{"id":"https://openalex.org/W373459504","doi":"https://doi.org/10.1007/s11481-015-9618-9","title":"Regulation of the Neurodegenerative Process Associated to Parkinson\u2019s Disease by CD4+ T-cells","display_name":"Regulation of the Neurodegenerative Process Associated to Parkinson\u2019s Disease by CD4+ T-cells","publication_year":2015,"publication_date":"2015-05-27","ids":{"openalex":"https://openalex.org/W373459504","doi":"https://doi.org/10.1007/s11481-015-9618-9","mag":"373459504","pmid":"https://pubmed.ncbi.nlm.nih.gov/26018603"},"language":"en","primary_location":{"id":"doi:10.1007/s11481-015-9618-9","doi":"https://doi.org/10.1007/s11481-015-9618-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11481-015-9618-9","pdf_url":null,"source":{"id":"https://openalex.org/S137872405","display_name":"Journal of Neuroimmune Pharmacology","issn_l":"1557-1890","issn":["1557-1890","1557-1904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmune Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hugo Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108487","display_name":"Fundaci\u00f3n Ciencia and Vida","ror":"https://ror.org/01p6hjg61","country_code":"CL","type":"nonprofit","lineage":["https://openalex.org/I4210108487"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Hugo Gonz\u00e1lez","raw_affiliation_strings":["Laboratory of Neuroimmunology, Fundaci\u00f3n Ciencia & Vida, Avenida Za\u00f1artu #1482, \u00d1u\u00f1oa, 7780272, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroimmunology, Fundaci\u00f3n Ciencia & Vida, Avenida Za\u00f1artu #1482, \u00d1u\u00f1oa, 7780272, Santiago, Chile","institution_ids":["https://openalex.org/I4210108487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002508362","display_name":"Francisco Contreras","orcid":"https://orcid.org/0000-0003-4272-8860","observed_orcids":["https://orcid.org/0000-0003-4272-8860"]},"institutions":[{"id":"https://openalex.org/I4210108487","display_name":"Fundaci\u00f3n Ciencia and Vida","ror":"https://ror.org/01p6hjg61","country_code":"CL","type":"nonprofit","lineage":["https://openalex.org/I4210108487"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Francisco Contreras","raw_affiliation_strings":["Laboratory of Neuroimmunology, Fundaci\u00f3n Ciencia & Vida, Avenida Za\u00f1artu #1482, \u00d1u\u00f1oa, 7780272, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroimmunology, Fundaci\u00f3n Ciencia & Vida, Avenida Za\u00f1artu #1482, \u00d1u\u00f1oa, 7780272, Santiago, Chile","institution_ids":["https://openalex.org/I4210108487"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009961267","display_name":"Rodrigo Pacheco","orcid":"https://orcid.org/0000-0001-8057-9806","observed_orcids":["https://orcid.org/0000-0001-8057-9806"]},"institutions":[{"id":"https://openalex.org/I13897259","display_name":"Universidad Andr\u00e9s Bello","ror":"https://ror.org/01qq57711","country_code":"CL","type":"education","lineage":["https://openalex.org/I13897259"]},{"id":"https://openalex.org/I4210108487","display_name":"Fundaci\u00f3n Ciencia and Vida","ror":"https://ror.org/01p6hjg61","country_code":"CL","type":"nonprofit","lineage":["https://openalex.org/I4210108487"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Rodrigo Pacheco","raw_affiliation_strings":["Facultad de Ciencias Biol\u00f3gicas, Universidad Andres Bello, 8370146, Santiago, Chile. rpacheco@cienciavida.org","Laboratory of Neuroimmunology, Fundaci\u00f3n Ciencia & Vida, Avenida Za\u00f1artu #1482, \u00d1u\u00f1oa, 7780272, Santiago, Chile. rpacheco@cienciavida.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias Biol\u00f3gicas, Universidad Andres Bello, 8370146, Santiago, Chile. rpacheco@cienciavida.org","institution_ids":["https://openalex.org/I13897259"]},{"raw_affiliation_string":"Laboratory of Neuroimmunology, Fundaci\u00f3n Ciencia & Vida, Avenida Za\u00f1artu #1482, \u00d1u\u00f1oa, 7780272, Santiago, Chile. rpacheco@cienciavida.org","institution_ids":["https://openalex.org/I4210108487"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009961267"],"corresponding_institution_ids":["https://openalex.org/I13897259","https://openalex.org/I4210108487"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.2009,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.1836394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"4","first_page":"561","last_page":"575"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.43459999561309814,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8029999732971191},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9879999756813049},{"id":"https://openalex.org/keywords/encephalitogenic-t-cells","display_name":"encephalitogenic T cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/neurotransmitter-alterations","display_name":"neurotransmitter alterations","score":0.593999981880188},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.9599999785423279},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.828000009059906},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.6449999809265137},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.9620000123977661},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8649529218673706},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.8332290649414062},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6461689472198486},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.629380464553833},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5982683897018433},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5502809882164001},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.5006370544433594},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4996461868286133},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48423242568969727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4841078519821167},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4149662256240845},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3800008296966553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3016217350959778},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29416507482528687},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.23630553483963013},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14564022421836853}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11481-015-9618-9","doi":"https://doi.org/10.1007/s11481-015-9618-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11481-015-9618-9","pdf_url":null,"source":{"id":"https://openalex.org/S137872405","display_name":"Journal of Neuroimmune Pharmacology","issn_l":"1557-1890","issn":["1557-1890","1557-1904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmune Pharmacology","raw_type":"journal-article"},{"id":"pmid:26018603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26018603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334812","display_name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/02ap3w078"},{"id":"https://openalex.org/F4320338073","display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","ror":"https://ror.org/02ap3w078"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":142,"referenced_works":["https://openalex.org/W175006040","https://openalex.org/W1496790952","https://openalex.org/W1501518736","https://openalex.org/W1505719764","https://openalex.org/W1511770968","https://openalex.org/W1527671059","https://openalex.org/W1546232808","https://openalex.org/W1548690558","https://openalex.org/W1556870397","https://openalex.org/W1558808632","https://openalex.org/W1579132652","https://openalex.org/W1669165205","https://openalex.org/W1678167583","https://openalex.org/W1835937600","https://openalex.org/W1894723323","https://openalex.org/W1967640115","https://openalex.org/W1967782952","https://openalex.org/W1969307826","https://openalex.org/W1970320304","https://openalex.org/W1972931472","https://openalex.org/W1975308788","https://openalex.org/W1975352555","https://openalex.org/W1976217131","https://openalex.org/W1976597647","https://openalex.org/W1977213877","https://openalex.org/W1979710783","https://openalex.org/W1984111865","https://openalex.org/W1985337246","https://openalex.org/W1989369404","https://openalex.org/W1991538811","https://openalex.org/W1991873176","https://openalex.org/W1991961055","https://openalex.org/W1993918716","https://openalex.org/W1995032030","https://openalex.org/W1995089933","https://openalex.org/W1995191747","https://openalex.org/W1996024251","https://openalex.org/W1997128521","https://openalex.org/W1997211020","https://openalex.org/W1997570073","https://openalex.org/W1998000193","https://openalex.org/W1998252425","https://openalex.org/W2002287054","https://openalex.org/W2003129702","https://openalex.org/W2004820885","https://openalex.org/W2007633164","https://openalex.org/W2008423294","https://openalex.org/W2008640006","https://openalex.org/W2008745522","https://openalex.org/W2008953930","https://openalex.org/W2010867882","https://openalex.org/W2013932229","https://openalex.org/W2014144616","https://openalex.org/W2014182955","https://openalex.org/W2016575029","https://openalex.org/W2017802764","https://openalex.org/W2018206879","https://openalex.org/W2018264373","https://openalex.org/W2018465274","https://openalex.org/W2025408360","https://openalex.org/W2025810715","https://openalex.org/W2026778930","https://openalex.org/W2026918258","https://openalex.org/W2027879303","https://openalex.org/W2031924346","https://openalex.org/W2034990013","https://openalex.org/W2041158634","https://openalex.org/W2041858687","https://openalex.org/W2042630261","https://openalex.org/W2044077555","https://openalex.org/W2046302119","https://openalex.org/W2047402066","https://openalex.org/W2050397606","https://openalex.org/W2050731687","https://openalex.org/W2055487345","https://openalex.org/W2056436885","https://openalex.org/W2057249855","https://openalex.org/W2057968168","https://openalex.org/W2058077554","https://openalex.org/W2058448231","https://openalex.org/W2060330802","https://openalex.org/W2061660439","https://openalex.org/W2061995199","https://openalex.org/W2062524799","https://openalex.org/W2062785609","https://openalex.org/W2068642804","https://openalex.org/W2070855360","https://openalex.org/W2071959799","https://openalex.org/W2073607297","https://openalex.org/W2073845471","https://openalex.org/W2076344205","https://openalex.org/W2078385788","https://openalex.org/W2081372975","https://openalex.org/W2081689799","https://openalex.org/W2081710098","https://openalex.org/W2082026408","https://openalex.org/W2084143268","https://openalex.org/W2084212509","https://openalex.org/W2086438617","https://openalex.org/W2088590019","https://openalex.org/W2091486815","https://openalex.org/W2091868439","https://openalex.org/W2093459949","https://openalex.org/W2096877847","https://openalex.org/W2097811455","https://openalex.org/W2098247882","https://openalex.org/W2098382378","https://openalex.org/W2098889184","https://openalex.org/W2101321540","https://openalex.org/W2104575230","https://openalex.org/W2106773303","https://openalex.org/W2108398194","https://openalex.org/W2110495699","https://openalex.org/W2110729320","https://openalex.org/W2111344966","https://openalex.org/W2114312101","https://openalex.org/W2115757753","https://openalex.org/W2117223239","https://openalex.org/W2118921031","https://openalex.org/W2123011060","https://openalex.org/W2123805036","https://openalex.org/W2124116262","https://openalex.org/W2133759882","https://openalex.org/W2134685106","https://openalex.org/W2136879071","https://openalex.org/W2139463652","https://openalex.org/W2141976392","https://openalex.org/W2144971684","https://openalex.org/W2145328167","https://openalex.org/W2149404667","https://openalex.org/W2150681175","https://openalex.org/W2151417786","https://openalex.org/W2154911070","https://openalex.org/W2157837362","https://openalex.org/W2160733114","https://openalex.org/W2165339984","https://openalex.org/W2168126136","https://openalex.org/W2168216500","https://openalex.org/W2169749019","https://openalex.org/W2170785039","https://openalex.org/W2407847489","https://openalex.org/W4230384856"],"related_works":["https://openalex.org/W3202432987","https://openalex.org/W2136879071","https://openalex.org/W4414561306","https://openalex.org/W2943768381","https://openalex.org/W2953906329","https://openalex.org/W1995089933","https://openalex.org/W245956071","https://openalex.org/W3193963761","https://openalex.org/W7159692664","https://openalex.org/W4401661568"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}