{"id":"https://openalex.org/W372271735","doi":null,"title":"IMPLICATION DES CALCIUM/CALMODULINE- D\u00c9PENDENTE KINASE KINASES ET DU FACTEUR NEUROTROPHIQUE BDNF DANS LE M\u00c9CANISME D'ACTION DES ANTID\u00c9PRESSEURS","display_name":"IMPLICATION DES CALCIUM/CALMODULINE- D\u00c9PENDENTE KINASE KINASES ET DU FACTEUR NEUROTROPHIQUE BDNF DANS LE M\u00c9CANISME D'ACTION DES ANTID\u00c9PRESSEURS","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W372271735","mag":"372271735"},"language":"fr","primary_location":{"id":"pmh:oai:corpus.ulaval.ca:20.500.11794/19422","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11794/19422","pdf_url":null,"source":{"id":"https://openalex.org/S4306400293","display_name":"Corpus Universit\u00e9 Laval (Universit\u00e9 Laval)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43406934","host_organization_name":"Universit\u00e9 Laval","host_organization_lineage":["https://openalex.org/I43406934"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"th\u00e8se de doctorat"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025008442","display_name":"Jonathan Vinet","orcid":"https://orcid.org/0000-0001-9011-6207","observed_orcids":["https://orcid.org/0000-0001-9011-6207"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jonathan Vinet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9011-6207","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025008442"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6700000166893005},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.875},{"id":"https://openalex.org/keywords/antidepressant-mechanism-of-action","display_name":"antidepressant mechanism","score":0.8289999961853027},{"id":"https://openalex.org/keywords/camkkbeta","display_name":"CaMKK\u03b2","score":1.0},{"id":"https://openalex.org/keywords/calcium-calmodulin-dependent-protein-kinase","display_name":"calcium/calmodulin-dependent protein kinase","score":0.7760000228881836},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9259999990463257},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.43299999833106995},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.7523051500320435},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.48209384083747864},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.4561324715614319},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.3578002452850342},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35777172446250916},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34770452976226807},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33695676922798157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.331233412027359},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3057505786418915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2654758095741272},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2555430233478546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15422403812408447},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10876083374023438}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:corpus.ulaval.ca:20.500.11794/19422","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11794/19422","pdf_url":null,"source":{"id":"https://openalex.org/S4306400293","display_name":"Corpus Universit\u00e9 Laval (Universit\u00e9 Laval)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43406934","host_organization_name":"Universit\u00e9 Laval","host_organization_lineage":["https://openalex.org/I43406934"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"th\u00e8se de doctorat"},{"id":"pmh:oai:theses.ulaval.ca:2005/22416","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.ulaval.ca/2005/22416/22416.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},{"id":"mag:372271735","doi":null,"is_oa":false,"landing_page_url":"https://corpus.ulaval.ca/jspui/bitstream/20.500.11794/19422/1/22416.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":204,"referenced_works":["https://openalex.org/W4322545","https://openalex.org/W20284704","https://openalex.org/W60547861","https://openalex.org/W172520768","https://openalex.org/W177049143","https://openalex.org/W613594210","https://openalex.org/W1483911606","https://openalex.org/W1484384039","https://openalex.org/W1496297920","https://openalex.org/W1500240510","https://openalex.org/W1509868652","https://openalex.org/W1512847190","https://openalex.org/W1524361670","https://openalex.org/W1524944192","https://openalex.org/W1527035699","https://openalex.org/W1530078108","https://openalex.org/W1540436551","https://openalex.org/W1543637004","https://openalex.org/W1570137929","https://openalex.org/W1625103160","https://openalex.org/W1653656108","https://openalex.org/W1666500994","https://openalex.org/W1709410479","https://openalex.org/W1761323037","https://openalex.org/W1871684389","https://openalex.org/W1914011667","https://openalex.org/W1950744654","https://openalex.org/W1952592959","https://openalex.org/W1965174921","https://openalex.org/W1968735663","https://openalex.org/W1970658476","https://openalex.org/W1970982006","https://openalex.org/W1972706999","https://openalex.org/W1973125755","https://openalex.org/W1974776346","https://openalex.org/W1976441097","https://openalex.org/W1976872805","https://openalex.org/W1977237592","https://openalex.org/W1977411622","https://openalex.org/W1979519830","https://openalex.org/W1981724466","https://openalex.org/W1982421931","https://openalex.org/W1982446401","https://openalex.org/W1985223341","https://openalex.org/W1985239587","https://openalex.org/W1985898337","https://openalex.org/W1987463590","https://openalex.org/W1988564692","https://openalex.org/W1988612597","https://openalex.org/W1988793757","https://openalex.org/W1988843909","https://openalex.org/W1989218867","https://openalex.org/W1989260964","https://openalex.org/W1991625714","https://openalex.org/W1991974510","https://openalex.org/W1993246724","https://openalex.org/W1995556701","https://openalex.org/W1995930538","https://openalex.org/W1995991193","https://openalex.org/W1996067368","https://openalex.org/W1997338432","https://openalex.org/W1997510672","https://openalex.org/W1998815610","https://openalex.org/W1999270780","https://openalex.org/W2000402650","https://openalex.org/W2003708984","https://openalex.org/W2003838450","https://openalex.org/W2004118951","https://openalex.org/W2005231219","https://openalex.org/W2005843543","https://openalex.org/W2006119116","https://openalex.org/W2006770638","https://openalex.org/W2007441077","https://openalex.org/W2008671190","https://openalex.org/W2008719521","https://openalex.org/W2010269783","https://openalex.org/W2010643465","https://openalex.org/W2015365608","https://openalex.org/W2018257089","https://openalex.org/W2019316537","https://openalex.org/W2019786994","https://openalex.org/W2019823288","https://openalex.org/W2019939591","https://openalex.org/W2019954639","https://openalex.org/W2020897240","https://openalex.org/W2021440803","https://openalex.org/W2021892782","https://openalex.org/W2022713347","https://openalex.org/W2024398910","https://openalex.org/W2024618244","https://openalex.org/W2024709318","https://openalex.org/W2025733830","https://openalex.org/W2026224576","https://openalex.org/W2026282737","https://openalex.org/W2027478213","https://openalex.org/W2027509507","https://openalex.org/W2027914056","https://openalex.org/W2028764771","https://openalex.org/W2029037289","https://openalex.org/W2029887922","https://openalex.org/W2030801076","https://openalex.org/W2032827544","https://openalex.org/W2034694738","https://openalex.org/W2036257349","https://openalex.org/W2037329949","https://openalex.org/W2039236418","https://openalex.org/W2040465695","https://openalex.org/W2042551807","https://openalex.org/W2044069216","https://openalex.org/W2044710410","https://openalex.org/W2045381482","https://openalex.org/W2046274893","https://openalex.org/W2047924526","https://openalex.org/W2048429102","https://openalex.org/W2048557710","https://openalex.org/W2048595403","https://openalex.org/W2051575011","https://openalex.org/W2051788298","https://openalex.org/W2053265248","https://openalex.org/W2053427125","https://openalex.org/W2054595891","https://openalex.org/W2054737420","https://openalex.org/W2055516348","https://openalex.org/W2057125590","https://openalex.org/W2058658179","https://openalex.org/W2059565695","https://openalex.org/W2060307846","https://openalex.org/W2062815987","https://openalex.org/W2063633439","https://openalex.org/W2064295273","https://openalex.org/W2068246413","https://openalex.org/W2068289571","https://openalex.org/W2070771391","https://openalex.org/W2072219714","https://openalex.org/W2073216156","https://openalex.org/W2074549291","https://openalex.org/W2074796005","https://openalex.org/W2074815848","https://openalex.org/W2075034621","https://openalex.org/W2075652092","https://openalex.org/W2076034797","https://openalex.org/W2076728391","https://openalex.org/W2078316783","https://openalex.org/W2078407522","https://openalex.org/W2079841860","https://openalex.org/W2081704409","https://openalex.org/W2083909523","https://openalex.org/W2084413012","https://openalex.org/W2085588932","https://openalex.org/W2087955490","https://openalex.org/W2088033659","https://openalex.org/W2088318915","https://openalex.org/W2089296932","https://openalex.org/W2089609187","https://openalex.org/W2090215646","https://openalex.org/W2091077356","https://openalex.org/W2091293351","https://openalex.org/W2091585770","https://openalex.org/W2095435531","https://openalex.org/W2095465583","https://openalex.org/W2096604840","https://openalex.org/W2117830068","https://openalex.org/W2117924155","https://openalex.org/W2121651624","https://openalex.org/W2121878996","https://openalex.org/W2125508089","https://openalex.org/W2127722821","https://openalex.org/W2132993734","https://openalex.org/W2134539998","https://openalex.org/W2134736486","https://openalex.org/W2136761139","https://openalex.org/W2136827845","https://openalex.org/W2137385309","https://openalex.org/W2137932281","https://openalex.org/W2140178312","https://openalex.org/W2143629083","https://openalex.org/W2144323120","https://openalex.org/W2145450525","https://openalex.org/W2146747402","https://openalex.org/W2149785766","https://openalex.org/W2150760153","https://openalex.org/W2151912439","https://openalex.org/W2153242416","https://openalex.org/W2154727263","https://openalex.org/W2155623382","https://openalex.org/W2155709733","https://openalex.org/W2157974953","https://openalex.org/W2158698313","https://openalex.org/W2159692236","https://openalex.org/W2160305772","https://openalex.org/W2162710298","https://openalex.org/W2164590669","https://openalex.org/W2166687069","https://openalex.org/W2168950597","https://openalex.org/W2170298556","https://openalex.org/W2180410797","https://openalex.org/W2282306508","https://openalex.org/W2317060418","https://openalex.org/W2332800117","https://openalex.org/W2395243848","https://openalex.org/W2405894137","https://openalex.org/W2406615226","https://openalex.org/W2419470416","https://openalex.org/W2432251707"],"related_works":["https://openalex.org/W2029887922","https://openalex.org/W2073779138","https://openalex.org/W1964725788","https://openalex.org/W145207159","https://openalex.org/W7029551601","https://openalex.org/W7143449688","https://openalex.org/W7147244866","https://openalex.org/W4392397620","https://openalex.org/W1521487375","https://openalex.org/W6981704731"],"abstract_inverted_index":{"La":[0],"d\u00e9pression":[1],"est":[2,34],"un":[3,29,145],"trouble":[4],"de":[5,11,21,31,68,74,83,86,109,120,124,126,152,155,163,173,180,241,249,254,288,293,298],"l\u2019humeur":[6],"qui":[7,16],"affecte":[8],"environ":[9],"15%":[10],"la":[12,72,84,91,94,107,121,127,133,136,153,156,161,174,191,194,242,285,296],"population":[13],"mondiale":[14],"et":[15,93,135,158,236,253,275],"peut":[17,102],"\u00eatre":[18,47,104],"d\u00e9clench\u00e9":[19],"par":[20,106,203,281],"nombreux":[22],"facteurs":[23],"incluant":[24],"le":[25,48,50,66,139,169,272],"stress.":[26],"De":[27,220],"plus,":[28,221],"d\u00e9balancement":[30],"l\u2019axe":[32],"Hypothalmo-hypophyso-surr\u00e9nalien":[33],"pr\u00e9sent":[35],"chez":[36],"plusieurs":[37],"patients":[38],"d\u00e9pressifs.":[39],"\u00c0":[40],"l\u2019heure":[41],"actuelle,":[42],"les":[43,187],"antid\u00e9presseurs":[44,58,214,264],"se":[45,277],"r\u00e9v\u00e8lent":[46,278],"moyen":[49],"plus":[51,131],"efficace":[52],"pour":[53,207],"traiter":[54],"cette":[55,117],"maladie.":[56],"Les":[57,113],"exercent":[59],"leur":[60,282],"fonction":[61],"th\u00e9rapeutique":[62],"principalement":[63],"en":[64,80],"activant":[65],"facteur":[67],"transcription":[69,85],"CREB":[70,101],"via":[71],"voie":[73,108,128,297],"signalisation":[75,110,299],"AMPc-d\u00e9pendante.":[76],"Cette":[77],"activation":[78],"r\u00e9sulte":[79],"une":[81,225,229,304],"augmentation":[82],"certains":[87],"g\u00e8nes":[88],"impliqu\u00e9s":[89],"dans":[90,116,138,168,186,190,284],"protection":[92],"survie":[95],"cellulaire":[96],"tel":[97],"que":[98,257,295],"BDNF.":[99],"Or":[100],"aussi":[103],"activ\u00e9":[105],"du":[111,129,300],"calcium.":[112],"travaux":[114],"rapport\u00e9s":[115],"th\u00e8se":[118],"traitent":[119],"possible":[122],"implication":[123,283],"prot\u00e9ines":[125],"calcium,":[130],"particuli\u00e8rement":[132,279],"CaMKK\u03b1":[134],"CaMKK\u03b2,":[137],"m\u00e9canisme":[140],"d\u2019action":[141],"des":[142,166,197,218,231,245,251,268,306],"antid\u00e9presseurs.":[143,307],"Dans":[144,193],"premier":[146],"temps,":[147],"nous":[148,177,199,222,291],"avons":[149,159,200,223],"cl\u00f4n\u00e9":[150],"l\u2019ARNm":[151,250],"CaMKK\u03b2":[154],"souris":[157,226],"\u00e9tudi\u00e9":[160],"distribution":[162],"l\u2019expression":[164,216],"g\u00e9nique":[165,217],"CaMKKs":[167,252],"syst\u00e8me":[170],"nerveux":[171],"central":[172],"souris.":[175],"Ceci":[176],"a":[178],"permis":[179],"constater":[181],"qu\u2019elles":[182],"\u00e9taient":[183],"exprim\u00e9es":[184],"fortement":[185],"r\u00e9gions":[188,259],"impliqu\u00e9es":[189],"d\u00e9pression.":[192,243,286],"deuxi\u00e8me":[195],"phase":[196],"travaux,":[198],"utilis\u00e9":[201,224],"l\u2019approche":[202],"hybridation":[204],"in":[205],"situ":[206],"\u00e9tudier":[208],"l\u2019effet":[209],"d\u2019un":[210],"traitement":[211,262],"chronique":[212],"aux":[213,233,263],"sur":[215],"CaMKKs.":[219],"transg\u00e9nique":[227],"poss\u00e9dant":[228],"dysfonction":[230],"r\u00e9cepteurs":[232],"glucocortico\u00efdes":[234],"(GR)":[235],"servant":[237],"comme":[238],"mod\u00e8le":[239],"neuroendocrine":[240],"L\u2019analyse":[244],"diff\u00e9rents":[246],"degr\u00e9s":[247],"d\u2019expression":[248],"BDNF":[255],"montre":[256],"diff\u00e9rentes":[258],"r\u00e9agissent":[260],"au":[261,266],"ou":[265],"dysfonctionnement":[267],"GR.":[269],"Parmi":[270],"celles-ci,":[271],"cortex":[273],"pr\u00e9frontal":[274],"l\u2019hippocampe":[276],"int\u00e9ressants":[280],"L\u2019ensemble":[287],"nos":[289],"r\u00e9sultats":[290],"permet":[292],"proposer":[294],"calcium":[301],"soit":[302],"\u00e9galement":[303],"cible":[305]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}