{"id":"https://openalex.org/W36716614","doi":null,"title":"Improvement of physical stability and dissolution rate of celecoxib suspensions by complexation with beta-cyclodextrins.","display_name":"Improvement of physical stability and dissolution rate of celecoxib suspensions by complexation with beta-cyclodextrins.","publication_year":2004,"publication_date":"2004-08-01","ids":{"openalex":"https://openalex.org/W36716614","mag":"36716614","pmid":"https://pubmed.ncbi.nlm.nih.gov/15378853"},"language":"en","primary_location":{"id":"pmid:15378853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15378853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Pharmazie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112986298","display_name":"Gorantla Chandra Sekhara Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099853","display_name":"Roland Institute of Pharmaceutical Sciences","ror":"https://ror.org/01vva4430","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210099853"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"G Chandra Sekhara Rao","raw_affiliation_strings":["Pharmaceutics Division, Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa, India. gonuguntac@yahoo.co.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutics Division, Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa, India. gonuguntac@yahoo.co.in","institution_ids":["https://openalex.org/I4210099853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103753104","display_name":"M. Satish Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Satish Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022953255","display_name":"Nirmal Mathivanan","orcid":"https://orcid.org/0000-0002-0959-5894","observed_orcids":["https://orcid.org/0000-0002-0959-5894"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Mathivanan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108554385","display_name":"M.E Bhanoji Rao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Bhanoji Rao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2336,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.45535714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"59","issue":"8","first_page":"627","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/celecoxib","display_name":"celecoxib","score":1.0},{"id":"https://openalex.org/keywords/beta-cyclodextrin","display_name":"\u03b2-cyclodextrin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/inclusion-complexes","display_name":"inclusion complexes","score":0.7730000019073486},{"id":"https://openalex.org/keywords/solid-dispersion","display_name":"solid dispersion","score":0.9279999732971191},{"id":"https://openalex.org/keywords/drug-suspension","display_name":"drug suspension","score":0.7429999709129333},{"id":"https://openalex.org/keywords/physical-stability","display_name":"physical stability","score":0.9490000009536743},{"id":"https://openalex.org/keywords/dissolution-rate","display_name":"dissolution rate","score":0.9440000057220459},{"id":"https://openalex.org/keywords/freeze-thaw-cycles","display_name":"freeze-thaw cycles","score":0.8539999723434448},{"id":"https://openalex.org/keywords/kneading-method","display_name":"kneading method","score":0.9449999928474426},{"id":"https://openalex.org/keywords/slugging","display_name":"slugging","score":0.6499999761581421},{"id":"https://openalex.org/keywords/carboxymethyl-cellulose","display_name":"carboxymethyl cellulose","score":0.972000002861023},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.7279999852180481},{"id":"https://openalex.org/keywords/sedimentation-volume","display_name":"sedimentation volume","score":0.8050000071525574},{"id":"https://openalex.org/keywords/redispersibility","display_name":"redispersibility","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.8578182458877563},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.6850394010543823},{"id":"https://openalex.org/C2776467144","wikidata":"https://www.wikidata.org/wiki/Q408801","display_name":"Celecoxib","level":2,"score":0.6138470768928528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6051734685897827},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5417429208755493},{"id":"https://openalex.org/C105341887","wikidata":"https://www.wikidata.org/wiki/Q1307987","display_name":"Suspension (topology)","level":3,"score":0.5182085633277893},{"id":"https://openalex.org/C127172972","wikidata":"https://www.wikidata.org/wiki/Q128709","display_name":"Viscosity","level":2,"score":0.47140267491340637},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.46903643012046814},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.44773995876312256},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.31324636936187744},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1975668966770172},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.07922622561454773},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.06969073414802551},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.057851821184158325},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.056352704763412476},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C5961521","wikidata":"https://www.wikidata.org/wiki/Q746083","display_name":"Homotopy","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000068579","descriptor_name":"Celecoxib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002498","descriptor_name":"Centrifugation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003505","descriptor_name":"Cyclodextrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013535","descriptor_name":"Suspensions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:15378853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15378853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Pharmazie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047698253","https://openalex.org/W1997239598","https://openalex.org/W2014881131","https://openalex.org/W2027948774","https://openalex.org/W2113118463","https://openalex.org/W2414049641","https://openalex.org/W3183873603","https://openalex.org/W4391610270","https://openalex.org/W2182803788","https://openalex.org/W2803770713"],"abstract_inverted_index":{"Solid":[0],"dispersions":[1,34,79,100],"of":[2,124],"celecoxib":[3,93],"with":[4,35,92,120],"beta-cyclodextrins":[5],"were":[6,29,44,56],"prepared":[7,97],"by":[8,23,46,102],"physical":[9,82,126],"mixing,":[10],"slugging":[11],"and":[12,17,21,65,69,84,113,128],"kneading":[13,104],"methods":[14],"at":[15],"1:1":[16],"1:2":[18],"molar":[19],"ratios":[20],"characterized":[22],"differential":[24],"scanning":[25],"calorimetry.":[26],"Celecoxib":[27,73,115],"suspensions":[28,50,55,74,123],"formulated":[30,75,91],"employing":[31,76],"its":[32,77],"solid":[33,78,99],"sodium":[36],"carboxymethylcellulose":[37],"as":[38],"the":[39,49,103,107,117],"suspending":[40],"agent.":[41],"Stability":[42],"studies":[43],"conducted":[45],"subjecting":[47],"all":[48],"to":[51],"freeze-thaw":[52],"cycling.":[53],"The":[54,95],"evaluated":[57],"for":[58],"particle":[59],"size,":[60],"sedimentation":[61],"volume,":[62],"viscosity,":[63],"redispersibility":[64],"dissolution":[66,87,111,129],"rate":[67,112],"initially":[68],"after":[70],"stability":[71,83,127],"testing.":[72],"exhibited":[80],"good":[81],"gave":[85,106],"higher":[86],"rates":[88],"than":[89],"those":[90],"alone.":[94],"suspension":[96],"from":[98],"(1:2)":[101],"method":[105],"highest":[108],"improvement":[109],"in":[110,116],"efficiency.":[114],"inclusion":[118],"complex":[119],"beta-cyclodextrin":[121],"produced":[122],"better":[125],"rate.":[130]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}