropics","display_name":"nootropic drugs","score":0.902999997138977},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7990000247955322},{"id":"https://openalex.org/keywords/therapeutic-index","display_name":"therapeutic index","score":0.7459999918937683},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C2777496795","wikidata":"https://www.wikidata.org/wiki/Q410069","display_name":"Piracetam","level":2,"score":0.961175799369812},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.7665698528289795},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6983324289321899},{"id":"https://openalex.org/C2776239663","wikidata":"https://www.wikidata.org/wiki/Q742487","display_name":"Nootropic","level":2,"score":0.6408922672271729},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.6329858899116516},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6107133030891418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5855951309204102},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.46816110610961914},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.41125011444091797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18741604685783386}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007928","descriptor_name":"Lethal Dose 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010889","descriptor_name":"Piracetam","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D023382","descriptor_name":"Toxicity Tests, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14558352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14558352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eksperimental'naia i klinicheskaia farmakologiia","raw_type":"English Abstract"},{"id":"mag:37394658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14558352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W15560177","https://openalex.org/W1540040314","https://openalex.org/W1965416461","https://openalex.org/W1979575311","https://openalex.org/W1985274320","https://openalex.org/W1994597521","https://openalex.org/W1996441317","https://openalex.org/W2001435406","https://openalex.org/W2006711104","https://openalex.org/W2035647453","https://openalex.org/W2064979268","https://openalex.org/W2072414567","https://openalex.org/W2081913577","https://openalex.org/W2093295082","https://openalex.org/W2099442862","https://openalex.org/W2125489497","https://openalex.org/W2128980203","https://openalex.org/W2129178038","https://openalex.org/W2132768923","https://openalex.org/W2147750192","https://openalex.org/W2521594527","https://openalex.org/W2792664296","https://openalex.org/W2977678272","https://openalex.org/W3197403709","https://openalex.org/W4247495170","https://openalex.org/W6604191488"],"related_works":["https://openalex.org/W2010217098","https://openalex.org/W2399642591","https://openalex.org/W2418648319","https://openalex.org/W19745542","https://openalex.org/W2056109055","https://openalex.org/W2062949968","https://openalex.org/W1964247625","https://openalex.org/W2049074481","https://openalex.org/W2107030899","https://openalex.org/W3163186237"],"abstract_inverted_index":{"A":[0],"comparative":[1],"acute":[2],"toxicity":[3],"test":[4],"of":[5,23,26,36,69],"the":[6,21,27,31,42,50,70],"nootropic":[7],"drugs":[8],"piracetam":[9],"and":[10,33,56],"picamilon":[11],"was":[12,18,39],"performed":[13],"on":[14,20],"rats.":[15],"The":[16],"study":[17],"based":[19],"principles":[22],"integral":[24],"evaluation":[25],"drug":[28],"effect":[29],"upon":[30],"functional":[32],"behavioral":[34],"state":[35],"animals.":[37],"It":[38],"found":[40],"that":[41],"conventional":[43],"therapeutic":[44,52,71],"index":[45],"does":[46],"not":[47],"coincide":[48],"with":[49],"actual":[51],"activity":[53],"range.":[54],"Piracetam":[55],"picamilon,":[57],"while":[58],"exhibiting":[59],"significantly":[60],"different":[61],"toxicity,":[62],"are":[63],"characterized":[64],"by":[65],"approximately":[66],"equal":[67],"ranges":[68],"activity.":[72]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
