{"id":"https://openalex.org/W37061574","doi":null,"title":"Significance of increased serum elastase 1 level during the hyperosmolar hyperglycemic non-ketotic syndrome.","display_name":"Significance of increased serum elastase 1 level during the hyperosmolar hyperglycemic non-ketotic syndrome.","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W37061574","mag":"37061574","pmid":"https://pubmed.ncbi.nlm.nih.gov/2445640"},"language":"en","primary_location":{"id":"pmid:2445640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2445640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109158740","display_name":"Shigenobu Umeki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189996419","display_name":"Kawasaki Medical School","ror":"https://ror.org/059z11218","country_code":"JP","type":"education","lineage":["https://openalex.org/I189996419"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Umeki","raw_affiliation_strings":["Department of Medicine, Kawasaki Medical School, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Kawasaki Medical School, Okayama, Japan","institution_ids":["https://openalex.org/I189996419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018199873","display_name":"Masaki Watanabe","orcid":"https://orcid.org/0000-0001-5586-0743","observed_orcids":["https://orcid.org/0000-0001-5586-0743"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Watanabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110216154","display_name":"S Yagi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Yagi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113754635","display_name":"R Soejima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Soejima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2827,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50568568,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"5","first_page":"212","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.10779999941587448,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.09749999642372131,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/alpha-2-macroglobulin","display_name":"alpha2-macroglobulin","score":0.968999981880188},{"id":"https://openalex.org/keywords/serum-amylase","display_name":"serum amylase","score":0.8519999980926514},{"id":"https://openalex.org/keywords/intravenous-hyperalimentation","display_name":"intravenous hyperalimentation","score":0.921999990940094},{"id":"https://openalex.org/keywords/dehydration","display_name":"dehydration","score":0.574999988079071},{"id":"https://openalex.org/keywords/electrolyte-imbalance","display_name":"electrolyte imbalance","score":0.7879999876022339},{"id":"https://openalex.org/keywords/rehydration-therapy","display_name":"rehydration therapy","score":0.7160000205039978},{"id":"https://openalex.org/keywords/lung-cancer-chemotherapy","display_name":"lung cancer chemotherapy","score":0.4399999976158142},{"id":"https://openalex.org/keywords/anorexia","display_name":"anorexia","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7732155323028564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7142363786697388},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6930299997329712},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5638695955276489},{"id":"https://openalex.org/C2778654693","wikidata":"https://www.wikidata.org/wiki/Q254327","display_name":"Anorexia","level":2,"score":0.5066242814064026},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.46918416023254395},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.4414498507976532},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.43393415212631226},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4170129597187042},{"id":"https://openalex.org/C2993808720","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Serum glucose","level":3,"score":0.4121336340904236},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3614426851272583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18708887696266174},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13176202774047852},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07581084966659546}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000511","descriptor_name":"alpha-Macroglobulins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003926","descriptor_name":"Diabetic Coma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006029","descriptor_name":"Glycosuria","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006944","descriptor_name":"Hyperglycemic Hyperosmolar Nonketotic Coma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006944","descriptor_name":"Hyperglycemic Hyperosmolar Nonketotic Coma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006944","descriptor_name":"Hyperglycemic Hyperosmolar Nonketotic Coma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010289","descriptor_name":"Parenteral Nutrition, Total","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2445640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2445640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Case Reports"},{"id":"mag:37061574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2445640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":124,"referenced_works":["https://openalex.org/W879479010","https://openalex.org/W1549853453","https://openalex.org/W1842896948","https://openalex.org/W1970195004","https://openalex.org/W1993105537","https://openalex.org/W1993211211","https://openalex.org/W1994112020","https://openalex.org/W1995392776","https://openalex.org/W2001320403","https://openalex.org/W2012599652","https://openalex.org/W2013995112","https://openalex.org/W2022160170","https://openalex.org/W2024803597","https://openalex.org/W2030914021","https://openalex.org/W2031272027","https://openalex.org/W2036475326","https://openalex.org/W2038554653","https://openalex.org/W2064434771","https://openalex.org/W2071889908","https://openalex.org/W2073307176","https://openalex.org/W2086833250","https://openalex.org/W2089938437","https://openalex.org/W2099631990","https://openalex.org/W2106232004","https://openalex.org/W2112979354","https://openalex.org/W2130594874","https://openalex.org/W2133892659","https://openalex.org/W2141150979","https://openalex.org/W2145584128","https://openalex.org/W2161208630","https://openalex.org/W2163674612","https://openalex.org/W2164670204","https://openalex.org/W2164692317","https://openalex.org/W2168970487","https://openalex.org/W2212076220","https://openalex.org/W2282724676","https://openalex.org/W2479533342","https://openalex.org/W2514287253","https://openalex.org/W2547781691","https://openalex.org/W2589517296","https://openalex.org/W2591994964","https://openalex.org/W2610264107","https://openalex.org/W2730058881","https://openalex.org/W2735527928","https://openalex.org/W2763193663","https://openalex.org/W2767856718","https://openalex.org/W2768367424","https://openalex.org/W2775690235","https://openalex.org/W2796239548","https://openalex.org/W2802540563","https://openalex.org/W2802626256","https://openalex.org/W2883017776","https://openalex.org/W2885829397","https://openalex.org/W2891420275","https://openalex.org/W2937725692","https://openalex.org/W2949458744","https://openalex.org/W2952643930","https://openalex.org/W2982464725","https://openalex.org/W2983920349","https://openalex.org/W2997148967","https://openalex.org/W3007924766","https://openalex.org/W3009912996","https://openalex.org/W3013369257","https://openalex.org/W3014003872","https://openalex.org/W3014370465","https://openalex.org/W3014980743","https://openalex.org/W3016489853","https://openalex.org/W3016661132","https://openalex.org/W3017434281","https://openalex.org/W3020863653","https://openalex.org/W3022285953","https://openalex.org/W3023140107","https://openalex.org/W3029383808","https://openalex.org/W3030573714","https://openalex.org/W3037899818","https://openalex.org/W3042239956","https://openalex.org/W3092286767","https://openalex.org/W3092996142","https://openalex.org/W3097452207","https://openalex.org/W3104639833","https://openalex.org/W3108409372","https://openalex.org/W3112629806","https://openalex.org/W3112902030","https://openalex.org/W3126538466","https://openalex.org/W3126869524","https://openalex.org/W3128447522","https://openalex.org/W3130206057","https://openalex.org/W3135838854","https://openalex.org/W3137841630","https://openalex.org/W3156060652","https://openalex.org/W3160585082","https://openalex.org/W3163006786","https://openalex.org/W3165015648","https://openalex.org/W3170771910","https://openalex.org/W3173341277","https://openalex.org/W3176528055","https://openalex.org/W3182232455","https://openalex.org/W3184172540","https://openalex.org/W3192651086","https://openalex.org/W3194214992","https://openalex.org/W3197448026","https://openalex.org/W3197807723","https://openalex.org/W3198379317","https://openalex.org/W3200628015","https://openalex.org/W3201179075","https://openalex.org/W3208026592","https://openalex.org/W3214297587","https://openalex.org/W4207044800","https://openalex.org/W4212856118","https://openalex.org/W4214904315","https://openalex.org/W4248219898","https://openalex.org/W4280504529","https://openalex.org/W4281552311","https://openalex.org/W4283818255","https://openalex.org/W4287881851","https://openalex.org/W4293455494","https://openalex.org/W4294867779","https://openalex.org/W4295206892","https://openalex.org/W4297089155","https://openalex.org/W4310211240","https://openalex.org/W4311564107","https://openalex.org/W4311695565","https://openalex.org/W4311703170","https://openalex.org/W4311822402"],"related_works":["https://openalex.org/W2263127682","https://openalex.org/W4254573889","https://openalex.org/W2031190723","https://openalex.org/W3012449161","https://openalex.org/W2591446785","https://openalex.org/W2394712659","https://openalex.org/W2804507773","https://openalex.org/W4312660762","https://openalex.org/W3143475610","https://openalex.org/W1582509810"],"abstract_inverted_index":{"An":[0],"alteration":[1],"in":[2,8,83,95],"the":[3,16,33,37,111,126,145],"serum":[4,65,84,96,100,112,122,129,146],"elastase":[5,66,113,147],"1":[6,67,114,148],"level":[7,103,115,149],"a":[9,46],"previously":[10],"non-diabetic":[11],"patient,":[12],"who":[13],"unfortunately":[14],"developed":[15],"hyperosmolar":[17],"hyperglycemic":[18],"non-ketotic":[19],"syndrome":[20],"(HHNS),":[21],"was":[22,87,116],"observed":[23],"after":[24,153],"intravenous":[25],"hyperalimentation":[26],"for":[27],"6":[28],"days.":[29],"The":[30,108],"patient":[31],"underwent":[32],"therapy":[34,134],"because":[35],"of":[36,39,49,51,64,78,110,128,155],"occurrence":[38],"severe":[40],"persistent":[41],"anorexia":[42],"which":[43],"appeared":[44],"as":[45],"side":[47],"effect":[48],"treatment":[50],"lung":[52],"cancer":[53],"with":[54,60,135],"combined":[55],"anticancer":[56],"drugs.":[57],"In":[58],"parallel":[59],"progressive":[61],"dehydration,":[62],"levels":[63],"and":[68,99,125],"urine":[69,142],"glucose":[70],"became":[71],"greatly":[72],"elevated":[73],"at":[74],"an":[75],"earlier":[76],"stage":[77],"HHNS.":[79,107,156],"A":[80],"slight":[81],"increase":[82],"alpha":[85,101,130],"1-antitrypsin":[86],"observed.":[88],"However,":[89],"there":[90],"were":[91],"no":[92],"significant":[93],"changes":[94],"amylase":[97],"activity":[98],"2-macroglobulin":[102],"before":[104],"or":[105],"during":[106],"elevation":[109],"considered":[117],"to":[118,121],"be":[119],"due":[120],"electrolyte":[123],"abnormalities":[124],"defect":[127],"2-macro-globulin":[131],"elevation.":[132],"Rehydration":[133],"half-normal":[136],"saline":[137],"solution":[138],"immediately":[139],"produced":[140],"negative":[141],"glucose,":[143],"but":[144],"only":[150],"gradually":[151],"normalized":[152],"improvement":[154]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
