{"id":"https://openalex.org/W37155980","doi":null,"title":"Reduction of basement membrane thickening in diabetic cat retina by sulindac.","display_name":"Reduction of basement membrane thickening in diabetic cat retina by sulindac.","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W37155980","mag":"37155980","pmid":"https://pubmed.ncbi.nlm.nih.gov/2318584"},"language":"en","primary_location":{"id":"pmid:2318584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2318584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S Z Mansour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Z Mansour","raw_affiliation_strings":["Department of Ophthalmology, Duke University, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Duke University, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113554663","display_name":"Diane L. Hatchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D L Hatchell","raw_affiliation_strings":["Department of Ophthalmology, Duke University , Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Duke University , Durham, North Carolina","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071647385","display_name":"David Chandler","orcid":"https://orcid.org/0000-0002-1949-7438","observed_orcids":["https://orcid.org/0000-0002-1949-7438"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Chandler","raw_affiliation_strings":["Department of Ophthalmology, Duke University , Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Duke University , Durham, North Carolina","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041591370","display_name":"Peter Saloupis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Saloupis","raw_affiliation_strings":["Department of Ophthalmology, Duke University , Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Duke University , Durham, North Carolina","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029157924","display_name":"M. C. Hatchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M C Hatchell","raw_affiliation_strings":["Department of Ophthalmology, Duke University , Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Duke University , Durham, North Carolina","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":1.5329,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.7957395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"31","issue":"3","first_page":"457","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.2793000042438507,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/basement-membrane-thickening","display_name":"basement membrane thickening","score":0.8309999704360962},{"id":"https://openalex.org/keywords/sulindac","display_name":"sulindac","score":0.9810000061988831},{"id":"https://openalex.org/keywords/aldose-reductase-inhibitors","display_name":"aldose reductase inhibitors","score":0.8740000128746033},{"id":"https://openalex.org/keywords/retinal-capillaries","display_name":"retinal capillaries","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9100000262260437},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8299999833106995},{"id":"https://openalex.org/keywords/pericytes","display_name":"pericytes","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.8590308427810669},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.7870927453041077},{"id":"https://openalex.org/C2776241388","wikidata":"https://www.wikidata.org/wiki/Q963093","display_name":"Sulindac","level":3,"score":0.7737106084823608},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.5702906847000122},{"id":"https://openalex.org/C2777374081","wikidata":"https://www.wikidata.org/wiki/Q4713968","display_name":"Aldose reductase inhibitor","level":4,"score":0.5607088804244995},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.536749005317688},{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.5253279209136963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45348024368286133},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44465333223342896},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.43961530923843384},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42795297503471375},{"id":"https://openalex.org/C2776115139","wikidata":"https://www.wikidata.org/wiki/Q1753456","display_name":"Glomerular basement membrane","level":4,"score":0.41698259115219116},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.40275612473487854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3440505564212799},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3031255006790161},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2911851704120636},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2605537176132202},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.18653210997581482},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.08311545848846436},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010180","descriptor_name":"Pancreatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013467","descriptor_name":"Sulindac","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2318584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2318584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:37155980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2318584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000905508","display_name":"Center Core Grant for Vision Research","funder_award_id":"P30EY005722","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1215131164","https://openalex.org/W1968415431","https://openalex.org/W1999889646","https://openalex.org/W2104738423","https://openalex.org/W2441341106","https://openalex.org/W3188569878","https://openalex.org/W4240304626"],"related_works":["https://openalex.org/W307186808","https://openalex.org/W2047255263","https://openalex.org/W2095266621","https://openalex.org/W1981411389","https://openalex.org/W2155061358","https://openalex.org/W2125108260","https://openalex.org/W2068786544","https://openalex.org/W1968415431","https://openalex.org/W1999889646","https://openalex.org/W2514007040"],"abstract_inverted_index":{"Capillary":[0],"basement":[1,47,73],"membrane":[2,48,74,99],"thickening":[3,49],"is":[4,16],"one":[5],"of":[6,55,125],"the":[7,37,53,114],"earliest":[8],"histologic":[9],"lesions":[10],"in":[11,52,79,104,136,145,147],"diabetic":[12,38,80,106,116,149,156],"retinopathy.":[13],"Its":[14],"pathogenesis":[15],"not":[17,143],"understood;":[18],"however,":[19],"recent":[20],"evidence":[21],"suggests":[22],"that":[23,140],"aldose":[24,68],"reductase":[25,69],"may":[26],"play":[27],"a":[28,33],"role.":[29],"In":[30,122],"this":[31],"study,":[32],"new":[34],"animal":[35],"model,":[36],"cat,":[39],"was":[40,76,101],"used":[41],"to":[42,83,113,152],"determine":[43],"whether":[44,60],"retinal":[45],"capillary":[46,72],"occurred":[50],"early":[51],"course":[54],"hyperglycemia,":[56],"and":[57,129,134],"if":[58],"so,":[59],"it":[61],"could":[62],"be":[63],"inhibited":[64],"by":[65],"sulindac,":[66],"an":[67],"inhibitor.":[70],"Retinal":[71],"thickness":[75,100],"significantly":[77,102],"increased":[78],"cats":[81,85,107,117,150],"compared":[82,112,151],"normal":[84,153],"(114":[86,118],"+/-":[87,91,95,109,119],"15":[88,120],"vs":[89],"72":[90],"12":[92],"nm,":[93],"mean":[94],"SD)":[96],"[corrected].":[97],"Basement":[98],"less":[103],"sulindac-treated":[105,155],"(93":[108],"9":[110],"nm)":[111],"untreated":[115,148],"nm).":[121],"addition,":[123],"quantitation":[124],"endothelial":[126,132],"cells,":[127],"pericytes,":[128],"contacts":[130],"between":[131],"cells":[133],"pericytes":[135],"electron":[137],"micrographs":[138],"revealed":[139],"they":[141],"were":[142],"reduced":[144],"number":[146],"or":[154],"animals.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}