{"id":"https://openalex.org/W36917484","doi":null,"title":"SV40 T-antigen induces breast cancer formation with a high efficiency in lactating and virgin WAP-SV-T transgenic animals but with a low efficiency in ovariectomized animals.","display_name":"SV40 T-antigen induces breast cancer formation with a high efficiency in lactating and virgin WAP-SV-T transgenic animals but with a low efficiency in ovariectomized animals.","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W36917484","mag":"36917484","pmid":"https://pubmed.ncbi.nlm.nih.gov/8637705"},"language":"en","primary_location":{"id":"pmid:8637705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8637705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Comparative Study"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053618298","display_name":"Roberta Santarelli","orcid":"https://orcid.org/0000-0002-9416-7594","observed_orcids":["https://orcid.org/0000-0002-9416-7594"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Santarelli","raw_affiliation_strings":["Institut f\u00fcr Molekularbiologie und Biochemie, Freien Universit\u00e4t Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Molekularbiologie und Biochemie, Freien Universit\u00e4t Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004558779","display_name":"Yin\u2010Jeh Tzeng","orcid":"https://orcid.org/0000-0001-6767-7452","observed_orcids":["https://orcid.org/0000-0001-6767-7452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y J Tzeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Zimmermann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Zimmermann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029420990","display_name":"Eva Guhl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Guhl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109142872","display_name":"Adolf Graessmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Graessmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"3","first_page":"495","last_page":"505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4595000147819519,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4595000147819519,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.1670999974012375,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.11330000311136246,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sv40-t-antigen","display_name":"SV40 T antigen","score":0.9919999837875366},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7360000014305115},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.847000002861023},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8489999771118164},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/transgene-expression","display_name":"transgene expression","score":0.5580000281333923},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.3889999985694885},{"id":"https://openalex.org/keywords/ovarian-hormones","display_name":"ovarian hormones","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8571703433990479},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5822511911392212},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5756576657295227},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.5601708889007568},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5410398840904236},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.5304170250892639},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5254606008529663},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5129820704460144},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.49150311946868896},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.48917654156684875},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.46030429005622864},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4051021337509155},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38750404119491577},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2822866439819336},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19611123204231262},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18797627091407776},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0521063506603241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05092465877532959},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000952","descriptor_name":"Antigens, Polyomavirus Transforming","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000952","descriptor_name":"Antigens, Polyomavirus Transforming","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8637705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8637705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Comparative Study"},{"id":"pmh:oai:iris.uniroma1.it:11573/247930","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1996TV59700005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:36917484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8637705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1986734481","https://openalex.org/W2004778872","https://openalex.org/W2033002423","https://openalex.org/W2083987900","https://openalex.org/W2155411553","https://openalex.org/W2166091513","https://openalex.org/W2297270956","https://openalex.org/W2429180991","https://openalex.org/W2548799346","https://openalex.org/W2559813426","https://openalex.org/W2588149348","https://openalex.org/W2610602137","https://openalex.org/W2890405230","https://openalex.org/W2896017321","https://openalex.org/W2948738336","https://openalex.org/W3045320869","https://openalex.org/W3083953786","https://openalex.org/W3087157762","https://openalex.org/W3087672497","https://openalex.org/W4220946720","https://openalex.org/W6911044421"],"related_works":["https://openalex.org/W2413202266","https://openalex.org/W1517351216","https://openalex.org/W2045598991","https://openalex.org/W2332205007","https://openalex.org/W2326062076","https://openalex.org/W2913850678","https://openalex.org/W2136928694","https://openalex.org/W2242012428","https://openalex.org/W2051591827","https://openalex.org/W1671211416"],"abstract_inverted_index":{"The":[0,49,156],"whey":[1],"acid":[2],"protein":[3,10],"(WAP)":[4],"is":[5,15],"a":[6,57,105,141,172],"major":[7],"mouse":[8],"milk":[9],"and":[11,82,94,101,123,144],"its":[12],"gene":[13,125],"expression":[14,63,84,116,126],"induced":[16],"by":[17,88],"various":[18],"lactotrophic":[19],"hormones":[20,170],"(eg,":[21],"estrogen,":[22],"progesterone).":[23],"Transgenic":[24],"animals":[25,135,149],"harboring":[26],"the":[27,34,38,45,53,67,74,99,118,131,168],"early":[28],"SV40":[29,54],"coding":[30],"region":[31],"(T/t-antigen)":[32],"under":[33],"transcriptional":[35],"control":[36],"of":[37,73,117,147],"WAP":[39,122],"promoter":[40],"develop":[41],"breast":[42,154,176],"cancer":[43,177],"after":[44,66],"first":[46],"lactation":[47,68],"period.":[48,69,133],"tumor":[50,80,96,157],"cells":[51,97],"synthesize":[52],"T-antigen":[55,77,92,152],"with":[56,140],"high":[58],"efficiency":[59,143],"indicating":[60,108,166],"that":[61,109,167],"WAP-SV-T":[62,83,119,124],"escapes":[64],"down-regulation":[65],"However":[70],"about":[71,145],"5-10%":[72],"tumors":[75],"became":[76],"negative":[78,95],"during":[79],"progression":[81],"was":[85,160],"only":[86],"demonstrable":[87],"PCR":[89],"analysis.":[90],"Both":[91],"positive":[93,153],"expressed":[98],"estrogen":[100],"progesterone":[102],"receptor":[103,111],"at":[104],"comparable":[106],"rate,":[107],"hormone":[110],"levels":[112],"do":[113],"not":[114,128],"determine":[115],"transgene.":[120],"Furthermore,":[121],"are":[127],"restricted":[129],"to":[130],"pregnancy-lactation":[132],"Virgin":[134],"also":[136,150],"express":[137],"both":[138],"genes":[139],"low":[142],"70%":[146],"these":[148],"developed":[151],"tumors.":[155],"rate":[158],"however":[159],"strongly":[161],"reduced":[162],"in":[163,175],"ovariectomized":[164],"animals,":[165],"ovary":[169],"play":[171],"critical":[173],"role":[174],"formation.":[178]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
