{"id":"https://openalex.org/W3668025","doi":null,"title":"A suspension model for hypokinetic/hypodynamic and antiorthostatic responses in the mouse.","display_name":"A suspension model for hypokinetic/hypodynamic and antiorthostatic responses in the mouse.","publication_year":1984,"publication_date":"1984-07-01","ids":{"openalex":"https://openalex.org/W3668025","mag":"3668025","pmid":"https://pubmed.ncbi.nlm.nih.gov/6466257"},"language":"en","primary_location":{"id":"pmid:6466257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6466257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113586694","display_name":"Joseph M. Steffen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Steffen","raw_affiliation_strings":["Louisville, University KY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisville, University KY, United States","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R Robb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Robb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065226779","display_name":"M. J. Dombrowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Dombrowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110121848","display_name":"X. J. Musacchia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X J Musacchia","raw_affiliation_strings":["Louisville Univ. Louisville, KY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisville Univ. Louisville, KY, United States","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109203539","display_name":"Adrian D. Mandel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280536761","display_name":"Ames Research Center","ror":"https://ror.org/02acart68","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280536761","https://openalex.org/I4210124779"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A D Mandel","raw_affiliation_strings":["NASA Ames Research Center Moffett Field, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NASA Ames Research Center Moffett Field, CA, United States","institution_ids":["https://openalex.org/I1280536761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014094376","display_name":"Gerald Sonnenfeld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Sonnenfeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.0003635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"55","issue":"7","first_page":"612","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/suspension-model","display_name":"suspension model","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hypokinesia","display_name":"hypokinesia","score":0.7250000238418579},{"id":"https://openalex.org/keywords/hypodynamia","display_name":"hypodynamia","score":0.8849999904632568},{"id":"https://openalex.org/keywords/simulated-microgravity","display_name":"simulated microgravity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/bed-rest","display_name":"bed rest","score":0.699999988079071},{"id":"https://openalex.org/keywords/hindlimb-unloading","display_name":"hindlimb unloading","score":0.8339999914169312},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.8149999976158142},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.8820000290870667},{"id":"https://openalex.org/keywords/diuresis","display_name":"diuresis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.8569999933242798},{"id":"https://openalex.org/keywords/urinary-potassium-excretion","display_name":"potassium excretion","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5249999761581421},{"id":"https://openalex.org/keywords/rat-comparison","display_name":"rat comparison","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2775880387","wikidata":"https://www.wikidata.org/wiki/Q1036662","display_name":"Hypokinesia","level":2,"score":0.9647247791290283},{"id":"https://openalex.org/C2780011235","wikidata":"https://www.wikidata.org/wiki/Q3192210","display_name":"Kaliuresis","level":4,"score":0.9299191236495972},{"id":"https://openalex.org/C37752432","wikidata":"https://www.wikidata.org/wiki/Q4299309","display_name":"Weightlessness","level":2,"score":0.6092133522033691},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.5774832367897034},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5591678023338318},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5451133251190186},{"id":"https://openalex.org/C105341887","wikidata":"https://www.wikidata.org/wiki/Q1307987","display_name":"Suspension (topology)","level":3,"score":0.5362666845321655},{"id":"https://openalex.org/C2779547328","wikidata":"https://www.wikidata.org/wiki/Q584691","display_name":"Diuresis","level":3,"score":0.5186213850975037},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.5160012245178223},{"id":"https://openalex.org/C174459258","wikidata":"https://www.wikidata.org/wiki/Q6980232","display_name":"Natriuresis","level":3,"score":0.4758691191673279},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.46618741750717163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46328917145729065},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.410087525844574},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.3840750455856323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29122984409332275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2580815851688385},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.11572608351707458},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C5961521","wikidata":"https://www.wikidata.org/wiki/Q746083","display_name":"Homotopy","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000641","descriptor_name":"Ammonia","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001510","descriptor_name":"Bed Rest","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004231","descriptor_name":"Diuresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004326","descriptor_name":"Drinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6466257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6466257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},{"id":"mag:3668025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6466257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W138728364","https://openalex.org/W2414257184"],"related_works":["https://openalex.org/W854381178","https://openalex.org/W800023145","https://openalex.org/W2161392476","https://openalex.org/W582523768","https://openalex.org/W780317722","https://openalex.org/W856233817","https://openalex.org/W2078390743","https://openalex.org/W806160171","https://openalex.org/W2032487893","https://openalex.org/W43546210"],"abstract_inverted_index":{"Hypokinetic/hypodynamic":[0],"and":[1,6,28,47,50,79,103,108,134,139,147,160,174],"antiorthostatic":[2,26],"responses":[3,131,144],"to":[4,30,57,132,149],"weightlessness":[5,173],"bedrest":[7],"were":[8,17,87,110],"simulated":[9],"in":[10,24,54,73,83,113,136,142,168],"mice":[11,43,146],"using":[12],"a":[13,58],"suspension":[14,68,158],"technique.":[15],"Animals":[16],"suspended":[18,74,85,114],"for":[19,63],"1":[20],"or":[21],"2":[22],"weeks":[23],"an":[25],"posture":[27],"positioned":[29],"permit":[31],"freedom":[32],"of":[33,66,106,145,156],"movement":[34],"but":[35,76],"eliminate":[36],"load":[37],"bearing":[38],"by":[39],"the":[40,64,67,77,84,121,137,143,154,157,163],"hindlimbs.":[41],"Suspended":[42],"exhibited":[44],"reduced":[45],"food":[46],"water":[48],"intakes":[49],"rapid":[51],"10%":[52],"decrease":[53],"body":[55],"weight":[56],"level":[59],"which":[60],"was":[61,71,124],"maintained":[62],"remainder":[65],"period.":[69],"Diuresis":[70],"evident":[72],"mice,":[75],"natriuresis":[78],"kaliuresis":[80],"previously":[81],"observed":[82],"rat":[86],"not":[88],"evident.":[89],"Differential":[90],"hindlimb":[91],"muscle":[92],"atrophy":[93],"(soleus":[94],"greater":[95,100],"than":[96,101],"plantaris":[97],"=":[98],"gastrocnemius":[99],"EDL)":[102],"increased":[104],"excretion":[105],"urea":[107],"ammonia":[109],"also":[111],"noted":[112],"mice.":[115],"Postsuspension":[116],"recovery":[117,122],"studies":[118,152,170],"indicated":[119],"that":[120,162],"process":[123],"highly":[125],"effective.":[126],"These":[127,151],"results":[128],"document":[129],"specific":[130],"hypokinesia/hypodynamia":[133],"antiorthostasis":[135],"mouse":[138,164],"demonstrate":[140],"similarities":[141],"rats":[148],"suspension.":[150],"expand":[153],"utility":[155],"model":[159],"suggest":[161],"may":[165],"be":[166],"useful":[167],"future":[169],"simulating":[171],"both":[172],"bedrest.":[175]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
