{"id":"https://openalex.org/W3727278","doi":null,"title":"Characterization of the human PIM-1 gene: a putative proto-oncogene coding for a tissue specific member of the protein kinase family.","display_name":"Characterization of the human PIM-1 gene: a putative proto-oncogene coding for a tissue specific member of the protein kinase family.","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W3727278","mag":"3727278","pmid":"https://pubmed.ncbi.nlm.nih.gov/3329711"},"language":"en","primary_location":{"id":"pmid:3329711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3329711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109168462","display_name":"T C Meeker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T C Meeker","raw_affiliation_strings":["The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104","Wistar Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"Wistar Institute","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110954700","display_name":"L Nagarajan","orcid":"https://orcid.org/0009-0006-5942-8038","observed_orcids":["https://orcid.org/0009-0006-5942-8038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Nagarajan","raw_affiliation_strings":["Genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073170798","display_name":"A ar-Rushdi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A ar-Rushdi","raw_affiliation_strings":["Wistar Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113684477","display_name":"G Rovera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Rovera","raw_affiliation_strings":["Wistar Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111570513","display_name":"Kay Huebner","orcid":"https://orcid.org/0000-0002-2848-1382","observed_orcids":["https://orcid.org/0000-0002-2848-1382"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Huebner","raw_affiliation_strings":["Wistar Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079700663","display_name":"Carlo Maria Croce","orcid":"https://orcid.org/0000-0003-3788-1457","observed_orcids":["https://orcid.org/0000-0003-3788-1457"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C M Croce","raw_affiliation_strings":["Wistar Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute","institution_ids":["https://openalex.org/I102322052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.317,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.80307739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":"1","first_page":"87","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.3319999873638153,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.07840000092983246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.7409999966621399},{"id":"https://openalex.org/keywords/proto-oncogenes","display_name":"proto-oncogenes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/human-lymphoma","display_name":"human lymphoma","score":0.6819999814033508},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.9470000267028809},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.5189999938011169},{"id":"https://openalex.org/keywords/exon-intron-organization","display_name":"exon-intron organization","score":0.7770000100135803},{"id":"https://openalex.org/keywords/promoter","display_name":"promoter","score":0.7139999866485596},{"id":"https://openalex.org/keywords/sp1-binding-site","display_name":"Sp1 binding site","score":0.984000027179718},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.6740000247955322},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.6470000147819519},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8259999752044678},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7157453894615173},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6792175769805908},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5868591070175171},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5632414221763611},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.5297010540962219},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.5147476196289062},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.5133509039878845},{"id":"https://openalex.org/C6393950","wikidata":"https://www.wikidata.org/wiki/Q17855994","display_name":"RUNX1T1","level":4,"score":0.4712021052837372},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.45517000555992126},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45285728573799133},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.34414201974868774}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3329711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3329711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene research","raw_type":"Journal Article"},{"id":"mag:3727278","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3329711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2037337676","https://openalex.org/W1977611294","https://openalex.org/W2414085023","https://openalex.org/W1979361468","https://openalex.org/W1998037458","https://openalex.org/W2411182029","https://openalex.org/W2050936670","https://openalex.org/W2159374588","https://openalex.org/W4229633271","https://openalex.org/W4255706882"],"abstract_inverted_index":{"The":[0,50,85,105,149],"mouse":[1,11,23],"PIM-1":[2,24,86,154],"gene":[3,25,128,155],"is":[4],"involved":[5],"in":[6,30,142,163,167],"the":[7,18,22,62,75,152,158],"pathogenesis":[8],"of":[9,21,61,95,124,126,132,151,160],"virally-induced":[10],"lymphomas.":[12],"We":[13],"have":[14,68,116],"cloned":[15],"and":[16,33,48,100,145,166],"analyzed":[17],"human":[19,31,133,153],"homologue":[20],"to":[26,58,90,138],"investigate":[27],"its":[28,161],"role":[29,162],"lymphoma":[32],"leukemia.":[34],"Overlapping":[35],"cDNA":[36],"clones":[37,73],"from":[38,74,92],"a":[39,59,69],"K562":[40],"(human":[41,79],"erythroleukemia":[42],"cell":[43,77,81,134,147],"line)":[44],"library":[45],"were":[46,83,103],"isolated":[47],"sequenced.":[49],"deduced":[51],"amino":[52],"acid":[53],"sequence":[54],"showed":[55,136],"significant":[56],"homology":[57],"number":[60],"protein":[63],"kinases":[64],"but":[65,114],"did":[66,115],"not":[67],"transmembrane":[70],"region.":[71],"Genomic":[72],"380":[76],"line":[78],"B":[80,143],"leukemia)":[82],"analyzed.":[84],"transcript":[87],"was":[88],"found":[89],"derive":[91],"5":[93],"Kb":[94],"genomic":[96],"DNA.":[97],"Six":[98],"exons":[99],"five":[101],"introns":[102],"identified.":[104],"promoter":[106],"region":[107],"has":[108],"no":[109],"TATA":[110],"or":[111],"CAAT":[112],"boxes,":[113],"multiple":[117],"potential":[118],"Sp1":[119],"binding":[120],"sites":[121],"(CCGCCC).":[122],"Studies":[123],"expression":[125],"this":[127],"using":[129],"Northern":[130],"blots":[131],"lines":[135],"it":[137],"be":[139],"transcribed":[140],"primarily":[141],"lymphoid":[144],"myeloid":[146],"lines.":[148],"characterization":[150],"will":[156],"allow":[157],"definition":[159],"hemopoietic":[164],"malignancies":[165],"hematolymphoid":[168],"differentiation.":[169]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}