{"id":"https://openalex.org/W373238124","doi":null,"title":"Palmitate-induced skeletal muscle insulin resistance does not require NF-jB activation Pascal P. H. HommelbergJogchum PlatLauren M. Sparks \u2022 Annemie M. W. J. ScholsAnon L. M. van EssenMarco C. J. M. Kelders \u2022 Denis van BeurdenRonald P. MensinkRamon C. J. Langen","display_name":"Palmitate-induced skeletal muscle insulin resistance does not require NF-jB activation Pascal P. H. HommelbergJogchum PlatLauren M. Sparks \u2022 Annemie M. W. J. ScholsAnon L. M. van EssenMarco C. J. M. Kelders \u2022 Denis van BeurdenRonald P. MensinkRamon C. J. Langen","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W373238124","mag":"373238124"},"language":"en","primary_location":{"id":"mag:373238124","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007/s00018-010-0515-3.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013717261","display_name":"Annemie M.W.J. Schols","orcid":"https://orcid.org/0000-0001-9878-0428","observed_orcids":["https://orcid.org/0000-0001-9878-0428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annemie M.W.J. Schols","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9878-0428","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069467323","display_name":"Kelders R. C. J. Langen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelders R. C. J. Langen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02485767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.23960000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.23960000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.22390000522136688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.12999999523162842,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/palmitate","display_name":"palmitate","score":0.9940000176429749},{"id":"https://openalex.org/keywords/skeletal-muscle-insulin-resistance","display_name":"skeletal muscle insulin resistance","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/diacylglycerol-accumulation","display_name":"diacylglycerol accumulation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/diacylglycerol-acyltransferase","display_name":"diacylglycerol acyltransferase","score":0.7699999809265137},{"id":"https://openalex.org/keywords/carnitine-palmitoyltransferase-1","display_name":"carnitine palmitoyltransferase 1","score":0.7689999938011169},{"id":"https://openalex.org/keywords/etomoxir","display_name":"etomoxir","score":0.996999979019165},{"id":"https://openalex.org/keywords/myotubes","display_name":"myotubes","score":0.7870000004768372},{"id":"https://openalex.org/keywords/lipid-metabolites","display_name":"lipid metabolites","score":0.6259999871253967},{"id":"https://openalex.org/keywords/nf-kappab-transactivation","display_name":"NF-\u03baB transactivation","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8601053357124329},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.8016074895858765},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6623561382293701},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6457011103630066},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6423923969268799},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.571693480014801},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.5669244527816772},{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.5480197072029114},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4414270222187042},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4318392276763916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35664403438568115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2153932750225067},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19186419248580933},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09768494963645935},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06938639283180237}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:373238124","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007/s00018-010-0515-3.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1563050098","https://openalex.org/W1633034930","https://openalex.org/W1965583590","https://openalex.org/W1968357607","https://openalex.org/W1970306975","https://openalex.org/W1970468997","https://openalex.org/W1985534077","https://openalex.org/W1990035305","https://openalex.org/W1997398344","https://openalex.org/W2000823512","https://openalex.org/W2003755391","https://openalex.org/W2005040360","https://openalex.org/W2010930949","https://openalex.org/W2028068170","https://openalex.org/W2028212562","https://openalex.org/W2028289438","https://openalex.org/W2029188728","https://openalex.org/W2031637294","https://openalex.org/W2035187068","https://openalex.org/W2038018821","https://openalex.org/W2039194194","https://openalex.org/W2043106623","https://openalex.org/W2044131015","https://openalex.org/W2054903611","https://openalex.org/W2070026236","https://openalex.org/W2082463182","https://openalex.org/W2094644629","https://openalex.org/W2097838137","https://openalex.org/W2102434966","https://openalex.org/W2108266286","https://openalex.org/W2108462699","https://openalex.org/W2108546663","https://openalex.org/W2109820048","https://openalex.org/W2127056938","https://openalex.org/W2130850001","https://openalex.org/W2133290655","https://openalex.org/W2133545849","https://openalex.org/W2139785109","https://openalex.org/W2142416266","https://openalex.org/W2146243104","https://openalex.org/W2149609961","https://openalex.org/W2152211462","https://openalex.org/W2158020636","https://openalex.org/W2162178233","https://openalex.org/W2162493104","https://openalex.org/W2169401893","https://openalex.org/W2171699473","https://openalex.org/W2171977696","https://openalex.org/W2174864163","https://openalex.org/W4313343508"],"related_works":["https://openalex.org/W1965955937","https://openalex.org/W2032109449","https://openalex.org/W2129962371","https://openalex.org/W1601351999","https://openalex.org/W1986351438","https://openalex.org/W2117693758","https://openalex.org/W1990248738","https://openalex.org/W2145530897","https://openalex.org/W2385703530","https://openalex.org/W593272580"],"abstract_inverted_index":{"Palmitate":[0],"activates":[1],"the":[2,31,120,138],"NF-jB":[3,44,60,93,112,121,139],"pathway,":[4],"and":[5,11,23,52,59,79],"induces":[6],"accumulation":[7,78,103],"of":[8,88,119,137],"lipid":[9,38],"metabolites":[10,39],"insulin":[12,47,57,84,107,127,147],"resistance":[13,48,58,108,148],"in":[14,42,49,149],"skeletal":[15,50,150],"muscle":[16,51,151],"cells.":[17,152],"Little":[18],"information":[19],"is":[20,104,141],"available":[21],"whether":[22,36,55],"how":[24],"these":[25],"processes":[26],"are":[27,40,62],"causally":[28,63],"related.":[29,64],"Therefore,":[30],"objectives":[32],"were":[33],"to":[34,53,82],"investigate":[35,54],"intra-cellular":[37],"involved":[41],"FA-induced":[43,56],"activation":[45,61],"and/or":[46],"Inhibiting":[65],"DGAT":[66],"or":[67,74,116],"CPT-1":[68],"by":[69],"using,":[70],"respectively,":[71],"amidep-":[72],"sine":[73],"etomoxir":[75,91],"increased":[76,92],"DAG":[77,102],"sensitized":[80],"myotubes":[81],"palmitate-induced":[83,126],"resistance.":[85,128],"While":[86],"co-incubation":[87,95],"palmitate":[89],"with":[90,96,106,111],"transactivation,":[94],"amidepsine":[97],"did":[98],"not,":[99],"indicating":[100],"that":[101,134],"associated":[105],"but":[109],"not":[110,124,142],"activation.":[113],"Furthermore,":[114],"pharmacological":[115],"genetic":[117],"inhibition":[118],"pathway":[122,140],"could":[123],"prevent":[125],"In":[129],"conclusion,":[130],"we":[131],"have":[132],"demonstrated":[133],"acti-":[135],"vation":[136],"required":[143],"for":[144],"palmitate-":[145],"induced":[146]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}